Hsa-miR-21-5p is induced by interleukin-6 and affects multiple pathogenic factors associated with fibroblast-like synoviocytes in rheumatoid arthritis by Kei Araki, Sho Mokuda, Hiroki Kohno, Naoya Oka, Hirofumi Watanabe, Michinori Ishitoku, Tomohiro Sugimoto, Yusuke Yoshida, Junya Masumoto, Shintaro Hirata

“…The induction of miR-21-5p mimic decreased the expression of Programmed Cell Death 4 (PDCD4) and Osteoprotegerin (OPG), while upregulating Semaphorin 5A (SEMA5A). …”
Get full text

Divergent response associates with the differential amplitudes of immunity against Magnaporthe oryzae by different blast resistance genes by Beenish Hassan, Sadam Hussain Bhutto, Xiao-Xiao Yin, Xiu-Lian Yan, Rong Liao, Mao-Lin Guo, Ya-Ping Tang, Dai-Ming Guo, Si-Jia Yang, Faiza Gulzar, Yan Li, Xian-Yin Zeng, Zhi-Xue Zhao, Wen-Ming Wang

“…Here, we demonstrated that different blast R genes confer differential amplitudes of immunity against M. oryzae, presumably due to divergent reprogramming of transcriptional responses. We detected that three rice restorer lines exhibited differential amplitudes of immune responses, despite all lines displaying resistance to M. oryzae. …”
Get full text

Longitudinal analysis of passively and actively acquired SARS-CoV-2 antibodies in infants with repeat newborn screening samples by Amanda K. Damjanovic, Alexander Keyel, Jean M. Rock, Dylan Ehrbar, Rachel Bievenue, Katherine L. Nemeth, Erica Yauney, Denise M. Kay, Michele Caggana, Monica M. Parker, Linda M. Styer

“…Seroconversion was confirmed by retesting IgG seroconverting infants for detectable IgA and IgM SARS-CoV-2 antibodies.…”
Get full text

Autoimmune Diseases and Molecular Mimicry in Tuberculosis by Leonid P. Churilov, Muslimbek G. Normatov, Hong Ling, Min Zhuang, Dmitry Kudlay, Anna Starshinova

“…Results: The high level of antibodies to modified citrulinated vimentin (anti-MCV) was most frequently detected (57%) in comparison with other antibodies. …”
Get full text

Multiple molecular diagnoses identified through genome sequencing in individuals with suspected rare disease by Alka Malhotra, Erin Thorpe, Alison J. Coffey, Revathi Rajkumar, Josephine Adjeman, Naomi Dianne Naa Adjeley Adjetey, Sharron Aglobitse, Felix Allotey, Todor Arsov, Joyce Ashong, Ebenezer Vincent Badoe, Donald Basel, Yvonne Brew, Chester Brown, Kerri Bosfield, Kari Casas, Mario Cornejo-Olivas, Laura Davis-Keppen, Abbey Freed, Kate Gibson, Parul Jayakar, Marilyn C. Jones, Martina Kawome, Aimé Lumaka, Ursula Maier, Prince Makay, Gioconda Manassero, Marilyn Marbell-Wilson, Charles Marcuccilli, Diane Masser-Frye, Julie McCarrier, Hannah-Sharon Mills, Jeny Balazar Montoya, Gerrye Mubungu, Mamy Ngole, Jorge Perez, Eniko Pivnick, Milagros M. Duenas-Roque, Hildegard Pena Salguero, Arturo Serize, Marwan Shinawi, Fabio Sirchia, Claudia Soler-Alfonso, Alan Taylor, Lauren Thompson, Gail Vance, Adeline Vanderver, Keith Vaux, Danita Velasco, Samuel Wiafe, Ryan J. Taft, Denise L. Perry, Akanchha Kesari

“…Summary: Genome sequencing is a powerful and comprehensive test that detects multiple variants of different types. The interrogation of variants across the genome enables the identification of multiple molecular diagnoses (MMDs) in a single individual. …”
Get full text

The ALMA Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO). X. Dust Substructures, Disk Geometries, and Dust-disk Radii by Miguel Vioque, Nicolás T. Kurtovic, Leon Trapman, Anibal Sierra, Laura M. Pérez, Ke Zhang, Pietro Curone, Giovanni P. Rosotti, John Carpenter, Benoît Tabone, Paola Pinilla, Dingshan Deng, Ilaria Pascucci, James Miley, Carolina Agurto-Gangas, Lucas A. Cieza, Rossella Anania, Dary A. Ruiz-Rodriguez, Camilo González-Ruilova, Estephani E. TorresVillanueva, Aleksandra Kuznetsova

“…We examine the presence of continuum substructures in the AGE-PRO sample by using these radial profiles and their residuals. We detect substructures in 15 out of 30 disks. We report five disks with large (>15 au) inner dust cavities. …”
Get full text

Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer by Yixiao Zhang, Lisha Sun, Haonan Li, Liping Ai, Qingtian Ma, Xinbo Qiao, Jie Yang, Hao Zhang, Xunyan Ou, Yining Wang, Guanglei Chen, Jinqi Xue, Xudong Zhu, Yu Zhao, Yongliang Yang, Caigang Liu

“…Western blot and RT-PCR were used to detect the expression of TLN1 and integrin pathway in cells. …”
Get full text

Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB by Hasan Mohammad Al-Amin, Narayan Gyawali, Melissa Graham, Mohammad Shafiul Alam, Audrey Lenhart, Zhiyong Xi, Gordana Rašić, Nigel W. Beebe, Leon E. Hugo, Gregor J. Devine

“…The existing insecticide-based control program is challenged by issues of insufficient household coverage and high levels of insecticide resistance in the primary dengue virus (DENV) vector, Aedes aegypti. …”
Get full text

Confirmation of highly pathogenic avian influenza H5N1 in skuas, Antarctica 2024 by Benjamín Bennett-Laso, Benjamín Bennett-Laso, Bárbara Berazay, Bárbara Berazay, Gabriela Muñoz, Gabriela Muñoz, Naomi Ariyama, Naomi Ariyama, Nikita Enciso, Christina Braun, Lucas Krüger, Lucas Krüger, Miloš Barták, Marcelo González-Aravena, Victor Neira

“…From December 2023 to March 2024, a surveillance program aiming to detect Highly Pathogenic Avian Influenza (HPAI) H5N1 was conducted on Antarctica territories, specifically at Fildes Peninsula (King George Island, Maritime Antarctic), and James Ross Island. …”
Get full text

Naringin Regulates the Growth and Apoptosis of Ovarian Cancer Cells via the TGF-β Signaling Pathway: A Prospective Laboratory Based Study by Xiaoni Zhou, Ying Yu, Bingqing Xie, Tingtao Chen, Liping Cai

“…Finally, small interfering RNA (siRNA) targeting TGF-β was synthesized, and the recombinant plasmid vector overexpressing TGF-β was constructed to detect the mRNA and protein expression of Snail1/SMAD2. …”
Get full text

Prevalence of human papillomavirus genotypes in Latvia among women participating in cervical cancer screening by Anna Stasulane, Anna Stasulane, Justine Grundmane, Justine Grundmane, Kristiana Sulte, Kristiana Sulte, Janis Stasulans, Janis Stasulans, Solvita Cernavska, Solvita Cernavska, Laura Smite, Laura Smite

“…The data were collected during the first two years of the reorganized screening program, from 1 July 2022 to 1 July 2024, which for the first time included HPV genotyping as a primary screening method in women aged 30–70. …”
Get full text

Genetic Mapping of QTL Associated with 100-Kernel Weight Using a DH Population in Maize by Huawei Li, Hao Li, Jian Chen, Xiangbo Zhang, Baobao Wang, Shujun Zhi, Haiying Guan, Weibin Song, Jinsheng Lai, Haiming Zhao, Rixin Gao

“…The total phenotypic variation explained by QTLs detected in three different environments (BJ2016, BJ2107, and HN2018) was 22.2%, 32.9%, and 51.38%, respectively. …”
Get full text

Formation of All Three C2H4O Isomers—Ethylene Oxide (c-C2H4O), Acetaldehyde (CH3CHO), and Vinyl Alcohol (CH2CHOH)—in Ethanol-containing Interstellar Analog Ices by Jia Wang, Chaojiang Zhang, Joshua H. Marks, Ralf I. Kaiser

“…These biorelevant species were detected in the gas phase through isomer-selective photoionization reflectron time-of-flight mass spectrometry during temperature-programmed desorption. …”
Get full text

Clinical profile of hypertension patients in primary health Care in Cirebon Regency, Indonesia by Tiar Masykuroh Pratamawati, Ahmad Fariz Malvi Zamzam Zein, Uswatun Khasanah, Donny Nauphar, Vincentius S.W. Budhyanto, Idrus Alwi, Asmarinah

Get full text

The prevalence and antimicrobial resistance of respiratory pathogens isolated from feedlot cattle in Canada by Porjai Rattanapanadda, Porjai Rattanapanadda, Dana Ramsay, Alyssa Butters, Calvin W. Booker, Sherry J. Hannon, Steve Hendrick, Joyce Van Donkersgoed, Brian N. Warr, Sheryl P. Gow, Paul S. Morley

Get full text

Pulmonary and functional hallmarks after SARS-CoV-2 infection across three WHO severity level-groups: an observational study by Patrícia Blau Margosian Conti, Maria Ângela Gonçalves Oliveira Ribeiro, Carla Cristina Souza Gomez, Aline Priscila Souza, Daniela Souza Paiva Borgli, Eulália Sakano, Mauro Alexandre Pascoa, Silvana Dalge Severino, Tayná Castilho, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson, José Dirceu Ribeiro, UNICOVID Study Group, Adyléia Aparecida Dalbo Contrera Toro, Aline Cristina Gonçalves, Andrea de Melo Alexandre Fraga, André Moreno Morcillo, Andressa Oliveira Peixoto, Andrei Carvalho Sposito, Bianca Aparecida Siqueira, Emília Silva Gonçalves, Emília Raposo Nascimento, Gil Guerra Junior, Jenniffer Tayna Orzechowski Furtado, Lucas Rodrigues de Moraes, Maria de Fatima Corrêa Pimenta Servidoni, Mariana Zorron, Marcos Tadeu Nolasco da Silva, Maíra Seabra Assumpção, Milena Baptistela Grotta, Renan Marrichi Mauch, Simone Appenzeller, Thiago Luís Infanger Serrano

Get full text

First record of mermithid parasitism in adult biting midges, Culicoides huffi (Diptera: Ceratopogonidae), collected from Southern Thailand, with ultrastructural and molecular chara... by Chulaluk Promrangsee, Vivornpun Sanprasert, Arunrat Thepparat, Sakone Sunantaraporn, Rinnara Ampol, Rungfar Boonserm, Padet Siriyasatien, Kanok Preativatanyou

“…Methods As part of the leishmaniasis surveillance program in Nakhon Si Thammarat Province, Southern Thailand, we collected Culicoides midges near the residence of a leishmaniasis patient in November 2024. …”
Get full text

Genotypic Analysis of Transmitted and Acquired HIV Drug Resistance in People Living with HIV/AIDS in Surabaya, Indonesia, from 2018 to 2019 by Brian Eka Rachman, Ni Luh Ayu Megasari, Siti Qamariyah Khairunisa, Tomohiro Kotaki, M Vitanata Arfijanto, Usman Hadi, Nasronudin Nasronudin, Masanori Kameoka

Get full text

Implementation of C-reactive protein point of care testing to improve antibiotic targeting in respiratory illness in Vietnamese primary care (ICAT): a study protocol for a cluster... by H Rogier van Doorn, Behzad Nadjm, Yoel Lubell, Rachel Claire Greer, Sabine Dittrich, Sonia Lewycka, Nga Thi Thuy Do, Maida Vandendorpe, Van Anh Nguyen, Pham Ngoc Thach, Ta Thi Dieu Ngan, Nguyen Van Kinh, Cao Hung Thai, Le Thi Kim Dung, Tu Nguyen Thi Cam, Thanh Ha Nguyen

Get full text

Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy by Amanda K. Slagle, Amanda K. Slagle, Nicolo Ghiringhelli Borsa, Kai Wang, Amanda O. Taylor, Nicole C. Meyer, Michael B. Jones, William D. Walls, Angela F. M. Nelson, Sarah M. Roberts, Mingyao Sun, Elena Goicoechea de Jorge, Santiago Rodriguez de Cordoba, Diana I. Jalal, Diana I. Jalal, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith, Richard J. H. Smith

Get full text