Mitochondrial neurogastrointestinal encephalomyopathy in china: a novel TYMP variant and comprehensive clinical-genetic insights by Xuebi Xu, Junhui Xia, Fei Xu, Mingshan Wang, Lihong Yang, Xiaoli Chen

“…Molecular analysis of other 11 family members detected heterozygous carriers of either the c.1268T > G or c.131G > C variant in six asymptomatic individuals. …”
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Hylotelephium mingjinianum Extract Attenuates Oxidative Stress and Inflammation in Experimental Periodontitis by Yuan L, Kong C, Shi N, Chen J, Zhang T, Wang X

“…In vitro experiments confirmed HME’s cytocompatibility at concentrations below 200μg/mL and its resistance to LPS stimulation, reducing ROS overaccumulation by 16.46% through modulation of the Nrf2/NF-κB axis.Conclusion: HME inhibits the progression of periodontitis in rats by downregulating the expression of inflammatory factors, alleviating oxidative stress, and repairing the Nrf2/NF-κB signaling pathway. …”
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Feasibility and Safety of Anlotinib Plus Docetaxel versus Docetaxel Monotherapy in Patients with Previously Immunotherapy-Treated NSCLC: A Retrospective Exploratory Study by Li DW, Li YD, Jin H

“…The primary endpoints included overall survival (OS) and secondary endpoints were progression-free survival (PFS), objective response rate (ORR) and disease control rate (DCR).Results: ORR in the experimental and control groups was 30.2% (95% CI: 17.2– 46.1%) and 13.9% (95% CI: 5.3– 27.9%), respectively, showing a trend towards significance (P=0.069). …”
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Epidemiology, antimicrobial resistance, and risk factors of infection among liver transplant patients: a retrospective study 2010–2023 by Lei Liu, Zhongyi Jiang, Huanjin Liao, Zhiwei Xu, Yang Yu, Lin Zhong, Pusen Wang

“…Additionally, it analyzes high-risk factors for post-transplant infections and innovatively examines the risk factors that contribute to the progression from infection to severe infection and sepsis. …”
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Hirsutism or Hyperandrogenemia, Which is More Noteworthy for Adolescent Girls with Irregular Menses? A Case–Control Study Based on an Epidemiological Survey by Yu Hong, Lili Huang, Dongzi Yang, Zehong Zhou, Zhe Dong

“…Background: Polycystic ovarian syndrome (PCOS) develops from early puberty on and progresses afterward, and a persistent hyperandrogenic state puts adult PCOS patients at risk of metabolic abnormality. …”
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X-inactive-specific transcript: a long noncoding RNA with a complex role in sex differences in human disease by Dan N. Predescu, Babak Mokhlesi, Sanda A. Predescu

“…Plain language summary Many human diseases show differences between males and females in penetrance, presentation, progression, and survival. In humans, the X and Y sex chromosomes determine the biological sex, XX specifying for females and XY for males. …”
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Assessment of Troponin Levels as a Biomarker of Myocardial Injury in Patients with Fatal Covid-19 for the Period 2020 to 2022: A Literature Review by Zainab Tawfeeq Al-Joubouri, Shaymaa Galeel Shamran, Rehab Mazi Jabbar, Entesar Gh. Ajeena

“…Therefore, measuring cTn levels is critical to monitor the progression of heart disease and effectively manage patients'  …”
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Alternative splicing in ovarian cancer by Liwei Wei, Yisheng Li, Jiawang Chen, Yuanmei Wang, Jianmin Wu, Huanming Yang, Yi Zhang

“…Abstract Ovarian cancer is the second leading cause of gynecologic cancer death worldwide, with only 20% of cases detected early due to its elusive nature, limiting successful treatment. …”
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Transcriptional responses to direct and indirect TGFB1 stimulation in cancerous and noncancerous mammary epithelial cells by Patryk Janus, Paweł Kuś, Roman Jaksik, Natalia Vydra, Agnieszka Toma-Jonik, Michalina Gramatyka, Monika Kurpas, Marek Kimmel, Wiesława Widłak

“…It also provides cells with the plasticity to form metastases during tumor progression. Noncancerous and cancer cells respond differently to TGFβ. …”
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Mesangial cell-derived CircRNAs in chronic glomerulonephritis: RNA sequencing and bioinformatics analysis by Ji Hui Fan, Xiao Min Li

“…Background Circular RNAs (circRNAs) have been shown to play critical roles in the initiation and progression of chronic glomerulonephritis (CGN), while their role from mesangial cells in contributing to the pathogenesis of CGN is rarely understood. …”
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Bulk and single-cell RNA sequencing identify prognostic signatures related to FGFBP2+ NK cell in hepatocellular carcinoma by Yinbing Wu, Huanjun Peng, Guangkang Chen, Yinuo Tu, Xinpei Yu

“…As a specific immune cell subpopulation, FGFBP2+ NK cells play a crucial part in immune surveillance of HCC progression. This study set out to identify prognostic signature related to FGFBP2+ NK cell in HCC. …”
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Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. by Fanggeng Zou, High Seng Chai, Curtis S Younkin, Mariet Allen, Julia Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Asha A Nair, Sumit Middha, Sooraj Maharjan, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Ryan Palusak, Sarah Lincoln, Gina Bisceglio, Constantin Georgescu, Naomi Kouri, Christopher P Kolbert, Jin Jen, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Alzheimer's Disease Genetics Consortium, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner

“…These results demonstrate the significant contributions of genetic factors to human brain gene expression, which are reliably detected across different brain regions and pathologies. …”
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Early Atherosclerosis and Acute Vascular Events in Ulcerative Colitis Patients – a Case Series by Ana Maria NEGREANU, Ana STEMATE, Teodora SPATARU, Lucian NEGREANU

“…Introduction: In inflammatory bowel disease uncontrolled inflammation may play a role in the early progression of systemic atheromatosis with increased cardiovascular risk. …”
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Diagnostic Value Investigation and Bioinformatics Analysis of miR-31 in Patients with Lymph Node Metastasis of Colorectal Cancer by Wu-wen Zhang, Xin-liang Ming, Yuan Rong, Chao-qun Huang, Hong Weng, Hao Chen, Jun-mei Bian, Fu-bing Wang

“…Hence, upregulated miR-31 and miR-21 expression might be a miRNA signature in CRC metastasis. Moreover, we detected a higher miR-31 level in the plasma of CRC patients with LNM compared to patients without LNM or healthy individuals. …”
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Changes in cerebral haemodynamics in patients depending on the severity and catamnesis of combat traumatic brain injury by I. Chernenko

“…No pathological turbulence was detected. Interhemispheric asymmetry in the carotid basin was within acceptable limits. …”
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Evaluation of the relationship of immuno-inflammatory process with dyslipidemia and myocardial morphofunctional parameters in patients with chronic heart failure on the background... by A. S. Ankudinov, A. N. Kalyagin

“…This relationship may affect the progression of left ventricular diastolic dysfunction in the group of CHF and RA, but prospective studies are needed to clarify its role.…”
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Gene prediction of immune cells association between gut microbiota and colorectal cancer: a Mendelian randomization study by Yan Zhong, Guanglei Chen, Menglu Chen, Junsong Cui, Qianren Tan, Zhenghua Xiao

“…MR-PRESSO was used to detect and correct outliers by excluding anomalous instrumental variables. …”
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Correlation between abdominal aortic calcification and peripheral blood lymphocyte subsets in patients with peritoneal dialysis by Ren Cai-xia, Han Kun, Liu Yuan, Xing Wen-xiu, Lu En-bang, Gong Xue, Wan Mei-yan

“…Objective To explore the relationship between abdominal aortic calcification（AAC）and peripheral blood lymphocyte subsets in patients on peritoneal dialysis（PD）.Methods The clinical data of 86 patients on PD were collected.Abdominal lateral plain film was taken for determining the occurrence of AAC and abdominal aortic calcification（AAC）score was calculated.Based upon the AAC scores, they were divided into three groups of non/mild calcification（0≤AACs≤4,n=41）,moderate calcification（5≤AACs≤15,n=28）and severe calcification（16≤AACs≤24,n=17）.Flow cytometry was utilized for detecting lymphocyte subsets in peripheral blood.The percentage of CD3⁺,CD3⁺CD4⁺,CD3⁺CD8⁺,CD4⁺/CD8⁺,Treg, CD19⁺,CD16⁺CD56⁺ and CD8⁺DR⁺lymphocyte count and ratio of CD4⁺/CD8⁺were calculated.Spearman’s correlation analysis was performed for analyzing the correlation between AAC and peripheral blood lymphocyte subsets and clinical parameters.Logistic regression was employed for analyzing the risk factors of AAC in PD patients.Results Among three groups, statistically significant differences existed in age, diabetic nephropathy, chronic glomerulonephritis, albumin, blood phosphorus and alkaline phosphatase levels（P<0.05）.Spearman’s correlation analysis indicated that degree of AAC was positively correlated with patient age, dialysis age, parathyroid hormone, blood phosphorus, alkaline phosphatase, high-sensitivity C-reactive protein, CD4⁺/CD8⁺,CD16⁺CD56⁺ and CD8⁺DR⁺（r=0.352,0.284,0.226,0.299,0.265,0.285,0.236,0.228,0.292,P<0.05）and negatively correlated with albumin and Treg（r=-0.222,-0.354,P<0.05）.Logistic regression model results implied that age（OR=1.060,95%CI 1.008～1.116,P<0.05）,CD4⁺/CD8⁺（OR=25.441,95% CI1.561～414.659,P<0.05）and Treg（OR=0.427,95%CI 0.255～0.715,P<0.05）were independent risk factors for moderate-to-severe AAC in PD patients.Conclusion The degree of AAC in PD patients has a certain correlation with the changes of lymphocyte subsets in peripheral blood.Lower percentage of Treg cells and higher ratio of CD4⁺/CD8⁺accelerate the progression of AAC.The change of peripheral blood lymphocyte subsets of PD patients may provide a new direction for the prevention and treatment of AAC.…”
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Dynamics of the RRNN interval of the cardiointervalogram depending on the specialization of the training process, stage of the annual preparation cycle and other factors (review) by D. A. Kataev, V. I. Tsirkin, V. V. Kishkina, A. N. Trukhin, S. I. Trukhina

“…The authors conclude that even a palpatory calculation of the heart rate of a cross-country skier in conditions of clinostasis (rest) can serve as a guideline in managing the training process, since an increase in heart rate with exercise therapy indicates a decrease in physical performance, and a progressive decrease in heart rate (up to 38 beats/min) – on its increase, as well as on the formation of the synthesis of non-neuronal acetylcholine (ACh). …”
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Diaphragm Assessment by Multimodal Ultrasound Imaging in Patients with Chronic Obstructive Pulmonary Disease: A Prospective Observational Study by Zhang T, Liu Y, Wang M, He M, Yu M, Li Y, Song Y

“…Diaphragm ultrasound parameters correlate with pulmonary function and COPD severity, indicating that these parameters can provide valuable insights into disease progression and management.Keywords: diaphragm assessment, multimodal ultrasound imaging, diaphragmatic dysfunction, COPD…”
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