GluR2 overexpression in ACC glutamatergic neurons alleviates cancer-induced bone pain in rats by Futing Ba, Jinrong Wei, Qi-Yan Feng, Chen-Yang Yu, Meng-Xue Song, Shufen Hu, Guang-Yin Xu, Hai-Long Zhang, Guo-Qin Jiang

“…The anterior cingulate cortex (ACC) plays a critical role in processing and modulating chronic pain. This study investigates how the GluR2 receptors (calcium impermeable AMPA receptors) in ACC glutamatergic neurons regulate CIBP. …”
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Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina by Tatyana Appelbaum, David A. Smith, Kei Takahashi, Jennifer C. Kwok, Hannah Sorenson, William A. Beltran

“…The data suggest that transfection efficiency in retinal cells is influenced by both intracellular processing of mRNA lipoplexes and their uptake, with the former playing a predominant role.…”
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Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway by Ping-Cheng Shih, I-Shiang Tzeng, Yi-Chyan Chen, Mao-Liang Chen

“…<b>Background/Objects</b>: Rho signaling plays a role in calcium-regulated cytoskeletal reorganization and cell movement, processes linked to neuronal function and cancer metastasis. …”
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Inter-seasonal phytoplankton dynamics in the UAE coastal waters by Nadia Solovieva, Nadia Solovieva, Dunya Medhat, Fatin Samara, Fatin Samara, Maria Saburova

“…Phytoplankton are key indicators of marine ecosystem health and drivers of biogeochemical processes, yet their seasonal patterns in the southern Arabian Gulf are insufficiently understood. …”
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Profiling of Circulating Cell-free DNA Methylation Patterns Identifies Aberrant Methylated CTBP1 Promotor Sites for Prediction of Alzheimer’s Disease by Zhiwu Dong, Kewen Zhao, Hongjun Gu, Wenwei Yang, Xin Zhang

“…Functional annotation and pathway enrichment analysis underscored processes and pathways inherent in the nervous system. …”
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Study on Enzyme Activity and Metabolomics during Culture of Liquid Spawn of <i>Floccularia luteovirens</i> by Yanqing Ni, Qiuhong Liao, Siyuan Gou, Tongjia Shi, Wensheng Li, Rencai Feng, Zhiqiang Zhao, Xu Zhao

“…To comprehensively investigate the physiological characteristics and metabolic processes of the mycelium of <i>Floccularia luteovirens</i> (<i>F. luteovirens</i>), a wild edible fungus unique to the plateau region, we conducted an in-depth analysis of the mycelium enzyme activity and metabolites during different culture periods. …”
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Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults by Jose Bernal, Inga Menze, Renat Yakupov, Oliver Peters, Julian Hellmann-Regen, Silka Dawn Freiesleben, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Enise I. Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Sebastian Sodenkamp, Annika Spottke, Anna Esser, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler

“…Conclusions Our study suggests that cortical thinning and WMH progression could be mutually reinforcing rather than parallel, unrelated processes, which become entangled before cognitive deficits are detectable. …”
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Discovery of a Pair of Galaxies with Both Hosting X-Ray Binary Candidates at z = 2.544 by Sijia Cai, Zheng Cai, Jianwei Lyu, Yunjing Wu, Xiaojing Lin, Mingyu Li, Junjie Mao, Jiayi Chen, Pengjun Lu

“…This galaxy pair represents the highest redshift non-AGN-dominated galaxies with individual X-ray detections reported to date. This finding suggests that the contribution of XRBs to galaxy X-ray emission at high redshift may be underestimated.…”
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Hybrid deep learning enables multi-institutional delineation of active bone marrow for gynecologic radiotherapy by Zhe Zhang, Xiao Lu, Sicheng He, Tao Huang, Shaobin Wang, Mingjun Lu, Xiaomin Zhang, Zhibo Tan, John Moraros, Lei Zhang, Xin Li, Zhan Li, Zihao Deng, Yimeng Zhang, Mengjie Dong, Shuihua Wang, Yajie Liu

“…Using 18F-FDG PET/CT as a reference, we developed a deep learning method to detect hematopoietic active bone marrow (ABM) on CT in gynecologic cancer patients and assess clinical benefits. …”
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Association Between the Effectiveness and Magnitude of Foot Microcirculation Assessed by Radionuclide Angiography and One Year Limb Outcomes in Patients with Chronic Limb Threateni... by Takuya Hashimoto, Yoshitaka Kumakura, Kenichi Ichikawa, Satoshi Yamamoto, Takashi Endo, Masaya Sano, Osamu Sato, Juno Deguchi

“…Novel parameters (pedal transit time and peak pedal count) were derived by processing the time–activity curves of the detected tracers in each region of interest in the limbs. …”
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Pre-Hospital Point-of-Care Troponin: Is It Possible to Anticipate the Diagnosis? A Preliminary Report by Cristian Lazzari, Sara Montemerani, Cosimo Fabrizi, Cecilia Sacchi, Antoine Belperio, Marilena Fantacci, Giovanni Sbrana, Agostino Ognibene, Maurizio Zanobetti, Simone Nocentini

“…<b>Results</b>: The Atellica VTLi demonstrated reasonable sensitivity for detecting AMI, with sensitivity increasing from 60% at the first measurement (time 0) to 80% at the second measurement (time 1 h). …”
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Pyropheophorbide-α methyl ester-mediated photodynamic therapy triggers pyroptosis in osteosarcoma cells via the ROS/caspase-3/GSDME pathway by Qiu Huang, Yong Tao, Ye Zhang, Yuxing Chen, Fuqiang Tan, Yunsheng Ou

“…Cell viability and apoptosis ratio were detected using CCK-8 and Annexin V–Propidium Iodide staining, respectively. …”
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The association between the Glutathione S-transferase polymorphisms and addiction to opioids and methamphetamine in the Iranian population by Mohammad Reza Eskandarion, Mohammad Reza Eskandarion, Simin Jafaripour, Farid Heidari, Elham Talebi, Maryam Rezakhani Taleghani, Neda Maserat, Maryam Forutan, Raheb Ghorbani, Jaber Gharehdaghi, Reza Shirkoohi, Reza Raoofian

“…Considering the oxidative stress induced by morphine and methamphetamine and the potential of GST as a therapeutic option for SUD, we aimed to investigate the association of common genetic variations of two genes from GST family, GSTT1 and GSTM1, with addiction to morphine and METH in Iranian population.Material and methodsA total of 160 blood and urine samples were randomly collected from 50 opiums and 30 methamphetamine users and 80 healthy controls. All samples were processed by thin layer chromatography (TLC), high performance liquid chromatography, and Gas Chromatography-Mass Spectrometry (GC-MS) techniques to detect opium alkaloids (morphine, codeine, papaverine, noscapine, etc.), methamphetamine stimulants, and other legal and illegal drugs. …”
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Exosome-related genes influence the progression of stroke through neuroinflammatory responses by Boyan Zhao, Boyan Zhao, Jianing Wu, Mingyang Han, Xuan Rong, Jin Jin, Shiya Liu, Cheng Zhang, Ruotian Zhang, Xin Chen, Fei Peng, Xingli Dong, Shiguang Zhao, Shiguang Zhao

“…Enrichment analyses were conducted to examine biological processes. CIBERSORT and MCPcounter were applied to assess immune infiltration, and Principal Component Analysis was utilized to explore the associations of feature genes and hub genes with immune cells. …”
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Sustaining forest biodiversity: Exploring the effect of long-term natural disturbance dynamics on contemporary lichen communities in primary forest ecosystems by Rhiannon Gloor, Marek Svitok, Martin Mikoláš, Jeňýk Hofmeister, Josef Halda, Pavel Janda, Francesco Maria Sabatini, Lucie Zemanová, Arne Buechling, Daniel Kozák, Matej Ferenčík, Michal Frankovič, Martin Dušátko, Miroslav Svoboda

“…Mixed modelling revealed that natural historical disturbance processes have decades-long effects on forest structural attributes, which had both congruent and divergent impacts on lichen community richness and composition. …”
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Can Zinc Oxide Nanoparticles Alleviate the Adverse Effects of Salinity Stress in <i>Coffea arabica</i>? by Jegnes Benjamín Meléndez-Mori, Yoiner K. Lapiz-Culqui, Eyner Huaman-Huaman, Marileydi Zuta-Puscan, Manuel Oliva-Cruz

“…An increase in proline content ranging from 33% to 77% was detected in stressed plants treated with ZnO-NPs, in contrast to stressed plants that did not receive the application. …”
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Circulating exosomes with unique lipid signature in relapsing remitting multiple sclerosis by Claudia Palazzo, Ilaria Asci, Silvia Russo, Cinzia Buccoliero, Vincenzo Mangialardi, Pasqua Abbrescia, Onofrio Valente, Maddalena Ruggieri, Damiano Paolicelli, Simona Lobasso, Antonio Frigeri

“…The specific phospholipid marker of exosomal membranes, bis(monoacylglycero)phosphate (BMP), was clearly detected in both MALDI lipid profiles, with no significant differences in its content between the two sample groups. …”
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Edible caterpillars (Gonimbrasia belina and Gynanisa maja) as emerging source of nutrients and bioactive compounds by Chrysantus M. Tanga, Brian O. Ochieng, Dennis Beesigamukama, Changeh J. Ghemoh, Cynthia Mudalungu, Xavier Cheseto, Isaac M. Osuga, Sevgan Subramanian, Segenet Kelemu

“…These findings suggests that both edible caterpillars contain sufficient nutrients and therapeutic compounds, which when integrated into human food products, either whole, in-part, or processed will greatly contribute towards countering nutritional insecurity and improve livelihoods of people in many countries.…”
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6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols by Stef Bannink, Kateryna O. Bila, Joosje van Weperen, Nina A.M. Ligthart, Maria J. Ferraz, Rolf G. Boot, Daan van der Vliet, Daphne.E.C. Boer, Herman S. Overkleeft, Marta Artola, Johannes M.F.G. Aerts

“…Moreover, significant increases in 6-O-acyl-glycosyl-phytosterols were detected in GD spleens. Our findings suggest uptake of (6-O-acyl)-glycosyl-phytosterols from plant food and subsequent lysosomal processing by GBA1, and comprise the first example of accumulation of an exogenous class of glycolipids in GD. …”
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Identification of Single Nucleotide Polymorphisms Through Genome-Wide Association Studies of pH Traits in Goose Meat by Haiwei Wang, Zhuping Chen, Lin Ma, Yifan Wu, Xianzhi Zhao, Keshan Zhang, Jiajia Xue, Yi Luo, Chao Wang, Zuohua Liu, Youhui Xie, Ying Chen, Guangliang Gao, Qigui Wang

“…High-throughput sequencing on the Illumina HiSeq X Ten platform facilitated gene resequencing and SNP evaluation, and GWAS was employed to detect key genes within quantitative trait loci (QTL) intervals. …”
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