Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendiciti... by Suvi Sippola, Juha Grönroos, Saija Hurme, Paulina Salminen, Sirpa Jalkanen, Erkki Eerola, Antti J Hakanen, Sanja Vanhatalo, Eveliina Munukka, Harri Marttila, V Sallinen, A Leppäniemi, T Rautio, S Meriläinen, P Nordström, J Laukkarinen, T Rantala, H Savolainen, M Aarnio, A Mattila, J Haijanen, E-L Sävelä, I Imre, H Paajanen, J Rintala, T Pinta, T Sippola, P Böckerman

“…In addition, MAPPAC aims to determine antibiotic and placebo effects on gut microbiota composition and antimicrobial resistance.Methods and analysis MAPPAC is a prospective clinical trial with both single-centre and multicentre arm conducted in close synergy with concurrent trials APPendicitis ACuta II (APPAC II) (per oral (p.o.) vs intravenous+p.o. antibiotics, NCT03236961) and APPAC III (double-blind trial placebo vs antibiotics, NCT03234296) randomised clinical trials. …”
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Subcellular mass spectrometric detection unveils hyperglycemic memory in the diabetic heart by Jiabing Zhan, Yufei Zhou, Yifan Chen, Kunying Jin, Zhaoyang Chen, Chen Chen, Huaping Li, Dao Wen Wang

“…The present study tried to investigate whether the dysregulated proteins/biological pathways, which persistently altered in diabetic hearts during normoglycemia, participate in the hyperglycemic memory. Methods Hearts of streptozotocin‐induced diabetic mice, with or without intensive glycemic control using slow‐release insulin implants, were collected. …”
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Evaluation of antimicrobial photodynamic therapy and minimal intervention associated with deproteinisation in permanent teeth with molar incisor hypomineralisation: study protocol... by Ana Paula Taboada Sobral, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Raquel Agnelli Mesquita Ferrari, Amanda Rafaelly Honório Mandetta, Carolina Carvalho Bortoletto, Renato Araujo Prates, Alessandro Melo Deana, Rita de Cássia Loiola Cordeiro, Lourdes Aparecida Martins dos Santos Pinto

“…Pearson’s correlation coefficients will be calculated to determine the strength of correlations between variables. …”
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Psychological correlates of COVID-19 vaccine attitudes among medical professionals: An exploratory data analysis by Aldo SITIBONDO, Aanuoluwapo AFOLABI, Jamel HAJJI, Abdulmohsen Mohammed Abdullah ALKHULAYFI, Izaddin Ahmad AZIZ, Zane Asher GREEN, Francesca BRUNO, Martina BARBERA, Murat YLDIRIM

“…This study aims to assess the relationship between emotional states—particularly anxiety-related feelings—and COVID-19 vaccination status among Italian medical professionals. Methods: A cross-sectional analysis was conducted using data from 160 healthcare workers who completed a structured questionnaire. …”
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Implementing an enhanced recovery from surgery pathway to reduce hospital length of stay for primary hip or knee arthroplasty: a budget impact analysis by Melanie Lloyd, Zanfina Ademi, Ian A. Harris, Justine Naylor, Peter Lewis, Richard de Steiger, Rachelle Buchbinder, Anthony Wan, Ilana N. Ackerman

“…Abstract Background Given growing demand for hip and knee arthroplasty and unsustainable resource requirements, safe and efficient models of care are critical. This study aims to determine the impact on healthcare costs of implementing an enhanced short-stay model of care (ESS-MOC) for arthroplasty at a national level. …”
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Effects of Legume–Grass Mixture Combinations and Planting Ratios on Forage Productivity and Nutritional Quality in Typical Sand-Fixing Vegetation Areas of the Mu Us Sandy Land by Yuqing Mi, Hongbin Xu, Lei Zhang, Ruihua Pan, Shengnan Zhang, Haiyan Gao, Haibing Wang, Chunying Wang

“…Monoculture and legume–grass mixed cropping are the two most common planting methods, with mixed cropping generally demonstrating higher hay yield and superior nutritional quality compared to monoculture. …”
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Continuous versus intermittent cuff pressure monitoring in preventing ventilator-associated pneumonia: a multicentre randomised controlled trial by Yanshuo Wu, Yunhao Su, Liping Zhao, Xi Wang, Kun Zhang, Yuhong Chen, Xiaokun Zhang, Peng Gao, Kangkang Shen, Chencong Li, Yanling Yin, Congcong Zhao

“…This study aimed to investigate whether CCPM reduces VAP incidence compared with intermittent cuff pressure monitoring (ICPM) and its impact on nursing workload. Methods We conducted a multicentre, open-label randomised controlled trial across eight tertiary hospitals in China. …”
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The Effect of Hydrogen Peroxide on Biogas and Methane Produced from Batch Mesophilic Anaerobic Digestion of Spent Coffee Grounds by Siham Sayoud, Kerroum Derbal, Antonio Panico, Ludovico Pontoni, Massimiliano Fabbricino, Francesco Pirozzi, Abderrezzaq Benalia

“…This paper aims to explore both experimental and modeling anaerobic digestion (AD) processes as innovative methods for managing the substantial quantities of spent coffee grounds (SCG) generated in Algeria, transforming them into valuable renewable energy sources (biogas/methane). …”
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Gender difference in cross-sectional area and fat infiltration of thigh muscles in the elderly population on MRI: an AI-based analysis by Sara Bizzozero, Tito Bassani, Luca Maria Sconfienza, Carmelo Messina, Matteo Bonato, Cecilia Inzaghi, Federica Marmondi, Paola Cinque, Giuseppe Banfi, Stefano Borghi

“…Gender differences and correlations between fat, muscle parameters, and age were also analyzed. Methods We retrospectively analyzed 141 participants (67 females, 74 males) aged 52–82 years. …”
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Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso by Mahamadi Kientega, Ioanna Morianou, Nouhoun Traoré, Nace Kranjc, Honorine Kaboré, Odette N Zongo, Abdoul-Azize Millogo, Patric Stephane Epopa, Franck A. Yao, Adrien M G Belem, Austin Burt, Abdoulaye Diabaté

“…Conclusion These findings will guide the implementation of doublesex-targeted gene drives to support the current control tools in malaria elimination efforts. Our methods can be applied to efficiently monitor the evolution of any sequence of interest in a natural population via pooled amplicon sequencing, surpassing the need for WGS.…”
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Hospice and palliative care utilization in 16 004 232 medicare claims: comparing trauma to surgical and medical inpatients by Matthew M Carrick, Samir M Fakhry, Yan Shen, Ransom J Wyse, Jeneva M Garland, Dorraine D Watts, Melissa Red Hoffman

“…The goal of this study was to determine whether there are differences among these three groups in rates of hospice and PC utilization.Methods Patients from Centers for Medicare & Medicaid Services (CMS) Inpatient Standard Analytical Files for 2016–2020 aged ≥65 years were analyzed. …”
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Optimising a multi-strategy implementation intervention to improve the delivery of a school physical activity policy at scale: findings from a randomised noninferiority trial by Cassandra Lane, Luke Wolfenden, Alix Hall, Rachel Sutherland, Patti-Jean Naylor, Chris Oldmeadow, Lucy Leigh, Adam Shoesmith, Adrian Bauman, Nicole McCarthy, Nicole Nathan

“…Methods A noninferiority cluster randomised controlled trial was undertaken with 48 primary schools in New South Wales, Australia. …”
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HUMAn, a Real-Time Evolutive Patient Model for Major Incident Simulation: Development and Validation Study by Maxence Laurent, Arnaud Jaccard, Laurent Suppan, Elio Erriquez, Xavier Good, Eric Golay, Dominique Jaccard, Mélanie Suppan

“…ObjectiveThis study aimed to develop and validate a simplified mathematical model of physiology, capable of plausibly simulating the real-time evolution of several injuries. MethodsA modified version of the user-centered design framework, including a relevance, development, and validation phase, was used to define the development process of the physiological model. …”
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Migrant parent-child separation in the first three years of life and mental health problems at preschool age: A cross-sectional study by Hailati Akezhuoli, Minghui Tan, Yuyin Ma, Xintian Liu, Jiayao Xu, Jingjing Lu, Xudong Zhou

“…Methods: We conducted a kindergarten-based parent-reported questionnaire survey in Nanling, Anhui Province, from October 30 to November 3, 2023. …”
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Comparing immobilisation devices in gynaecological external beam radiotherapy: improving inter‐fraction reproducibility of pelvic tilt by Shimon Prasad, Linda J. Bell, Benjamin Zwan, Florence Ko, Tayla Blackwell, Kevin Connell, Cameron Stanton, Meegan Shepherd, John Atyeo, Mark Stevens, Marita Morgia

“…Methods Sixteen patients were retrospectively reviewed, eight immobilised using the BodyFIX system (BodyFIX®, Elekta, Stockholm, Sweden) and eight using the Butterfly Board (BB) (Bionix Radiation Therapy, Toledo, OH, USA). …”
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Merging of the Fukushima Health Management Survey With the National and Local Cancer Registry to Refine the Detection of Thyroid Cancer Cases After the 2011 Fukushima Daiichi Nucle... by Reiko Kimura‐Tsuchiya, Masanori Nagao, Shigehira Saji, Fumikazu Hayashi, Tetsuya Ohira, Hiroki Shimura, Fumihiko Furuya, Satoru Suzuki, Satoshi Suzuki, Tetsuo Ishikawa, Susumu Yokoya, Hitoshi Ohto, Seiji Yasumura

“…Methods The FHMS‐eligible residents' information was supplemented by merging and cross‐validating the FHMS and CR data using the Fukushima Prefectural Cancer Registry (FPCR), 2008–2015, and the National Cancer Registry (NCR), 2016–2018. …”
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Increasing the appropriate seedling density for higher yield in dry direct-seeded rice sown by a multifunctional seeder after wheat-straw return by Jin-yu TIAN, Shao-ping LI, Shuang CHENG, Qiu-yuan LIU, Lei ZHOU, Yu TAO, Zhi-peng XING, Ya-jie HU, Bao-wei GUO, Hai-yan WEI, Hong-cheng ZHANG

“…However, this method of rice production may produce lower yields in a rice–wheat rotation system because of its poor seedling establishment. …”
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Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…It is imperative that high-risk areas be subjected to stringent control to prevent the indiscriminate expansion of construction land and to reinforce the efficient and intensive utilization of existing land resources. …”
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Frog Skin Peptides Hylin-a1, AR-23, and RV-23: Promising Tools Against Carbapenem-Resistant <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Infections by Annalisa Chianese, Annalisa Ambrosino, Rosa Giugliano, Francesca Palma, Preetu Parimal, Marina Acunzo, Alessandra Monti, Nunzianna Doti, Carla Zannella, Massimiliano Galdiero, Anna De Filippis

“…A microdilution assay evaluated the antibacterial effect, determining the peptides’ minimum inhibitory concentration (MIC). …”
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Genomic insights of predominant international high-risk clone ST2 Acinetobacter baumannii isolates in Saudi Arabia by Thamer M. Brek, Abdulrahman A. Muhajir, Khalil K. Alkuwaity, Moayad A. Haddad, Elaf M. Alattas, Zaki M. Eisa, Majid S. Al-Thaqafy, Ahmed M. Albarraq, Ibrahim A. Al-Zahrani

“…Objectives: Carbapenem-resistant Acinetobacter baumannii (CRAB), particularly the globally prevalent ST2 clone, poses significant threats in the Gulf Cooperation Council region through extensive drug resistance, high virulence, and efficient gene transfer. This study investigates the epidemiological and genomic characteristics of CRAB in the Jazan region, using whole genome sequencing to understand its transmission and genetic determinants. …”
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