From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody by Shuyuan Cao, Bo Sun, Feng Gao, Feng Gao, Feng Gao

“…This study uses molecular dynamics (MD) simulations to analyze the immune evasion mechanisms of class 1 nanobodies against emerging SARS-CoV-2 variants, and to develop an efficient in silico pipeline for rapid affinity optimization.MethodsWe employed MD simulations and binding free energy calculations to investigate the immune evasion mechanisms of four class 1 nanobodies (R14, DL4, VH ab6, and Nanosota9) against wild-type (WT) and Omicron variants, including BA.2, JN.1, and KP.3/XEC. …”
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Eksplorasi Bahan Aktif Rumput Laut Coklat (Phaeophyceae) sebagai Biolarvasida Aedes aegypti <br><i>[Exploration of Brown Seaweed (Phaeophyceae) Active Subtance as Aedes aegypti Bi... by Moch. Amin Alamsjah, Ike Nur Firdhayani, Sri Subekti

“…The research methods is experimental with 50% Ae. aegypti larvae mortality (LC50 ) or probit analyzis. …”
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Parametric optimization of aloe vera coagulant for nitrate removal from textile wastewater using response surface methodology (RSM) by Lukman Shehu Mustapha, Kehinde Shola Obayomi

“…This objective was to use response surface methods to optimize operating parameters on the removal efficiency of nitrate removal through the application of response surface methodology (RSM). …”
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Research Progress on Development of PVP-Ag-Doped LaMnO₃ Composites for Methyl Orange Degradation by Adina Căta, Madalina-Gabriela Ivanovici, Paula Svera, Ioana Maria Carmen Ienașcu, Paula Sfirloaga

“…Water pollution caused by emerging contaminants is increasing due to rising urbanization, industrialization, and agriculture production; therefore, new materials with high efficiency for wastewater decontamination are needed. …”
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Improvement of End-of-Synthesis Radiochemical Purity of ¹⁷⁷Lu-DOTA-PSMA-Ligands with Alternative Synthesis Approaches: Conversion Upswing and Side-Products Minimization by Anton Larenkov, Iurii Mitrofanov, Marat Rakhimov

“…The joint improvement of analytical methods capable of identifying related radiochemical impurities and determining the actual radiochemical purity, as well as the improvement of synthesis methods to minimize the formation of possible radiochemical impurities, is integral to the implementation of high-tech nuclear medicine procedures. …”
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Effect of different light qualities on photosynthetic characteristics and fruit quality of Shine Muscat grapevines grown under rain-sheltered cultivation by GONG Xiaomin, YU Guanghui, LI Xiujie, WANG Rong, CHEN Guangxia, WU Yusen, WU Xinying, ZHANG Zhichang, LI Bo, MA Yujiao

“…Under grape facility cultivation, particularly with rain-shelter systems, insufficient light frequently constrains photosynthetic efficiency and reproductive development. To address this limitation, spectral-modulated supplementary lighting emerges as a promising agronomic intervention. …”
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Automated Line for Post-Harvest Processing of Root Crops and Potatoes by A. S. Dorokhov, M. A. Mosyakov, N. V. Sazonov

“…They developed approaches and basic technical, technological and constructive solutions aimed at improving the efficiency of root crops and potatoes post-harvest processing. …”
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The function and significance of SELENBP1 downregulation in human bronchial epithelial carcinogenic process. by Gu-Qing Zeng, Hong Yi, Peng-Fei Zhang, Xin-Hui Li, Rong Hu, Mao-Yu Li, Cui Li, Jia-Quan Qu, Xingming Deng, Zhi-Qiang Xiao

“…However, there is little information on expression and function of SELENBP1 during human lung squamous cell cancer (LSCC) carcinogenesis.<h4>Methods</h4>iTRAQ-tagging combined with 2D LC-MS/MS analysis was used to identify differentially expressed proteins in the human bronchial epithelial carcinogenic process. …”
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A Rechtsgutstheorie Lens on the Legal Aspects of the States’ Cyber Interest Concept by Y. A. Abdelkarim

“…Objective: to show the evolution of the state interests concept and its application in cyberspace, where it turns out to be fundamental for the development of state military policy aimed at protecting national interests.Methods: the research is based on the intersection of the theory of law and the concept of cyber interests of the state through the prism of the theory of legitimate interests (Rechtsgutstheorie). …”
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An Engineering Model of a Knife Roller for Thinning Forest Crops by Leonid D. Bukhtoyarov, Sergey V. Malyukov, Mikhail N. Lysych

“…A review of modeling methods has shown that the most widely used approaches today are those based on numerical calculations. …”
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Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein. by Brian T Grimberg, Rachanee Udomsangpetch, Jia Xainli, Amy McHenry, Tasanee Panichakul, Jetsumon Sattabongkot, Liwang Cui, Moses Bockarie, Chetan Chitnis, John Adams, Peter A Zimmerman, Christopher L King

“…<h4>Conclusions</h4>These results show, for what we believe to be the first time, that both rabbit and human antibodies directed against PvDBPII reduce invasion efficiency of wild P. vivax isolated from infected patients, and suggest that a PvDBP-based vaccine may reduce human blood-stage P. vivax infection.…”
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Ways to Reduce In-Hospital Mortality in Patients with Cardiogenic Shock in Acute Coronary Syndrome by G. V. Artamonova, V. Yu. Kheraskov, E. V. Grigoryev, O. V. Kushch, D. V. Kryuchkov, L. S. Barbarash

“…In the examined period, the introduction of innovation clinical and organizational approaches provided a reduction in this indicator by 17.6 and 37.5%, respectively. Conclusion. The efficiency of risk management for CS and its poor outcomes in patients with ACS is determined by the unique principles of medical care rendering at all levels on the basis of risk management methodology.…”
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English-language training at a maritime university as a mandatory condition for the successful professional activity of a deck officer by Regina Vladislavovna Drazhan

“…The research methods used are analysis, synthesis, generalization. …”
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Evaluation of interferon β-1b therapy effects on the level and abnormal nature of immunoglobulin G in patients with multiple sclerosis by K. M. Hychka, M. O. Boichuk, T. I. Dumych, S. Yа. Paryzhak, R. O. Bilyi, T. I. Nehrych

“…Aim: to study and evaluate the interferon β-1b (INF) therapy efficiency on the level and abnormal nature of immunoglobulin G in patients with multiple sclerosis (MS). …”
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Modeling the Rating system of Export-Oriented Companies in the Agro-Industrial Complex of the Russian Federation. subsidy Mechanism by E. G. Semyashkin, A. M. Karminsky

“…The authors propose a combined mechanism for supporting enterprises, depending on the rating determined by the model. It is concluded that the implementation of this approach will significantly increase the level of economic efficiency of budget support funds aimed at stimulating exports. …”
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Power Plant for a 0.6­0.8 Class Mobile Vehicle Based on the T­16 Self­Propelled Tractor Chassis by V. A. Gusarov

“…(Research purpose) To develop and study a new kinematic scheme of a mobile vehicle based on a self-propelled tractor T-16 chassis, which provides increased reliability, comfortable working conditions for the operator, a significant improvement in the environmental situation, and better economic efficiency. (Materials and methods) The authors listed the advantages of the new hybrid vehicle kinematic scheme. …”
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Diagnostic value of thromboelastogram and thrombus molecular markers in early detection of deep vein thrombosis in patients with lower extremity fracture by E. Jianfei, Mao Zheng, Wei Wei, Shaoping He, Chengliang Yuan, Zongyao Chen

“…The aim of this study was to identify independent risk factors for deep vein thrombosis (DVT) in patients with traumatic lower extremity fractures and assess the diagnostic value of thromboelastogram (TEG) and thrombus molecular markers. Methods Reviewed patients with lower extremity fractures were admitted from October 2022 to September 2023. …”
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Innovating health prevention models in detecting infectious disease outbreaks through social media data: an umbrella review of the evidence by Monica Giancotti, Milena Lopreite, Marianna Mauro, Michelangelo Puliga

“…The quality of the included reviews was determined using A Measurement Tool to Assess Systematic Reviews 2.ResultsSynthesis included 32 systematic reviews and 3,704 primary studies that investigated how the social media listening could improve the healthcare system’s efficiency in terms of a timely response to treat epidemic situations. …”
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DEVELOPMENT OF THE STATE SUPPORT FORMS PROJECTS IN INDUSTRIAL BUILDING by I. M. Meilanov, A. M. Esetova

“…It is stipulated that state investment policy in industrial building mechanism oriented to define rational investment volumes and their branch, reproductive, technological and territorial structure; option of the building branch development priority; increase of the investment projects efficiency realization. The dynamics of the state support in the form of subsidies and budget investments into creation of the industrial building objects is analytically summarized. …”
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Evapotranspiration-Based Irrigation Management Effects on Yield and Water Productivity of Summer Cauliflower on the California Central Coast by Michael Cahn, Lee Johnson, Sharon Benzen

“…Evapotranspiration (ET)-based methods can inform crop water requirements and boost irrigation efficiency, but in practice, they can be challenging for farmers to implement, especially in vegetable systems. …”
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