Effect of chemoradiotherapy on the dynamics of circulating lymphocyte subsets in patients with non-metastatic nasopharyngeal carcinoma by Lilan Yi, Lilan Yi, Yinfang Gu, Yinfang Gu, Longhua Guo, Longhua Guo, Xiaofang Zou, Xiaofang Zou, Guowu Wu, Guowu Wu

“…Flow cytometry was employed to detect the expression of CD3, CD4, CD8, CD56, and CD19 on peripheral blood cells. …”
Get full text

Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy by Zhihe Chen, Zhongying Yang, Lifen Rao, Changgen Li, Na Zang, Enmei Liu

“…Additionally, evidence of leaky lung blood vessels and ALI was observed, including progressive weight loss, elevated pulmonary vascular permeability, and severe lung consolidation. …”
Get full text

Mechanisms of impaired expression of p53-responsive microRNA genes in diffuse B-large cell lymphoma by E. N. Voropaeva, T. I. Pospelova, M. I. Churkina, A. A. Gurazheva, O. V. Berezina, V. N. Maksimov

“…A more in-depth description of molecular events that disrupt the functioning of the p53 signaling pathway is important for understanding the mechanisms of formation and progression of diffuse B-large cell lymphoma (DCCL), as well as its sensitivity to treatment. …”
Get full text

Predicting clinical outcomes at hospital admission of patients with COVID-19 pneumonia using artificial intelligence: a secondary analysis of a randomized clinical trial by Caio César Souza Conceição, Camila Marinelli Martins, Mayck Medeiros Silva, Hugo Caire de Castro Faria Neto, Davide Chiumello, Davide Chiumello, Davide Chiumello, Patricia Rieken Macedo Rocco, Fernanda Ferreira Cruz, Pedro Leme Silva

“…The analysis assessed clinical, laboratory, and blood markers at admission to predict clinical improvement, defined as a two-point increase on the World Health Organization clinical progression scale after 7 days. LASSO and CombiROC were used to select optimal predictive variables. …”
Get full text

Automated Image-Based Wound Area Assessment in Outpatient Clinics Using Computer-Aided Methods: A Development and Validation Study by Kuan-Chen Li, Ying-Han Lee, Yu-Hsien Lin

“…This objective and practical method can aid clinical decision-making by tracking wound progression over time.…”
Get full text

Dalpiciclib combined with pyrotinib and endocrine therapy in women with ER-positive, HER2-positive advanced breast cancer: A prospective, multicenter, single-arm, phase 2 trial. by Jian Zhang, Yanchun Meng, Biyun Wang, Xinhong Wu, Hongmei Zheng, Jing Hu, Wei Liu, Wenyan Chen, Leiping Wang, Jun Cao, Zhonghua Tao, Ting Li, Sujie Ni, Zhengyan Yu, Lichun Sun, Yun Wang, Qiang Peng, Song Wang, Xin Hu, Jianfei Wang, Yijia Wu, Xichun Hu

“…The primary endpoint was the objective response rate (ORR), while secondary endpoints included progression-free survival (PFS), duration of response (DOR), disease control rate (DCR), clinical benefit rate (CBR), safety, plasma pharmacokinetics (PK), and biomarker analysis. …”
Get full text

Final analysis of ArtemisR, a European real-world retrospective study of apalutamide for the treatment of patients with metastatic hormone-sensitive prostate cancer by Martin Boegemann, Mostefa Bennamoun, Louis Marie Dourthe, Juan Antonio Encarnacion, Axel Hegele, Eva Hellmis, Igor Latorzeff, Wolfgang Leicht, Julián Oñate-Celdrán, Antonio Rosino-Sánchez, Krystelle Hanna, Joana Lencart, Martin Lukac, Claudio A. Schioppa, Suzy Van Sanden, Gero Kramer

“…At 12 months after treatment initiation, 94% of patients were alive, 91% had not progressed to mCRPC, and 81% remained on apalutamide plus ADT. …”
Get full text

Therapeutic time window of sodium of Danshensu on cerebral ischemia and its mechanism of inhibiting oxidative stress and ferroptosis through Nrf2 pathway by Chao Guo, Zhongying Ma, Xingru Tao, Kai Gao, Wei Zhang, Aidong Wen, Yi Ding, Jingwen Wang

“…Ferroptosis exerts a crucial feature in the development and progression of IS. Nuclear factor-E2-related factor 2 (Nrf2) can positively regulate the transcription of Recombinant Solute Carrier Family 7, member 11 (SLC7A11) and glutathione peroxidase (GPX4) genes that combat lipid peroxidation in ferroptosis. …”
Get full text

The Influence of Non-Alc oholic Fatty Liver Disease on Indicators of Arterial Stiffness and Risk of Cardiovascular Complications in Patients with Arterial Hypertension by M. E. Statsenko, A. M. Streltsova, M. I. Turovets

“…To determine the value of concomitant non-alcoholic fatty liver disease in patients with arterial hypertension in the progression of rigidity of the main arteries and in increase of risk of cardiovascular complications. …”
Get full text

Peri-coronary adipose tissue attenuation and its association with plaque vulnerability and clinical outcomes in coronary artery disease using combined CCTA and OCT by Caifeng Yang, Chancui Deng, Jie Xia, Sha Wang, Long Zhang, Zhijiang Liu, Wei Zhang, Yi Deng, Shiwan Lu, Guanxue Xu, Bei Shi

“…Abstract Vascular inflammation plays a pivotal role in the pathogenesis of atherosclerotic plaques, driving their progression from a stable to an unstable phenotype. …”
Get full text

Features of Development and Course of Disseminated Intravascular Coagulation Syndrome During Surgical Interventions in Children with Oncological Diseases by N. P. Leonov, V. V. Schukin, G. A. Novichkova, M. A. Maschan, F. I. Ataullakhanov, S. S. Yashin, A. M. Zeynalov, Е. A. Spiridonova

“…The extreme expression of the «organ» type DIC is the progression of thrombotic syndrome to life threatening complications, which reduces the 90-day survival by 12%.…”
Get full text

Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico? by Adriana da Rocha Tomé, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas

“…Pilocarpine group presented seizures which progressed to status epilepticus in 75% of the animals. …”
Get full text

Is it true that lower PTH control is associated with lower levels of inflammatory cytokines in patients with chronic kidney disease? by Xu Qin, Wang Shasha, Xiong Qiuyue, Wang Ning, Hu Yifeng, Yan Lei, Cao Huixia, Shao Fengmin

“…Background The body of patients with chronic kidney disease (CKD)is in a state of microinflammation, which further aggravates the progression of CKD and the occurrence and development of its complications. …”
Get full text

Culture, self-esteem and menstrual hygiene management among adolescent girls in Uganda: the impact of economic and family strengthening by Flavia Namuwonge, Samuel Kizito, Vicent Ssentumbwe, Phionah Namatovu, Florence Namuli, Nhial T. Tutlam, Proscovia Nabunya, Fred M. Ssewamala

“…No significant moderation by menstrual hygiene knowledge or cultural attitude was detected. Conclusion The YDA + MFG intervention and natural age progression improved self-esteem, though reliance on self-reported data may introduce bias. …”
Get full text

Dysregulated metabolic pathways of pulmonary fibrosis and the lipids associated with the effects of nintedanib therapy by Yasuo Shimizu, Yasuhiro Horibata, Mariko Domae, Yusuke Nakamura, Tatsuya Yokoyama, Ryo Arai, Taichi Shiobara, Akihiro Takemasa, Ryosuke Koike, Nobuhiko Uchida, Meitetsu Masawa, Rinna Tei, Taiji Watanabe, Hiroko Morita, Masaaki Miyoshi, Sayo Soda, Seiji Niho, Ko Igami, Hiroyuki Sugimoto

“…Under nintedanib therapy, pPE species were correlated with progressive fibrosis, and pPE 18:0p/22:6 was considered an endothelial-related lipid. …”
Get full text

Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective... by Christine A Parkinson, Davina Gale, Anna M Piskorz, Heather Biggs, Charlotte Hodgkin, Helen Addley, Sue Freeman, Penelope Moyle, Evis Sala, Karen Sayal, Karen Hosking, Ioannis Gounaris, Mercedes Jimenez-Linan, Helena M Earl, Wendi Qian, Nitzan Rosenfeld, James D Brenton

“…In nearly all relapsed patients with disease volume > 32 cm3, ctDNA was detected at ≥20 amplifiable copies per millilitre of plasma. …”
Get full text

Participation of the immune response and oxidative stress in alcoholism and liver cirrhosis due to alcohol by Leonardo S. Juárez-Chávez, José L. Pérez-Hernández, Abigail Hernández-Barragán, Zaira Medina-Avila, Marisela Hernandez-Santillan, Moisés Martínez-Castillo, Fátima Higuera-De la Tijera, Gabriela Gutiérrez-Reyes

“…Normally distributed data were obtained and ANOVA and orthogonal analyses were performed to detect group differences. A U-Mann Whitney test was used. …”
Get full text

ROLE OF INFLAMMATION MARKERS IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS COMPICATIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS by Tatiyana Valentinovna Popkova, T A Panafidina, D S Novikova, E N Aleksandrova, A A Novikov, T E Novoselova, A N Gerasimov, E L Nasonov

“…Cardiovascular events caused by early development and rapid progression of atherosclerotic vascular disease are the main reason behind early lethality among patients with systemic lupus erythematosus (SLE). …”
Get full text

Application of machine learning in early childhood development research: a scoping review by Akbar K Waljee, Amina Abubakar, Patrick N Mwangala, Faith Neema Benson, Daisy Chelangat, Willie Brink, Cheryl A Moyer

“…Artificial intelligence techniques, particularly machine learning (ML), offer an innovative approach by analysing complex datasets to detect subtle developmental patterns.Objective To map the existing literature on the use of ML in ECD research, including its geographical distribution, to identify research gaps and inform future directions. …”
Get full text

Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model by Zhang K, Zhou F, Zhu C, Yuan L, Li D, Wang J, Lu W

“…Therefore, in the present study, we chose digoxin as the inhibitor to investigate whether HIF-1α contributes to the progression in a mouse model of COPD and possible mechanism.Methods: The COPD model was established by cigarette smoke (CS) exposed; animals were intragastrically treated with vehicle or different doses of digoxin (0.02 mg/kg and 0.1 mg/kg). …”
Get full text