Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression by Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang

“…Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective therapies. …”
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MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions by Hai-Yu Mo, Ruo-Bing Wang, Meng-Yao Ma, Yi Zhang, Xin-Yu Li, Wang-Rong Wen, Yi Han, Tian Tian

“…Here, we aimed to identify the key metabolic enzymes that protect gastric cancer (GC) cells from oxidative stress.Methods: ROS level was detected by DCFH-DA probes. Multiple cell biological studies were performed to identify the underlying mechanisms. …”
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DNMT3B promotes the progression of pheochromocytoma by mediating the hypermethylation of LRP1B promoter by Min Sun, Yanrong Ma, Jing Wan, Bingli Zheng, Zhenfeng Shi, Jiuzhi Li

“…As a tumor suppressor gene, LRP1B is involved in the regulation of tumor progression. However, the precise regulatory mechanism of LRP1B in Pheo remains elusive. …”
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RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers by Xueda Hu, Jingyi Chen, Xiaoshun Shi, Fenglan Feng, King Wai Lau, Yaoqi Chen, Yusong Chen, Long Jiang, Fei Cui, Yalei Zhang, Xin Xu, Jin Li

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Research progress on formation mechanism of health factor 2,3,5,6-tetramethylpyrazine in Baijiu by HU Zhihui, CHEN Fang, GUO Xuefeng, ZHAO Tengfei, LUO Zhenbiao, WU Deguang

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Construction of a Dual-Fluorescence Reporter System to Monitor the Dynamic Progression of Pluripotent Cell Differentiation by Wu-Sheng Sun, Ju-Lan Chun, Jeong-Tae Do, Dong-Hwan Kim, Jin-Seop Ahn, Min-Kyu Kim, In-Sul Hwang, Dae-Jin Kwon, Seong-Soo Hwang, Jeong-Woong Lee

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C20orf27 promotes hepatocellular carcinoma progression via NT5E by Yu He, Wen Zhang, Ming Chang, Yuanjie Chen, Risheng Lin, Xinyu Ye, Wei Mao, Yubin Lu, Yi Lu, Erbao Chen

“…In this study, we identified C20orf27 as a critical gene that facilitates liver cancer progression. We detected that C20orf27 was upregulated in liver cancer samples. …”
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MICROVASCULAR CHANGES AND DIABETIC RETINOPATHY AND NEPHROPATHY PROGRESSION IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS by Valeria Draganova, Dimitar Dzhelebov, Hristinka Krasimirova Borisova-Zhecheva, Petya Goycheva

“…Conclusion: It is important to detect microvascular changes and start appropriate treatments early in the development of DR in children and young adults with T1DM to prevent progression. …”
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Clinical and diagnostic study of ovine chronic progressive pneumonia (Maedi-Visna) in sheep of Basrah, Iraq by Kamal M. AlSaad, Ali J. Lafta, Mohand H. Lafta, Jihad A. Ahmed

“…Moreover, Variable whitish patches on the parietal surface of the affected lung were also detected. The histopathological appearance shows lobar pneumonia consists of progressive inflammatory exudation filling the lobar alveolar spaces with severe infiltration of inflammatory cells and erythrocytes inside alveolar spaces. …”
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Analysis of the circadian rhythm of intraocular pressure in stable and progressive forms of primary open-angle glaucoma by T. N. Malishevskaya, D. G. Gubin, I. V. Nemcova, A. S. Vlasova, Ju. E. Filippova, E. E. Farikova, D. S. Bogdanova

“…To analyze the daily dynamics and the parameters of intraocular pressure circadian rhythm (IOP CR) in patients with primary open-angle glaucoma (POAG) (stable and progressive forms) and determine chronobiological regularities of glaucoma progression depending on the patterns of restructuring the daily dynamics of IOP CR and body temperature.Material and methods. …”
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ZSCAN16 expedites hepatocellular carcinoma progression via activating TBC1D31 by Xiaofang Wang, Bo Xiao, Fuping Zhong, Yong Zhou, Qibo Wang, Jihao Jiang

“…This paper sought to expound the function of Zinc finger and SCAN domain-containing protein 16 (ZSCAN16) and TBC1 domain family member 31 (TBC1D31) in HCC progression. Methods ZSCAN16 and TBC1D31 levels were detected by RT-qPCR, Western blot, and immunohistochemistry. …”
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Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases. by Euiheon Chung, Hiroshi Yamashita, Patrick Au, Bakhos A Tannous, Dai Fukumura, Rakesh K Jain

“…Thus techniques that can sensitively detect metastatic colonization and assess treatment response in real-time are urgently needed. …”
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Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis by Dan-Dan Yao, Xiao-Wei Yan, Yan Zhou, Zuo-Lin Li, Fang-Xin Qiu

“…Background Vascular calcification is common and progressive in patients with chronic kidney disease. …”
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Complete mucosal healing prevents stricture progression after endoscopic balloon dilation in Crohn's disease by Jun Owada, Kunihiko Oguro, Tomonori Yano, Yusuke Ono, Takuma Kobayashi, Shoko Miyahara, Hirotsugu Sakamoto, Hironori Yamamoto

“…However, 73% of patients experienced stricture progression. The presence of ulcers between sessions was identified as a significant risk factor for stricture progression (odds ratio 7.59, p = 0.031). …”
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KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus by Yanming Hu, Jing Zhou, Xinru Ling, Kun Zhao, Peng Huang, Max Gao, Xiaoqing Li, Ming Sun, Yanfen Zou, Guannan Feng

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Senescence-related circRNA circHIF-1α is associated with pancreatic cancer progression by Hao Hua, Yazu Deng, Dijie Zheng, Changhao Wu, Liwen Chen, Binbin Shi, Zhiwei He, Chao Yu

“…Abstract Recently, there has been growing interest in the role of circular RNAs (circRNAs) in the progression of human cancers. Cellular senescence, a known anti-tumour mechanism, has been observed in several types of cancer. …”
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Plasma exchange for Alzheimer's disease Management by Albumin Replacement (AMBAR) trial: Study design and progress by Mercè Boada, Oscar López, Laura Núñez, Zbigniew M. Szczepiorkowski, Mireia Torres, Carlota Grifols, Antonio Páez

“…Secondary efficacy variables include change from the baseline in scores on cognitive, functional, behavioral, and overall progression tests; changes in plasma and cerebrospinal fluid levels of amyloid β and tau protein; and assessment of structural and functional changes in brain areas of interest. …”
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A case of rapidly progressing sarcomatous intrahepatic cholangiocarcinoma with suddenly appearing lymph node metastasis by Eisho Kanemitsu, Rei Takahashi, Setsuko Nakanishi, Satoru Sueyoshi, Atsushi Kobayashi, Takao Nishimura, Hiromitsu Nagata

“…Here, we report a case of rapidly progressing SICC that showed a clinically significant tumor growth rate. …”
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Lactoferrin influences atherosclerotic progression by modulating macrophagic AMPK/mTOR signaling-dependent autophagy by Bing Xia, Jingwei Liang, Yanlin Lu, Jiuyang Ding, Jin Peng, Fangqin Li, Jialin Dai, Yubo Liu, Jie Wang, Changwu Wan, Peng Luo

“…LTF, P62 and 4-HNE levels in plaques increased as plaque stability decreased, and LTF was significantly correlated with plaque progression and autophagy levels. Autophagy inhibition by U0126 leads to the worsening of aortic luminal stenosis, increased necrotic core and foam cell deposits, decreased autophagosomes, reduced LTF expression, and upregulated P62 expression in AS mice. …”
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TRAF2 regulates the progression of pulmonary fibrosis through β-catenin-Snail signaling pathway by Zhijie Wan, Jingwen Gu, Wanli Duan, Yuanyuan Chen, Shuya Song, Jingyu Luo, Xide Zhang, Yanyong Yang, Yanyong Yang, Fu Gao, Fu Gao, Ying Xu

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