Molecular profile of non-small cell lung cancer in a predominantly Black African population in Kenya: A single institution review by Sitna Mwanzi, Shahin Sayed, Swati Das, Jonathan Wawire, Priscilla Njenga, Jasmit Shah, Asim Jamal Shaikh

“…Testing for epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangement, c-ros oncogene 1 (ROS1) rearrangement and programmed death ligand 1 (PDL 1) testing are now highly recommended for all patients with NSCLC. …”
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The Impact of a Mobile Money–Based Intervention on Maternal and Neonatal Health Outcomes in Madagascar: Cluster-Randomized Controlled Trial by Lisa Bogler, Bítia Vieira, Harizaka Emmanuel Andriamasy, Zavaniarivo Rampanjato, Sebastian Vollmer, Till Bärnighausen, Andriamampianina Ralisimalala, Julius Valentin Emmrich, Samuel Knauss

“…Maternal health care is particularly suitable for a savings program using mobile money due to the predictable timing and costs of delivery. …”
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Associations between the SMARS score derived from CT and MRI with histopathological features in HCC by Daniele Romeo, Theresa Richter, Anne-Kathrin Höhn, Hans-Michael Tautenhahn, Daniel Seehofer, Uwe Scheuermann, Timm Denecke, Hans-Jonas Meyer

“…The pathological specimens were analyzed for programmed death ligand 1 (PD-L1), Glypican-3, CD3-tumour infiltrating lymphocyte, CD68 positive cells, CD34 positive microvessel density (MVD). …”
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Electronic Sensor-Based Automated Irrigation System for Rice Cultivated Under Alternate Wetting and Drying Technique by Mukesh Kumar, Ramesh Kumar Sahni, Abhishek M. Waghaye, Manoj Kumar, Ravindra D. Randhe

“…The controller has been programmed for different growth stages that need to be set manually during the cropping period. …”
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Morphofunctional Characteristic of Edema-Swelling of the Cerebral Cortex of White Rats After Severe Traumatic Brain Injury Without the Use of L-Lysine Escinate and Against the Back... by I. P. Koshman, S. S. Stepanov, A. Y. Shoronova, A. G. Kalinichev, V. A. Akulinin, D. B. Avdeyev, V. I. Sergeyev

“…Consequently, morphometric signs of hydropic dystrophy after STBI were detected in both studied groups during the 15 days of observation.Conclusion The degree of SSC nervous tissue hydration increased after STBI. …”
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Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment by Barbara M. Crisol, Matheus B. Rocha, Beatriz Franco, Ana Paula Morelli, Carlos K. Katashima, Scylas J.A. Junior, Fernanda S. Carneiro, Renata R. Braga, Rafael S. Brícola, Graciana de Azambuja, Raul Gobato Costa, Andrea M. Esteves, Marcelo A. Mori, Maria C.G. Oliveira, Dennys E. Cintra, José R. Pauli, Filip J. Larsen, Adelino S.R. da Silva, Eduardo R. Ropelle

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Comprehensive analysis of the functional and immunological significance of ETV4 in pan-cancer and its validation in digestive tumors by Lingli Huang, Lingli Huang, Lingli Huang, Lingli Huang, Xujia Li, Xujia Li, Xujia Li, Xujia Li, Silan Huang, Silan Huang, Silan Huang, Silan Huang, Qi Jiang, Qi Jiang, Qi Jiang, Qi Jiang, Chang Jiang, Chang Jiang, Chang Jiang, Chang Jiang, Wenzhuo He, Wenzhuo He, Wenzhuo He, Wenzhuo He, Yuchen Cai, Yuchen Cai, Yuchen Cai, Yuchen Cai, Guifang Guo, Guifang Guo, Guifang Guo, Guifang Guo

“…Among them, ETV4 plays a crucial role in cancer progression. However, its broader impact on prognosis and immune regulation across different malignancies remains insufficiently understood.MethodsBased on public databases and our experimental validation, we systematically investigated the role of ETV4 in various cancers. …”
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Hospital register of patients with acute cerebrovascular accident (REGION): characteristics of patient and outcomes of hospital treatment by S. Yu. Martsevich, N. P. Kutishenko, M. M. Lukyanov, A. V. Zagrebelny, N. A. Dmitrieva, E. Yu. Okshina, A. V. Akimova, V. P. Voronina, O. V. Lerman, M. P. Gladilkina, G. I. Krasnikova, V. N. Palamarchuk, N. E. Parsadanyan, M. I. Chernyshova, E. N. Belova, E. V. Kudryashov, N. A. Shamalov, G. P. Arutyunov, O. M. Drapkina, S. A. Boytsov

“…There was a sharp increase in hospital mortality in 2014, which coincided with the organization of the vascular center, in subsequent years there was a progressive decrease in hospital mortality.Conclusion. …”
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Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia by Cong Zhu, Lu-Yao Li, Ming-Hui Shi, Cheng Fang, Lu Yang, Ting Li, Fei Li, Shi-Song Yang, Tian-Kun Wang, Dao-Jing Ming, Tong Deng, Hao-Yue Sun, Wen-Ting Li, Jia Zhang, Yu-Sen Zhang, Zhi-Yuan Jian, Chang-Jiang Qin, Shuang-Ying Wang, Xian-Tao Zeng

“…Abstract Background Fibrosis constitutes a significant pathophysiological mechanism in the clinical progression of benign prostatic hyperplasia (BPH) and represents a contributing factor to the ineffectiveness of prevailing pharmacological treatments. …”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…BackgroundMyelodysplastic neoplasms (MDS) are characterized by ineffective hematopoiesis, peripheral blood cytopenias, and an increased risk of progression to acute myeloid leukemia. One of the main treatment goals is improving quality of life (QoL), particularly for patients with lower-risk MDS (LR-MDS) who may live longer with compromised QoL. …”
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Physical activity of moderate-intensity optimizes myocardial citrate cycle in a murine model of heart failure by Lucyna Widacha, Joanna Szramel, Zenon Nieckarz, Anna Kurpinska, Ryszard T. Smolenski, Stefan Chlopicki, Stefan Chlopicki, Jerzy A. Zoladz, Joanna Majerczak

“…IntroductionThere is growing body of evidence that an enhanced concentration of branched-chain amino acids (BCAAs), as a consequence of an impaired myocardial oxidative metabolism, is involved in the occurrence and progression of heart failure (HF). The purpose of this study was to examine the effect of 8 weeks of spontaneous wheel running (8-sWR) (reflecting low-to-moderate intensity physical activity) on the myocardial [BCAAs] and mitochondrial oxidative metabolism markers, such as tricarboxylic acid (TCA) cycle intermediates (TCAi), mitochondrial electron transport chain (ETC) proteins and mitochondrial DNA copy number (mtDNA/nDNA) in a murine model of HF.MethodsAdult heart failure (Tgαq*44) and wild-type (WT) mice were randomly assigned to either the sedentary or exercising group. …”
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Microcirculatory Response to Strength Training in Postmastectomy Lymphedema: an Interventional Comparative Study by Varvara V. Krasnikova, Olga V. Fionik, Maria L. Pospelova, Mikhail M. Galagudza, Albina M. Makhanova, Samvel N. Tonyan, Alexandra E. Nikolaeva, Anastasia O. Milder, Mark S. Voynov, Ekaterina E. Vyalykh, Elena A. Demchenko

“…In the main group, a change in the functioning of the microcirculatory bed was detected: a decrease in nutritive blood flow to 2.52 and signs of stagnation in the venous segment. …”
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Moxibustion regulates KDM4D expression and modulates lipid metabolism to inhibit tumor proliferation in CAC mice by Guona Li, Jindan Ma, Luyi Wu, Hanxiao Zhang, Yaying Lin, Hongxiao Xu, Muen Gu, Kunshan Li, Hongsheng Dong, Yan Huang, Huangan Wu

“…Abstract Background Lysine demethylase 4D (KDM4D) and aberrant lipid metabolism are implicated in the development and progression of colitis-associated cancer (CAC). Moxibustion, a therapeutic approach in traditional Chinese medicine, can inhibit intestinal inflammation and improve the intestinal mucosa. …”
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Alternative N-forms cause differential response to the soil-borne disease Fusarium oxysporum f. sp. melongenae in eggplant (Solanum melongena L.) by MR Tassone, TM Sirangelo, G Puccio, K Gazzetti, A Mauceri, MR Abenavoli, F Sunseri, GL Rotino, L Toppino, F Mercati

“…Mineral nutrition may strongly influence plant resistance or susceptibility to disease onset and progression, affecting plant growth and crop yield. …”
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Clinical and Genomic Landscape of FGFR3 Alterations Across Different Stages of Urothelial Cancer by Maximilian Haas, Roman Mayr, Danijel Sikic, Bernd Wullich, Niklas Klümper, Philipp Erben, Ralph Wirtz, Christian Bolenz, Florian Roghmann, Robert Stöhr, Veronika Bahlinger, Arndt Hartmann, Maximilian Burger, Johannes Breyer, Markus Eckstein

“…FGFR3 alterations were associated with better progression-free survival and overall survival in the overall population (p < 0.001), but not in subgroup analyses for different disease stages. …”
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Pregnancy outcomes in patients with systemic lupus erythematosus compared to a high‐risk tertiary cohort and to standard population from the Austrian birth registry by Klara Rosta, Florian Heinzl, Valerie Kuczwara, Stefanie Schindler, Veronica Falcone, Anja Catic, Marina Riedmann, Hermann Leitner, Elisabeth Simader, Valentin Ritschl, Tanja Stamm, Alexandra Szlatinay, Peter Mandl, Antonia Mazzucato‐Puchner

“…SR p < 0.001) while the higher incidence of adverse fetal outcome was detected in the HR than in the SLE group (55% vs. 75% SLE vs. …”
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Microsurgical Clipping of Unruptured Middle Cerebral Artery Bifurcation Aneurysms: A Single-Center Experience by Nico Stroh-Holly, Philip Rauch, Harald Stefanits, Philipp Hermann, Helga Wagner, Michael Sonnberger, Maria Gollwitzer, Stefan Aspalter, Andreas Gruber, Matthias Gmeiner

“…Continuous intraoperative enhancements over time have contributed to a progressive improvement in clinical outcomes in recent years. …”
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Optimising (re-)irradiation for locally recurrent head and neck cancer: impact of dose-escalation, salvage surgery, PEG tube and biomarkers on oncological outcomes—a single centre... by Julia Katharina Schleifenbaum, Janis Morgenthaler, Shachi Jenny Sharma, Jens Peter Klußmann, Philipp Linde, Simone Wegen, Johannes Rosenbrock, Christian Baues, Emmanouil Fokas, Richard Khor, Sweet Ping Ng, Simone Marnitz, Maike Trommer

“…Overall survival (OS), progression-free survival (PFS) and toxicities according to Common Terminology Criteria for Adverse Events (CTCAE) v5.0 were assessed. …”
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Alpha-Lipoic Acid-Mediated Inhibition of LTB4 Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer... by María José Torres, PhD, Juan Carlos Ríos, PhD, Alexandra Valle, MSc, Sebastián Indo, PhD, Kevin Brockway GV, MSc, Fernanda López-Moncada, PhD, Mario Faúndez, PhD, Enrique A. Castellón, PhD, Héctor R. Contreras, PhD

“…Background: Leukotriene B4 (LTB4) plays a crucial role in carcinogenesis by inducing epithelial-mesenchymal transition (EMT), a process associated with tumor progression. The synthesis of LTB4 is mediated by leukotriene A4 hydrolase (LTA4H), and it binds to the receptors BLT1 and BLT2. …”
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HHLA2 activates c-Met and identifies patients for targeted therapy in hepatocellular carcinoma by Xubo Huang, Runya Fang, Yuqian Pang, Zhe Zhang, Jieru Huang, Yingchang Li, Tao Yuan, Yuyi Zeng, Ziying Yao, Silvia Vega-Rubín-de-Celis, Josephine Thinwa, Qisheng Zhang, Hao Shen, Jiahong Wang, Feng Shen, Yongjie Wei

“…Conclusions HHLA2 acts as an oncogene in HCC by activating c-Met, promoting tumor progression and metastasis. HHLA2 expression correlates with c-Met activation and predicts poor prognosis in HCC patients. …”
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