Plasma biomarkers for early detection of alzheimer’s disease: a cross-sectional study in a Japanese cohort by Masahito Kubota, Shogyoku Bun, Keisuke Takahata, Shin Kurose, Yuki Momota, Yu Iwabuchi, Toshiki Tezuka, Hajime Tabuchi, Morinobu Seki, Yasuharu Yamamoto, Ryo Shikimoto, Yu Mimura, Takayuki Hoshino, Sho Shimohama, Natsumi Suzuki, Ayaka Morimoto, Azusa Oosumi, Yuka Hoshino, Kenji Tai, Hirofumi Aoyagi, Yoshiaki Sato, Junro Kuromitsu, Jin Nakahara, Masaru Mimura, Daisuke Ito

“…P-tau217 exhibited a linear increase with disease progression. All biomarkers correlated strongly with logical memory scores. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…To compare the performance of screening tools for detecting undiagnosed psoriatic arthritis (COMparison of Psoriatic Arthritis scREening tools study). …”
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Novel PCR-Based Detection Methods for the Lettuce Bacterial Leaf Spot Pathogen, <i>Xanthomonas hortorum</i> pv. <i>vitians</i> Morinière et al., 2020 by Emma R. Martinez, Mozhde Hamidizade, Ana B. Zacaroni, Carolee T. Bull

“…Our protocol demonstrated <i>Xhv</i>-specific detection from two sample types, including genomic DNA extracts and bacterial suspensions. …”
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Expressions of plasma cystatin C, D-dimer and hypersensitive C-reactive protein in patients with intracranial progressive hemorrhagic injury after craniocerebral injury, and their... by Qibin PENG, Jiannong ZHAO, Pengcheng WANG, Chuixue HUANG, Baozhi CHEN, Jian SONG, Guozheng XU

“…ABSTRACT Objective To investigate the expressions of plasma cystatin C (Cys-C), D-dimer (D-D) and hypersensitive C-reactive protein (hs-CRP) in patients with intracranial progressive hemorrhagic injury (IPHI) after craniocerebral injury, and their clinical significance. …”
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ESR1 testing on FFPE samples from metastatic lesions in HR + /HER2- breast cancer after progression on CDK4/6 inhibitor therapy by Konstantinos Venetis, Giulia Cursano, Roberta Scafetta, Pier Paolo Maria Berton Giachetti, Alberto Concardi, Elisa De Camilli, Marianna D’Ercole, Eltjona Mane, Chiara Frascarelli, Antonio Marra, Sara Gandini, Francesco Pepe, Simone Scagnoli, Silvia Maria Rossi, Raffaella Troiano, Elena Speziale, Carmine De Angelis, Giancarlo Troncone, Umberto Malapelle, Giuseppe Perrone, Andrea Botticelli, Giuseppe Viale, Giuseppe Curigliano, Elena Guerini Rocco, Carmen Criscitiello, Nicola Fusco

“…Next-generation sequencing (NGS) was performed on FFPE biopsy samples obtained from metastatic sites at the time of disease progression. ESR1 mutations were detected in 24 out of 38 patients (63.2%), with p.D538G identified in 10 patients (45.5%) and p.Y537S in 6 patients (27.2%) as the most frequent alterations. …”
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卵圆孔未闭诊断方法与技术的研究进展 Research Progress of the Diagnostic Methods and Techniques for Patent Foramen Ovale by 朱佳倩1，曹黎明2

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Functional Near‐Infrared Spectroscopy Signal as a Potential Biomarker for White Matter Hyperintensity Progression in Patients With Subcortical Vascular Cognitive Impairment: A Pilo... by Qi Wang, Byoung‐Soo Shin, Sun‐Young Oh, Seungbae Hwang, Ko Woon Kim

“…Abstract Background White matter hyperintensities (WMH) are a common cause of subcortical vascular cognitive impairment (SVCI). The silent yet progressive nature of WMH in cognitive decline underscores the need for reliable biomarkers for early detection and monitoring of its progression. …”
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Myopic choroidal neovascularization with dilated choroid vessels is prone to progression into subretinal fibrosis following anti-vascular endothelial growth factor therapy: a retro... by Xiangjun She, Qiwei Cai, Wangjing Yao, Shixin Zhao, Zhe Lv, Suyan Shan, Jiwei Tao, Yun Zhang

“…The presence of DCV under the fovea compared to the peripheral zone achieved a poorer therapeutic response and was prone to progress to SF after anti-VEGF therapy (P = 0.041). …”
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Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application by Lin Su, Jiawen Bu, Jiahui Yu, Mila Jin, Guanliang Meng, Xudong Zhu

“…Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis and malignant progression. However, a comprehensive analysis of the DNA methylation mechanism driving HCC progression and its potential as a therapeutic biomarker remains lacking. …”
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Bilateral Iridocorneal Endothelial Syndrome by Theresa Gladiola B. Merca, MD, Manuel B. Agulto, MD, Rainier Victor A. Covar, MD, MMed

“…Results: A 12-year old female consulted for a one-year history of progressive blurring of vision in both eyes associated with abnormal pupils and occasional eye pain. …”
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The impact of ctDNA on metastatic cancer management: Current trends and future directions by Omveer Singh, Usha Kumari Sah, Jay Chandra, Saraswati Patel

“…This report examines recent advancements in ctDNA technology and its impact on oncology. ctDNA enables early cancer detection with high sensitivity (up to 85 %) and specificity (95 %) and provides valuable insights into disease progression and treatment efficacy. …”
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Edaravone-Dexborneol slows down pathological progression and cognitive decline via inhibiting S100A9 in APPswe/PS1dE9 mice by Rui Mao, Shu Shu, Min Sun, Jiang Chen, Mengsha Hu, Lei Ye, Siyi Xu, Junqiu Jia, Wenxuan Shao, Xinyu Bao, Yun Xu, Xiaolei Zhu

“…Conclusion Our results indicate that EDB can improve cognitive function and slow down AD progression, and it may serve as a potential agent for AD and other S100A9-related diseases.…”
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m6A-modified circXPO1 accelerates colorectal cancer progression via interaction with FMRP to promote WWC2 mRNA decay by Xiaowen Zhu, Pengxia Zhang

“…Abstract Background Recent evidence has demonstrated the vital roles of circular RNAs (circRNAs) in the progression of colorectal cancer (CRC); however, their functions and mechanisms in CRC need to be further explored. …”
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Helicobacter pylori induced miR-362-5p upregulation drives gastric cancer progression and links hepatocellular carcinoma through an exosome-dependent pathway by Jianhui Zhang, Shuzhen Liu, Juan Zhang, Mingzhu Feng, Shu Chen, Yinuo Zhang, Zekun Sun, Xinying Cao, Chao Gao, Xiaofei Ji, Xiaofei Ji, Huilin Zhao, Huilin Zhao

“…MKN45 xenograft model in nude mice was employed to evaluate impacts of miR-362-5p on GC progression in vivo. Target gene of miR-362-5p was screened by bioinformatic analysis and verified by using dual-luciferase assay. …”
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Identifying Hub Genes and Immune Cell Infiltration for the Progression of Carotid Atherosclerotic Plaques in the Context of Predictive and Preventive Using Integrative Bioinformati... by Han Zhang, Yinde Huang, Xin Li, Wenbin Chen, Yu Lun, Jian Zhang

“…Here, the expression profiles of the genes expressed during the progression of the carotid atherosclerotic plaques were retrieved from the Gene Expression Omnibus database and 178 differentially expressed genes were examined. …”
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Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes. by Emre Bektik, Adrienne Dennis, Prateek Prasanna, Anant Madabhushi, Ji-Dong Fu

“…In conclusion, HAND2 and microRNA-1 could help 7 factors to facilitate the early progress of iCM-reprogramming from human fibroblasts. …”
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Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in R... by Dan Zhu, Tingting Fan, Xinyue Huo, Jian Cui, Chi Wai Cheung, Zhengyuan Xia

“…Moreover, CXCR4 and TNF-α of spinal cord dorsal and dorsal root ganglia (DRG) were detected by western blotting and immunostaining over time. …”
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CircSEC24A induces KLF8 expression to promote the malignant progression of non‐small cell lung cancer by regulating miR‐1253 by Wei Xiong, Jinhua Yang

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Hsa-circVIM regulates breast cancer tumor progression and tamoxifen sensitivity by sponging miR-1294 in hormone receptor-positive breast cancer cells by Ying Chen, Zhenhua Zhang, Xue Luo, Meini Cen, Peng Dai, Xiaoyan Zhu

“…Abstract Background The progression and metastasis of breast cancer patients are regulated by genetics and epigenetics. …”
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Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway... by Bai Gao, Yuchen Jing, Xi Li, Shuyan Cong

“…Conclusions Collectively, USP11 knockdown protects R6/1 mouse neurons from oxidative stress by alleviating mitochondrial dysfunction, thereby preventing the HD progression. This is achieved by inhibiting PTEN expression, which in turn activates the AKT pathway. …”
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