Strategy for prophylactic application of peripheral va-ecmo in transplantation involving expected extremely prolonged ischemia time by V. N. Poptsov, V. M. Zakharevich, E. A. Spirina, A. I. Skokova, A. K. Solodovnikova, A. S. Ignatkina, A. A. Kuznetsova, G. B. Glinkin

“…Materials and methods. Thirty-eight recipients (33 (86.8%) males and 5 (13.2%) females), age 11–66 (44.7 ± 12.0) years (median 48.0 years) were examined. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…To provide detailed understanding of parent and health professionals’ attitudes to, and experiences of, participating in the BATCH RCT. Methods A pragmatic, multicentre, open-label, parallel two-arm, individually RCT conducted in 15 hospitals in the UK. …”
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Freehand ventricular catheter placement in ventriculoperitoneal shunt surgery is associated with higher rates of proximal catheter failure compared to image guidance by Nikhil Sharma, Jeffery R. Head, Regan M. Shanahan, Shovan Bhatia, Michael R. Kann, Sydney Scanlon, Amogh Vellore, Michael Raver, Hussam Abou-Al-Shaar, Nicolas M. Kass, Fritz Steuer, Lucille Cheng, Stephen P. Canton, Arka N. Mallela, Peter C. Gerszten, Edward G. Andrews

“…Methods: We conducted a retrospective review of all consecutive adult VPS procedures performed at a single hospital during a two-year period. …”
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Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis by Aznamariam Ayres, Yawkal Tsega, Abel Endawkie, Shimels Derso Kebede, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Amare Muche, Fekade Demeke Bayou, Mastewal Arefaynie, Asnakew Molla Mekonen, Abiyu Abadi Tareke, Awoke Keleb, Kaleab Mesfin Abera, Natnael Kebede, Endalkachew Mesfin Gebeyehu

“…To appreciate the residence-based differences of composite index of anthropometric failure in under-5 children, the Blinder-Oaxaca decomposition analysis and its extensions were employed to determine the effects of covariates and coefficients. …”
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Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: A meta-analysis by Fatemeh Sedghi, Elaheh Foroughi, Farzad Sheikhzadeh, Mahya Ahmadpour Youshanlui, Ata Akhtari Kohnehshahri, Omid Karimzadeh, Sayedeh-Fatemeh Sadat-Madani, Hani Ghadri, Peyman Parhiz, Amirhesam Amirbeyk, Shaghayegh Afshari, Yegane Ebrahimnia, Mahsa Soleimanzadeh, Mahsa Asadi Anar, Parviz Aghaei Borzabad, Niloofar Deravi

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La gestion de l’eau à Bibracte (Saône-et-Loire), avant et après la Conquête romaine by Laetitia Borau

“…Thanks to the present study it can be assumed that in Bibracte there were specific construction methods used for the hydraulic structures corresponding to local, i.e. …”
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Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice by Xuemeng Mu, Xinyi Du, Huitian Han, Fei Liu, Zhifa Zheng, Jing Hao, Lijin Liu, Su Liu, Ze Wei, Changfa Huang, Annan Liang, Wei Zou, Lina Zhao, Zhihong Wu, Jia Zhang

“…This study explores the potential of LNPs as an effective delivery system to treat osteoporosis. <b>Methods</b>: LNPs were prepared using microfluidic techniques with varying lipid compositions, and characterized in terms of size, zeta potential, and entrapment efficiency (EE%). …”
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Phase I-IIa clinical trial to evaluate the safety, feasibility and efficacy of the use of a palate mucosa generated by tissue engineering for the treatment of children with cleft p... by Ingrid Garzón, Antonio Campos, Miguel Alaminos, Gloria Carmona, Antonio España-López, Ricardo Fernández-Valadés, Elisa Cubiles, Miguel Angel Martin-Piedra, Víctor Carriel, Fernando Campos, Adoración Martínez-Plaza, Daniel Vallejo, Esther Liceras-Liceras, Jesús Chato-Astrain, Oscar Dario García-García, David Sánchez-Porras, Paula Ávila-Fernández, Miguel Etayo-Escanilla, Blanca Quijano, Elisabet Aguilar

“…This trial aims to evaluate the potential of a bioengineered artificial palate mucosa, created through tissue engineering with autologous stromal and epithelial cells and nanostructured fibrin–agarose biomaterials, to enhance treatment outcomes for patients with unilateral cleft lip and palate.Methods and analysis This phase I-IIa clinical trial aims to evaluate the feasibility and biosafety of a procedure involving grafting bioartificial palate mucosa onto the areas of denudated bone in patients undergoing uranostaphylorrhaphy. …”
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Organizational Culture and Stock Price Crash Risk by Gholamreza Kordestani, Ramin Eskandari, Mahdi Shams

“…For this research, financial data from companies were collected and analyzed using panel data analysis and multivariate regression methods. The tests include descriptive statistics of the variables, and to determine the degree of relationship between the research variables, multivariate regression coefficients were employed. …”
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Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes by Edwin De Jesus Lopez Gonzalez, SWT Lai, Kelani Sun, Caree R. Carson, Carlos Hernandez-Castillo, Tala Zoukari, Kassandra Lopez, Jianying Zhang, Thomas Blevins, John Termini, Sarah C. Shuck

“…Methods: We employed liquid chromatography-tandem mass spectrometry (LC-MS/MS), nuclear magnetic resonance (NMR), and other spectroscopic techniques to characterize MG-induced RNA adducts formed in vitro and in biological samples. …”
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Centrifugation versus filtration-based cell salvage: impact on perioperative bleeding in cardiac surgery—the COLTRANE randomised clinical trial – study protocol by Christine Mouton, Nicolas Nesseler, Antoine Bénard, Mathieu Pernot, Alexandre Ouattara, Antoine Beurton, Alexandre Mansour, Victor-emmanuel Brett, Corinne Batsale, Anais Aitgougam, Anais Cordon, Aurelie Fresselinat, Geraldine Robert, Julien Imbault

“…The main objective is to determine whether the filtration-based SAME device reduces significant perioperative bleeding compared with the centrifugation-based system in high-risk cardiac surgery patients.Methods and analysis The Centrifugation-based vs filtration-based intraOperative cell saLvage on qualiTy of peRioperAtive haemostasis iN cardiac surgEry (COLTRANE) trial is a multicentre, parallel-group, single-blinded, superiority-randomised clinical trial. …”
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Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients by Nermine Laaboub, Setareh Ranjbar, Séverine Crettol, Nicolas Ansermot, Frederik Vandenberghe, Carole Grandjean, Marianna Piras, Julien Elowe, Martin Preisig, Armin Von Gunten, Philippe Conus, Chin Bin Eap

“…We aimed to investigate associations between metabolic disturbances and LOS in a psychiatric hospital and to identify other clinical and sociodemographic LOS predictors. Methods Patients admitted to one of the units of the general psychiatric or psychogeriatric departments between January 1, 2007 and December 31, 2020, were included. …”
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Spectrum of mutations and their phenotypic manifestations in children and adults with long QT syndrome by N. N. Chakova, S. M. Komissarova, E. A. Zasim, T. V. Dolmatovich, E. S. Rebeko, S. S. Niyazova, E. V. Zaklyazminskaya, L. I. Plashchinskaya, M. V. Dudko

“…Aim. To determine the spectrum of mutations in the genes responsible for the long QT syndrome (LQTS) and study their phenotypic manifestations in patients with LQTS in different age groups.Materials and methods. …”
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The Diagnostic Value of Serum Gastrin-17 and Pepsinogen for Gastric Cancer Screening in Eastern China by Hongzhang Shen, Kangwei Xiong, Xiangyu Wu, Sile Cheng, Qifeng Lou, Hangbin Jin, Xiaofeng Zhang

“…Methods. The serum concentrations of G-17 and pepsinogen I and II (PGI and PGII) in 834 patients were analyzed, and the PGI/PGII ratio (PGR) was calculated. …”
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Effects of autolytical fish protein hydrolysate on growth performance, survival rate, and hematological indices in farmed juvenile beluga, Huso huso by Ali Hosseinpour Zelaty

“…They have been found to enhance fish growth, feed efficiency, immune responses, and disease resistance. …”
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Experiment of double grits scribing 2D SiCf/SiC composite by Jinzhu GUO, Yao LIU, Youzhe WANG, Dong WANG

“…ObjectivesTo improve the grinding quality and efficiency, reveal the material removal mechanism of SiCf/SiC composites, and determine the coupling effect among abrasives during grinding.MethodsFirstly, uniaxial tensile, shearing, and bending experiments of SiC fiber bundles are conducted to observe damage modes. …”
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THE FIRST RUSSIAN STRATEGIC STUDY OF PHARMACOTHERAPY FOR RHEUMATOID ARTHRITIS (REMARCA TRIAL): RESULTS OF 12-MONTH TREATMENT IN 130 PATIENTS by D. E. Karatee, E. L. Luchikhina, N. V. Demidova, G. S. Gridneva, M. A. Kanonirova, Yu. V. Muravyev, G. V. Lukina, Yu. A. Olyunin, K. A. Kasumova, E. N. Aleksandrova, A. A. Novikov, A. A. Avdeeva, T. V. Popkova, D. S. Novikova, A. V. Smirnov, A. V. Volkov, E. L. Nasonov

“…To introduce treat-to-target recommendations is an important task of modern rheumatology; however, there is still a diversity of serious problems relating to a scientific rationale and a clinical one for this strategy and to the possibilitiesof its implementation in real clinical practice, in the rheumatology service of the Russian Federation in particular, by taking into account the specific features of funding for high-tech medical care.Objective: to determine the efficiency and safety of combined therapy with subcutaneous methotrexate (MT) and biological agents (BA) when using the treat-to-target strategy in patients with active early and extended-stage rheumatoid arthritis (RA) who have risk factors for a poor prognosis.Subjects and methods. …”
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Dynamics of T cell subpopulation in patients with aplastic anemia during immunosuppressive therapy by A. V. Abramova, E. A. Mikhailova, I. V. Galtseva, Z. T. Fidarova, A. V. Luchkin, N. M. Kapranov, Yu. O. Davydova, S. M. Kulikov, V. V. Troitskaya, E. N. Parovichnikova

“…To investigate the T cells subpopulation in bone marrow of AA patients during IST.Materials and methods. The study included 41 patients over 18 years of age with newly diagnosed acquired AA without previous IST. …”
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CYP2C9 Polymorphism Study in Patients with Acute Back Pain and its Impact on the Effectiveness of Treatment with the Non-Steroidal Anti-Inflammatory Drugs by Maslova I., Mykhailovska N., Slobodin T.

“…All patients underwent a genetic test – the determination of the allelic variants CYP2C9*2 and CYP2C9*3 CYP2C9 gene with polymerase chain reaction (PCR). …”
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Patient-informed outpatient intervention to improve pregnancy outcomes through connections to social services: protocol for the BETTER randomised controlled trial by William A Grobman, Laura J Rush, Ann Scheck McAlearney, Anna Bartholomew, Timothy R Huerta, Sarah R MacEwan, Nicole R Thomas, Lindsey N Sova, Leah Roth, Kaprea F Johnson

“…The Better Birth Outcomes Through Technology, Education and Reporting (BETTER) intervention attempts to account for these barriers by encouraging patients to address social needs through motivational interviewing and by sending recurring text messages that provide links to multiple kinds of social service resources.Methods and analysis We will use a two-arm randomised controlled trial to evaluate the effects of providing patients with a motivational interviewing session and text messages with links to multiple resources to address their social needs compared with patients receiving usual care. …”
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