Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Results In lactotroph PitNET, we detect a highly proliferative gene profile with significantly increased expression levels in aggressively growing tumors within bulk RNA-seq data of an independent cohort of 134 PitNET samples. …”
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Prevalence, Awareness, Treatment, and Control of Diabetes Among 0.98 Million Patients With Stroke/TIA in China: Insights From a Nationwide Cohort Study by Siqi Chen, Gulbahram Yalkun, Hongqiu Gu, Xin Yang, Chunjuan Wang, Xingquan Zhao, Yilong Wang, Liping Liu, Xia Meng, Yong Jiang, Hao Li, Yongjun Wang, Zixiao Li, Jue Liu, Donghua Mi

“…Methods Data from the Chinese Stroke Center Alliance program, a nationwide multi‐center registry study, were used to detect the prevalence, awareness, treatment, and control of diabetes among stroke/TIA. …”
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HypoFocal SRT Trial: Ultra-hypofractionated focal salvage radiotherapy for isolated prostate bed recurrence after radical prostatectomy; single-arm phase II study; clinical trial p... by Daniel Zwahlen, Thomas Zilli, Etienne Mathier, Alexander Althaus, Jens Lustenberger, Constantinos Zamboglou, Berardino De Bari, Daniel M Aebersold, Matthias Guckenberger, Mohamed Shelan

“…Secondary outcomes include acute side effects (until 90 days after the end of RT) of grade 3 or higher based on Common Terminology Criteria for Adverse Events V.5, progression-free survival, metastasis-free survival, late side effects and the quality of life (based on European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30, QLQ-PR25).Ethics and dissemination The study has received ethical approval from the Ethics Commission of the Canton of Bern (KEK-BE 2022-01026). …”
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Interferon Regulatory Factor 3 Exacerbates the Severity of COVID-19 in Mice by Wendy E. Walker, PhD, Luiz F. Garcia, MS, Pedro M. Palermo, PhD, Nawar Hakim, MD, Dinesh G. Goswami, PhD, Alok K. Dwivedi, PhD, Douglas M. Watts, PhD

“…While most infected people experienced mild illness, others progressed to severe disease, characterized by hyperinflammation and respiratory distress. …”
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The comparative study of chondrogenic differentiation of mesenchymal stromal cells allocated from different sources by Yu. B. Basok, A. M. Grigoriev, L. A. Kirsanova, I. V. Vakhrushev, A. V. Tsvetkova, A. A. Gryadunova, K. N. Yarygin, V. I. Sevastianov

“…A histological analysis of all microspheres after 14 days of culturing in the chondrogenic medium revealed the signs of differentiation in the chondrogenic direction, a progressive increase of the ECM produced by cells, and the presence of total collagen and GAG in it. …”
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Suppression effect of folate on poly- and perfluoroalkyl substance-induced alterations in lipids and the atherogenic index of plasma in adolescents by Yuxin Pan, Ziye Du, Yuyang Ma, Cheng Chen, Shaoyu He, Manling Zhang, Krishna Baral, Linyong Xu, Mengchang Xu, Mingyi Zhao

“…Abstract Background The specific mechanisms by which poly - and polyfluoroalkyl substances (PFAS) influence the particular lipid levels of adolescents and the progression of early subclinical atherosclerosis remain unclear. …”
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Cesium Accumulation Patterns and Stress Response in Hydroponic Radish (<i>Raphanus sativus</i> L.): A Physiological–Transcriptomic Study by Yu-Han Wen, Xi Chen, Ming Sun, Chao-Hui Yang, Meng-Yuan Xu, Feng-Xiang Lai, Si-Qi Fu, Yu-Meng Fan, Xin-Peng Guo, Qun Li, Guo Wu

“…The results showed that the Cs content in radish roots, stems, and cotyledons increased progressively with rising Cs concentrations (0.25–2 mM), and Cs mainly accumulated in the cotyledon. …”
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Relapse-specific genetic patterns in the exomic mutational landscape in acute myeloid leukemia by Wardah Qureshi, Aisha Jamal, Atia Gohar, Marium Imran Mansuri, Muhammad Irfan, Ishtiaq Ahmad Khan, Muhammad Shakeel

“…Abstract Background Acute myeloid leukemia (AML) is a blood malignancy that develops in the bone marrow due to uncontrolled cell proliferation and undifferentiating blood cells. This fast-progressing cancer has a higher percentage of relapses due to clonal evolution and the re-emergence of resistant clones. …”
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Features of brain magnetic resonance imaging (MRI) changes under the influence of renal denervation in patients with resistant hypertension by V. A. Lichikaki, V. F. Mordovin, S. E. Pekarskiy, I. V. Zyubanova, M. A. Manukyan, E. I. Solonskaya, A. A. Vtorushina, S. A. Khunkhinova, A. E. Sukhareva, V. Yu. Usov, A. Yu. Falkovskaya

“…RD contributes to a significant decrease in blood pressure levels and exerts a cerebral protective effect by reducing lateral brain ventricles, subarachnoid spaces, and absence of ischemia progression and intracranial hypertension after intervention.…”
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The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice by Jifei Chen, Fan Yang, Song Shi, Xuexiang Liu, Fengxian Qin, Xiaomou Wei, Yujie Huang, Wenwu Liang, Lin Miao

“…In this work, the change patterns of NLRP3- and Th17-related factors were detected during the pathological process of CVB3-induced VMC in Balb/c mice. …”
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Association between the atherogenic index of plasma and risk of large-artery atherosclerotic ischemic stroke by Wen Zhong, Wen Zhong, Nini Zhu, Nini Zhu, Xiaozhu Shen, Xiaozhu Shen, Zhonglin Ge, Xiguang Liu, Guanghui Zhang, Qi Fang, Jingxian Liao

“…Restricted cubic spline (RCS) analysis was used to detect the potential non-linear relationship, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive ability of AIP. …”
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Pan-cancer analysis identified CD248 as a potential target for multiple tumor types by Li Guo, Yan Liao, Xuyang Zhang, Rongjuan Guo, Zheng Wang, Deqin Yang, Deqin Yang, Deqin Yang

“…Furthermore, siCD248 was used to detect the effect of CD248 on the invasion, migration, and proliferation of HNSC cells by transwell assay, scratch wound healing assay, and EdU assay, respectively.ResultsCD248 expression was significantly increased and correlated with advanced stage and poor prognosis in various tumors. …”
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Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial–Neuronal Interactions in a Genetic Parkinson’s Disease Model of <i>UQCRC1</i> Mutation... by Jui-Chih Chang, Chin-Hsien Lin, Cheng-Yi Yeh, Mei-Fang Cheng, Yi-Chieh Chen, Chi-Han Wu, Hui-Ju Chang, Chin-San Liu

“…External mitochondria were detected in multiple brain areas through BrdU tracking, showing a 3.6-fold increase in the ST compared to the SN. …”
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Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth by Hao Wang, Ruixue Huo, Kexin He, Weihan Li, Yuan Gao, Wei He, Minhao Yu, Shu-Heng Jiang, Junli Xue

“…Abstract Background The colon and rectum are highly innervated, with neural components within the tumor microenvironment playing a significant role in colorectal cancer (CRC) progression. While perineural invasion (PNI) is associated with poor prognosis in CRC, the impact of nerve density and diameter on tumor behavior remains unclear. …”
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A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions. by Jessica B Hostetler, Sumana Sharma, S Josefin Bartholdson, Gavin J Wright, Rick M Fairhurst, Julian C Rayner

“…<h4>Background</h4>A vaccine targeting Plasmodium vivax will be an essential component of any comprehensive malaria elimination program, but major gaps in our understanding of P. vivax biology, including the protein-protein interactions that mediate merozoite invasion of reticulocytes, hinder the search for candidate antigens. …”
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Prevalence, associated risk factors and satellite imagery analysis in predicting soil-transmitted helminth infection in Nakhon Si Thammarat Province, Thailand by Jarawadee Muenjak, Jutarat Thongrod, Chanakan Choodamdee, Pongphan Pongpanitanont, Manachai Yingklang, Tongjit Thanchomnang, Sakhone Laymanivong, Penchom Janwan

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Exploring disparities in oral health: a comparative study of cochlear implanted and normal-hearing children by Serpil Mungan Durankaya, Gülser Kılınç, Hande Evin Eskicioğlu, Enis Alpin Güneri, Yüksel Olgun, Günay Kırkım

“…Statistical analyses were performed using IBM SPSS Statistics 29.0.0.0 and Open Epi Program. The normality of the data distribution was assessed with the Kolmogorov‒Smirnov test. …”
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Psychological impacts of the Gaza war on Palestinian young adults: a cross-sectional study of depression, anxiety, stress, and PTSD symptoms by Belal Aldabbour, Amal Abuabada, Amro Lahlouh, Mohammed Halimy, Samah Elamassie, Abd Al-Karim Sammour, Adnan Skaik, Saralees Nadarajah

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Genetic surveillance of Plasmodium–Anopheles compatibility markers during Anopheles stephensi associated malaria outbreak by Elizabeth Waymire, Dejene Getachew, Isuru Gunarathna, Joseph Spear, Grace Lloyd, Madison Follis, Avery A. Kaye, Said Ali, Solomon Yared, Tamar E. Carter

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Reinfection with SARS-CoV-2 variants: The issues of hybrid immunity efficiency by I. A. Pobozhaya, N. M. Kalinina, N. V. Makarova

“…Statistical evaluation was carried out using the STATISTICA 13.0 program. The group differences were considered statistically significant at p &lt; 0.05. …”
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