Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response by Maja Đanić, Nebojša Pavlović, Natalija Dedić, Dragana Zaklan, Slavica Lazarević, Bojan Stanimirov, Momir Mikov

“…In silico analysis suggested that azathioprine absorption may involve intestinal transport proteins, including P-gp, and that DC, as a P-gp inhibitor, could additionally affect its absorption and bioavailability through this mechanism.ConclusionThe findings indicate significant interactions between probiotic bacteria, DC, and azathioprine that may affect azathioprine absorption. Since the PAMPA method is exclusively suited for evaluating passive transport, additional in vitro and in vivo studies are required to further investigate the interactions of azathioprine with intestinal bacteria and bile acids, ultimately determining their impact on intestinal absorption and bioavailability.…”
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Error disclosure: what residents say and what patients find effective by Emily Grossniklaus, Angelo D'Addario, Ann King, Thomas H. Gallagher, Kathleen Mazor, Andrew A. White

“…The Video-based Communication Assessment (VCA) software enables trainees to receive feedback on their error disclosure communication skills. The VCA method also allows examination of the specific types of error disclosure responses that patients value most.ObjectiveThe primary aim of this study was to describe the language medical residents use to disclose a hypothetical harmful medical error, and to determine the language associated with higher ratings by crowdsourced laypeople. …”
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Frequency Characteristics of the Electrical Fields of the Cylindrical System of the Piezoceramic Radiators with the Baffle in the Inner Cavity by A.G. Leiko, Y.I. Starovoit

“…Analysis of the results of the numerical experiments allow us to determine some special features in the electrical fields, that influence on the energetical efficiency of the radiating systems. …”
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Genetic analysis of fruit traits and bacterial canker resistance in hybrid offspring of Actinidia rufa × Actinidia chinensis by ZHENG Li, XIA Wenjuan, QIU Shouzhe, LIU Zhixin, YANG Shuo, XU Shengwu, SHI Shisheng, FANG Jinbao, SUN Leiming

“…[Objective] This study aimed to breed new kiwifruit varieties with strong resistance to bacterial canker disease through hybridization between Actinidia rufa (Siebold and Zuccarini) Planchon ex Miquel and Actinidia chinensis var. chinensis C. F. Liang. [Methods] A. rufa 5-10, characterized by small fruit size but strong tolerance to bacterial canker, was selected as the female parent, while A. chinensis var. chinensis 2-41, known for the yellow flesh and average fruit mass of approximately 80 g for its sister line, served as the male parent. …”
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EVALUATION OF PERSONNEL PERFORMANCE WITHIN A COMPANY’S HR DEPARTMENT by Nicoleta ISAC, Waqar BADSHAH

“…The objective of the paper is to carry out an assessment of the staff of the HR department and the method chosen for determining the results is that of the questionnaire.…”
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Pengaruh Total Quality Management pada Sistem Pengukuran Kinerja Terhadap Pengembangan Produk dan Efisiensi Biaya: Studi Kasus pada PT Bintang Alam Semesta by Meyliana -, Agus Yoan Renata

“…Performance measurement system include product development and cost efficiency. Samples taken by using purposive sampling method. …”
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Peony diagram modeling for improving the easy disassembly design of mobile electronic products by Junling Huang, Chuangchuang Cui, Wei Jiang, Libin Zhu

“…The findings demonstrate that the proposed method can accurately assess the ease of disassembly of key components during product repair and recycling. …”
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Selection and Verification of the Agitator in the Regeneration Tank by Lv Wei, WANG Shu-ying, LI Gui-hui, LI Jian

“…The regeneration efficiency of sodium ion is low because the regeneration reaction is not enough in the regeneration tankAccording to the data and requirements provided by the factory, combined with the experience of the design of the stirrer and the national standard, two agitators were designed for the regeneration tank, and the values of the two kinds of agitators were used We adopt simulation method to determine the speed distribution within the regeneration pool, turbulence distribution and then verify the success of the design of the mixer.…”
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Status and methodology of publicly available national HIV care continua and 90-90-90 targets: A systematic review. by Reuben Granich, Somya Gupta, Irene Hall, John Aberle-Grasse, Shannon Hader, Jonathan Mermin

“…<h4>Conclusions</h4>Relatively few complete national continua of care are available in the public domain, and there is considerable variation in the methods for determining progress towards the 90-90-90 target. …”
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Convalescent plasma therapy for COVID-19 – Donor selection strategies and establishment of a plasma bank by Mikael Kajova, Tamim Khawaja, Iris Levonen, Jukka-Pekka Pietilä, Jenni Virtanen, Sari H. Pakkanen, Hanna Välimaa, Arttu Nousiainen, Jussi Hepojoki, Tarja Sironen, Antti Vierikko, Jarkko Ihalainen, Olli Vapalahti, Anu Kantele

“…This study details the process of setting up a CP bank, containing high- and low-titre CP for a clinical trial. Study design and methods: We identified 18–65-year-old convalescents with SARS-CoV-2 NAb titres of ≥1:40 in microneutralisation test (MNT). …”
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Deloading Algorithm for Highly Effective Suppressing Locomotive Slip and Slide by LI Jianghong, CHEN Huaguo, HU Zhaowen, XU Li, PENG Huishui

“…Because over deloading would reduce wheel-rail adhesion utilization efficiency, it was important to determine the critical time when deloadding should be stopped. …”
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Modern strategies for study of tumor’s markers in clinical practic by I. B. Zborovskaya

“…Essentially new capacities of clinical oncology are uncovered with the help of modern molecular biology methods that allow to determine structural and functional changes of genes and their products. …”
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Simulations of Microwave Land Surface Emissivity Using FengYun-3D Microwave Radiation Imager Data: A Case in the Tibetan Plateau by Yonghong Liu, Fuzhong Weng, Fei Tang, Rui Li, Yongming Xu, Yang Han, Jun Yang, Qingyang Liu

“…The RF model can effectively simulate the MLSE in the frequency range of 10.65&#x2013;89.0 GHz under all-sky conditions. The coefficients of determination (<italic>R</italic>²) for horizontal polarization and vertical polarization range from 0.86 (10.65 GHz) to 0.91 (18.7 GHz) and from 0.60 (10.65 GHz) to 0.74 (89.0 GHz), respectively. …”
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Real time thermal environment monitoring and interior design of intelligent buildings based on the Internet of Things by Lang Jiaoyu

“…We adopted thermal energy environment evaluation technology, deeply explored the characteristics of indoor thermal energy environment, and evaluated the effectiveness of different evaluation methods. Designed an intelligent building indoor real-time thermal environment monitoring system based on the Internet of Things, constructed the system architecture, and proposed effective indoor monitoring algorithms to determine the monitoring effect of the system through data analysis. …”
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Calculation of Optical Parameters of Thin Films of Structural Materials of Thermal Uncooled Bolometric Type Detector by Van Trieu Tran, K. V. Korsak, P. E. Novikov, I. Yu. Lovshenko, S. M. Zavadski, D. A. Golosov, A. A. Stepanov, A. A. Hubarevich, V. V. Kolos, Ya. A. Solovjov, D. S. Liauchuk, V. R. Stempitsky

“…The investigation showcases the results of determining optical constants (refractive indexes n and absorption coefficients k) of thin films from the transmission curve by applying the reflection-transmission method. …”
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Prediction of Compressive Strength by Considering Practical Consideration Non-destructive Test by Artificial Neural Network by Priyesh GANGELE, Arun Kumar PATEL

“…The prediction results show that the coefficients of determination (R2) of the Regression analysis and the CFBPNN prediction models for the test set of concrete compressive strength are 95% and 99% respectively ANN model founded to be more accurate as compare to regression analysis. …”
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Commissioning a clinical proton pencil beam scanning beamline for pre-clinical ultra-high dose rate irradiations on a cyclotron-based system by Jatinder Saini, Jatinder Saini, Danielle P. Johnson Erickson, François Vander Stappen, Matt Ruth, Matt Ruth, Sunan Cui, Sunan Cui, Vanessa Gorman, Séverine Rossomme, Ning Cao, Ning Cao, Eric C. Ford, Eric C. Ford, Juergen Meyer, Juergen Meyer, Charles Bloch, Charles Bloch, Tony Wong, Tony Wong, Clemens Grassberger, Ramesh Rengan, Ramesh Rengan, Jing Zeng, Jing Zeng, Marco Schwarz, Marco Schwarz

“…BackgroundThis manuscript describes modifications to a pencil beam scanning (PBS) proton gantry that enables ultra-high dose rates (UHDR) irradiation, including treatment planning and validation.MethodsBeamline modifications consisted of opening the energy slits and setting the degrader to pass-through mode to maximize the dose rate. …”
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EVALUATION OF CURRENT SIGNALS AT OBSERVED POINTS OF THE ELECTRICAL NETWORK IN PROBLEMS OF IDENTIFICATION OF CURRENT TRANSFORMER SATURATION by P. Shagimardanov

“…This article proposes a method for determining the saturation of a current transformer, due to the magnitude of the correla nun coefficients of adjacent measuring devices.…”
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Calculation of electron-optical characteristics of a quadrupole-cylindrical field by A.O. Saulebekov, A.A. Trubitsyn, Zh.T. Kambarova

“…The main aberration coefficients that determine the conditions of secondorder angular focusing are calculated. …”
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ADAPTIVE FUZZY CACHING ALGORITHM FOR PROXY SERVERS by Alexander Igorevich Zhukov

“…The problem of increasing the efficiency of cache systems using artificial intelligence techniques is considered. …”
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