Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy by Han-han He, Xiao-ge Zhang, Fen-fang Chen

“…Increasing evidence suggests that autophagy plays a crucial role in the initiation and progression of epilepsy. However, the precise mechanisms by which autophagy deficiencies involved in epileptogenesis are still not fully understood.MethodsTwo datasets of epilepsy (GSE143272 and GSE256068) were downloaded from the Gene Expression Omnibus (GEO) database. …”
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17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway by Tao Liu, Zhaohui Li, Wei Zhang, Xuzhao Guo, Guobin Liu, Dalong Yang, Sidong Yang

“…Furthermore, cellular immunofluorescence and Western blot showed that E2 can maintain extracellular matrix (ECM) balance and inhibits apoptosis of nucleus pulposus cells (NPCs) by activating the p70 S6K1 signaling pathway.ConclusionIn summary, 17β-estradiol mitigates IVDD progression by maintaining ECM homeostasis and inhibiting NPCs apoptosis through activation of the p70 S6K1 signaling pathway downstream of mTOR.…”
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Whole genome comparisons reveal gut-to-lung translocation of Escherichia coli and Burkholderia cenocepacia in two cases of ventilator-associated pneumonia in ICU patients by Huihui Gao, Lei Xu, Yixin Liu, Xiaolong Wang, Siyuan Zhu, Huai Lin, Yuting Gao, Daqing Mao, Xing Lu, Yi Luo

“…Conclusions This study demonstrates the gut-to-lung translocation of E. coli and B. cenocepacia, highlighting their role in the development and progression of VAP in ICU patients. These findings provide valuable insights for implementing targeted prevention and treatment strategies for VAP in ICU settings. …”
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Prognostic impact of depth of response and early tumour shrinkage in patients with -mutated metastatic colorectal cancer treated with targeted therapy by Guglielmo Vetere, Marco Maria Germani, Carlotta Antoniotti, Lisa Salvatore, Filippo Pietrantonio, Sara Lonardi, Maria Bensi, Filippo Ghelardi, Maria Alessandra Calegari, Rossana Intini, Alessandro Minelli, Francesco Giulio Sullo, Chiara Boccaccio, Ada Taravella, Alberto Puccini, Daniele Lavacchi, Laura Noto, Massimiliano Salati, Mario Scartozzi, Chiara Cremolini

“…Relationships of DpR and ETS, both as binary, according to conventional (30% for DpR and 20% for ETS) and median cut-off values, and continuous variables, with progression-free (PFS), overall survival (OS) and duration of response (DoR) were assessed in non-primary resistant patients. …”
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Repeatability of Fractal Analysis in OCT Angiography of the Macula and Optic Nerve Head by Gustavo Rosa Gameiro, MD, PhD, Alessandro A. Jammal, MD, PhD, Verônica Vilasboas-Campos, MD, Jianhua Wang, MD, PhD, Felipe A. Medeiros, MD, PhD

“…Future studies should investigate its diagnostic accuracy and ability to detect disease progression. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.…”
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High-Expressed Macrophage Scavenger Receptor 1 Predicts Severity Clinical Outcome in Transplant Patient in Idiopathic Pulmonary Fibrosis Disease by Mingfeng Zheng, Tian Tian, Jialong Liang, Shugao Ye, Jingyu Chen, Yong Ji

“…Our study indicates the clinical significance of Klebsiella pneumoniae infection-related MSR1-positive cells in IPF progression, and it could be a prognostic marker in IPF after the lung transplant; development strategies to reduce the expression of MSR1-positive macrophages in IPF may be beneficial for the lung transplant.…”
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The mechanism of high mobility group box-1 in the proliferation and macrophage polarization in esophageal squamous cell carcinoma cells by Liling Luo, Chao Jiang, Songxi Xie

“…Abstract Background Previous studies showed that high mobility group box-1 (HMGB1) facilitates the initiation and progression of esophageal squamous cell carcinoma (ESCC), and the current research investigated the detailed mechanisms implicated. …”
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Quantitative Ultrashort Echo Time Magnetization Transfer Imaging of the Osteochondral Junction: An In Vivo Knee Osteoarthritis Study by Dina Moazamian, Mahyar Daskareh, Jiyo S. Athertya, Arya A. Suprana, Saeed Jerban, Yajun Ma

“…The osteochondral junction (OCJ), a critical structural interface between deep cartilage and subchondral bone, plays an essential role in OA progression but is challenging to assess using conventional magnetic resonance imaging (MRI) due to its short T2 relaxation times. …”
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The etiological profile and alterations in cerebrospinal fluid characteristics in patients with bacterial meningitis by O. O. Chernysheva, M. S. Potemkina, M. M. Gadzhikulieva, I. V. Davydova, T. Yu. Smirnova, I. Ch. Partilkhaeva, S. A. Shutko

“…Within the group of meningococcal meningitis cases, serovariants A and W135 were the most frequently detected, accounting for 49.3% and 33.3%, respectively. …”
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The Macular Choroidal Thickness in Danish Children with Myopia After Two-Year Low-Dose Atropine and One-Year Wash-Out: A Placebo-Controlled, Randomized Clinical Trial by Niklas C. Hansen, Anders Hvid-Hansen, Toke Bek, Flemming Møller, Nina Jacobsen, Line Kessel

“…One-way analysis of variance was used to detect baseline ChT differences between AL-stratified groups (< 24 mm, 24–25 mm, or > 25 mm). …”
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Thiol-disulfide homeostasis and ischemia modified albumin levels in patients diagnosed with ovary carcinoma by Denizcan Hasturk, Selin Akturk Esen, Enes Seyda Sahiner, Ozcan Erel, Salim Neselioglu, Nurullah Aydogan, Muge Buyukaksoy, Ismet Seven, Sebnem Yucel, Dogan Uncu

“…Our study suggests that TD homeostasis may be an important guide in terms of disease progression, complications during chemotherapy treatment, appropriate dose reductions, and modifications in chemotherapy depending on the toxicities experienced and the goals of the treatment.…”
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Long-Term Monitoring of Liver Fibrosis and Steatosis in Patients with Chronic Hepatitis C after Achieving a Sustained Virologic Response to Antiviral Therapy by K. R. Dudina, P. A. Belyy, I. V. Maev, N. Kh. Safiullina, E. A. Klimova, S. A. Shutko, O. O. Znoyko, N.  D. Yushchuk

“…In the long-term period after reaching SVR, regression of liver fibrosis was diagnosed in 80 % of cases (including in patients with cirrhosis), and the progression of fibrosis was in 3 % of patient. At the same time, regression of liver steatosis was detected only in 31 % of the patient, worsening of the results was in 23 % (26 % of them had the appearance of steatosis (S) of the liver of 1–3 degrees in persons with no fatty liver before the start of AVT). …”
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Comparative transcriptome and metabolome analysis of sweet potato (Ipomoea batatas (L.) Lam.) tuber development by Yanhui Lin, Yapeng Li, Yapeng Li, Honglin Zhu, Liqiong Tang, Jing Xu

“…A total of 1566 metabolites were detected, which were mainly divided into 12 categories. …”
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Machine learning based identification of anoikis related gene classification patterns and immunoinfiltration characteristics in diabetic nephropathy by Jing Zhang, Lulu Cheng, Shan Jiang, Duosheng Zhu

“…After that, receiver operating characteristic (ROC) analysis was employed to assess the diagnostic accuracy of each gene and the real-time quantitative polymerase chain reaction (RT-qPCR) was adopted to quantitatively detect the expression of biomarkers in DN cell models. …”
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Effect of vitexin on Aspergillus fumigatus keratitis in mice and its mechanism by XU Haining, YI Wendan, JIA Yiyi, LI Cui, YIN Min, GU Lingwen, ZHAO Guiqiu

“…Hematoxylin-eosin staining was used to detect the inflammatory cell infiltration in the mice. …”
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Expression of RNA-binding motif 10 is associated with advanced tumor stage and malignant behaviors of lung adenocarcinoma cancer cells by Guofang Guan, Ranwei Li, Wenfang Tang, Tiecheng Liu, Zhenzhong Su, Yan Wang, Jingjin Tan, Shan Jiang, Ke Wang

“…Molecularly, RNA-binding motif 10 regulates many gene pathways involving in the tumor development or progression.…”
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Comparative analysis of clinical characteristics of symptomatic pituitary adenomas in elderly patients: a consecutive series of 114 patients by Run Wang, Xiaodi Han, Cheng Xie, Qinghua Zhang, Liang Kan, Sheng Han

“…However, in elderly patients, the disease progression renders some clinical features difficult to detect and identify in time. …”
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Morphologic Pattern Differences in Reconstructive Tissue Repair of Bone Defects Mediated by Bioactive Ceramics and Hydrogels: A Microscopic Follow-Up Evaluation of Re-Ossification by Róbert Boda, Viktória Hegedűs, Sándor Manó, Andrea Keczánné-Üveges, Balázs Dezső, Csaba Hegedűs

“…In addition to lateral ossification, multiple and intense intralesional osseous foci developed as early as the 1st month, and grew progressively thereafter, reflecting the osteo-inductive effects of all compounds. …”
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INNOVATION AND SUCCESS: PERCEPTIONS, ATTITUDES AND PRACTICES OF YOUNG FARMERS by Maria G. BOTSIOU, Stavriani KOUTSOU, Vassilios DAGDILELIS

“…The adoption of innovations in business refers to a set of practices and actions which can contribute decisively to the successful development and progression of the enterprise. According to the National Development Low 3299/2004 (GR), innovation is an applied use of knowledge in the production and marketing of new or improved products, processes and services that find immediate productive, utilitarian and commercial application. …”
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Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration by Mandy Hector, Verena Behnke, Paulina Dabrowska-Schlepp, Andreas Busch, Andreas Schaaf, Thomas Langmann, Anne Wolf

“…Abstract Background AMD is a multifactorial progressive disease of the central retina that leads to severe vision loss among the elderly. …”
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