Serum C-C motif chemokine ligand 17 as a predictive biomarker for the progression of non-idiopathic pulmonary fibrosis interstitial lung disease by Takatoshi Enomoto, Yoshito Takeda, Yuya Shirai, Takehiro Hasegawa, Feng Zhao, Hanna Lunding, Moritz Pohl, Ryuya Edahiro, Shigeyuki Shichino, Takahiro Kawasaki, Hanako Yoshimura, Reina Hara, Saori Amiya, Makoto Yamamoto, Daisuke Nakatsubo, Satoshi Tanizaki, Mana Nakayama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Mari Tone, Yuko Abe, Maiko Naito, Kentaro Masuhiro, Yujiro Naito, Takayuki Shiroyama, Kotaro Miyake, Shohei Koyama, Kiyoharu Fukushima, Kota Iwahori, Haruhiko Hirata, Izumi Nagatomo, Satoshi Nojima, Masahiro Yanagawa, Yoshikazu Inoue, Atsushi Kumanogoh

“…Early therapeutic intervention is required to enhance the efficacy of antifibrotic drugs, highlighting the importance of early detection of ILD progression. Although candidate biomarkers for predicting ILD progression have been recently reported through omics analyses, clinically measurable biomarkers remain unestablished. …”
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Mf-net: multi-feature fusion network based on two-stream extraction and multi-scale enhancement for face forgery detection by Hanxian Duan, Qian Jiang, Xin Jin, Michal Wozniak, Yi Zhao, Liwen Wu, Shaowen Yao, Wei Zhou

“…Therefore, researchers have worked on face forgery detection studies and have made significant progress. …”
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Effects of Somatic Mutations Are Associated with SNP in the Progression of Individual Acute Myeloid Leukemia Patient: The Two-Hit Theory Explains Inherited Predisposition to Pathog... by Soyoung Park, Youngil Koh, Sung-Soo Yoon

“…This study evaluated the effects of somatic mutations and single nucleotide polymorphisms (SNPs) on disease progression and tried to verify the two-hit theory in cancer pathogenesis. …”
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Siglec6 CAR T cells suppressed progression of AML via inhibiting Siglec6 and SHP2 induced Src and ERK signaling activation by Qian Li, Li Lin, Shuang Gao, Lin Chen, Zhiying Zhang, Jing Ma, Su Liu, Zeng Cao, Haifeng Zhao, Yafei Wang

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MiR-145-5p arrests the cell cycle by modulating SMAD5/cyclin D1 to inhibit gastric cancer progression by Li Wang, Li Wang, Jianghong Guo, Caixia Lv, Luke Kong, Luke Kong, Jing Cui, Zhongshuai Wang, Yuanyuan Guo, Ruirui Jia, Tao Guan, Tao Guan, Baofeng Yu, Feng Li

“…Immunohistochemistry was used to detect the expression of SMAD5 in GC tissues. Western blot was used to detect cell cycle-related proteins that were regulated by siRNA SMAD5.ResultsThe expression of miR-145-5p was lower in GC tissues and cells compared with adjacent tissues and GES-1, and was related to the poor prognosis of patients with GC. …”
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DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3 by Wenjian Yao, Linlin Shang, Yinghao Wang, Lei Xu, Yu Bai, Mingyu Feng, Xiangbo Jia, Sen Wu

“…The functions of RORA were assessed by detecting its regulatory effects on cell viability, motility, invasion, and tumor growth. …”
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Jujuboside B Reverse CUMS-Promoted Tumor Progression via Blocking PI3K/Akt and MAPK/ERK and Dephosphorylating CREB Signaling by Zhen Yang, Weijia Cai, Yitian Chen, Zhijun Guo, Zhijun Xiao, Ting Zhou, Yuanchi Cheng, Feng Xu

“…E), and reversing CUMS-induced tumor progression. Meanwhile, JUB decreased inflammatory cytokine levels. …”
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EPHA2 promotes triple-negative breast cancer progression by suppressing pyroptosis via the AKT/PI3K/mTOR pathway by Xiaoying Huang, Li Na, Qingkai Han, Qilun Liu, Ligang Wu

“…KOBAS bioinformatics, transmission electron microscopy (TEM), ELISA, western blot and quantitative real-time PCR experiments were employed to detect the association and effects of EPHA2 on pyroptosis in BRCA.ResultsEPHA2 was highly expressed in TNBC, and showed a negative correlation with survival. …”
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Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7 by Tianliang Bai, Ping Li, Yabin Liu, Bindan Cai, Gang Li, Wenbin Wang, Rui Yan, Xiangkui Zheng, Shangkun Du

“…Knockdown of miR-411-3p upregulates MMP7 and induces M2 macrophage polarization, which in turn promotes malignant biological progression of CRC. …”
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Urinary Albumin-to-Creatinine Ratio (uACR) Point-of-Care (POC) Device with Seamless Data Transmission for Monitoring the Progression of Chronic Kidney Disease by Artitaya Thiengsusuk, Napaporn Youngvises, Runtikan Pochairach, Rehab Osman Taha, Kridsada Sirisabhabhorn, Nadda Muhamad, Wanchai Meesiri, Wanna Chaijaroenkul, Kesara Na-Bangchang

“…Chronic kidney disease (CKD) continues to pose a critical global health challenge, making ongoing monitoring vital for effective management and preventing its progression to end-stage renal disease. The urinary albumin-to-creatinine ratio (uACR) stands out as a reliable biomarker. …”
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RECLAIM—A retrospective, multicenter observational study aimed at enabling the development of artificial intelligence-driven prognostic models for disease progression in multiple s... by Jelle Praet, Lina Anderhalten, Giancarlo Comi, Giancarlo Comi, Dana Horakova, Tjalf Ziemssen, Patrick Vermersch, Carsten Lukas, Koen Van Leemput, Koen Van Leemput, Koen Van Leemput, Marjan Steppe, Noemí Manero, Ella Kadas, Alexis Bernard, Jean van Rampelbergh, Erik de Boer, Vera Zingler, Dirk Smeets, Annemie Ribbens, Friedemann Paul, Friedemann Paul, Friedemann Paul, Friedemann Paul, Friedemann Paul

“…Multiple sclerosis (MS) is characterized by a progressive worsening of disability over time. As many regulatory-cleared disease-modifying treatments aiming to slow down this progression are now available, a clear need has arisen for a personalized and data-driven approach to treatment optimization in order to more efficiently slow down disease progression and eventually, progressive disability worsening. …”
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A review of machine learning techniques for urban resilience research: The application and progress of different machine learning techniques in assessing and enhancing urban resili... by Yu Chen, Wenxing You, Lu Ou, Hui Tang

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P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study by Jussi Lehto, Richard Aarnio, Jouni Tuisku, Marcus Sucksdorff, Esa Mikko Koivumäki, Marjo Nylund, Semi Helin, Johan Rajander, Jonathan Danon, Jayson Gilchrist, Michael Kassiou, Vesa Oikonen, Laura Airas

“…Abstract Background PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at ‘smoldering’ lesion rims have been implicated as drivers of disability progression. …”
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PLEKHA4 is transcriptionally regulated by HOXD9 and regulates glycolytic reprogramming and progression in glioblastoma via activation of the STAT3/SOCS-1 pathway by Dainan Zhang, Xiaoyin Wang, Meng Xiao, Shunchang Ma, Shaomin Li, Wang Jia

“…In vitro and in vivo experiments were conducted to detect the effect of PLEKHA4 on glioblastoma cell glycolytic reprogramming and progression. …”
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A Comprehensive Analysis of the Impact of HIV on HCV Immune Responses and Its Association with Liver Disease Progression in a Unique Plasma Donor Cohort. by Yong-Hong Zhang, Yan Zhao, Ushani S Rajapaksa, Tessa M Lawrence, Yan-Chun Peng, Jinghua Liu, Keyi Xu, Ke Hu, Ling Qin, Ning Liu, Huanqin Sun, Hui-Ping Yan, Emmanouela Repapi, Sarah Rowland-Jones, Robert Thimme, Jane A McKeating, Tao Dong

“…<h4>Results</h4>HIV-1 accelerated liver disease progression and decreased HCV specific T cell immunity. …”
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microRNA-875-5p-conjugated gold nanoparticles suppress breast cancer progression through the MTDH/PTEN/AKT signaling pathway by Bin Xiong, Junfeng Zhang, Yanmei Si, Jia Fu

“…Then, the effect of AuNP-miR-875-5p on the proliferative, migratory, invasive activities, and apoptosis of BC cells was detected, as well as on tumor growth in animals. The involvement of the MTDH/PTEN/AKT pathway in miR-875-5p-mediated BC progression was identified. …”
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MiR-638 suppresses the progression of oral squamous cell carcinoma through wnt/β-catenin pathway by targeting phospholipase D1 by Kai-Liang Tang, Han-Ying Tang, Yi- Du, Tian Tian, Shi-Jiang Xiong

“…Objective The current study aimed to explore the function of miR-638 on the progression of oral squamous cell carcinoma (OSCC) and relevant molecular mechanisms.Methods Expression profile of miR-638 in OSCC tissues and cells was detected using quantitative real-time polymerase chain reaction (qRT-PCR) method. …”
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Flavokawain B Weakens Gastric Cancer Progression via the TGF-β1/SMAD4 Pathway and Attenuates M2 Macrophage Polarization by Yongzhao Zhu, Weining Fan, Yuanzhen Wang, Huan Ding, Shaoqi Yang, Fang He

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METTL14-mediated miR-122-5p maturation stimulated tumor progression by targeting KAT2A in hepatocellular carcinoma by Xiangyu Fan, Wenjuan Qiao, Xu Guo, Jiaqi Wang, Lisong Zhao

“…Therefore, this study was aimed to explore the mechanism of miR-122-5p in regulating hepatocellular carcinoma (HCC) progression. mRNA expression and transfection efficiency were detected by RT-qPCR. …”
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SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway by Ping Qiu, Xing Li, Min Gong, Ping Wen, Jianbo Wen, Linfang Xu, Guiliang Wang

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