Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression. by Mahmoud El Maassarani, Alice Barbarin, Gaëlle Fromont, Ouafae Kaissi, Margot Lebbe, Brigitte Vannier, Ahmed Moussa, Paule Séité

“…The nuclear localization of ErbB3 has been reported in various cancer tissues and cell lines but the nuclear functions and the putative correlation with tumour progression and resistance to therapy remain unclear. …”
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Estimating fish stock biomass using a Bayesian state-space model: accounting for catchability change due to technological progress by Makoto Nishimoto, Yoshinori Aoki, Naoto Matsubara, Paul Hamer, Yuichi Tsuda

“…Although time-varying catchability poses challenges for accurate biomass estimation due to the large range of uncertainty, the decreasing trend in stock status is still detected. The estimated recent decline in the skipjack stock around Japan provides a warning for stock assessments that do not incorporate technological progress, despite the species’ high natural population growth rate and presumed stable stock status. …”
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Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2‐Dependent Manner by Ming‐Yu Hua, Guo‐Liang Wang, Wen‐Hao Duan, Xiao‐Heng Tang

“…Circular RNA (circRNA) has been reported to be associated with OA progression. This study aims to explore the role and potential mechanism of hsa_circ_0006646 in OA. …”
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MiR-106b-5p improving the progression of chronic kidney disease by inhibiting the TGF-β/Smad pathway by Qihao Ma, Li Xu, Peng Zhou, Bo Yang, Yong Li, Danan Sun

“…Abstract Background Chronic Kidney Disease (CKD) is a progressive disorder marked by renal impairment and declining kidney function. …”
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Two functional indel polymorphisms in the promoter region of the Brahma gene (BRM) and disease risk and progression-free survival in colorectal cancer. by Yajun Yu, Dangxiao Cheng, Patrick Parfrey, Geoffrey Liu, Sevtap Savas

“…A stronger association was detected in the male patients under the recessive genetic model where the homozygosity for the variant allele of BRM-741 was associated with shorter progression-free survival time.…”
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Progressive Adaptation of Subtype H6N1 Avian Influenza Virus in Taiwan Enhances Mammalian Infectivity, Pathogenicity, and Transmissibility by Zuoyi Zheng, Xifeng Chen, Rutian Zheng, Zhigang Yan, Long Li, Rirong Chen, Lifeng Li, Yongmei Liu, Yi Guan, Huachen Zhu

“…., PB2-E627K or HA-Q226L) were detected. These findings demonstrate progressive mammalian adaptation, replication efficiency, and transmissibility within the Taiwan H6N1 lineage. …”
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The P4HB/LGALS3BP/NF-kB axis promotes the progression of MIA to IAC in lung adenocarcinoma by Guang Mu, Wenhao Zhang, Yan Gu, Hongchang Wang, Jingjing Huang, Chengyu Bian, Ke Wei, Yang Xia, Jun Wang

“…Abstract Prolyl 4-hydroxylase β-subunit (P4HB) is a class of molecular chaperones that inhibits the misfolding of endoplasmic reticulum proteins, and its role in microinvasive adenocarcinoma (MIA) progresses to invasive adenocarcinoma (IAC) is currently unclear. …”
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Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis by Yu Zhang, Rong Wu, Xi Zhan, Xuan-Yi Wang, Lin-Wei Xiang, Ya-Qian Duan, Yan You, Jian-Bo Zhang, Rui Wu, Yun-Yuan Zhang, Liang Duan

“…In vitro and in vivo experiments were used to analyze their effects on the progression of hepatic inflammation/fibrosis as well as their clinical importance. …”
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A spatio-temporal fusion-based approach for multi-dimensional classification of Parkinson’s disease progression using multi-modal dataset by Vinay Kukreja, Vandana Ahuja, Modafar Ati, Hariharan Shanmugasundaram, Murugaperumal Krishnamoorthy, Rishabh Sharma, Abhishek Bhattacherjee

“…Context: The progressive neurodegenerative disorder Parkinson’s disease (PD) features diverse symptom presentation that progresses at different speeds and demands effective disease classification with precise patient management. …”
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Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling by Ming Tong, Camilla Homans, William Pelit, Busra Delikkaya, Suzanne M. de la Monte

“…Additional research is needed to better understand the mechanisms of ARBD progression to advanced stages with permanent disability. …”
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Resection of lesions in the ileum of patients with IgG4-related disease may ameliorate disease progression without steroid administration by Akihiro Watanabe, Takashi Goto, Hitomi Kamo, Ryuji Komine, Naomi Kuroki, Takanobu Sugase, Tsuyoshi Takaya, Rintaro Koga, Hiroshi Hojo, Shoji Taniguchi, Kazuhiko Ibusuki, Kazumi Koga

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Rasal2 inhibits autophagic-exosomes secretion via regulating Rab27a in triple-negative breast cancer progression by Xuan Wang, Guocui Qi, Kunning Yang, Linlin Ma, Yuansai Kang, Xiaojing Tang, YanTao Han

“…Exosomes (Exos) secreted by cancer cells to tumor microenvironment play an important role in cancer progression. We have demonstrated that the function of Rasal2 in the modulation of breast cancer progression is exos-mediated, but the relationship between Rasal2 and exosome secretion remains elusive. …”
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The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing <i>AP1S2</i> by B. Zhang, R. Liu, T. Ma, X. Li, Y. Zhao, H. Su, J. Li, Y. Li, H. Jiang, Q. Zhang

“…Furthermore, reduction in melanin content in the skin was detected. These results showed that miRNA-211 significantly affected the melanogenesis progress via downregulating <i>AP1S2</i> and advantageously affected the melanin content of Cashmere goat skin.…”
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IGF2BP1-mediated methylation of ABCA1 facilitates tumor progression by affecting cholesterol metabolism in lung adenocarcinoma by Shaohua Xu, Kai Liu, Zhao Chen, Weijian Tang, Zhoumiao Chen

“…Abstract ABCA1 is a key protein in maintaining cholesterol homeostasis, and its abnormal expression is associated with the progression of many cancers. Nonetheless, the specific molecular mechanisms by which ABCA1 facilitates the development of LUAD remain largely unexplored, necessitating further in-depth investigation. …”
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LncRNA GAS5 inhibits glioma progression through miR-135b-5p/APC axis by ZHANG Jidong, WANG Yutao, JI Jianwen

“…Conclusion‍　‍GAS5 inhibits the progression of glioma via miR-135b-5p/APC axis, which revealing the molecular regulatory mechanism of GAS5/miR-135b-5p/APC. …”
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Targeting the nuclear orphan receptor NR4A1: a key target in lung cancer progression and therapeutic resistance by Minhan Jin, Minhan Jin, Yuhui Wang, Mingze Song, Wenfei Guo, Shirong Li, Zeqing Pu

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RBM47 promotes cell proliferation and immune evasion by upregulating PDIA6: a novel mechanism of pancreatic cancer progression by Yihui Ma, Enjie Liu, Huijie Fan, Chenfei Li, Pei Huang, Meiying Cui, Zhengyang Wang, Jing Zhou, Kuisheng Chen

“…Therefore, we supposed that RBM47 might affect PC progression by regulating PDIA6. Methods Bioinformatics analysis was performed to screen the candidate gene affecting PC progression using public databases. …”
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Ginsenoside C-K inhibits Aβ oligomer-induced Alzheimer's disease pathology progression by regulating microglia-neuron interactions by Chenghu Xie, Cunxin Zhang, Kefeng Zhang, Shanshan Zhang

“…Background: Alzheimer’s disease is a progressive neurodegenerative disorder. Current therapeutic agents primarily focus on symptom alleviation and fail to effectively halt disease progression. …”
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Relationships between ultrasonic, immunological changes in the progression of liver steatosis and fibrosis in patients with chronic diffusive liver diseases of various etiologies by Yu. M. Stepanov, V. I. Didenko, I. S. Konenko, O. M. Tatarchuk

“…To determine the relationships between ultrasound and immunological changes in the progression of steatosis and liver fibrosis in patients with chronic diffuse liver diseases (CLD) of various etiologies. …”
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Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy by Xiongbao Wang, Xiongbao Wang, Xiongbao Wang, Liang Fang, Liang Fang, Lixiang Xiao, Guangxin Zhong, Minghao Han, Bingshen Wang, Juchao Ren, Yuanwei Zang, Yuanwei Zang

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