Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer’s Disease Targeting by Hasan Turkez, Sena Oner, Ozge Caglar Yıldırım, Mehmet Enes Arslan, Marilisa Pia Dimmito, Çigdem Yuce Kahraman, Lisa Marinelli, Erdal Sonmez, Özlem Kiki, Abdulgani Tatar, Ivana Cacciatore, Antonio Di Stefano, Adil Mardinoglu

“…Recognizing this hurdle, our study aimed to utilize niosomes as delivery vehicles, leveraging the “molecular Trojan horse” technology, to enhance the transport of molecules across the BBB. <b>Methods:</b> Previously synthesized memantine derivatives (<b>MP1–4</b>) were encapsulated into niosomes for improved BBB permeability, hypothesizing that this approach could minimize peripheral drug toxicity while ensuring targeted brain delivery. …”
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TREAT-TO-TARGET STRATEGY FOR EARLY PSORIATIC ARTHRITIS (PRELIMINARY RESULTS OF THE REMARCА STUDY) by T. V. Korotaeva, E. Yu. Loginova, D. E. Karateev, A. A. Glazkov, E. L. Nasonov

“…Subjects and methods. Twenty-three patients (8 men and 15 women) with ePsA, who met the CASPAR criteria (mean age was 39.1±10.6 years; the median duration of ePsA was 7 [4; 24] months and that of psoriasis was 36 [12; 84] months), were examined. …”
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TREAT-TO-TARGET STRATEGY FOR EARLY PSORIATIC ARTHRITIS (PRELIMINARY RESULTS OF THE REMARCА STUDY) by T. V. Korotaeva, E. Yu. Loginova, D. E. Karateev, A. A. Glazkov, E. L. Nasonov

“…The aim of a treat-to-target (T2T) strategy is to achieve a remission or minimal disease activity (MDA).Objective: to investigate the efficiency of the T2T strategy for early psoriatic arthritis (ePsA).Subjects and methods. …”
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Use of a multidimensional RAPID3 questionnaire to assess the achievement of remission and minimal disease activity in patients with early psoriatic arthritis treated according to T... by E. Yu. Loginova, T. V. Korotaeva, A. D. Koltakova

“…The possibilities of using the RAPID3 questionnaire in patients with early PsA (ePsA) with T2T strategy have not yet been studied.Objective: to investigate whether the multi-dimensional RAPID3 questionnaire may be used to assess the achievement of remission and MDA in ePsA patients with a T2T (Treat-to-target) strategySubjects and methods. The investigation enrolled 61 patients (29 men and 32 women) with ePsA meeting the 2006 CASPAR criteria; the mean age of the patients was 37±10.6 years; the duration of PsA and psoriasis was 11.3±10.2 and 75.4±80.9 months, respectively. …”
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On Robustness to a Topological Perturbation in Fluid Mechanics by Abdelbari Merwan, Nachi Khadra, Sokołowski Jan, Novotny Antonio Andre

“…Numerical examples illustrate the efficiency of the proposed topological derivative method.…”
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Clinical efficacy of gliclazide with modified release after myocardial infarction in patients with concomitant type 2 diabetes by N. S. Mykhailovska

“…The main group consisted of 28 patients who in addition to basic therapy were prescribed gliclazide modified release in a dose of 30-60 mg;71 patients were in the comparison group, treated with glibenclamide. Immunoenzyme method was carried out to determine the level of IL-1α, IL-6, TNF-α (Diaclone, France), endothelin-1 (Biomedica, Austria), insulin-like growth factor, insulin, C-peptide, leptin, C-reactive protein (DAI, USA), tissue plasminogen activator inhibitor-1 (Biopool, USA).The concentration of glucose, glycosylated hemoglobin investigated using a set of reagents BIOLATEST company PLIVA-Lachema. …”
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Self-organizing expert communities in educational projects by Gennadiy P. Vinogradov, Vladimir N. Kuznetsov

“…The paper proposes a system that provides a direction for finding solutions and ideas, as well as filtering, summarizing information, determining its value and prospects. It is shown that the method of improving the quality of solutions on an educational project is the synthesis of crowdsourcing technologies, network expertise and the methodology of the active systems theory.Conclusions. …”
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ANTIBIOTIC SENSITIVITY ISOLATION EVALUATION OF MAJOR MICROORGANISMS IN PERIODONTAL TISSUE PATHOLOGY by S.B. Kostenko

“…Determination of levels antibiotic sensitivity was carried out using a disco-diffusion method with the advice and algorithm identified by order MOH Ukraine 05.04.2007 № 167 "On Approval of guidelines" Determination of the sensitivity of microorganisms to antibiotics and in accordance with the recommendations EUCAST (Eurepean Committee on Antimicrobial Susceptibility Testing). …”
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Advances in high-pressure materials discovery enabled by machine learning by Zhenyu Wang, Xiaoshan Luo, Qingchang Wang, Heng Ge, Pengyue Gao, Wei Zhang, Jian Lv, Yanchao Wang

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A Bi-level Stochastic-Robust Optimal Bidding Model of Wind-Storage System in Spot Markets Considering Internal and External Uncertainties by Haowen Xu, Minglei Bao, Xun Yao, Xiaocong Sun, Yi Ding, Zhenglin Yang

“…At the upper level, the bidding strategy of WSS is developed based on the market clearing results by using the stochastic-robust method to consider uncertainties. In the lower level, the clearing process of the day-ahead market is modeled to determine the clearing market price and quantity. …”
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A survey of neural architecture search by Mingjie HE, Jie ZHANG, Shiguang SHAN

“…Recently,deep learning has achieved impressive success on various computer vision tasks.The neural architecture is usually a key factor which directly determines the performance of the deep learning algorithm.The automated neural architecture search methods have attracted more and more attentions in recent years.The neural architecture search is the automated process of seeking the optimal neural architecture for specific tasks.Currently,the neural architecture search methods have shown great potential in exploring high-performance and high-efficiency neural architectures.In this paper,a survey in this research field and categorize existing methods based on their performance estimation methods,search spaces and architecture search strategies were presented.Specifically,there were four performance estimation methods for computation cost reduction,two typical neural architecture search spaces and two types of search strategies based on discrete and continuous spaces respectively.Neural architecture search methods based on continuous space are becoming the trend of researches on neural architecture search.…”
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Gas source and contribution identification for coal measure gas commingled production in Wulihou mining area by NI Xiaoming, FENG Dong, HAO Shaowei, WANG Kai, SU Erlei

“…The production split coefficients calculated based on catastrophe theory closely matched experimental results, confirming the feasibility of this method. …”
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Effect of temperature on the modal parameters of continuous rigid frame bridge by Yang Yang, Md Sulayman Hossen, Giuseppe Lacidogna, Wenming Xu, Ibna Kawsar, Junbo Sun, Shameem Hossain

“…Mode shape and damping ratio were analyzed using MATLAB software using the covariance-driven stochastic subspace identification method (SSI-COV) and the logarithmic decrement method. …”
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Optimal Viewpoint Assistance for Cooperative Manipulation Using D-Optimality by Kyosuke Kameyama, Kazuki Horie, Kosuke Sekiyama

“…This study proposes a D-optimality-based viewpoint selection method to improve visual assistance for a manipulator by optimizing camera placement. …”
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Development of Degree-of-Priority Based Control Strategy for Emergency Vehicle Preemption Operation by Jiawen Wang, Wanjing Ma, Xiaoguang Yang

“…A simulation model based on field data was developed, and the performance of the proposed strategy was compared with the conventional local detection based method under the microscopic simulation model. The results validated the efficiency of the proposed strategy in terms of minimizing the delay of emergency vehicles and reducing adverse impacts on normal traffic.…”
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Stochastic Demand-Side Management for Residential Off-Grid PV Systems Considering Battery, Fuel Cell, and PEM Electrolyzer Degradation by Mohamed A. Hendy, Mohamed A. Nayel, Mohamed Abdelrahem

“…The uncertainty in demand forecasting is addressed through a scenario-based generation to enhance the robustness and accuracy of the proposed method. Then, stochastic optimization was employed to determine the optimal operating schedules for deferable appliances and optimal water heater (WH) settings. …”
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Modeling study of uniaxial compressive strength prediction from similar analog drilling test signals by Heqing LIU, Jiankang LIU, Jian HAO, Lijin ZHAO, Jianquan TANG

“…By varying the number of hidden layers, population and training function of GA−BP neural network, the factors affecting the prediction model and the results are discussed and analyzed to determine the optimal prediction model structure. The results indicate that there is a responding relationship between the vibration signal with drilling and the UCS of similar simulated materials, and the accuracy of the constructed prediction models are above 70%, and the research method of predicting the UCS with the perception of vibration signal with drilling has certain feasibility; The model results are optimal when trainlm is chosen for the training function, the hidden layer is 8, and the number of populations is 20,with coefficients of determination of 0.761 and 0.745 for the training set and the test set, respectively, the root-mean-square errors are 6.039 MPa and 4.254 MPa, and the mean absolute errors are 6.574 MPa and 4.716 MPa, respectively. …”
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Analysis and Design of Holographic Reflectarray Antennas Using Collective Polarizability Tensors of Patch Scatterers by Shakiba Paloudi, Nader Komjani, Mohammad Yazdi

“…By adopting this approach, both the computational load and the time required for input admittance calculations are significantly reduced compared to previous methods based on numerical approaches. Additionally, in this method, increasing the number of elements or altering the feed antenna&#x2019;s position has no impact on the calculation time. …”
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HPTLC-fluorescent densitometry for screening aflatoxin B1 in millet and buckwheat by Xudong Shi, Xingjun Xi, Yuetao Jia, Zhijian Wang, Jiawei Guo, Shiyao Wang, Xiaoqian Tang, Yisheng Chen

“…Given severe health-hazardous effects of aflatoxin B1 (AFB1) widely occurring in cereal grains and animal feeds, it is highly urgent to develop analytical methods for its rapid screening. In this work, we proposed a simple and high-throughput method for the determination of AFB1 in millet and buckwheat samples using high performance thin layer chromatography (HPTLC) linked to fluorescence densitometry. …”
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MANAGEMENT AND LEGAL ASPECTS OF ECONOMIC SECURITY OF ENTERPRISES IN THE PROCESS OF INNOVATION by V. Blikhar, М. Kopytko, O. Patsula, V. Synenkyi, V. Bulachek

“…The research methodology includes methods of graphic display, abstraction, analysis and synthesis. …”
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