IMPACT OF ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C ON CYTOKINE SYNTHESIS AND HEPATIC FIBROSING PROCESSES by V. V. Shchekotov, I. A. Bulatova, A. P. Shchekotova, N. I. Nasibullina, G. G. Larionova, A. I. Pavlov

“…Objective: to estimate the time course of changes in the levels of tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, and the hepatic fibrosis indicators hyaluronic acid (HA) and liver elasticity index during combined antiviral therapy (AVT) with interferon alpha-2b and ribavirin in patients with chronic hepatitis C (CHC). Subjects and methods. Fifty patients with CHC were examined. Serum TNF-α, IL-6, IL-4, and HA were estimated using an enzyme immunoassay. …”
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Prognostic and clinicopathological impact of systemic inflammation response index (SIRI) on patients with esophageal cancer: a meta-analysis by Zhong Wu, Zongxin Zhang, Chao Gu

“…We focused on identifying SIRI’s precise role in forecasting EC prognosis through performing this meta-analysis. Methods This work searched PubMed, Web of Science, Embase, Cochrane Library, and CNKI till November 16, 2024, and determined pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for evaluating EC prognosis forecasting efficiency of SIRI. …”
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Long-term results (60 months) of anti-VEGF therapy of macular diseases in real clinical practice. Part 2. by E. V. Bobykin, R. V. Buslaev, V. Y. Krokhalev, O. V. Morozova, N. S. Beresneva

“…Purpose: to study long-term results of anti-VEGF therapy for macular diseases of patients followed up for 60 months in real clinical practice. Materials and methods. The research group included 57 patients (43 women, 14 men; median age 62 years) who received antiVEGF therapy (ranibizumab, aflibercept) and remained under regular observation for 60 months. …”
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Developing a Model for Measuring and Evaluating the Role of Commodities as Hedging Tools in Investor Portfolios by Zahra Mohammadi Pourmazaheri, Babak Jamshidinavid, Mehrdad Ghanbari, Alireza Moradi

“…The primary goal was to examine the diversification and hedging (safe haven) properties of assets and future commodities in Iran's exchange market compared to stocks during "bull and bear periods of the stock market" and to determine the minimum variance portfolio.   Methods This research was applied in purpose and quantitative in methodology. …”
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The status of machine learning in HIV testing in South Africa: a qualitative inquiry with stakeholders in Gauteng province by Musa Jaiteh, Edith Phalane, Yegnanew A. Shiferaw, Refilwe Nancy Phaswana-Mafuya

“…This study explored the perspectives of key stakeholders in Gauteng Province on the status of machine learning applications in HIV testing in South Africa.MethodsThe study used an exploratory qualitative approach to recruit 15 stakeholders working in government and non-government institutions rendering HIV testing services. …”
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2-Deoxy-D-Glucose and ES-936 sensitize cancer- but not normal cells to both low- and high LET irradiation by Katja Kratz, Henrieke Förster, Kira Vogel, Marco Durante, Marco Durante, Burkhard Jakob, Burkhard Jakob

“…Furthermore, NADP+/NADPH-, NAD(P)H- and ROS levels were determined using bioluminescent assays, Fluorescence Lifetime Imaging Microscopy (FLIM) and fluorescent microscopy. …”
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Epidemiological Situation of Schigеllosis in the Republic of Dagestan and Directions for Improving Epidemiological Surveillance by Z. G. Tagirovа, N. M-G. Zulpukarova, Z. M. Daniyalbekova

“…The introduction of modern sensitive, specific, standardized methods of laboratory diagnostics will make it possible to effectively carry out risk-oriented epidemiological surveillance, which makes it possible to identify the transition of risk factors from potential to real, activating the epidemic process.…”
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Stability of tenogenic secretomes optical density, colour, weight, TGF-b concentration and bacterial growth after 30-day storage under room or refrigerator temperature by Aziz Mukhlis, Soesilawati Pratiwi, Lestari Pudji, Suroto Heri

“…Background/Aim: The effectiveness and efficiency of tenogenic secretomes products are crucial to assess. …”
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Prospects for the application of recombinant antigens Treponema pallidum TР0163 and TР0971 in enzyme-linked immunosorbent assay for the detection of immunoglobulin M in the serum o... by N. V. Arbuzova, M. V. Shpilevaya, G. L. Katunin, N. Yu. Nosov

“…The efficiency of the assay depends on the antigens used to detect antitreponemal antibodies and the clinical stage of the infection. …”
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Repurposing of an inotropic drug dobutamine to enhance the production of human hematopoietic stem cells from human induced pluripotent stem cells by Chuti Laowtammathron, Pimonwan Srisook, Pakpoom Kheolamai, Rangsun Parnpai, Chanchao Lorthongpanich, Surapol Issaragrisil

“…Therefore, this study investigates the effect of DH on enhancing the hematopoietic differentiation of hiPSCs toward HSPCs. Methods This study used isogenic hiPSCs to study the effect of DH during various stages of their hematogenic differentiation using an in vitro culture system. …”
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High vector competence for chikungunya virus but heavily reduced locomotor activity of Aedes albopictus from Germany at low temperatures by Renke Lühken, Leif Rauhöft, Björn Pluskota, Unchana Lange, Michelle Helms, Norbert Becker, Jonas Schmidt-Chanasit, Carola Kuhn, Egbert Tannich, Stephanie Jansen, Anna Heitmann

“…Infection rates and transmission efficiencies (TEs) were determined after 14 days of incubation at constant and fluctuating (± 5 °C) mean temperatures of 15 °C, 18 °C, 21 °C and 24 °C. …”
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Effect of sanitation on soil-transmitted helminth infection: systematic review and meta-analysis. by Kathrin Ziegelbauer, Benjamin Speich, Daniel Mäusezahl, Robert Bos, Jennifer Keiser, Jürg Utzinger

“…However, rapid reinfection of humans occurs after successful deworming, and therefore effective preventive measures are required to achieve public health goals with optimal efficiency and sustainability.<h4>Methods and findings</h4>We conducted a systematic review and meta-analysis to assess the effect of sanitation (i.e., access and use of facilities for the safe disposal of human urine and feces) on infection with soil-transmitted helminths. …”
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Clinical significance of lactate-to-albumin ratio in patients with influenza A virus-induced acute respiratory distress syndrome: a single-center retrospective study by Jinhui Gao, Xuanzhe Yang, Xiang Fang, Ziyi Zhang, Dapeng Wang, Jiajia Wang

“…This study aims to investigate whether LAR can be used as a predictor of influenza A virus-induced ARDS. Methods In this single-center retrospective study, we enrolled 105 patients with influenza A virus pneumonia into the study and divided the patients into an ARDS group (74 patients) and a non-ARDS group (31 patients) during hospitalization. …”
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Evaluation of the Shear Bond Strength of Orthodontic Adhesive Incorporated with Titanium Dioxide Nanoparticle: An In-vitro Study by M Ashfaq Ahmed, S Sumalatha, N Narendran, G Dinesh Nandakumar, A Agasthiya

“…Materials and Methods: The present in-vitro study was conducted in the Department of Orthodontics and Dentofacial Orthopaedics, Best Dental Science College, Madurai, Tamil Nadu, India, between July 2022 and December 2023. …”
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Genistein Improves the Cytotoxic, Apoptotic, and Oxidative-Stress-Inducing Properties of Doxorubicin in SK-MEL-28 Cancer Cells by Andrea Roman, Andrei Motoc, Iasmina Marcovici, Cristina Dehelean, Laura Nicolescu, Casiana Boru

“…Therefore, this study investigated the combination therapy regimen comprising GEN and DOX in terms of anti-melanoma activity and safety profile. <i>Materials and Methods</i>: The in vitro experiments were performed on SK-MEL-28 and HaCaT cells. …”
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Effect of Periodic Fluctuations of Cutting Mode Parameters on the Temperature of the Front Face of a Turning Tool by E. V. Fominov, V. E. Gvindjiliya, A. A. Marchenko, C. G. Shuchev

“…This research is aimed at determining the mechanism of influence of periodic fluctuations of processing parameters caused by vibration disturbances on the temperature of the front face of the turning cutter, which is the key indicator of the development of diffusion wear of the carbide tool.Materials and Methods. …”
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Design, Construction, and Evaluation of a Spatial Depth Measurement System for Subsoiler in Sugarcane Fields by N. Loveimi, A. Azizi, A. Kaab, A. Neisi

“…The main plots are the three depth measurement techniques: based on the angles of the driving profiles of the subsoiler shanks (T1), the laser distance measurement method (T2), and the ultrasonic distance measurement method (T3), and sub-plots are depth ranges at three levels: 0-30 cm (R1: surface range), 30-60 cm (R2: mid-range), and 60-90 cm (R3: deep range). …”
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BEACON—automated aberration correction for scanning transmission electron microscopy using Bayesian optimization by Alexander J. Pattison, Stephanie M. Ribet, Marcus M. Noack, Georgios Varnavides, Kunwoo Park, Earl J. Kirkland, Jungwon Park, Colin Ophus, Peter Ercius

“…Here, we present an automated method of correcting first- and second-order aberrations called BEACON, which uses Bayesian optimization of the normalized image variance to efficiently determine the optimal corrector settings. …”
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Comparison of inter- and intraobserver agreement between [18F]AlF-NOTA-octreotide and [68Ga]Ga-DOTA-SSA PET/CT by Hannes Leupe, Niloefar Ahmadi Bidakhvidi, Karolien Goffin, Bliede Van den Broeck, Sander Jentjens, Annouschka Laenen, Elin Pauwels, Willem Lybaert, Eric Van Cutsem, Guy Bormans, Timon Vandamme, Frederik Cleeren, Jeroen Dekervel, Karen Geboes, Sigrid Stroobants, Chris Verslype, Christophe M. Deroose

“…Abstract Purpose This study compares inter- and intraobserver agreement between [18F]AlF-NOTA-octreotide ([18F]AlF-OC) and [68Ga]Ga-DOTA-somatostatin analogues (SSAs) in PET/CT imaging for neuroendocrine neoplasm (NEN) patients. Materials and methods This is a secondary endpoint analysis from our multicenter trial (clin trial.gov identifier: NCT04552847) including 75 NEN patients who received both [68Ga]Ga-DOTATATE (n = 56) or [68Ga]Ga-DOTA-NOC (n = 19) and [18F]AlF-OC PET imaging. …”
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Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis by Tadamune Kinjo, Hirosuke Inoue, Takeshi Kusuda, Junko Fujiyoshi, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Yuhki Koga, Toshiro Hara, Shouichi Ohga

“…The objective is to search for biomarkers predicting the development of hepatic failure in DS infants with TAM. Methods: Among 60 newborn infants with DS consecutively admitted to our institutions from 2003 to 2016, 41 infants with or without TAM were enrolled for the study. …”
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