Natural Course of Electrocardiographic Features in Arrhythmogenic Right Ventricular Cardiomyopathy and Their Relation to Ventricular Arrhythmic Events by Anneli Svensson, Henrik Kjaerulf Jensen, Machteld J. Boonstra, Marianne Tétreault‐Langlois, Pia Dahlberg, Henning Bundgaard, Alex Hørby Christensen, Rebecca T. Rylance, Jesper H. Svendsen, Julia Cadrin‐Tourigny, Anneline S. J. M. te Riele, Pyotr G. Platonov

“…Electrocardiographic abnormalities may be detected before diagnosis and might, although not fulfilling the 2010 Task Force Criteria, be markers of early disease. …”
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3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay by Di Wu, Xiaoqi Guan, Tao Yang, Jiashuai Yan, Biwen Zhu, Junchao Zhou, Yibing Guo, Yuhua Lu

“…Further, biomimetic local stiffness niches were engineered using the digital light-processing (DLP) 3D-printing technology and the desmoplastic bioink (gelatin methacrylate & hyaluronic acid methacrylate, GelMA&HAMA) encapsulating PDAC cells, which permits modulation of mechanical properties without altering the biochemical ligand density. …”
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SULT2B1: a novel therapeutic target in colorectal cancer via modulation of AKT/PKM2-mediated glycolysis and proliferation by Jianxing Ma, Fengyao Sun, Wen Li, Ruihang Du, Mingchan Liu, Qiuya Wei, Boxiong Kang, Siyuan Yan, Chen Wang

“…Chromatin immunoprecipitation (CHIP) assay was utilized to detect the effect of SULT2B1 in regulating transcription. …”
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Effects of Qingyangshen glycosides on neuroplasticity in a mouse model of social defeat by Jingru Wang, Weishi Chen, Qiang Zhu, Yao Liu, Zheng Kang, Dingding Liu, Guirong Zeng

“…The pathological processing of social defeat and the therapeutic effects of QYS on it was confirmed through behavioral assessment associated with morphologic observation. …”
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Risk Element Interaction with an Emerging Contaminant in Mammals: The Case of Arsenic and Carbamazepine Orally Taken up by <i>Microtus arvalis</i> L. as a Model Organism by Frank Boahen, Jiřina Száková, Zuzana Čadková, Jana Štanderová, Christiane Schwarz, Martin Gierus, Lukáš Praus, Filip Mercl, Pavel Tlustoš

“…This study assessed As and CBZ accumulation, their biotransformation processes, and antioxidant enzyme defence responses after sole and combined exposure. …”
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Does Freediving Lead to Hippocampal Adaptability to Hypoxia and Maintenance of Episodic Memory? by Julia Micaux, Clément Poiret, Jingwen Zhao, Aya El Hajj, Morgane Tillenon, Abir Troudi Habibi, Franck Mauconduit, Fawzi Boumezbeur, Catherine Chiron, Marion Noulhiane

“…This task specifically targeted HS-related memory processes by distinguishing between three types of items: (i) identical, (ii) similar, and (iii) new. …”
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RBM20 nucleotide sequence variant in a family with a dilated phenotype of left ventricular non-compaction by O. V. Kulikova, R. P. Myasnikov, A. N. Meshkov, E. A. Mershina, A. V. Kiseleva, E. A. Sotnikova, M. M. Kudryavtseva, M. S. Kharlap, M. G. Divashuk, A. A. Zharikova, R. K. Angarsky, S. N. Koretsky, D. А. Filatova, V. E. Sinitsyn, O. M. Drapkina

“…RBM20 is a key splicing regulator that controls the processing of several important transcripts predominantly expressed in striated muscle, especially cardiac tissue. …”
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Volatile organic compounds from typical industries in North China Plain: emissions, air pollution contribution, health risks, and policy implications by Jiqi Zhu, Shoujun Xia, Hejingying Niu, Jian Xu, Yueqian Wang, Xuena Yu, Ling Huang, Kun Zhang, Yangjun Wang, Limin Zeng, Qing Li, Li Li

“…Results indicate that: (1) Current emission factors of industrial VOCs diverged substantially, with petrochemical (15.93 kg/t) and pharmaceutical (135 kg/t) industries being the most obvious emission sectors. (2) Chemical composition of VOCs varied across different industries, with surface coating emitting 69 % halogenated hydrocarbons, petrochemicals releasing 58 % aromatics, and pharmaceuticals discharging 53 % oxygenated VOCs (OVOCs). (3) Ozone formation potential peaked in surface coating (351.9 mg/m3, aromatics-driven) and olefin-rich organic chemical processes, while secondary organic aerosol potential was dominated by petrochemical aromatics (5,750 μg/m3). (4) Health risks are high in resin and plastic, pharmaceutical, and petroleum industries, with acrolein (HQ = 0.96) and acetaldehyde (cancer risk = 3.9 × 10-7) as priority hazards. (5) Based on detected greenhouse-effect VOCs, Freon-12/11 emissions dominated climate impacts (83 %, 467.1 tCO2-eq) in the petrochemical industry. (6) Entropy-weighted analysis prioritized petroleum for Tier-1 controls. …”
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Gut Microbiota‐Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High‐Altitude by Yongqiang Zhou, Zhexin Ni, Jingjing Liu, Dezhi Sun, Pan Shen, Xi Chen, Gaofu Li, Zhijie Bai, Yangyi Hu, Ningning Wang, Rui Wang, Lina Guan, Yihao Wang, Xianglin Tang, Yungang Lu, Baokun He, Haitao Lu, Wei Zhou, Yue Gao

“…Lower abundances of Veillonella rogosae, Streptococcus rubneri, and gut microbiota‐associated serum metabolites promoted the remodeling of metabolic processes, thereby increasing susceptibility to high‐altitude heart health abnormalities. …”
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Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury by Jason-Alexander Hörauf, Cora Rebecca Schindler, Inna Schaible, Minhong Wang, Birte Weber, André El Saman, Christiane Pallas, Marek Widera, Ingo Marzi, Dirk Henrich, Liudmila Leppik

“…BackgroundExtracellular vesicles (EVs), a heterogeneous group of cell-derived, membrane-enclosed vesicles bearing cell-specific epitopes, have been demonstrated to play a crucial role in neuronal-glial communication and the orchestration of neuroinflammatory processes. However, the existing evidence regarding their function as biomarkers and their role in the pathobiology of traumatic spinal cord injuries (tSCI), particularly in humans, is scarce.ObjectiveThe primary goal of this study was to investigate whether a distinct pattern of EV surface epitopes detected in the plasma of individuals suffering from spinal cord injury is indicative of tSCI.MethodsThe study includes patients with isolated tSCI (n=8), polytrauma patients without tSCI (PT; ISS ≥16, n=8), and healthy volunteers (HV; n=8). …”
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Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters by Antonietta Canna, Silvia Mangia, Shalom Michaeli, Sara Ponticorvo, Maria Claudia Russillo, Valentina Andreozzi, Renzo Manara, Francesco Di Salle, Marina Picillo, Paolo Barone, Fabrizio Esposito, Maria Teresa Pellecchia

“…Abstract Rotating frame relaxation (RFR) techniques provide robust and sensitive quantitative MRI (qMRI) metrics able to detect subtle alterations of brain tissue integrity in multiple neurological disorders. …”
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Increased [¹⁸F]DPA-714 Uptake in the Skeletal Muscle of SOD1^G93A Mice: A New Potential of Translocator Protein 18 kDa Imaging in Amyotrophic Lateral Sclerosis by Cecilia Marini, Mattia Riondato, Edoardo Dighero, Alessia Democrito, Serena Losacco, Laura Emionite, Lucilla Nobbio, Irene Di Patrizi, Mattia Camera, Chiara Ghersi, Maddalena Ghelardoni, Francesco Lanfranchi, Francesca Vitale, Sonia Carta, Sabrina Chiesa, Carola Torazza, Marco Milanese, Matteo Bauckneht, Mehrnaz Hamedani, Federico Zaottini, Angelo Schenone, Carlo Martinoli, Federica Grillo, Gianmario Sambuceti

“…Here, we aimed to verify whether PET imaging of the translocator protein 18 kDa (TSPO) can detect a muscular abnormality in an experimental model of ALS. …”
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Twilight Near-Infrared Radiometry for Stratospheric Aerosol Layer Height by Lipi Mukherjee, Dong L. Wu, Nader Abuhassan, Thomas F. Hanisco, Ukkyo Jeong, Yoshitaka Jin, Thierry Leblanc, Bernhard Mayer, Forrest M. Mims, Isamu Morino, Tomohiro Nagai, Stephen Nicholls, Richard Querel, Tetsu Sakai, Ellsworth J. Welton, Stephen Windle, Peter Pantina, Osamu Uchino

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Bacterial indicators during storage of slaughter products of turkeys of the meat sector of productivity with the use of the prebiotic drug Aktigen by A. V. Konopelko, V. P. Lyasota

“…Variational and statistical processing of experimental data was carried out using computer software packages “Microsoft Exel”, “Maple-12” (Company Maplesoft, 2008) for variational and statistical processing of digital data. …”
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Effects of Different Drying Methods on Nutritional Components, Antioxidant Activity and Volatile Components of Five Kinds of Dried Figs by Zhenzhen DING, Na XIA, Yanquan LIU, Tian ZHANG, Lei JIANG, Yanchang WANG, Chao ZHANG

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A Detailed Single-pulse Study of Four-component Pulsar PSR J1239+0326 Discovered by FAST by R. Rejep, W. W. Zhu, N. Wang, W. M. Yan, J. P. Yuan, M. Kramer, L. Q. Meng, E. Gügercinoğlu, M. Yuan, W. Y. Wang, Z. W. Wu, Q. D. Wu, D. Zhao, S. Q. Wang, H. M. Tedila, S. J. Dang, M. Y. Xue, P. Wang, The FAST Collaboration

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The Potential of Hydrogeodesy to Address Water‐Related and Sustainability Challenges by Fernando Jaramillo, Saeid Aminjafari, Pascal Castellazzi, Ayan Fleischmann, Etienne Fluet‐Chouinard, Hossein Hashemi, Clara Hubinger, Hilary R. Martens, Fabrice Papa, Tilo Schöne, Angelica Tarpanelli, Vili Virkki, Lan Wang‐Erlandsson, Rodrigo Abarca‐del‐Rio, Adrian Borsa, Georgia Destouni, Giuliano Di Baldassarre, Michele‐Lee Moore, José Andrés Posada‐Marín, Shimon Wdowinski, Susanna Werth, George H. Allen, Donald Argus, Omid Elmi, Luciana Fenoglio, Frédéric Frappart, Xander Huggins, Zahra Kalantari, Simon Munier, Sebastián Palomino‐Ángel, Abigail Robinson, Kristian Rubiano, Gabriela Siles, Marc Simard, Chunqiao Song, Christopher Spence, Mohammad J. Tourian, Yoshihide Wada, Chao Wang, Jida Wang, Fangfang Yao, Wouter R. Berghuijs, Jean‐François Cretaux, James Famiglietti, Alice Fassoni‐Andrade, Jessica V. Fayne, Félix Girard, Matti Kummu, Kristine M. Larson, Martin Marañon, Daniel M. Moreira, Karina Nielsen, Tamlin Pavelsky, Francisco Pena, J. T. Reager, Maria Cristina Rulli, Juan F. Salazar

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Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acidA receptors by Anika Fuhr, Robin Roediger, Mariana Simelitidis, Jutta Gamper-Tsigaras, Markus Templin, Michael Kormann, Bernd Antkowiak, Uwe Rudolph, David Köhler, Peter Rosenberger, Kristian-Christos Ngamsri, Franziska M. Konrad

“…The ionotropic GABAA-receptors are known from the central nervous system (CNS) and have recently been detected in the lung. These receptors have been shown to influence inflammatory processes. …”
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Comparative Study of Free Amino Acid Profiles in Underground Organs of Several Species of the Genus Rumex During Different Phases of the Vegetation Cycle by A. M. Poluyanov, U. A. Matvienko, A. Yu. Sokolova, A. E. Savelyeva, N. A. Durnova, N. V. Bobkova

“…Amino acids (AA), the primary metabolites in plants, play a crucial role in various physiological processes, including the synthesis of phenolic compounds. …”
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Level of knowledge among the population of radiation safety basic issues by S. A. Zelencova, G. V. Arhangel'skaja, N. M. Vishnjakova, I. A. Zykova, V. S. Repin

“…Respondents of the same seven groups often correctly answered the question on how to detect ionising radiation (only with devices) – from 68 to 98 % in different groups. …”
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