Prospective exploration of the effect of adiposity and associated microbial factors on healing and progression of diabetic foot ulcers in Tanzania: study protocol of a longitudinal... by Fredirick Mashili, Agricola Joachim, Mabulla Mchembe, Faraja Chiwanga, Agbor Ako, Zulfiqar Abbas

“…The primary end point is complete wound healing at 24 weeks while secondary end points are ulcer progression (worsening or improving), amputation and death. …”
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LncRNA HOTTIP modulated by Hedgehog signaling drives colorectal cancer progression by promoting HUWE1-mediated ubiquitin‒proteasome degradation of p53 by Hui Wang, Weiwei Jiao, Defu Li, Zhengping Yu, Huqiao Luo, Jie Zhang, Yuanbing Zhang, Hai Rao, Quqin Lu, Bing Zhao, Shiwen Luo

“…Abstract The Hedgehog (Hh) pathway plays critical roles in regulating appropriate tissue morphogenesis and organ formation in the gastrointestinal tract, and its dysregulation has been closely linked to the malignant progression of colorectal cancer. However, the underlying mechanisms are poorly understood. …”
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Hsa_circ_0072088 promotes non-small cell lung cancer progression through modulating miR-1270/TOP2A axis by Sixuan Li, Zhigang Cui, Min Gao, Yanan Shan, Yihong Ren, Yuxin Zhao, Di Wang, Tingyu Meng, Hongxu Liu, Zhihua Yin

“…In conclusion, circ_0072088 is differentially highly expressed in non-small cell lung cancer and can affect the progression of non-small cell lung cancer through the circ_0072088/miR-1270/TOP2A axis.…”
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Geospatial patterns of progress towards UNAIDS ‘95-95-95’ targets and community vulnerability in Zambia: insights from population-based HIV impact assessments by Suilanji Sivile, Diego F Cuadros, Lloyd Mulenga, Sulani Nyimbili, Natalie Vlahakis, Theodora Savory, Tuhin Chowdhury, Masabho Milali, Daniel T Citron, Khozya Davie Zyambo, Anna Bershteyn

“…Multiple logistic regression models were used to examine the association between selected sociodemographic and behavioural covariates and the three main outcomes of study.Results Varied progress towards the ‘95-95-95’ targets were observed in different regions of Zambia. …”
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Progression from isolated growth hormone deficiency to a combined pituitary hormone deficiency in a cohort of paediatrics patients with pituitary morphology abnormalities on MRI by Cristina Aguilar-Riera, Diego Yeste, Núria González-Llorens, Eduard Mogas, Ariadna Campos-Martorell, Paula Fernandez-Alvarez, Elida Vázquez, María Clemente

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USP8‐mediated PTK7 promotes PIK3CB‐related pathway to accelerate the malignant progression of non‐small cell lung cancer by Wencui Kong, Xuegang Feng, Zongyang Yu, Xingfeng Qi, Zhongquan Zhao

“…Macrophage M2 polarization was assessed by detecting CD206+ cells using flow cytometry. The interaction between PTK7 and USP8 or PIK3CB was assessed by Co‐IP assay. …”
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Glucose-lowering medications and glucose levels as the major determinants of progression of carotid atherosclerosis in middle-aged adults and elders: a community-based prospective... by Chao-Liang Chou, Chao-Liang Chou, Shu-Xin Lu, Chun-Fang Cheng, Tzu-Wei Wu, Li-Yu Wang

“…BackgroundFew prospective studies explored the incidence and determinant of carotid atherosclerosis (CA) progression (CAP). This community-based prospective study focused on the effects of diabetes mellitus (DM) treatments and glucose levels on CAP risks.MethodsWe followed up a group of 657 CA-positive middle-aged adults and elders for CAP. …”
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MiR-493-5p functions as a tumour suppressor in head and neck squamous cell carcinoma progression by targeting HIF-1α by Jiahui Liu, Ruxian Tian, Xi Chen, Qing Song, Caiyu Sun, Dongxian Li, Yuhui Fang, Shijun Lv, Yumei Li, Xicheng Song

“…Here, we explored the association of miR-493-5p with HNSCC progression and elucidated the underlying mechanisms. …”
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Clinico-pathological factors and [18F]FDG PET/CT metabolic parameters for prediction of progression-free survival in radioiodine refractory differentiated thyroid carcinoma by Nguyen Thi Phuong, Mai Hong Son, Mai Huy Thong, Le Ngoc Ha

“…The aim of this study was to investigate the prognostic value of clinico-pathological features and semiquantitative [18F]FDG PET/CT metabolic parameters in predicting progression-free survival (PFS) in DTC patients with RAI-R. …”
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Intraocular pressure correlation to progressive retinal nerve fiber layer loss in primary open angle glaucoma as measured by standard and modified goldmann applanation tonometers by Sean McCafferty, Manjool Shah, Anupam Laul, Khin Kilgore

“…Conclusions Higher levels of GAT IOP during follow-up were related to higher rates of progressive RNFL loss detected by optic nerve OCT in treated POAG. …”
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Seroprevalence of Antibodies to Plasmodium spp. among Individuals without Detectable Infection in Etsako, Edo State, Nigeria by Mathew Folaranmi Olaniyan, Felix Abayomi Adeoye, Wakili Adelani Tijani, Tolulope Busayo Olaniyan, Kemi Felicia Ajiboye, Medinat Taiwo Adeniran, Christian Onosetale Ugege, David Olufemi Adebo, Obataze Josephine Akpoyovwere, Odekunle Bola Odegbemi

“…Tailored malaria control strategies considering local immunity dynamics are crucial for sustaining progress in malaria elimination efforts in similar settings.…”
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Optimized Hybrid Deep Learning Framework for Early Detection of Alzheimer’s Disease Using Adaptive Weight Selection by Karim Gasmi, Abdulrahman Alyami, Omer Hamid, Mohamed O. Altaieb, Osama Rezk Shahin, Lassaad Ben Ammar, Hassen Chouaib, Abdulaziz Shehab

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Laboratory validation of formal concept analysis of the methylation status of microarray-detected genes in primary breast cancer by Samar K Kassim, Hanan H Shehata, Marwa M Abou-Alhussein, Maha M Sallam, Islam Ibrahim Amin

“…The median levels of the percentage of methylated allele of both genes were significantly discriminative between luminal A and luminal B subtypes and benign and healthy control groups. Detection of MUC1 and HS3ST2 promoter methylation status appears to be useful molecular markers for assessing the progressive state of the disease and could be helpful in discriminating breast cancer molecular subtypes. …”
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Changes in Osteoblastic Bone Metastasis Detected Incidentally by Cone-Beam Computed Tomography: A Case Report by Uchina Hiya, Masashi Endo, Kohei Okada, Satoru Takahashi, Kazunari Ogawa, Machi Nakagawa, Michiko Nakamura, Chiaki Shibayama, Yukiko Fukuda, Keiko Akahane, Masahiro Kawahara, Harushi Mori, Katsuyuki Shirai

“…This report highlights a case where CBCT unexpectedly detected osteoblastic bone metastasis during radiotherapy for prostate cancer. …”
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Advanced structural damage detection in steel beams using discrete wavelet transform and fast Fourier transform by Thanh Q Nguyen, Dong Phuong Nguyen, Phuoc T Nguyen, Thuy T Nguyen

“…This paper introduces a novel method for detecting damage in beams based on energy distribution analysis of the power spectrum (PSD). …”
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Investigation of Effectiveness of Some Vibration-Based Techniques in Early Detection of Real-Time Fatigue Failure in Gears by Hasan Ozturk, Isa Yesilyurt, Mustafa Sabuncu

“…It has been found that the initiation and progression of fatigue crack cannot be easily detected by conventional time and frequency domain approaches until the fault is significantly developed. …”
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Picomolar Detection of Tau Protein Using 1D Photonic Crystal Biochips for Alzheimer's Disease Diagnosis by Alberto Sinibaldi, Francesco Chiavaioli, Agostino Occhicone, Norbert Danz, Peter Munzert, Francesco Baldini, Ambra Giannetti, Francesco Michelotti

“…However, elevated levels of Tau in cerebrospinal or other body fluids can be related to the progression of Alzheimer's disease. This study introduces an optical technique that employs a dual label‐free and fluorescence operation mode to detect Tau protein in both standard running buffer and cerebrospinal fluid. …”
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Ultrasonic Nondestructive Testing of Li-ion Batteries for Anomaly Detection and Quality Control: Applications and Signal Processing by Mohammadreza Kari

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Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities by Mathangi Palanivel, Krishna Kanta Ghosh, Madhav Mallam, Raghavan Bhuvanakantham, Parasuraman Padmanabhan, Kah-Leong Lim, Balázs Gulyás

“…Abstract Parkinson’s disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years. …”
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A hybrid deep learning framework for early detection of diabetic retinopathy using retinal fundus images by Mishmala Sushith, A. Sathiya, V. Kalaipoonguzhali, V. Sathya

“…Utilizing the sequential nature of disease progression, the proposed method integrates temporal information across multiple retinal scans to enhance detection accuracy. …”
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