Diagnostic value of combined magnetic resonance imaging examination of brachial plexus and electrophysiological studies in multifocal motor neuropathy by Basta Ivana, Nikolić Ana, Apostolski Slobodan, Lavrnić Slobodan, Stošić-Opinćal Tatjana, Banjalić Sandra, Knežević-Apostolski Slađana, Ilić Tihomir V., Marjanović Ivan, Milićev Milena, Lavrnić Dragana

“…Multifocal motor neuropathy (MMN) is an immune-mediated disorder characterized by slowly progressive asymetrical weakness of limbs without sensory loss. …”
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Diagnostic investigation, intervention, and outcome for post-subtotal gastrectomy patients who present with jaundice by Duan Wang, Duan Wang, Liang Zhu, Fanyi Kong, Fanyi Kong, Yingyu Pan, Yingyu Pan, Wei Liu, Xuan Wang, Weidong Pan, Jian Cao, Qiang Xu, Dong Wu, Dong Wu, Dong Wu

“…Despite the effectiveness of interventions, a significant number of patients experienced short-term disease progression.…”
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miR-1225-3p regulates fibrosis in mesangial cells via SMURF2-mediated ubiquitination of ChREBP in diabetic kidney disease by Juntai Zhang, Yan Cai, Yan Qin, Jie Liu, Jie Ding, Mengying Xu, Li Yang, Yuanxin Zheng, Xi Zhang

“…Studies have shown that miRNAs are closely related to the progression of DKD. Therefore, in this study, we aimed to explore whether miR-1225-3p can regulate Smad ubiquitin regulatory factor 2 (SMURF2)-mediated carbohydrate response element binding protein (ChREBP) ubiquitination through Rho GTPase-activating protein 5 (ARHGAP5) to affect fibrosis in DKD.Methods DKD mice were established by intraperitoneally injecting streptozocin (STZ), and a DKD cell model was generated by culturing in media supplemented with 25 mmol/L glucose (high glucose, HG). …”
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Anti-Tumor Efficacy of a Mesothelin-Based Nanovaccine in a KPC Orthotopic Mouse Model of Pancreatic Cancer by Daniele P. Ferrari, Özmen Çobanoglu, Sana Sayedipour, Omar Luna, Sonia A. M. Ferkel, David Agorku, Yomkippur Perez, Luis J. Cruz, Fernando Albericio, François Trottein, Frauke Alves, Marietta Andrea Markus, Fernanda Ramos-Gomes

“…Higher levels of MSLN-specific IgM and IgG antibodies were detected in the serum of vaccinated mice compared to that of control mice. …”
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Liuweizhiji Gegen-Sangshen beverage protects against alcoholic liver disease in mice through the gut microbiota mediated SCFAs/GPR43/GLP-1 pathway by Mingyun Tang, Mingyun Tang, Long Zhao, Long Zhao, Fuchun Huang, Fuchun Huang, Tiangang Wang, Tiangang Wang, Xu Wu, Shanshan Chen, Shanshan Chen, Juan Fu, Juan Fu, Chaoli Jiang, Chaoli Jiang, Shulin Wei, Shulin Wei, Xuseng Zeng, Xuseng Zeng, Xiaoling Zhang, Xiaoling Zhang, Xin Zhou, Xin Zhou, Mei Wei, Zhi Li, Zhi Li, Zhi Li, Guohui Xiao, Guohui Xiao

“…Notably, regarding most detected indices, the effect of LGS (particularly at medium and high dose) was comparable to the positive drug MTDX. …”
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Safety, immunogenicity, and protective efficacy of the intranasal live pertussis vaccine GamLPV in an infant monkey model (<i>Papio hamadryas</i>) by D. T. Kubrava, A. Yu. Medkova, A. Z. Matua, I. G. Kondzariya, A. A. Amichba, Kh. Z. Trapsh, L. V. Gamgiya, S. G. Kulikov, L. N. Sinyashina, Z. Ya. Mikvabiya, G. I. Karataev

“…INTRODUCTION. The current progressive increase in pertussis incidence and infant mortality rates is due to the insufficient effectiveness of existing vaccines, both in Russia and worldwide. …”
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En face swept-source optical coherence tomography (SS-OCT) and SS-OCT angiography findings of retinal astrocytic hamartomas in patients with tuberous sclerosis complex by Chen-Xi Zhang, Chen-Xi Zhang, Chen-Xi Zhang, Kai-Feng Xu, Qin Long, Qin Long, Qin Long, Xiao Zhang, Xiao Zhang, Xiao Zhang, Zhi-Kun Yang, Zhi-Kun Yang, Zhi-Kun Yang, Rong-Ping Dai, Rong-Ping Dai, Rong-Ping Dai, Zhi-Qiao Zhang, Zhi-Qiao Zhang, Zhi-Qiao Zhang

“…The tumor vascular density was positively correlated with tumor maximal thickness in type 1 RAHs (p = 0.037).ConclusionEn face SS-OCT provided a good display of RAH-related vitreoretinal traction and tumor calcification, while SS-OCTA, by clearly visualizing intratumoral vascularity, may assist in detecting signs of progressive tumor growth in TSC-associated RAHs.…”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Patients receiving targeted therapy based on molecular profile showed superior survival (progression-free survival, overall survival) compared with patients without targeted treatment. …”
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Efficacy and safety of KN026 and docetaxel for HER2‐positive breast cancer: a phase II clinical trial by Jianli Ma, Jingxuan Wang, Ting Xu, Quchang Ouyang, Xiaojia Wang, Jingfen Wang, Lu Gan, Zhong Ouyang, Daren Lin, Tao Sun, Changping Shan, Herui Yao, Baochun Zhang, Zhengguang Li, Zhixiang Zhuang, Ying Lu, Hongwei Yang, Jian Huang, Xingwang Yang, Hongmei Sun, Qingyuan Zhang

“…In addition, overall survival (OS), progression‐free survival (PFS), clinical benefit rate (CBR) and safety profile were examined. …”
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AAV-HBV mouse model replicates the intrahepatic immune landscape of chronic HBV patients at single-cell level by Nádia Conceição-Neto, Wim Pierson, Qinglin Han, Zhiyuan Yao, Qun Wu, Koen Dockx, Liese Aerts, Dries De Maeyer, Matthias Beyens, Koen Van den Berge, Chris Li, George Kukolj, Ren Zhu, Vinod Krishna, Ondřej Podlaha, Isabel Nájera, Ellen Van Gulck

“…IntroductionUnresolved hepatitis B virus (HBV) infection leads to a progressive state of HBV-specific immune dysfunctionality that characterizes chronic infection. …”
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Natural Course of Electrocardiographic Features in Arrhythmogenic Right Ventricular Cardiomyopathy and Their Relation to Ventricular Arrhythmic Events by Anneli Svensson, Henrik Kjaerulf Jensen, Machteld J. Boonstra, Marianne Tétreault‐Langlois, Pia Dahlberg, Henning Bundgaard, Alex Hørby Christensen, Rebecca T. Rylance, Jesper H. Svendsen, Julia Cadrin‐Tourigny, Anneline S. J. M. te Riele, Pyotr G. Platonov

“…Conclusions Depolarization and repolarization parameters evolved over time in patients with arrhythmogenic right ventricular cardiomyopathy, supporting the progressive nature of arrhythmogenic right ventricular cardiomyopathy. …”
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Porphyromonas gingivalis hijacks mitophagy and lysosomal function to persist in endothelial cells by Cheng Zheng, Jianmin Huang, Shengming Xu, Bin Lu, Hanxin Que, Tianhao Chen, Yubo Hou, Yubo Hou, Linlin He, Linlin He, Xia Fan, Fa-Ming Chen, Yi Wang, Yi Wang, Hui Deng, Hui Deng

“…This study provides new insights into the mechanisms by which P. gingivalis persists in endothelial cells and its potential role in atherosclerosis progression.…”
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SULT2B1: a novel therapeutic target in colorectal cancer via modulation of AKT/PKM2-mediated glycolysis and proliferation by Jianxing Ma, Fengyao Sun, Wen Li, Ruihang Du, Mingchan Liu, Qiuya Wei, Boxiong Kang, Siyuan Yan, Chen Wang

“…Chromatin immunoprecipitation (CHIP) assay was utilized to detect the effect of SULT2B1 in regulating transcription. …”
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Effects of Qingyangshen glycosides on neuroplasticity in a mouse model of social defeat by Jingru Wang, Weishi Chen, Qiang Zhu, Yao Liu, Zheng Kang, Dingding Liu, Guirong Zeng

“…Immunofluorescence double staining was used to detect the expression of synaptophysin (SYN) and postsynaptic density protein‐95 (PSD‐95), while western blot was employed to evaluate PSD‐95, SYN, and doublecortin (DCX) proteins. …”
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The Application and Validity of a New Composite Radiographic Index for Patients with Osteonecrosis of the Jaws by Zafeiroula Yfanti, Sotirios Tetradis, Nikolaos G. Nikitakis, Konstantina Eleni Alexiou, Emmanouil Vardas, Christos Angelopoulos, Kostas Tsiklakis

“…<b>Background/Objectives</b>: This study aims to determine the validity of a recently developed and published index (the modified Composite Radiographic Index—CRIm) as an indicator of disease gravity and progression in the CBCT scans of patients with medication-related osteonecrosis of the jaw (MRONJ) and to detect possible correlations between the radiologic findings and clinical staging of the disease. …”
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Impact of Harvest Periods on the Physicochemical and Flavour Characteristics of Sichuan Pepper (<i>Zanthoxylum bungeanum</i> Maxim) by Lian He, Yuwen Yi, Hongfeng Jia, Chengjian Xu, Mingfeng Qiao, Xuemei Cai, Sze Ying Leong, Nallammai Singaram, Sook Wah Chan, Hua Peng

“…Results showed that the moisture content, weight, and shape of Sichuan peppers improved progressively, peaking at the LSE harvest period. Throughout maturation, the energy content of the Sichuan pepper remained stable. …”
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Clinical and neuropathological associations of plasma Aβ42/Aβ40, p‐tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders by Binita Rajbanshi, Igor Prufer Q C Araujo, Lawren VandeVrede, Peter A. Ljubenkov, Adam M. Staffaroni, Hilary W. Heuer, Argentina Lario Lago, Eliana Marisa Ramos, Leonard Petrucelli, Tania Gendron, Jeffrey L. Dage, William W. Seeley, Lea T. Grinberg, Salvatore Spina, Randall J. Bateman, Howard J. Rosen, Bradley F. Boeve, Adam L. Boxer, Julio C. Rojas, for the ALLFTD Consortium

“…Abstract INTRODUCTION Plasma amyloid beta42/amyloid beta40 (Aβ42/Aβ40) and phosphorylated tau217 (p‐tau217) identify individuals with primary Alzheimer's disease (AD). They may detect AD co‐pathology in the setting of other primary neurodegenerative diseases, but this has not been systematically studied. …”
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Exosomal PSM-E inhibits macrophage M2 polarization to suppress prostate cancer metastasis through the RACK1 signaling axis by Xingliang Qin, Ruoxi Niu, Yongyao Tan, Yuxin Huang, Weishu Ren, Weiwei Zhou, Huiquan Wu, Junlong Zhang, Mingze Xu, Xiang Zhou, Hongyu Guan, Xun Zhu, Yu Chen, Kaiyuan Cao

“…Methods PSM-E levels in exosomes were detected by transmission electron microscopy and Western blotting analysis. …”
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THE IMPACT OF RISK FACTORS AND INSULIN ADMININSTRATION METHOD ON THE CONDITION OF THE RETINA IN CHILDREN WITH TYPE I DIABETES MELLITUS by A. N. Samoylov, T. R. Khaibrakhmanov, G. A. Fazleeva, P. A. Samoylova, M. A. Fazleeva

“…The use of a metering pump and regular self-control of the parameters help avoid the emergence and progression of diabetic retinal lesions in children with type I diabetes (p < 0.05). …”
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UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…Abstract Background Immune cells within tumor tissues play important roles in remodeling the tumor microenvironment, thus affecting tumor progression and the therapeutic response. The current study was designed to identify key markers of plasma cells and explore their role in high-grade serous ovarian cancer (HGSOC). …”
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