Spinocerebellar ataxias: microsatellite and allele frequency in unaffected and affected individuals Ataxias espinocerebelares: freqüência de alelos e microsatélites em indivíduos n... by Aline Andrade Freund, Rosana Hermínia Scola, Hélio A.G. Teive, Raquel Cristina Arndt, Magda Clara Vieira da Costa-Ribeiro, Lupe Furtado Alle, Lineu Cesar Werneck

“…We examined blood sample from 154 asymptomatic blood donors and 115 individuals with progressive ataxias. PCR products were submitted to capillary electrophoresis. …”
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Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy by Sadanand Dangari Akshay, Heli Upadhyaya, Nitin Shukla, Rohit Bhattacharjee, Sunilkumar Das, Urmi Vyas, Priyank Chavda, Nimesh Patel, Dixsha Jamkhandi, Pritesh Sabara, Neeta Khandelwal, Sumeeta Soni, Kamlesh Upadhyaya, Jayesh Katira, Geeti Maheshwari, Madhvi Joshi, Devarshi Gajjar, Chaitanya Joshi

“…The National Centre for Disease Control, Government of India, established a National Antimicrobial Surveillance Network to detect AMR in high-priority infections, including S. …”
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Balancing the benefits and risks of colchicine use among patients with atherosclerotic cardiovascular disease: an umbrella review of meta-analyses of randomised controlled trialsRe... by Rui-Han Bao, Na Zhao, Xiao-Feng Jiang, Zi-Han Cong, Jun Liu, Long-Dan Kang, Yu-Han Chen, Jia-Nan Sun, Wei-Yi Xing, Jia-Xin Liu, Xue-Li Bai, Hai-Chen Lv, Jing-Ying Zhao, Qi-Peng Ma, Ting-Ting Gong, Qi-Jun Wu

“…Publication bias was detected via funnel plot asymmetry or Egger’s test. …”
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Two decades of Lloviu virus in Europe: knowns and unknowns about the European filovirus by Dr Gábor Kemenesi, Dr Zsófia Lanszki, Ágota Ábrahám, Dr Sándor A Boldogh, Dr Simon Scott, professor Nigel Temperton, Dr Edward Wright, Dr Pierre Nouvellet, Dr Stefania Leopardi, Dr Paola Di Benedictis, Dr Adam Hume, Dr Elke Mühlberger, Levente Sipos-Szabó, Dr Dávid Bajusz, Dr Heliana Dundarova, Dr Szilárd L Bücs, Dr Branka Bajić, Dr Ivana Budinski, Dr Štefan Matis, Dr Tamás Görföl

“…Methods & Materials: We initiated a complex monitoring program for Lloviu virus in 2013. During the last decade we collected and screened more than 2000 blood samples with PCR and serology from eight countries. …”
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Thermonuclear Superburst of MAXI J1752−457 Observed with NinjaSat and MAXI by Amira Aoyama, Teruaki Enoto, Takuya Takahashi, Sota Watanabe, Tomoshi Takeda, Wataru Iwakiri, Kaede Yamasaki, Satoko Iwata, Naoyuki Ota, Arata Jujo, Toru Tamagawa, Tatehiro Mihara, Chin-Ping Hu, Akira Dohi, Nobuya Nishimura, Motoko Serino, Motoki Nakajima, Takao Kitaguchi, Yo Kato, Nobuyuki Kawai, (NinjaSat collaboration)

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Targeting YBX1‐m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma by Ouwen Li, Ke An, Han Wang, Xianbin Li, Yueqin Wang, Lan Huang, Yue Du, Nuo Qin, Jiasheng Dong, Jingyao Wei, Ranran Sun, Yong Shi, Yanjia Guo, Xiangyi Sun, Ying Yang, Yun‐Gui Yang, Quancheng Kan, Xin Tian

“…Abstract Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation of ferroptosis is closely associated with HCC. …”
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Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression by Lei Feng, Yan Chen, Liang Wang, Fei Huang, Yi-Yang Hu, Jun-Long Zhao, Shi-Qian Liang, Lei Dong, Heng-Chao Yu, Jian Bai, Jia-Meng Yang, Jie-Yi Fan, San-Zhong Li, Hua Han, Hong-Yan Qin

“…Background Accumulating evidence has shown that tumor-associated macrophages (TAMs) play a critical role in tumor progression. Targeting TAMs is a potential strategy for tumor immunotherapy. …”
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Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Ju Huang, Jing Li, Jing Li, Zhijun Geng, Zhijun Geng, Lixia Yin, Lixia Yin, Minzhu Niu, Qingqing Li, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Xue Song, Yueyue Wang, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu, Jianguo Hu

“…Background and aimsPatients with Crohn’s disease (CD) exhibit excessive apoptosis of intestinal epithelial cells (IECs), which contributes to damage to the intestinal barrier structure and function, thereby playing a role in the progression of colitis. Preventing IEC apoptosis and protecting the intestinal barrier are critical to alleviating colitis. …”
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Clinical and hematological factors predicting the effectiveness of ruxolitinib in primary and secondary myelofibrosis. Results of a prospective single-center study by O. Yu. Vinogradova, M. M. Pankraskina, A. L. Neverova, D. I. Shikhbabaeva, M. A. Murzabekova, M. V. Chernikov, A. V. Popova, V. P. Kosenkova, L. B. Egoryan, V. V. Ptushkin

“…The median allele burden of JAK2 V617F during observation decreased more than twice from the initial value in half of the patients. The median of progression-free survival (PFS) from the start of ruxolitinib therapy was 28 months, the median of overall survival (OS) has not been achieved. …”
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Elevated platelet-to-lymphocyte ratio predicts poor clinical outcomes in non-muscle invasive bladder cancer: a systematic review and meta-analysis by Wenfeng Hu, Jinze Liang, Jin Luo, Jin Luo, Jin Luo, Jie Fan, Jie Fan, Jie Fan, Huaichun Hu, Xinwen Wang, Xinwen Wang, Xinwen Wang, Peng Zhou, Xiaoyi Zhang, Jie Zhou, Jie Zhou, Jie Zhou

“…Elevated PLR notably correlated with inferior progression-free survival (PFS) (HR=2.132, 95% CI: 1.146-3.967, p=0.017) and relapse-free survival (RFS) (HR=1.732, 95% CI: 1.174-2.554, p=0.006). …”
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Invasive aspergillosis in adult patients with rheumatic diseases by V. I. Mazurov, A. M. Lila, O. V. Shadrivova, M. S. Tonkoshkur, M. S. Shostak, L. V. Martynova, O. V. Inamova, M. S. Petrova, A. Yu. Fonturenko, E. A. Desyatik, Yu. V. Borzova, Yu. E. Melekhina, I. S. Bogomolova, S. M. Ignatyeva, N. N. Klimko

“…The common site of IA was the lung (83%); the characteristic feature detected by computed tomography (CT) is pulmonary cavitation (44%). …”
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IFN-treated macrophage-derived exosomes prevents HBV-HCC migration and invasion via regulating miR-106b-3p/PCGF3/PI3K/AKT signaling axis by Jing Chen, Jing Chen, Jing Chen, Qi Yin, Qi Yin, Shiheng Xu, Xiaoqing Tan, Yu Liang, Chaohui Chen, Li Li, Li Li, Tao Zhang, Tao Shen, Tao Shen, Tao Shen, Tao Shen

“…Cell supernatants were collected to detect miR-106b-3p, HBsAg, HBeAg and HBV DNA levels. …”
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Ibrutinib in the Treatment of Refractory Chronic Lymphocytic Leukemia by EA Nikitin, EA Dmitrieva, MA Panteleev, EI Emelina, VL Ivanova, YuB Kochkareva, EG Arshanskaya, IE Lazarev, EE Markova, LA Mukha, NG Novitskaya, MM Pankrashkina, VV Glazunova, AV Shubina, SA Chernysh, NK Khuazheva, EV Naumova, SA Lugovskaya, ME Pochtar’, TN Obukhova, OYu Vinogradova, GE Gendlin, VV Ptushkin

“…Deletion of 17p/TP53 mutations were detected in 29 (33 %) of 87 patients. Seventy patients had refractory CLL. …”
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Childhood hand, foot and mouth disease sequelae cohort study in Henan, China: cohort profile by Chao Zhang, Dong Li, Yu Chen, Fang Liu, Fang Wang, Xiaolong Li, Kang Li, Shuang Li, Haiyan Yang, Guangcai Duan, Guowei Li, Ling Tao, Zhi Li, Chenyu Wang, Wenyi Liu, Yaodong Zhang, Wangquan Ji, Huifen Feng, Shouhang Chen, Yuanfang Shen, Jiaying Zheng, Demin Feng, Meili Sui, Shuaiyin Chen, Jinzhao Long, Zhuangzhuang Wang, Qingmei Wang, Shujuan Han, Bowen Dai, Dejian Dang, Peiyu Zhu, Zijie Li, Yuefei Jin

“…This dataset will be updated and expanded on an annual basis to support the continuous monitoring of patient health and disease progression. From HNHFMDCS, the study will provide a comprehensive overview of the potential harm caused by this common infectious disease, assess the social burden caused by this disease and make recommendations for the rehabilitation of survivors and prevention of further disability.…”
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Remdesivir associated with reduced mortality in hospitalized COVID-19 patients: treatment effectiveness using real-world data and natural language processing by José Ramón Arribas López, María Pilar Ruiz Seco, Francisco Fanjul, Beatriz Díaz Pollán, Patricia González Ruano Pérez, Adrián Ferre Beltrán, Rosa De Miguel Buckley, Laura Portillo Horcajada, Cristina De Álvaro Pérez, Paulo Jorge Barroso Santos Carvalho, Savana Research Group, Melchor Riera Jaume

“…Abstract Background Remdesivir (RDV) was the first antiviral approved for mild–to–moderate COVID-19 and for those patients at risk for progression to severe disease after clinical trials supported its association with improved outcomes. …”
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Molecular Docking, Bioinformatic Analysis, and Experimental Verification for the Effect of Naringin on ADHD: Possible Inhibition of GSK-3β and HSP90 by Hatem I. Mokhtar, Sawsan A. Zaitone, Karima El-Sayed, Rehab M. Lashine, Nada Ahmed, Suzan M. M. Moursi, Shaimaa A. Shehata, Afaf A. Aldahish, Mohamed A. Helal, Mohamed K. El-Kherbetawy, Manal S. Fawzy, Noha M. Abd El-Fadeal

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Effects of neoadjuvant immunotherapy on hearing in patients with head and neck squamous cell carcinoma by Bryce Hambach, Anhelina Bilokon, John Lee, L. Noelle Allemang, Jennifer Chisholm, Chris K. Zalewski, Julie Christensen, Carmen C. Brewer, James L. Gulley, Clint T. Allen, Lisa L. Cunningham, Katharine A. Fernandez

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Disease characteristics and outcomes of acute myeloid leukemia in germline RUNX1 deficiency (Familial Platelet Disorder with associated Myeloid Malignancy) by Martijn P. T. Ernst, Jurjen Versluis, Peter J. M. Valk, Marc Bierings, Rienk Y. J. Tamminga, Louise H. Hooimeijer, Konstanze Döhner, Paolo Gresele, Kiran Tawana, Saskia M. C. Langemeijer, Bert A. Van der Reijden, Helena Podgornik, Matjaz Sever, Tor H. A. Tvedt, Tom Vulliamy, Jude Fitzgibbon, Inderjeet Dokal, Panagiotis Baliakas, José M. Bastida, Christian Pohlkamp, Torsten Haferlach, Lise Larcher, Jean Soulier, Roger E. G. Schutgens, Kathleen Freson, Nicolas Duployez, Bob Löwenberg, Katrin Ericson, Jörg Cammenga, Tim Ripperger, Marc H. G. P. Raaijmakers

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Teleconsultation for infectious disease management in pediatric intensive care by Dr Jacopo Ceradini, MD Daniela Perrotta, MD Elio Tamburello, MD Marcella Aversa, MD Laura Lancella, MD Francesca Ippolita Calò Carducci, MD Maia De Luca, MD Lorenza Romani, Carmen D'amore, Gaetano Ciliento, Leonardo Vallesi, Massimiliano Raponi, MD Marta Luisa Ciofi degli Atti

“…Conclusion: Teleconsultation contributed to reducing antibiotic consumption in PICU suggesting its effectiveness in the multidisciplinary management of PICU patients within an antimicrobial stewardship program.…”
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Consumption effects of edible oils on the biochemical cardiovascular risks in hyperlipidemic rats by Suzan A. Abushal, Nashi K. Alqahtani, Ahmed M. Abdulfattah, Ahmed M. Abdulfattah, Mohammed F. Abuzinadah, Mohammed F. Abuzinadah, Abdullah M. Izmirly, Abdullah M. Izmirly, Rokayya Sami, Rowa K. Zarah, Hamida Hamdi, Nadiah Al-Sulami, Suad H. Almasoudi, Tasahil S. Albishi, Sameer H. Qari, Ehssan A. Hassan, Ehssan A. Hassan

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