MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…Abstract Background Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis and a high risk of progression to acute myeloid leukemia. Elucidating the mechanism underlying the dysfunction of MDS-HSCs is crucial for exploring the pathogenesis of the syndrome. …”
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Analysis of 5-year clinical and radiological outcomes in patients with psoriatic arthritis observed as part of the Treat to target strategy. Preliminary data by P. O. Tremaskina, E. Yu. Loginova, T. V. Korotaeva, S. I. Glukhova, A. V. Sukhinina, A. V. Smirnov, A. M. Lila

“…Me DAPSA was 3.85 [0.67; 21.76], MiDA was detected in 22 (59.5%) patients. After 5 years of observation, Me DAPSA was 7.67 [2.2; 14.5]. …”
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First assessment of biofouling assemblages in the northern Red Sea, an important region for marine non-indigenous species transfer by Juan Sempere-Valverde, Juan Sempere-Valverde, Eva Aylagas, Vitaly Syomin, Vitaly Syomin, Marcos A. L. Teixeira, Glafira D. Kolbasova, Glafira D. Kolbasova, Sofía Ruiz-Velasco, Sahar Chebaane, Arthur Anker, João Curdia, Ronald Cadiz, Dylan M. Cottrell, Andrea Desiderato, Luiz F. Andrade, Chakkiath Paul Antony, Carolina Bocanegra-Castano, Matilde Marzucchi, Angelo Poliseno, Doaa Baker, Basmah Alabdulaziz, Flor Torres, Ameer A. Eweida, Ameer A. Eweida, Susana Carvalho, Susana Carvalho

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Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model by Rongwan Sun, Leonie-Kim Zimbalski, Stefanie Schreyer, David Baidoe-Ansah, Aida Harutyunyan, Arnd Heuser, Rachel N. Lippert, Joachim Spranger, Knut Mai, Sebastian Brachs

“…Understanding these sex-specific metabolic differences could provide new insights into AD progression and highlight the need for targeted treatments.…”
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<i>EGFR</i>-Mutant Lung Adenocarcinoma Cell-Derived Exosomal miR-651-5p Induces CD8+ T Cell Apoptosis via Downregulating BCL2 Expression by Chao Zhao, Lei Cheng, Aiwu Li, Haowei Wang, Xuefei Li, Jun Xu

“…<b>Background</b>: The efficacy of programmed cell death 1 (PD-1) or ligand 1 (PD-L1) inhibitors in epidermal growth factor receptor (<i>EGFR</i>)-mutant non-small cell lung cancer (NSCLC) patients is not satisfactory. …”
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Clinicopathological features and outcome in elderly patients with idiopathic membranous nephropathy by Jinxiu Liang, Wenke Hao, Fangxiao Xia, Zhi Zhao, Yanhua Wu, Feng Yu, Wenxue Hu, Xiaowu Fang, Wei Liu

“…The glomerular PLA2R and IgG4 antigen deposition were frequently detected accompanied by glomerulosclerosis and severe tubulointerstitial injury. …”
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Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study by Michelle M. Mielke, Roger A. Fielding, Elizabeth J. Atkinson, Zaira Aversa, Marissa J. Schafer, Steven R. Cummings, Marco Pahor, Christiaan Leeuwenburgh, Nathan K. LeBrasseur

“…Design: The Lifestyle Interventions for Elders (LIFE) study was a randomized controlled trial of a group-based physical activity program compared to a “successful aging” health education program to assess effects on major mobility disability that was conducted from February 2010 to December 2013. …”
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Mixture of Experts for Depression and Anxiety Disorder Prediction From Textual and Non-Textual Social Media Data by Wesley Ramos Dos Santos, Ivandre Paraboni, Elton Hiroshi Matsushima, Camila Azevedo Da Silva, Emily Samara De Moura Meira, Joao Victor Rodrigues Ferreira Guimaraes, Julia Da Silva Lins, Laura Enham De Azeredo, Luiz Guilherme Cerqueira Nunes, Vittoria Thiengo Silveira Moreira Rego

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Altered gut microbiome in convalescent patients with coronavirus disease 2019 by Kyoung Hwa Lee, Yeong Ouk Kim, Yeong Ouk Kim, So Hee Dho, Jen J. H. Yong, Hyun-Seok Oh, Je Hee Lee, Seung-Jo Yang, Inseong Cha, Jongsik Chun, Eun Hwa Lee, Su Jin Jeong, Wonjin Woo, Jae-Phil Choi, Sang Hoon Han, Gloria B. Choi, Jun R. Huh, Jun R. Huh, Lark Kyun Kim, Young Goo Song

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Application of [18F]FLT‐PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type... by Liza Botros, Samara M.A. Jansen, Ali Ashek, Onno A. Spruijt, Jelco Tramper, Anton Vonk Noordegraaf, Jurjan Aman, Hans Harms, Frances S. deMan, Marc C. Huisman, Lan Zhao, Harm J. Bogaard

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Affective valence predictors from real-world based short sprint interval training by Stefano Benítez-Flores, Flávio A. de S. Castro, Eduardo Caldas Costa, Daniel Boullosa, Todd A. Astorino

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Study protocol and implementation details for a pragmatic, stepped-wedge cluster randomised trial of a digital adherence technology to facilitate tuberculosis treatment completion by Noah Kiwanuka, Rebecca Crowder, Alex Kityamuwesi, Maureen Lamunu, Catherine Namale, Lynn Kunihira Tinka, Agnes Sanyu Nakate, Joseph Ggita, Patricia Turimumahoro, Diana Babirye, Denis Oyuku, Christopher Allen Berger, Austin Tucker, Devika Patel, Amanda Sammann, David Dowdy, Turyahabwe Stavia, Adithya Cattamanchi, Achilles Katamba

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Understanding the etiology of diarrheal illness in Cambodia in a case-control study from 2020 to 2023 by Paksathorn Kietsiri, Siriporn Sornsakrin, Samon Nou, Wilawan Oransathid, Dutsadee Peerapongpaisarn, Wirote Oransathid, Panida Nobthai, Patcharawalai Wassanarungroj, Siriphan Gonwong, Pimmada Sakpaisal, Nuanpan Khemnu, Somethy Sok, Sokh Vannara, Chiek Sivhour, Sidonn Krang, Ly Sovann, Em Sovannarith, Woradee Lurchachaiwong, Sidhartha Chaudhury, Nattaya Ruamsap, Paphavee Lertsethtakarn

“…This case-control study aims to describe the prevalence of diarrhea etiologic agents and antimicrobial resistance in bacterial enteropathogens for acute diarrhea among children, adult civilians, and military personnel in Cambodia, detecting over 20 bacterial species, viruses, and parasites. …”
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Molecular Diversity and Agronomic Performance of Sesame (Sesamum indicum) Cultivars in Benin: Local Cultivars and Lines Introduced From China by Christel Ferréol Azon, Nicodème V. Fassinou Hotegni, Charlotte O. Adjé, Lewis Spencer Gnanglè, Evelyn Benjamin, Ruvarashe Loveness Mhuruyengwe, Abdou Mouizz Salaou, Aristide Carlos Houdegbe, Deedi Olga Sogbohossou, Paulin Sedah, Komivi Dossa, Clément Agbangla, Florent J. B. Quenum, Enoch G. Achigan‐Dako

“…A total of 62 alleles were detected, with each locus exhibiting 2 to 15 alleles. …”
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Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction by Qian Qin, Linlin Fan, Xin Zeng, Danyang Zheng, Han Wang, Mengyue Li, Yutong Jiang, Hui Wang, Hao Liu, Shengjun Liang, Lijie Wu, Shuang Liang

“…The inhibitory immune checkpoint programmed cell death protein 1 (PD-1) on immune cells is an important target for tumor immunotherapy. …”
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Background characterization of the CONUS+ experimental location by E. Sánchez García, N. Ackermann, S. Armbruster, H. Bonet, C. Buck, K. Fülber, J. Hakenmüller, J. Hempfling, G. Heusser, E. Hohmann, M. Lindner, W. Maneschg, K. Ni, M. Rank, T. Rink, I. Stalder, H. Strecker, R. Wink, J. Woenckhaus

“…Abstract CONUS+ is an experiment aiming at detecting coherent elastic neutrino-nucleus scattering (CE $$\nu $$ ν NS) of reactor antineutrinos on germanium nuclei in the fully coherent regime, continuing the CONUS physics program conducted at the Brokdorf nuclear power plant (KBR), Germany. …”
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Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022 by Lucia Inchauste, Elif Nurtop, Lissete Bautista Machicado, Yanine Leigue Roth, Shirley Lenz Gonzales, Maria Luisa Herrera, Katty Mina Villafan, Pedro Mamani Mamani, Marcelo Ramos Espinoza, Juan Carlos Pavel Suarez, Juan Cansio Garcia Copa, Yitzhak Leigue Zabala, Etzel Arancibia Cardozo, Pierre Gallian, Xavier de Lamballerie, Stéphane Priet

“…In 2022, Gamma continued to circulate in southernmost departments of the country, and the emergence of Omicron BA.1 was detected. These trends align with publicly available genomic data from neighboring countries. …”
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Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma by Ming Zhao, Qifeng Chen, Wenhua Lu, Ning Lyu, Zhenfeng Zhang, Qiankun Xie, Haijing Deng, Anna Kan, Meng He, Shuang Qiao, Shaolong Li, Huiming Chen, Jinfa Lai, Xiongying Jiang, Shousheng Liu

“…Background Neutrophils play a controversial role in tumor development. The function of programmed cell death-1 ligand (PD-L1+) neutrophils, however, may inhibit the cytotoxicity of anti-tumor immunity. …”
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Brain glucose metabolism in patients with traumatic brain injury undergoing rehabilitation: a longitudinal 18F-FDG PET study by Valeria Pingue, Valeria Pingue, Irene Bossert, Daniela D’Ambrosio, Antonio Nardone, Antonio Nardone, Giuseppe Trifirò, Nicola Canessa, Nicola Canessa, Diego Franciotta

“…BackgroundMeasuring 18F-FDG PET-detected brain glucose uptake provides reliable information on metabolic tissue abnormalities, cells dysfunction, and neurovascular changes after traumatic brain injury (TBI).ObjectivesWe aimed to study the relationship between post-traumatic brain glucose metabolism and functional outcomes in the so far unexplored field of longitudinally 18F-FDG PET-monitored patients undergoing rehabilitation after moderate-to-severe TBI.MethodsFourteen patients consecutively admitted to our unit in the post-acute phase after TBI underwent 18F-FDG-PET scans performed before and 6 months after inpatient rehabilitation program. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Interestingly, LAG-3 protein upregulation was detected as a unique pharmacodynamic effect mediated by PD1-LAG3, but not by PD1-TIM3 or anti-PD-1.Conclusions Our in vitro system reliably assessed responses to bispecific antibodies co-targeting PD-1 together with LAG-3 or TIM-3 using patients’ tumor infiltrating immune cells and revealed transcriptional and phenotypic imprinting by bispecific antibody formats currently tested in early clinical trials.…”
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