From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody by Shuyuan Cao, Bo Sun, Feng Gao, Feng Gao, Feng Gao

“…This study uses molecular dynamics (MD) simulations to analyze the immune evasion mechanisms of class 1 nanobodies against emerging SARS-CoV-2 variants, and to develop an efficient in silico pipeline for rapid affinity optimization.MethodsWe employed MD simulations and binding free energy calculations to investigate the immune evasion mechanisms of four class 1 nanobodies (R14, DL4, VH ab6, and Nanosota9) against wild-type (WT) and Omicron variants, including BA.2, JN.1, and KP.3/XEC. …”
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Enhanced optimisation of MPLS network traffic using a novel adjustable Bat algorithm with loudness optimizer by Mohsin Masood, Mohamed Mostafa Fouad, Rashid Kamal, Khursheed Aurangzeb, Sheraz Aslam, Zahid Ullah, Ivan Glesk

“…The performance of the proposed algorithm was evaluated on networks of varying scales and compared against the standard Bat Algorithm and other meta-heuristic methods. The evaluation focused on convergence rate and computational complexity, demonstrating that the proposed Adjustable Bat Algorithm outperforms existing methods in both metrics, offering a more robust and efficient solution for multi-objective path optimisation in MPLS networks. …”
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Environmental DNA Epigenetics Accurately Predicts the Age of Cultured Fish Larvae by Eliot Ruiz, Fabien Leprieur, Gérard Sposito, Martina Lüthi, Michel Schmidlin, Jacques Panfili, Loïc Pellissier, Camille Albouy

“…ABSTRACT While acquiring age information is crucial for efficient stock management and biodiversity conservation, traditional aging methods fail to offer a universal, non‐invasive, and precise way of estimating a wild animal's age. …”
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The Impact of Health Belief Model-Based Education on Self-Care Behaviors of Hypertensive Patients by Parisa Kasmaei, Pegah Yousefi, Rabiollah Farmanbar, Saeed Omidi, Mahmood Karimy, Sedighe Bab Eghbal, Maryam Shakiba, Morvarid Molaee

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Application of RSM- CCD methodology and image J. for modeling and optimization of orchid protocorm encapsulation by Zahra Mahdavi, Shirin Dianati Daylami, Ali Fadavi, Mandana Mahfeli

“…Synthetic seed technology is an excellent method for large-scale production of unique hybrids, valuable and unstable genotypes, and genetically modified plants that unable to produce plants that require symbiosis of mycorrhiza fungi for seed germination. …”
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Influence of Foliar Application of Boron on the Growth, Yield and Quality of Sesame (cv. BARI Til-4) by Apu Dey, Mahfuza Begum, Md. Sojib Kabiraj, Md. Harun Rashid, Swapan Kumar Paul

“…Therefore, it can be inferred that the most efficient method for increasing the sesame seed yield and oil content is thrice (30, 50, and 70 DAS) foliar spraying of 75 ppm boron.…”
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Remote clinical decision support tool for Parkinson’s disease assessment using a novel approach that combines AI and clinical knowledge by Harel Rom, Ori Peleg, Yovel Rom, Anat Mirelman, Gaddi Blumrosen, Inbal Maidan

“…Methods Facial image of 67 PD patients and 52 healthy-controls (HCs) were collected via standard video recording. …”
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Improved Surface Properties of Low-Carbon Steel by Chromizing–Titanizing Coating Using Pack Cementation Process by Ayman Yousef, A. M. Bastaweesy, Ibrahim M. Maafa, Ahmed Abutaleb

“…This research underscores the versatility of pack cementation as an effective method to engineer advanced coatings, offering a cost-efficient pathway to enhance the performance of low-carbon steel in demanding environments.…”
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Managing Minor Ailments; The Public's Preferences for Attributes of Community Pharmacies. A Discrete Choice Experiment. by Terry Porteous, Mandy Ryan, Christine Bond, Margaret Watson, Verity Watson

“…<h4>Method</h4>A UK-wide DCE survey of the general public was conducted using face-to-face computer-assisted personal interviews. …”
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Antimicrobial Activity of Piper marginatum Jacq and Ilex guayusa Loes on Microorganisms Associated with Periodontal Disease by Fredy Gamboa, Camila-Cristina Muñoz, Gloria Numpaque, Luis Gonzalo Sequeda-Castañeda, Sandra Janeth Gutierrez, Nohemi Tellez

“…Antimicrobial activity from total ethanol extracts and fractions from both plants were evaluated on P. gingivalis ATCC 33277, F. nucleatum ATCC 25586, and P. intermedia ATCC by the well diffusion method with Wilkins–Chalgren agar. Results. Piper marginatum Jacq total ethanol extract presented antimicrobial activity against all three bacteria, whereas Ilex guayusa Loes was only efficient against P. gingivalis ATCC 33277 and P. intermedia ATCC 25611, with inhibition halos from 9.3 to 30 mm. …”
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THE ROLE OF THE MINISTRY OF FINANCE OF UKRAINE IN SHAPING STATE CUSTOMS POLICY: ECONOMIC AND LEGAL ASPECT by Ivan Yaromii

“…Methodology: the study employs both general and specific methods of scientific knowledge, namely, systems analysis, the dialectical method, formal logic, as well as structural and functional approaches. …”
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Integration of well log analysis data with geochemical data to evaluate possible source rock. Case study from GM-ALEF-1 well, Ras Ghara oil Field, Gulf of Suez-Egypt by A.A. El-Khadragy, T.F. Shazly, D.A. Mousa, M. Ramadan, M.Z. El-Sawy

“…Consequently, the logs used for source rock evaluations and calculation of Total Organic Carbon most commonly include density, sonic, gamma ray, neutron and resistivity by using several methods.In this research, a suite of geophysical logs and geochemical data were applied for determining the Total Organic Carbon content (TOC) and compare them together, in addition to source rock evaluation of the study formation.Application of such techniques take place in one well GM-ALEF-1 well located in the Ras Ghara oil Field, Gulf of Suez, Egypt, represented by Miocene rock, Rudeis Formation. …”
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Identification of Diagnostically Relevant Biomarkers in Patients with Coronary Artery Disease by Comprehensive Analysis by Wu Z, Mo S, Huang Z, Zheng B

“…The purpose of this research is to determine the diagnostic value and therapeutic potential of the endoplasmic reticulum stress (ERS) genes in CAD.Methods: The clinical information and RNA sequence data were obtained from the GEO database and subsequently subjected to a series of optimization and visualization processes using various analytical techniques, including WGCNA, LASSO, SVM-RFE feature selection, random forest (RF), and XGBoost, as well as R software and Cytoscape. …”
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EWT多重分解与若干新型元启发式算法优化的多层感知器月径流预测 by CAI Liang, BAO Yanfei, CUI Dongwen

“…The prediction accuracy of the EWT^Ⅰ/EWT^Ⅱ/EWT^Ⅲ-FLOA/FLA/APO/ECO/PSO-MLP model improves with the increase of EWT decomposition weight. As a concise and efficient time series decomposition method, EWT^III can decompose the original monthly runoff series into more easily modeled and predictable components with a larger scale.…”
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A Novel Depression Risk Prediction Model Using NHANES Data With Mendelian Randomization Validation by Lin Lin, Liqun Zhang, Jingdong Zhang, Dapeng Ding

“…This study aimed to develop and validate a practical depression risk prediction model based on commonly available biochemical markers, facilitating widespread early screening and timely intervention in general clinical settings. Methods We formulated a model for depression, scrutinizing an assortment of biochemical indicators and their bidirectional interrelationships with depression, employing data derived from the National Health and Nutrition Examination Survey (NHANES) and leveraging the Mendelian randomization (MR) approach, a method that utilizes genetic variants as instrumental proxies to ascertain causal nexus between risk determinants and diseases. …”
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Exploring the synergy between fungal CE15 glucuronoyl esterases and xylanases for lignocellulose saccharification by Christina Pentari, Constantinos Katsimpouras, Mireille Haon, Jean-Guy Berrin, Anastasia Zerva, Evangelos Topakas

“…Results In this study, two CE15 glucuronoyl esterases from the white-rot fungi Artolenzites elegans and Trametes ljubarskyi were heterologously expressed in Pichia pastoris and biochemically characterized on the model substrate D-glucuronic acid ester with cinnamyl alcohol and a variety of pretreated lignocellulosic biomasses. The pretreatment method was shown to be a determining factor in revealing both the activity of the esterases on lignocellulose and their synergistic relationships with other hemicellulases. …”
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Detection of Invasive Species (Siam Weed) Using Drone-Based Imaging and YOLO Deep Learning Model by Deepak Gautam, Zulfadli Mawardi, Louis Elliott, David Loewensteiner, Timothy Whiteside, Simon Brooks

“…The study demonstrates the feasibility of using YOLO models to detect invasive species in natural landscapes, providing a safe alternative to the current method involving human spotters in helicopters. Future research will focus on developing tools to merge duplicates, gather georeference data, and report detections from large image datasets more efficiently, providing valuable insights for practical applications in environmental management at the catchment scale.…”
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Análise da qualidade visual da paisagem da região de Tibagi, PR, aplicando o sensoriamento remoto Landscape quality analysis of Tibagi, Paraná state, applying the remote sensing by Geraldo S. Landovsky, Daniela B. Batista, Hideo Araki

“…<br>The evaluation of landscapes has been showing an efficient tool for purposes of determining the appropriate land uses, considering the potential attraction of the several types of terrestrial surface covering. …”
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Use of Rapid Qualitative Analysis to Support Collaborative Synergy Within a Community Coalition for Health Equity in Detroit by Hayley S. Thompson, Ten-Niah Kinney, Carrie Leach, Alexandra Sass, Ariel Washington, Rhonda Dailey, Elizabeth Towner, Alyssa Beavers, Rodlescia Sneed, Karen Solomon Edwards, Ijeoma Nnodim Opara, Arthur Hampton, Zachary Cichon, Afsana Rinky, Joneigh Khaldun

“…Furthermore, by fostering better communication and alignment, RQA is an efficient and effective method to enhance coalition synergy. …”
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Injection well site optimization of carbon geological sequestration based on dynamic programming by Bin LIU, Chunsheng SHI

“…Geological storage of carbon dioxide (CO2) is one of the most effective methods for reducing carbon emissions and mitigating the greenhouse effect, critical challenges in combating climate change. …”
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