Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses by Yu Yin, Chenkai Zhao, Yibo Hua, Fei Yang, Dandan Qiu, Jiasheng Yan, Xiaodong Jin

“…Abstract Background Chronic kidney disease (CKD) is a globally prevalent chronic condition characterized by progressive renal function decline, imposing significant economic and psychological burdens on patients. …”
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Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy by Pei-Long Liu, Jia-Yu Diao, Qiong Wang, Huan Liu, Yan Zhang, Jing-Qi Liang, Feng Zhang, Xiao-Jun Liang, Hong-Mou Zhao

“…DNOAP is characterized by progressive destruction of bone and joint, but its pathogenesis remains elusive. …”
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Rural or urban living and Parkinson's disease Antecedente de vida rural ou de vida urbana e doença de Parkinson by Henrique B. Ferraz, Luiz A. F. Andrade, Vítor Tumas, Leandro C. Calia, Vanderci Borges

“…A minimum 6-month follow-up period was undertaken with 63 patients (average 20 months) and no difference in response to treatment or in progression of the illness was detected between the two groups. …”
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Does Artificial Intelligence Bring New Insights in Diagnosing Phlebological Diseases?—A Systematic Review by Sergiu-Ciprian Matei, Sorin Olariu, Ana-Maria Ungureanu, Daniel Malita, Flavia Medana Petrașcu

“…Furthermore, AI has proven capable of detecting subtle abnormalities, such as minor venous reflux or early-stage thrombi, which may be overlooked during manual evaluations. …”
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Application of bioinformatics analysis to construct the prognostic model and immune-related gene characteristics of low-grade glioma by Peng Liao, Xiaocui Zhang, Ruyan Yuan, Tingjun Tang, Feng Wang, Baowei Geng

“…Recent advancements in molecular profiling offer potential for better understanding of genetic and immune factors involved in LGG progression, guiding more effective treatments and improving patient outcomes. …”
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Risk factors of severe heart failure in HIV-positive patients by O. G. Goryacheva, N. A. Koziolova

“…In 62,7% of HIV-positive patients with HF, preserved EF was detected. Among the comorbidities, 9 risk factors of severe HF in HIV-positive patients with NT-proBNP >1500 pg/ml were identified. …”
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Diagnostic Accuracy of Serum Cystatin C for Early Recognition of Nephropathy in Type 2 Diabetes Mellitus by Suman Sapkota, Saroj Khatiwada, Shrijana Shrestha, Nirmal Baral, Robin Maskey, Shankar Majhi, Lal Chandra, Madhab Lamsal

“…This prospective study was conducted to assess the diagnostic accuracy of serum cystatin C in detecting diabetic nephropathy at earlier stages. Materials and Methods. …”
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Bone regeneration using moldable calcium phosphate with and without recombinant human BMP-2 in a rabbit critical-sized metaphyseal core defect model by Hyun Seung Ryu, Hyun Jung Park, Mi Young Ryu, Young-Hoon Kim, Sang-Il Kim, Hyung-Youl Park

“…Results Radiographic and μCT analyses showed progressive bone formation in all treatment groups. …”
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Esophageal oxyhemoglobin saturation as a resuscitative metric in hemorrhagic shock by Julia Garcia Mancebo, Kristen Sack, Padraic Romfh, Yifeng Peng, John Kheir

“…Using time-matched ShbO2-SvO2 pairs, the performance of ShbO2 to detect severe tissue hypoxia (SvO2<20%) was excellent (AUC 0.843 for eShbO2, 0.879 for tShbO2). …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…This study highlights the critical role of PTEN in RCC progression and suggests potential therapeutic targets for intervention.…”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Abstract Purpose Growing evidence suggests that the tyrosine phosphatase SHP2 is pivotal for tumor progression. Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, characterized by its high recurrence rate, aggressive metastasis, and resistance to chemotherapy. …”
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FSCN1 is a Potential Therapeutic Target for Atherosclerosis Revealed by Single-Cell and Bulk RNA Sequencing by Zhang L, Jiang H, Li L, Sun Z, Qian Y, Wang Z

“…Knockdown of FSCN1 reduced pyroptosis and increased the migration in MAECs.Conclusion: Knockdown of FSCN1 in EC could alleviate the development and progression of AS. FSCN1 may be a potential prognostic biomarker and therapeutic target in AS.Keywords: FSCN1, atherosclerosis, endothelial cells, pyroptosis, migration…”
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Early Aortic Valve Replacement of Asymptomatic Severe Aortic Stenosis: A Meta‐Analysis of Randomized Controlled Trials by Qingchun Song, Ruilin Liu, Kai Yang, Xiaokang Tu, Haoyu Tan, Chengming Fan, Xiaoxiao Li

“…Background Asymptomatic severe aortic stenosis may lead to the progression to both symptoms and adverse outcomes if left untreated. …”
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Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study by Alem Gebremariam, Adamu Addissie, Alemayehu Worku, Mathewos Assefa, Lydia E Pace, Eva Johanna Kantelhardt, Ahmedin Jemal

“…Ninety-five percent of the patients detected the first symptoms of breast cancer by themselves, with breast lump (78.0%) as the most common first symptom. …”
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A dataset of large ensemble of CMIP6-based transient climate scenarios for impact assessment in Great BritainZenodo by Mikhail A. Semenov, Nimai Senapati, Kevin Coleman, Adrian L. Collins

“…The dataset can be used to underpin assessments of future climate change risk and vulnerability, and their temporal patterns and progressive changes over time. Our data are designed to be used as a time series of climatic input to impact models for climate change assessments continuously over time related to various fields and disciplines, including land and water resources, agriculture and food production, soil carbon cycle, ecology and epidemiology, and human health and welfare. …”
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Digital Image Speckle Correlation (DISC): Facial Muscle Tracking for Neurological and Psychiatric Disorders by Shi Fu, Pawel Polak, Susan Fiore, Justin N. Passman, Raphael Davis, Lucian M. Manu, Miriam Rafailovich

“…This study explored the application of Digital Image Speckle Correlation (DISC) in detecting enervation of facial musculature and assessing reaction times in response to visual stimuli. …”
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Branch-type intraductal papillary neoplasm of the bile duct treated with laparoscopic anatomical resection: a case report by Rumi Matono, Mizuki Ninomiya, Kazutoyo Morita, Takahiro Tomino, Yumi Oshiro, Tomoyuki Yokota, Takashi Nishizaki

“…IPNB eventually invades the bile duct wall and progresses to invasive cholangiocarcinoma. IPNB resembles intraductal papillary mucinous neoplasm of the pancreas (IPMN), particularly the main pancreatic duct type. …”
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Volatile Organic Components and MS-e-nose Profiles of Indonesian and Malaysian Palm Sugars from Different Plant Origins by Aldia Katherinatama, Yonathan Asikin, Ryo Amano, Siti Hajar-Azhari, David Yudianto, Dhina Aprilia Nurani Widyahapsari, I Wayan Rai Widarta, Kensaku Takara, Koji Wada

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Preliminary Study on Some Blood Parameters of White Snook (<i>Centropomus viridis</i>) Broodstock Reared in Aquaculture Recirculating System (RAS) by Iris Adriana Hernández-López, Virginia Patricia Domínguez-Jiménez, Rosa María Medina-Guerrero, Rodolfo Lozano-Olvera, Oscar Basilio Del Rio-Zaragoza, Leonardo Ibarra-Castro, Juan Manuel Martínez-Brown, Emyr Saúl Peña-Marín

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Liver damage in infectious mononucleosis in children by S. V. Khaliullina, F. M. Yakupova, E. I. Nasyrova, K. V. Mikhailova, Yu. A. Raimova, O. A. Nazarova, V. A. Anokhin

“…Statistical analysis of the obtained results was carried out using the statistical program Statistica 8 (USA).Results. Epstein – Barr virus was the cause of the development of IMN clinic in 59% (118/200) of cases of monoinfection and in 14.5% (29/200) in combination with other herpesviruses. …”
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