Mitigating Antibiotic Resistance: The Utilization of CRISPR Technology in Detection by Xuejiao Zhang, Zhaojie Huang, Yanxia Zhang, Wen Wang, Zihong Ye, Pei Liang, Kai Sun, Wencheng Kang, Qiao Tang, Xiaoping Yu

“…This review offers an extensive examination of CRISPR/Cas systems, highlighting their unique attributes and applications in antibiotic detection. It outlines the current utilization and progress of the CRISPR/Cas toolkit for identifying both nucleic acid (resistance genes) and non-nucleic acid (antibiotic micromolecules) targets within the field of antibiotic detection. …”
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Uncovering critical transitions and molecule mechanisms in disease progressions using Gaussian graphical optimal transport by Wenbo Hua, Ruixia Cui, Heran Yang, Jingyao Zhang, Chang Liu, Jian Sun

“…Abstract Understanding disease progression is crucial for detecting critical transitions and finding trigger molecules, facilitating early diagnosis interventions. …”
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HPV 16 Is Related to the Progression of Cervical Intraepithelial Neoplasia Grade 2: A Case Series by Maria Gabriela Loffredo D’Ottaviano, Michelle Garcia Discacciati, Maria Antonieta Andreoli, Maria Cecília Costa, Lara Termini, Silvia H. Rabelo-Santos, Luisa Lina Villa, Luiz Carlos Zeferino

“…HPV 16 was detected at admission in 58% (11/19) of the cases that persisted/progressed and in 39% (7/18) of the cases that regressed. …”
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Hepatitis B virus pre-existing drug resistant mutation is related to the genotype and disease progression by Liping Wang, Fangzheng Han, Hualing Duan, Fang Ji, Xuebing Yan, Yuchen Fan, Kai Wang

“…Likewise, increasing prevalence of pre-existing drug-resistant mutations was shown, alongside with the progression of the disease. …”
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MiR-217 participates in the progression of postmenopausal osteoporosis by regulating the OPG/RANKL/RANK pathway by Xiaoxia Yang, Qihua Jin, Lihua Guo

“…Western blotting was used to detect the expression of relevant proteins. Enzyme-linked immunosorbent assay was used to detect the levels of related indicators in the serum of model rats. …”
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Exploring the Functional Disorder and Corresponding Key Transcription Factors in Intraductal Papillary Mucinous Neoplasms Progression by Guiying Bai, Chenxuan Wu, Yingtang Gao, Guiming Shu

“…And eight clusters of differentially expressed genes (DEGs) with similar expression pattern were detected by k-means clustering. Then a survey map of functional disorder in IPMN progression was established by functional enrichment analysis of these clusters. …”
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JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α by Zheng Chen, Xuan Zheng, Weijian Zeng, Juan Wang, Qin Lin

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Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization by Wei Yang, Xuanxuan Yan, Rui Chen, Xin Xin, Shuang Ge, Yongxiang Zhao, Xinlong Yan, Jinhua Zhang

“…Although the Smad4 signaling pathway has been implicated in the progression of NAFLD, the specific role of Smad4 in hepatocytes in NAFLD pathogenesis remains unclear. …”
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YTHDC1 Promotes Stemness Maintenance and Malignant Progression in Head and Neck Squamous Cell Carcinoma by Junquan Weng, Haidong Fan, Huijuan Liu, Su Tang, Yuyan Zheng

“…We detected YTHDC1 expression in The Cancer Genome Atlas (TCGA) database data and clinical samples. …”
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Factors of coxitis progression in patients with axial spondyloarthritis. Results of a two-year dynamic observation by E. M. Agafonova, Sh. Erdes, T. V. Dubinina, A. B. Demina, A. V. Smirnov

“…To detect the relationship between the clinical manifestations of axSpA and the radiographic progression of coxitis, a cluster analysis of the main parameters was performed.Results and discussion. …”
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Research progress on application of diffusion weighted imaging and introvoxel incoherent motion in the diagnosis of diabetic nephropathy by ZHENG Zai-qiong, WANG Deng-wei, LI Huan, XIE Xi-sheng, FENG Jie

“…Diabetic nephropathy(DN)is one of main chronic microvascular complications of diabetes mellitus(DM).Previous early diagnosis of DN mainly relied on medical history,laboratory examination and renal biopsy,but laboratory examination was easily affected by physiology,pathology and other factors.Renal biopsy was invasive and difficult to be accepted.Therefore,it is of great significance to explore new technologies for early diagnosis of DN.Diffusion weighted magnetic resonance imaging(DWI)and intravoxel incoherent motion magnetic resonance imaging(IVIM-MR)can indirectly reflect the changes of tissue microstructure by detecting the Brownian motion of water molecules in living tissues,and can study the pathophysiological status of diseases at the cellular and molecular levels.It may bring new methods to the diagnosis of DN.This article reviews the progress of application o DWI and IVIM in the diagnosis of DN in recent years.…”
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Research Progress Towards and Prospects of Carbon Dots Derived from Tea and Chinese Medicinal Materials by Xiaoxue Tang, Zhao Gong, Yan Lang, Hongyue Chen, Siqi Huang, Yuguang Lv

“…This review focuses on the research progress related to carbon dots (CDs) derived from Chinese herbal medicines and tea, covering preparation methods, physicochemical properties, and application fields. …”
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Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction by Yanping Zhang, Lei Lv, Zhaokai Zhou, He Zhang, Qi Li, Shuai Yang, Yibo Wen, Qingwei Wang, Jinjin Feng, Wei Lu, Wei Jia, Jian Guo Wen

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Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases by Xiaolong Liu, Jianguo Lu, Xinyu Dong, Yizhuo Zhang, Guixing Jiang, Yanlong Cao, Defei Hong

“…Background Pancreatic cancer is very difficult to detect in its early stages, and its rapid progression and poor prognosis make it a significant therapeutic challenge. …”
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Observation and treatment of patients with progressive metastatic differentiated thyroid cancer after establishment of radioiodine refractoriness by E. V. Borodavina, S.  I. Kutukova, A. Yu. Shurinov, E. B. Vasil’eva, A. O. Guz, I. V. Grishkevich, S. D. Karateeva, A. R. Shakhmatova, R. S. Slobodyanskiy, O. V. Romanchuk, M. R. Mukhitova, M. P. Karpovich, S. P. Dmitriev, O. S. Saypeeva, K. A. Tolpeykina, S. S. Tolstov, A. V. Makarova, Ya. A. Tyugina, E. G. Ovchinnikova

“…During both treatment and dynamic observation, distant metastases are detected in 10–15 % of patients. In these cases, the patients continue treatment with radioactive iodine. …”
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Diagnostic value of serum origin recognition complex protein 1 in the progression of HBVrelated liver fibrosis by LIANG Hongqian, HUANG Long, REN Aoli, SU Minghua, HU Bobin, LI Qingmei, SU Tumei, YIN Qianbing, LI Aining, JIANG Jianning

“…Conclusion The level of serum ORC1 in patients with chronic HBV infection is related to the progression of liver fibrosis, and its elevated level increases the risk of progression of liver fibrosis. …”
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POLE2 silencing inhibits the progression of colorectal carcinoma cells via wnt signaling axis by Weihua Jian, Lei Zhang

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Isolated Subtalar Repositional Arthrodesis Compared with Triple Arthrodesis for the Treatment of Progressive Collapsing Foot Deformity by Sunghoo Kim MD, HoSeong Lee MD, PhD

“…Category: Hindfoot; Midfoot/Forefoot Introduction/Purpose: The optimal extent of arthrodesis for severe and rigid progressive collapsing foot deformity is controversial. …”
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Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma. by Thomas C Booth, Timothy J Larkin, Yinyin Yuan, Mikko I Kettunen, Sarah N Dawson, Daniel Scoffings, Holly C Canuto, Sarah L Vowler, Heide Kirschenlohr, Michael P Hobson, Florian Markowetz, Sarah Jefferies, Kevin M Brindle

“…<h4>Purpose</h4>To develop an image analysis technique that distinguishes pseudoprogression from true progression by analyzing tumour heterogeneity in T2-weighted images using topological descriptors of image heterogeneity called Minkowski functionals (MFs).…”
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Potential role of matrix metalloproteinase-8 as a predictive marker for peri-implant mucositis progress by Noor I Dhaidan, Ghada I Taha, Maher AL Shayeb

“…The purpose of this study was to detect the role of MMP-8 as a biomarker of active and aggressive peri-implant mucositis. …”
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