Synthesis of Sm-Doped CuO–SnO₂:FSprayed Thin Film: An Eco-Friendly Dual-Function Solution for the Buffer Layer and an Effective Photocatalyst for Ampicillin Degradation... by Ghofrane Charrada, Bechir Yahmadi, Badriyah Alhalaili, Moez Hajji, Sarra Gam Derouich, Ruxandra Vidu, Najoua Turki Kamoun

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Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal by Carley N Gray, Manickam Ashokkumar, Derek H Janssens, Jennifer L Kirchherr, Brigitte Allard, Emily Hsieh, Terry L Hafer, Nancie M Archin, Edward P Browne, Michael Emerman

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An Evaluation of a Syndromic Molecular Panel in Optimising the Microbiological Diagnosis and Antimicrobial Therapy of Suspected Osteoarticular Infections in Paediatric Patients by Marilena Agosta, Venere Cortazzo, Manuela Onori, Barbara Lucignano, Gianluca Vrenna, Martina Rossitto, Maria del Carmen Pereyra Boza, Valeria Fox, Marco Roversi, Antonio Musolino, Andrzej Krzysztofiak, Laura Lancella, Marco Giordano, Francesco Falciglia, Ottavia Porzio, Alberto Villani, Carlo Federico Perno, Paola Bernaschi

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Integrative analysis of bulk and single-cell RNA sequencing data reveals increased arachidonic acid metabolism in osteoarthritic chondrocytes by Kan Wu, Zhaoqian Zhong, Li Chen, Haihua Luo, Aolin Jiang, Linlin Tao, Yong Jiang

“…BackgroundAbnormal lipid metabolism in chondrocytes, especially arachidonic acid (AA) metabolism, has attracted considerable attention in promoting osteoarthritis (OA) progression. However, the metabolic regulation of chondrocytes in OA remains to be investigated.MethodsBulk RNA sequencing (RNA-seq) data and single-cell RNA sequencing (scRNA-seq) data of human knee cartilage were downloaded from public databases. …”
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Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry by Jae Myeong Kang, Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, Sarah Tomaszewski Farias, Michael W. Weiner, Rachel L. Nosheny

“…Additionally we assessed the ability of ECog to identify ‘decliners’, who exhibited the worst PAL progression slopes corresponding to the fifth percentile and below. …”
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Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep by Samantha J. Murray, Mustafa M. Almuqbel, Simon A. Felton, Nickolas J. Palmer, Ashley R. Deane, Daniel J. Myall, Reza Shoorangiz, Arsène Ella, Matthieu Keller, David N. Palmer, Tracy R. Melzer, Nadia L. Mitchell

“…The diseases share a common set of symptoms, including motor and cognitive dysfunction, progressive loss of vision, and seizure activity. A naturally occurring model of CLN5 NCL exists in New Zealand Borderdale sheep, which exhibit similar clinical disease and post‐mortem pathology to the human disease. …”
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Inflammatory and metabolic markers mediate the association between urinary metals and non-alcoholic fatty liver disease in U.S. adults: a cross-sectional study by Shu-yue Li, Jia-jie Lv, Jia-jie Lv, Xi-tao Yang, Xi-tao Yang, Cheng-hao Yang, Cheng-hao Yang, Min-yi Yin, Min-yi Yin

“…Inflammation, oxidative stress, and insulin resistance are involved in the development and progression of NAFLD. Although the etiology of NAFLD remains unclear, environmental factors are increasingly recognized as non-negligible risk factors. …”
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Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma by Dirk Hose, Seemun Ray, Sina Rößler, Ulrich Thormann, Reinhard Schnettler, Kim de Veirman, Thaqif El Khassawna, Christian Heiss, Anne Hild, Daniel Zahner, Francisca Alagboso, Anja Henss, Susanne Beck, Martina Emde-Rajaratnam, Jürgen Burhenne, Juliane Bamberger, Eline Menu, Elke de Bruyne, Michael Gelinsky, Marian Kampschulte, Marcus Rohnke, Sabine Wenisch, Karin Vanderkerken, Thomas Hanke, Anja Seckinger, Volker Alt

“…Myeloma cells surviving treatment in the presumably protective environment of bone lesions impede their healing by continued impact on bone turnover and can explain regular progression of patients without detectable minimal residual disease (MRD). …”
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Construction and evaluation of nomogram for risk prediction of cognitive impairment in chronic obstructive pulmonary disease comorbidity by JiaFeng Luo, Wen Yang, Yang Liu, HongLian Ji, XinRan Li, Jing Bai, TieJun Liu, WeiBin Chen, Li Xiao, GuoXin Mo, JingShan Bai, CongHui Liu, WenQiang Li, AiShuang Fu, YanLei Ge

“…The aim of this study was to construct a nomogram prediction model for the risk of comorbid cognitive impairment in COPD patients and to evaluate its clinical application. It helps to detect cognitive impairment in COPD patients at an early stage and give them effective interventions in time, so as to delay the progression of COPD patients and improve their prognosis. …”
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Utilization of donor CLL-1 CAR-T cells for the treatment of relapsed of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation by Meng Zhang, Meng Zhang, Xiaomei Zhang, Xiaomei Zhang, Jiaxi Wang, Wenyi Lu, Xia Xiao, Hairong Lyu, Xiaoyuan He, Yedi Pu, Juanxia Meng, Cuicui Lyu, Xinping Cao, Mingfeng Zhao, Mingfeng Zhao

“…CAR-T cells expansion was detectable in all 12 patients, with the median time of peak expansion was 9 days (range: 7-11 days). …”
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Implantación de una estrategia para gestionar la multifrecuentación de urgencias hospitalarias en una zona de Barcelona by Emmanuel Giménez, María José Abadías, Antonio San-José, Marta Losada, Jordi Acezat, Jordi Ibáñez, Luis Marte, Miriam Barrecheguren, Ana Belén Méndez, Marta Aguayo-Álvarez, María Arranz, Rosa Ramos

“…The feasibility of this approach has been demonstrated, with 368 alerts detected, 85% of which were well-selected. Age, frailty, home care percentage, Barthel index, and cognition were progressively aligned with levels of care/referral (primary, intermediate, and specialized) according to previously agreed criteria. …”
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Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes by Edwin De Jesus Lopez Gonzalez, SWT Lai, Kelani Sun, Caree R. Carson, Carlos Hernandez-Castillo, Tala Zoukari, Kassandra Lopez, Jianying Zhang, Thomas Blevins, John Termini, Sarah C. Shuck

“…These findings highlight RNA MG-adducts as clinically relevant epitranscriptomic modifications that may contribute to RNA destabilization and impaired translation, suggesting a novel molecular mechanism by which metabolic stress may exacerbate disease progression.…”
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White Matter Microstructural Alterations in Type 2 Diabetes: A Combined UK Biobank Study of Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging by Abdulmajeed Alotaibi, Mostafa Alqarras, Anna Podlasek, Abdullah Almanaa, Amjad AlTokhis, Ali Aldhebaib, Bader Aldebasi, Malak Almutairi, Chris R. Tench, Mansour Almanaa, Ali-Reza Mohammadi-Nejad, Cris S. Constantinescu, Rob A. Dineen, Sieun Lee

“…NODDI identified microstructural changes in white matter that were proxies for reduced neurite density and disrupted fibre orientation, correlating with disease progression and poor glucose control. In conclusion, NODDI contributed to DTI in capturing white matter differences in participants with type 2 diabetes, suggesting the feasibility of NODDI in detecting white matter alterations in type 2 diabetes. …”
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Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling by Huiyu Luo, Jiexian Wang, Fengjuan Lin, Yuguo Liu, Xinglong Wu, Gan Li, Chuhong Su, Junbin Chen, Fei Xiong, Jiaqi Mo, Zhongdaixi Zheng, Xiangyi Zheng, Qing Li, Longying Zha

“…Introduction: High palmitic acid (PA) levels trigger metainflammation, facilitating the onset and progression of chronic metabolic diseases. Recently, exosomes were identified as new inflammation mediators. …”
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Role of High Serum Tenascin C Levels as Potential Biomarker of Persistent Inflammation in Patients with Ankylosing Spondylitis Despite Treatment with cs-DMARDS or Anti-TNF Agents by Alejandro Martelli-Garcia, Yussef Esparza-Guerrero, Heriberto Jacobo-Cuevas, Ana Miriam Saldaña-Cruz, Norma Guadalupe Gonzalez-Montoya, Cesar Arturo Nava-Valdivia, Eli Efrain Gomez-Ramirez, Maria Luisa Vazquez-Villegas, Juan Manuel Ponce-Guarneros, Melissa Ramirez-Villafaña, Norma Alejandra Rodriguez-Jimenez, Alberto Daniel Rocha-Muñoz, Ernesto German Cardona-Muñoz, Jaime Morales-Romero, Laura Gonzalez-Lopez, Jorge Ivan Gamez-Nava

“…<b>Conclusions:</b> We suggest that an elevated TNC level may be a useful biomarker of persistent disease activity despite treatment in AS; further studies should investigate the role of TNC levels in predicting the progression of the disease.…”
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Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis by Tainã Luís de Souza, Tainã Luís de Souza, Marta de Almeida Santiago, Francini Neves Ribeiro, Francini Neves Ribeiro, Fabiano Borges Figueiredo, Artur Augusto Velho Mendes Junior, Rodrigo Caldas Menezes, Renato Porrozzi, Fernanda Nazaré Morgado

“…This chronic exposure to antigenic and inflammatory stimuli likely contributes to persistent tissue damage, exemplified by splenic white pulp disorganization in the spleen, and exacerbates disease progression.…”
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Fatal HLH in patients with X-linked lymphoproliferative disease 1 due to a novel variant in SH2D1A: case report by Oksana Boyarchuk, Alla Volokha, Nataliia Yarema, Olga Dyvoniak, Tetyana Tomashivska, Ivanna Shymanska, Halyna Makukh, Jolan E. Walter, Jolan E. Walter

“…Despite intensive treatment, HLH progressed rapidly, leading to fatality within 35 days. …”
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<i>CIC</i>-Rearranged Sarcoma: A Clinical and Pathological Study of a Peculiar Entity by Ward Maaita, Nabil Hasasna, Sameer Yaser, Yacob Saleh, Ramiz Abu-Hijlih, Wafa Asha, Hadeel Halalsheh, Samer Abdel Al, Maysa Al-Hussaini, Omar Jaber

“…<i>CIC::DUX4</i> fusion was detected in four cases. FISH for <i>CIC</i> gene rearrangement was positive in seven cases, two of them confirmed by methylation analysis. …”
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Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation by Wencheng Zhang, Shuo Yang, Xinwen Yu, Shanshan Zhu, Xin Wang, Fei Sun, Shengru Liang, Xiaoguang Wang, Guohong Zhao, Bin Gao

“…The benefits of 4-MU in T1D have been proved to be associated with β cells self-replication, dedifferentiation inhibition and immune progression suppression, which help to maintain β cell mass.…”
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Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1α/YAP signaling in periodontitis by Lu Lin, Weijun Yu, Ruhan Yang, Mingzhi Liu, Yuanjie Shi, Shucheng Hu, Guanglong Li, Jiaqi Tang, Yue Shen, Zhurong Cui, Min Jin, Yuting Gu, Eryi Lu

“…Human umbilical vein endothelial cells were cultured with conditioned media from PDLSCs, and their proliferation, migration, and tube formation were detected to evaluate the pro-angiogenic capacity of PDLSCs. …”
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