miR-27a-5p, miR-21-5p, miR-1246 and miR-4508: a candidate microRNA signature in the protection and regulation of viral infection in mild COVID-19 by Malena Gajate-Arenas, Candela Sirvent-Blanco, Omar García-Pérez, Angélica Domínguez-de-Barros, José E. Piñero, Jacob Lorenzo-Morales, Elizabeth Córdoba-Lanús

“…Reduced expression of miR-21-5p may prevent pulmonary inflammation and the progression of fibrosis. The downregulation of miR-1246 and miR-4508 in mild COVID-19 cases may conduct the correct control of the infection. …”
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Phase II study of pembrolizumab and capecitabine for triple negative and hormone receptor-positive, HER2−negative endocrine-refractory metastatic breast cancer by Ami N Shah, Lisa Flaum, Irene Helenowski, Cesar A Santa-Maria, Sarika Jain, Alfred Rademaker, Valerie Nelson, Dean Tsarwhas, Massimo Cristofanilli, William Gradishar

“…The primary end point was median progression-free survival (mPFS) compared with historic controls and secondary end points were overall response rate (ORR), safety and tolerability. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…The role of cellular senescence in the progression of AKI has increasingly garnered attention in recent years. …”
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First results of long-term follow-up of children in Russia after gene therapy for hereditary retinal dystrophies associated with biallelic mutations in the RPE65 gene by V. V. Neroev, L. A. Katargina, M. P. Kharlampidi, L. V. Kogoleva, I. V. Zolnikova, P. A. Ilyukhin, E. V. Denisova, S. V. Milash, N. A. Osipova, S. I. Kutsev, A. V. Polyakov, R. A. Zinchenko, V. V. Kadyshev, Yu. A. Bobrovskaya

“…Initially, ERG could not be detected in 8 eyes, but after an VN injection, 6 eyes demonstrated a partial recovery at different times — from 1 to 12 months. …”
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Assessment of myocardial deformation by CMR tissue tracking reveals left ventricular subclinical myocardial dysfunction in patients with gynecologic cancer undergoing chemotherapy by Kai Tao, Kai Tao, Lu Ye, Yan-Jia-Ni Xu, Yan-Jia-Ni Xu, Meng-Xi Yang, Ru-Tie Yin, Qing-Li Li, Xiao-Juan Lin, Ke-Min Li, Liang Song, Yu Ma, Lan Zhong, Ying Hu, Hua-Yan Xu, Dan-Qing Wang, Ying-Kun Guo

“…Changes in deformation were assessed as chemotherapy progressed. Correlations between LV deformation parameters, clinical characteristics, and serum myocardial injury biomarkers were also analyzed.ResultsA total of 86 patients with gynecologic cancer and 30 normal controls were included. …”
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Development and Evaluation of a Promising Biomarker for Diagnosis of Latent and Active Tuberculosis Infection by Cong Peng, Fan Jiang, Yinping Liu, Yong Xue, Peng Cheng, Jie Wang, Liang Wang, Wenping Gong, Haijuan Wang

“…Immune responses induced by MEBDM were detected using enzyme-linked immunosorbent spot and cytometric bead assays. …”
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Paridis Rhizoma Saponins ameliorate CCl4-induced liver fibrosis via modulation of the Nrf2-HO-1/NQO-1 and TGF-β1/Smads signaling pathways by Yan Hong, Shuang Geng, Huihao Ao, Mengya Fu, Xiaojun Yang, Gang Cao, Yanquan Han

“…The mRNA and protein expressions of Nrf2-HO-1/NQO-1 and TGF-β1/Smads signaling pathways in liver tissues were detected using immunohistochemistry (IHC) staining, Western blot (WB), and RT-qPCR. …”
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Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device by Asako Otomo, Asako Otomo, Keiko Nishijima, Yuta Murakami, Mitsuru Ishikawa, Mitsuru Ishikawa, Haruka Yudahira, Kento Shimakura, Hideyuki Okano, Hideyuki Okano, Masashi Aoki, Hiroshi Kimura, Hiroshi Kimura, Shinji Hadano, Shinji Hadano

“…IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by the loss of upper and lower motor neurons. …”
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Plasma Sphingomyelins as Biomarkers for Diabetic Retinal Neurodegeneration: The Maastricht Study by Siddhita A. Jadhav, MSc, Birke J. Benedikter, PhD, Sara B.A. Mokhtar, MSc, Frank C.T. van der Heide, MD, PhD, Govindasamy Kumaramanickavel, MD, Marleen M.J. van Greevenbroek, PhD, Carroll A.B. Webers, MD, PhD, Tos T.J.M. Berendschot, PhD

“…These findings suggest that SMs could be explored as potential biomarkers for detecting diabetic retinal neurodegeneration at an early stage of diabetes. …”
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Different Mitotic Arrest Targets of Chemoprevention Curcumin Analog 1.1 (CCA-1.1) and Pentagamavunone-1 (PGV-1) in Leukemic K-562 Cells by Riris Istighfari Jenie, Dhania Novitasari, Dyaningtyas Dewi Pamungkas Putri, Ratna Asmah Susidarti, Ikuko Nakamae, Noriko Yoneda-Kato, Jun-ya Kato, Edy Meiyanto

“…A notable distinction between the two compounds lies in their respective effects on cell cycle progression. PGV-1 induced cell arrest at the prometaphase by 80% (p=0.0001), whereas CCA-1.1 was found to elicit around 20% of total cell arrest specifically at the metaphase (p=0.0035). …”
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Los objetivos y contenidos de las actividades de expresión motriz, según la opinión de los profesores de educación física en Chile (Objectives and contents of the activities of mot... by Alda Reyno Freundt

“…The general conclusion of this analysis indicates that in the surveyed teachers as well as in the Ministry of Education program there is a confusion in relation to what is understood by Content and Agent in Physical Education. …”
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Evaluation du système de surveillance de la méningite dans la région de Niamey, Niger en 2021 by Hadjara Aboubacar, Djibril Barry, Hermann Yoda, Pauline Yanogo, Issoufou Djibo

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The impact of a 6000-meter endurance exercise test on acid-base balance parameters by Justyna Pachciarek, Hanna Dziewiecka, Piotr Basta, Wojciech Każmierczak, Anna Skarpańska - Stejnborn

“…Data were analyzed using repeated measures ANOVA to detect differences across time points and between sexes. …”
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Access to context-specific lexical-semantic information during discourse tasks differentiates speakers with latent aphasia, mild cognitive impairment, and cognitively healthy adult... by Brielle C. Stark, Brielle C. Stark, Sarah Grace Dalton, Alyssa M. Lanzi, Alyssa M. Lanzi

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Deciphering cell cycle organization of Toxoplasma endodyogeny by Mrinalini Batra, Clem Marsilia, Danya Awshah, Lauren M. Hawkins, Chengqi Wang, Dale Chaput, Daria A. Naumova, Elena S. Suvorova

“…The ToxoFUCCIS probe efficiently detected G2/M and Spindle Assembly Checkpoints, as well as the SB505124-induced TgMAPK1-dependent block. …”
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Disulfidptosis-related gene in acute myocardial infarction and its diagnostic value and functions based on bioinformatics analysis and machine learning by Liwen Chen, Jinru Wei, Jinru Wei, Guoxiong Deng, Guoxiong Deng, Guien Xu

“…Disulfidptosis, a novel form of programmed cell death, has been largely unexplored in AMI. …”
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Prevention of thrombotic complications in patients with AL amyloidosis by V. A. Khyshova, I. G. Rekhtina, N. I. Zozulya, I. V. Gribkova, L. P. Mendeleeva

“…Induction therapy according to the program BorCyDex (bortezomib, cyclophosphamide, dexamethasone) was given to 59 (90 %) patients, of which 5 patients received the combination of BorCyDex with a monoclonal antibody to CD38 – daratumumab. …”
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Chronic dizziness: modern treatment methods taking into account comorbidity by E. N. Zastenskaia, L. M. Antonenko

“…Anxiety and depressive disorders were detected in 32 (53.33%) patients, migraine – in 20 (33.33%) and previous peripheral vestibular disorders – in 8 (13.33%) patients. …”
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CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWHResearch in context by Mehdi Benlarbi, Jonathan Richard, Tommaso Clemente, Catherine Bourassa, William D. Tolbert, Suneetha Gottumukkala, Marc Messier-Peet, Halima Medjahed, Marzena Pazgier, Frank Maldarelli, Antonella Castagna, Madeleine Durand, Andrés Finzi

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MTHFR and MTRR gene polymorphisms in patients with chronic hepatitis B virus infections in Zigong, Sichuan Province by Shunhua Qiu, Lifen Jin, Dan Yang, Dewen Zhang

“…The relationship between polymorphisms in the MTHFR gene and disease progression following HBV infection remains a controversial topic.Aim To study MTHFR and MTRR gene polymorphisms in patients with chronic HBV infections in Zigong, Sichuan Province.Subjects and methods One hundred and ninety-one patients with chronic HBV infections were divided into three groups: the chronic hepatitis B (CHB) group (n = 71), the hepatitis B-induced liver cirrhosis (LC) group (n = 56), and the hepatitis B-related primary liver cancer (PLC) group (n = 64). …”
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