A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells by Cristina Poggiana, Alessandro Francesco Piazza, Cristina Catoni, Ilaria Gallingani, Luisa Piccin, Stefania Pellegrini, Vittorio Aneloni, Valentina Salizzato, Jacopo Pigozzo, Alessio Fabozzi, Antonella Facchinetti, Chiara Menin, Paolo del Fiore, Simone Mocellin, Vanna Chiarion-Sileni, Antonio Rosato, Maria Chiara Scaini

“…The FDA-approved CellSearch platform enriches CD146-positive CMCs, whose number correlates with progression-free survival and overall survival. However, a single marker may not be sufficient to identify them all. …”
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Endothelial cell iron overload and ferroptosis mediate thrombosis and inflammation through the miR-32-5p/neurofibromin 2 pathway by Ying Deng, Xueguang Lin, Jun Wei, Bo Chen, Huafang Yan, Bo Wang, Jialong Li, Yuqun Zhao, Bo Yu, Jingdong Tang, Shuai Jiang

“…Abstract Thromboangiitis obliterans (TAO) is characterized by progressive inflammatory vasculopathy featuring thrombotic occlusion. …”
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Secondary bacterial infections of Carbapenem-Resistant Acinetobacter baumannii in patients with COVID-19 admitted to Chinese ICUs by Fuhong Chen, Jia Lin, Wei Yang, Jie Chen, Xiang Qian, Tao Yan, Xiuping Liu, Yewei Lu, Qi Chen

“…The median duration of illness for these patients was 7.95 days, highlighting the severity and rapid progression of CRAB infections in this patient population. …”
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Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation by Manzhen Liao, Manzhen Liao, Taoyue Yao, Yonghui Xie, Shelby Kutty, Jinqiao Liu, Wei Peng, Wei Peng, Ting Huang, Huaiyang Chen, Huaiyang Chen, Haoqin Fan, Zhenghui Xiao, Qiming Liu, Yunbin Xiao

“…BackgroundPulmonary arterial hypertension is a severe and life-threatening disease characterized by a progressive increase in pulmonary vascular resistance. …”
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Methyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction by Huimei Huang, Chuman Huang, Yinghua Li, Xingwei Liang, Namhyung Kim, Yongnan Xu

“…In conclusion, our findings indicate that MP disrupts redox balance and induces mitochondrial dysfunction during meiosis in porcine oocytes, resulting in the inhibition of meiotic progression. The present study reveals the mechanism underlying the effects of methyl para-hydroxybenzoate on oocyte maturation.…”
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B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry by Gregg J. Silverman, Abhimanyu N. Amarnani, Arnaldo A. Arbini, Angie Kim, Hannah Kopinsky, David Fenyo, Ilya Kister

“…Larger studies are now needed to determine whether these factors may lead to impaired therapeutic benefits of B cell targeted therapy and clinical progression, and these findings may be useful to guide future optimized personalized therapeutic strategies.…”
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Pathology of Red Blood Cells in Patients with SARS-CoV-2 by Sona Hakobyan, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Hranush Avagyan, Nane Bayramyan, Lyudmila Niazyan, Mher Davidyants, Knarik Sargsyan, Tehmine Ghalechyan, Anna Semerjyan, Elena Karalova, Zaven Karalyan

“…<b>Results:</b> Erythroblasts were detected in approximately 30% of SARS-CoV-2 patients, predominantly in the severe group. …”
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Surgical margin and other prognostic factors of invasive vulvar squamous cell carcinoma: A clinicopathological mono-center study by Binghong Guo, Jiaqi Qiu, Yulin Wang, Nuerbiya Abula, Longyi Chen, Heqing Zhao, Yongyi Zhu, Min Zheng, Zhimin Liu, Yongwen Huang

“…The Kaplan-Meier method assessed the overall survival (OS) and progression-free survival (PFS) time. Prognostic factors were identified using univariable and multivariable Cox regression analysis. …”
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Proteomics uncovers ICAM2 (CD102) as a novel serum biomarker of proliferative lupus nephritis by Dan Gao, Dongwei Liu, Zhangsuo Liu, Zhengyong Li, Yifang Sun, Yixue Wang, Fengxun Liu, Shaokang Pan, Songwei Li, Zuishuang Guo, Jinghua Yang

“…Objectives This study aimed to identify novel, non-invasive biomarkers for lupus nephritis (LN) through serum proteomics.Methods Serum proteins were detected in patients with LN and healthy control (HC) groups through liquid chromatography-tandem mass spectrometry. …”
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O-GlcNAc-modified HOXA9 suppresses ferroptosis via promoting UBR5-mediated SIRT6 degradation in nasopharyngeal carcinoma by Huai Liu, Yingzhou Fu, Ling Tang, Bo Song, Wangning Gu, Hongmin Yang, Tengfei Xiao, Hui Wang, Pan Chen

“…O-GlcNAcylation levels on HOXA9 and ubiquitination levels on SIRT6 were detected by immunoprecipitation. ChIP and luciferase assays were applied for determining the interaction of HOXA9 and UBR5. …”
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The role of Adiponectin and Leptin in Colorectal Cancer and Adenoma: a systematic review and meta-analysis by Iman Elahi Vahed, Mahsa Moshgelgosha, Abdolmajid Kor, Mona Minadi, Faezeh Ebrahimi, Aylar Azhdarian, Mobina Arjmandi, Aida Alamdar, Maede Zare, Niloufar Shabani, Hossein Soltaninejad, Mohammad Rahmanian

“…However, no notable connection was detected between higher leptin concentrations and risk of CRC (OR: 1.12, 95% CI: 0.96–1.31). …”
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AI-powered advances in type II endometrial cancer: global trends and African contexts by Thulo Molefi, Thulo Molefi, Thulo Molefi, Lloyd Mabonga, Rodney Hull, Motshedisi Sebitloane, Zodwa Dlamini

“…With rising incidence and increasing concerns in Africa, type II ECs are often detected in advanced stages, exhibit aggressive progression, and resist conventional therapies. …”
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Fluorescence lifetime imaging microscopy approach reveals quantitative signatures for hepatocellular carcinoma diagnosis by Lingyun Li, Lingyun Li, Aoshan Wang, Xiongqing Liu, Ganlu Wang, Shanjie Xu, Changjiang Li, Wenzhong Wu, Xiaoying Zhang, Zhendan He, Huiling Qiu, Xiao Peng, Wei Yan, Junle Qu

“…This approach not only preserves the diagnostic utility of H&amp;E but also adds metabolic profiling capabilities, facilitating deeper mechanistic exploration of tumor progression. Future work can be explored into integration and optimization of FLIM-H&amp;E protocols in larger samples for further clinical diagnosis.…”
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KIF2C Is a Novel Prognostic Biomarker and Correlated with Immune Infiltration in Endometrial Cancer by Lanfen An, Jun Zhang, Dilu Feng, Yingchao Zhao, Weixiang Ouyang, Rui Shi, Xing Zhou, Zhicheng Yu, Sitian Wei, Jie Min, Hongbo Wang

“…This study indicated that KIF2C is a novel prognostic biomarker that determines cancer progression and also a target for the therapy of EC and correlated with tumor immune cells infiltration in EC.…”
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Assessing Cardiomyocyte DNA Damage Using Cardiovascular Magnetic Resonance T1 Mapping by Mizuki Ichikawa, MD, Shiro Nakamori, MD, Masaki Ishida, MD, Ryuji Okamoto, MD, Rie Ito, BSc, Agr, Junko Ishiura, MD, Masaki Ishiyama, MD, Taku Omori, MD, Keishi Moriwaki, MD, Emiyo Sugiura, MD, Naoki Fujimoto, MD, Tairo Kurita, MD, Yasutaka Ichikawa, MD, Kakuya Kitagawa, MD, Kyoko Imanaka-Yoshida, MD, Hajime Sakuma, MD, Kaoru Dohi, MD

“…Background: DNA damage in cardiomyocytes is a key pathological pathway in heart failure progression. It is a reversible process that precedes apoptosis and fibrosis. …”
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Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project by Linda Sharp, Sarah Bailey, Colin Rees, Willie Hamilton, Dawn Craig, Joe West, David Humes, Gary Abel, James Turvill, Brian Nicholson, Chloe Thomas, Jim Chilcott, Colin Crooks, Olena Mandrik, John Whelpton

“…High structural uncertainty around cancer progression during diagnostic delay and diagnosis of other serious bowel diseases considerably affects cost-effectiveness.Conclusions COLOFIT is likely to be more cost-effective than FIT alone and could help alleviate pressure on diagnostic services. …”
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MiR-383-5p promotes schistosomiasis-induced liver fibrosis by targeting peroxiredoxin-3 by Yi-Xin Li, Xin-Yue Zhang, Ju-Lu Lu, Ying-Ying Yang, Cong-Jin Mei, Pan-Pan Dong, Chuan-Xin Yu, Jian-Feng Zhang, Chun-Rong Xiong, Li-Jun Song, Kun Yang

“…Our previous study revealed significantly reduced miR-383-5p expression in patients with advanced schistosomiasis, particularly in those with newly developed disease, suggesting a possible association between miR-383-5p and fibrotic progression. This study explores the role and mechanism of miR-383-5p in schistosomiasis-induced liver fibrosis. …”
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Rapid flips between warm and cold extremes in a warming world by Sijia Wu, Ming Luo, Gabriel Ngar-Cheung Lau, Wei Zhang, Lin Wang, Zhen Liu, Lijie Lin, Yijing Wang, Erjia Ge, Jianfeng Li, Yuanchao Fan, Yimin Chen, Weilin Liao, Xiaoyu Wang, Xiaocong Xu, Zhixin Qi, Ziwei Huang, Faith Ka Shun Chan, David Yongqin Chen, Xiaoping Liu, Tao Pei

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Focal Artefacts in Skeletal Scitigraphy by S. P. Mironov, E. I. Vasilenko, M. A. Karalkina, M. E. Bugriy, V. B. Sergienko

“…Focal artifacts were detected in 40 patients (2.55%) and were divided into “cold” and “hot” according to the nature of the bone system changes they simulated. …”
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Evaluating the Effects of 60°C Heating for 90 Min on Bacterial Pathogen Viability and IgG Concentration in Bovine Colostrum by Mostafa Moazeni, Aria Rasooli, Mohammad Nouri, Masoud Ghorbanpoor, Nader Mosavari, Amir Zakian

“…The findings indicated that heating colostrum at 60°C for 30 min resulted in detectability (viability) of E. coli and S. Enteritidis in 12.5% and 25% of replicates, respectively, and after 60 min in 0% of replicates. …”
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