Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…These results facilitate future research at the interface of genomic instability and replication stress during cancer progression.…”
Get full text

Survival analysis and clinical abnormalities in cats with progressive or regressive feline leukemia virus (FeLV) infection in Brazil. by Giovana Biezus, Thierry Grima de Cristo, Claudia Maria Flores Koehler, Flavia Yasmin de Quadros Kaveski, Thaís Sarria Viana Miranda, Paulo Eduardo Ferian, Renata Assis Casagrande

“…This study aimed to characterize the clinical presentations and effects of progressive and regressive outcomes of feline leukemia virus (FeLV) infection on the life expectancy of cats. …”
Get full text

Extracellular Mitochondrial‐Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction by Huihui Zhang, Zi Yan, Junyou Zhu, Ziyue Li, Lianglong Chen, Weihan Zheng, Zhenning Dai, Jiaxin Yang, Xinyi Yun, Yilin Wang, Hai Zhou, Ziwei Jiang, Qiuyi Yu, Shiyu Li, Wenhua Huang, Lei Yang

Get full text

CD44 and Its Role in Solid Cancers – A Review: From Tumor Progression to Prognosis and Targeted Therapy by João Martins Gama, Rui Caetano Oliveira

“…Immunohistochemistry effectively detects CD44 overexpression, enabling patients to be accurately selected for surgery and targeted anti-CD44 therapies. …”
Get full text

Radix Actinidia chinensis Suppresses Renal Cell Carcinoma Progression: Network Pharmacology Prediction and In Vivo Experimental Validation by Biao Liu, Liang Zhang

Get full text

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance by Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang

“…CXCL6 modulates CCA progression through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping its lipid metabolism. …”
Get full text

A study on mechanisms of DMBT1’s regulation of occurrence and progression of chronic glomerulonephritis based on WNT signaling pathway by LU Zuo-kui, XU Wei-Jia, SHI Xou-yan

“…Objective To study the relative expression and methylation level of DMBT1 in human chronic glomerulonephritis(GGN), and to analyze the correlation of DMBT1 with the WNT/β-catenin signaling pathway in occurrence and progression of GGN.Methods The specimens of normal human kidney tissue( normal kidney tissue near the cancer tissue excised during kidney cancer surgery) from 30 cases of normal people, and damaged kidney tissue from 86 cases of GGN patients, were collected. …”
Get full text

Changes in JC virus-specific T cell responses during natalizumab treatment and in natalizumab-associated progressive multifocal leukoencephalopathy. by Molly R Perkins, Caroline Ryschkewitsch, Julia C Liebner, Maria Chiara G Monaco, Danielle Himelfarb, Sara Ireland, Annelys Roque, Heather L Edward, Peter N Jensen, Gina Remington, Thomas Abraham, Jaspreet Abraham, Benjamin Greenberg, Charles Kaufman, Chris LaGanke, Nancy L Monson, Xiaoning Xu, Elliot Frohman, Eugene O Major, Daniel C Douek

“…Progressive multifocal leukoencephalopathy (PML) induced by JC virus (JCV) is a risk for natalizumab-treated multiple sclerosis (MS) patients. …”
Get full text

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice. by Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Issa Yusuf, Robert H Brown, Huaibin Cai, Zuoshang Xu

“…However, denervation was detected at the neuromuscular junction. These results demonstrate that low-level TDP-43 overexpression can cause diverse aspects of ALS, including late-onset and progressive motor dysfunction, neuroinflammation, and neurodegeneration. …”
Get full text

A positive feedback loop of SRSF9/USP22/ZEB1 promotes the progression of ovarian cancer by Jing Wang, Ming Hu, Jie Min, Xin Li

“…This study aimed to reveal the mechanism by which SRSF9 regulates OC progression. Cell proliferation was determined via CCK-8 assays, whereas cell migration and invasion were monitored via Transwell assays. …”
Get full text

Comparison of multi-state Markov models for cancer progression with different procedures for parameters estimation. An application to breast cancer by Leonardo Ventura, Giulia Carreras, Donella Puliti, Eugenio Paci, Marco Zappa, Guido Miccinesi

“…<p><strong>Background:</strong> the knowledge of sojourn time (the duration of the preclinical screen-detectable period) and screening test sensitivity is crucial for understanding the disease progression and the effectiveness of screening programmes. …”
Get full text

Escalating progression of mental health disorders during the COVID-19 pandemic: Evidence from a nationwide survey. by Li Ping Wong, Haridah Alias, Afiqah Alyaa Md Fuzi, Intan Sofia Omar, Azmawaty Mohamad Nor, Maw Pin Tan, Diana Lea Baranovich, Che Zarrina Saari, Sareena Hanim Hamzah, Ku Wing Cheong, Chiew Hwa Poon, Vimala Ramoo, Chong Chin Che, Kyaimon Myint, Suria Zainuddin, Ivy Chung

Get full text

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming by Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu

Get full text

METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling by Mei Pu, Xia Xiao, Shasha Lv, Daqing Ran, Qian Huang, Mingming Zhou, Qirong Lei, Lingshuang Kong, Qing Zhang

“…The METTL3-dependent regulation of DLG2 mRNA stability could be a critical factor in cervical cancer progression.…”
Get full text

TGFBR3 inhibits progression of papillary thyroid cancer by inhibiting the PI3K/AKT pathway and EMT by Hanrong Zhang, Junxin Chen, Xin Chen, Chuimian Zeng, Pengyuan Zhang, Jiewen Jin, Haipeng Xiao, Yanbing Li, Hongyu Guan, Hai Li

“…Transcriptome sequencing, quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR), and Western blotting were used to detect the underlying mechanism of TGFBR3 in PTC progression. …”
Get full text

Association of renin-angiotensin system genes polymorphism with progression of diabetic nephropathy in patients with type 1 diabetes mellitus by Ilić Vesna, Ilić Miroljub, Soldatović Ivan, Popović Srđan, Magić Zvonko

“…Diabetic nephropathy (DN) as a major microvascular complication of diabetes mellitus (DM) include a progressive increase in urinary albumin excretion in association with an increase in blood pressure and to end stage renal failure. …”
Get full text

The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population by Xianming Tang, Shuangfa Qiu, Xin Sun, Guifang Yang, Lijuan Sheng

Get full text

METTL3 mediates m6A methylation modification of ULBP2 and affects the progression of cervical cancer by Hongtao Ren, Yuting Wang, Jiao Yu, Lei An, Xiulong Ma, Jiyuan Pan

“…However, the precise molecular mechanism regulating CC progression through methyltransferase-like protein 3 (METTL3) and UL16 Binding Protein 2 (ULBP2) remains largely unknown. …”
Get full text

Dysregulation of miR-106a-5p/PTEN axis associated with progression and diagnostic of postmenopausal osteoporosis by Xiangjie Liu, Xiaogang Zhang, Meini Cen

Get full text

Interruption of the visual cycle in a novel animal model induces progressive vision loss resembling Stargardts Disease by Fabiana Sassone, Catherine Estay-Ahumada, Michel J. Roux, Dominique Ciocca, Paola Rossolillo, Marie-Christine Birling, Janet R. Sparrow, Diego Montenegro, David Hicks

Get full text