Watch-and-wait strategy in patients with objective response after immuno-chemotherapy for locally recurrent nasopharyngeal carcinoma: a pilot study by Quxia Zhang, Wanfang Huang, Xinlan Chen, Zhiwei Yan, Daqiang Huang, Hanchuan Xu, Yahan Zheng, Lili Zhu, Caizhu Pan, Jianji Pan, Shaojun Lin, Chaobin Huang, Qiaojuan Guo

“…The objective response rate (ORR), progression free survival (PFS), overall survival (OS) and safety profile were evaluated. …”
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Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats by Wafa A. AL-Megrin, Manal F. El-Khadragy, Manal H. Hussein, Shahenda Mahgoub, Doaa M. Abdel-Mohsen, Heba Taha, Ashraf A. A. Bakkar, Ahmed E. Abdel Moneim, Hatem K. Amin

“…Oxidative damage, inflammatory cytokines, and apoptotic cell death play a major role in the induction and progression of male testicular damage. Plant-derived phytochemicals such as green coffee (Coffea arabica) can possess antidiabetic effects with little toxicity. …”
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Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study by Zi-Han Yin, Qiong-Nan Bao, Ya-Qin Li, Yi-Wei Liu, Zi-Qi Wang, Fang Ye, Xia He, Xin-Yue Zhang, Wan-Qi Zhong, Ke-Xin Wu, Jin Yao, Zi-Wen Chen, Ling Zhao, Fan-Rong Liang

“…In addition, multi-omics was performed to detect changes in brain function, gut microbiota, and serum metabolites. …”
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Recent advances (2022–2024) in eye-tracking for Parkinson’s disease: a promising tool for diagnosing and monitoring symptoms by Laura Culicetto, Davide Cardile, Giulia Marafioti, Viviana Lo Buono, Francesca Ferraioli, Simona Massimino, Giuseppe Di Lorenzo, Chiara Sorbera, Amelia Brigandì, Carmelo Mario Vicario, Angelo Quartarone, Silvia Marino

“…Emerging evidence also supports its potential to detect eye movement biomarkers associated with disease stage, motor subtypes, and cognitive decline. …”
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Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment by Dongli Tian, Jiaying Li, Linfeng Zou, Min Lin, Xiaoxiao Shi, Yuting Hu, Jiaxin Lang, Lubin Xu, Wenling Ye, Xuemei Li, Limeng Chen

“…In this study, we aimed to explore the role of A1AR in the fibrosis progression of DN. Methods. We collected DN patients’ samples and established a streptozotocin-induced diabetes model in wild-type (WT) and A1AR-deficient (A1AR-/-) mice. …”
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Accumulation of long-chain unsaturated fatty acids in the airway inflammatory microenvironment drives eosinophil etosis and corticosteroid resistance by Yurong Bai, Pengda Fang, Shasha Li, Zhenhao Xiao, Wenyi Chen, Wenlong Li, Xinyue Wang, Jingyuan Chen, Yue Li, Junhai Chen, Weiqiang Huang, Xin Luo, Shigeharu Ueki, Deyu Fang, Qintai Yang, Yana Zhang

“…Eosinophil extracellular trap cell death (EETosis) was detected by immunofluorescence microscopy and transmission electron microscopy. …”
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Dasatinib demonstrates efficacy in organoid derived paclitaxel-resistant Trp53/Cdh1-deficient mouse gastric adenocarcinoma with peritoneal metastasis by Wenshuai Liu, Lingmeng Li, Leilei Guo, Haojie Li, Zhaoqing Tang, Xuefei Wang, Liyu Huang, Yihong Sun

“…DASA showed promise in ameliorating disease progression and improving overall survival in MTC-R GCPM model in C57BL/6 J mice. …”
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Real-time PCR technique for diagnosing respiratory diseases: miR-155, miR-17, miR-181 expression, and COPD by Abdolreza Mohamadnia, Seyedehnarges Tabatabaee, Parvaneh Safarian, Mohammad Bayat, Abdolah Farhadinasab, Mohammad Hossein Soltani, Shadi Shafaghi, Mohammad Varahram, Mehdi Kazempour Dizaji, Fatemeh Hashtrodi Mahmoudi, Yasamin Khorrami, Atefeh Akbarian, Mahdi Ahmadinia, Naghmeh Bahrami

“…Abstract Background and objective Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition with limited noninvasive biomarkers for diagnosis and monitoring. …”
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Pre-treatment tumour PET metrics and clinical outcomes of anal cancer in patients living with and without HIV by Michael Pennock, N. Patrik Brodin, Christian Velten, Megi Gjini, Nitin Ohri, Chandan Guha, Shalom Kalnicki, Wolfgang A. Tome, Madhur K. Garg, Rafi Kabarriti

“…Cox-proportional-hazard and Kaplan-Meier modelling were used to investigate tumour PET metrics and outcomes: overall survival (OS), progression-free survival (PFS), and locoregional control (LRC). …”
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DOCK2 protects against bacterial sepsis by constraining T helper 1 response by Shusen Ye, Shusen Ye, Linzi Huang, Yuhao Zheng, Shanshan Liu, Xiangyang Wang, Haoyuan Yu, Haoyuan Yu, Lisi Zhu, Texi Liang, Yifei Wang, Chunmin Zhang, Fan Wu, Lilin Ye, Lilin Ye, Yingjiao Cao, Yingjiao Cao

“…Flow cytometry and enzyme-linked immunosorbent assay (ELISA) were used to detect T helper 1 (Th1) cell subsets and serum pro-inflammatory cytokines in septic mice. …”
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Polymorphous corneal dystrophy subtype 3 and keratoconus aggravation after corneal refractive surgery in a three-generation family carrying both ZEB1 and ZNF469 pathogenic variant by Qinghong Lin, Qinghong Lin, Qinghong Lin, Qinghong Lin, Qinghong Lin, Qinghong Lin, Xuejun Wang, Xuejun Wang, Xuejun Wang, Xuejun Wang, Xuejun Wang, Xiaoliao Peng, Xiaoliao Peng, Xiaoliao Peng, Xiaoliao Peng, Xiaoliao Peng, Xiaosong Han, Xiaosong Han, Xiaosong Han, Xiaosong Han, Xiaosong Han, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Ling Sun, Ling Sun, Ling Sun, Ling Sun, Ling Sun, Yan Wang, Shengtao Liu, Shengtao Liu, Shengtao Liu, Shengtao Liu, Shengtao Liu, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou

“…One year later, visual acuity of III1 decreased significantly with KC aggravation and corneal opacification. The KC of III2 progressed significantly 6 months after surgery. Both were subsequently diagnosed with PPCD3. …”
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Synergistic effects of anlotinib and DDP on breast cancer: targeting the VEGF/JAK2/STAT3 axis by Hongmei Zhang, Hongmei Zhang, Chunling Liu, Ye Jin, Zheng Wang, Yi Guan, Zhenxian Jia, Tong Cui, Zhi Zhang, Xuemei Zhang, Xuemei Zhang

“…The proliferation, migration and invasion capabilities of BRCA cells were evaluated using CCK-8 assays, cell cycle distribution, clone formation assays, wound healing assays and transwell assays. Cell apoptosis was detected by flow cytometry technique and Hoechst33342 fluorescence staining. …”
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Initiation of China Alliance of Research in High Myopia (CHARM): protocol for an AI-based multimodal high myopia research biobank by Tien-Yin Wong, Zi-Bing Jin, Hai-Long He, Yi-Xin Liu, Hao Song, Tian-Ze Xu

“…The majority of data collected by CHARM is in the form of images that will be used to detect and predict the progression of high myopia through the identification and quantification of biomarkers such as fundus tessellation, optic nerve head and vascular parameters.Ethics and dissemination The study has received approval from the Ethics Committee of Beijing Tongren Hospital (TREC2022-KY045). …”
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Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer by Fang Fang, Mei Zhao, Jinming Meng, Jiaqi He, Chunlei Yang, Changhong Wang, Jiaxiao Wang, Sheng Xie, Xiaowei Jin, Wei Shi

“…Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot were initially employed to detect TTYH3 expression in NSCLC and normal lung epithelial cells. …”
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Mechanism of Fas-associated protein with death domain in promoting proliferation of head and neck squamous cell carcinoma cells by CHEN Yinan, ZHENG Yang, ZENG Hanlin, LEI Ming

“…IHC staining showed that FADD expression levels progressively increased from normal to dysplastic to tumor tissues in HNSCC patients. …”
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Dilatation of the main pulmonary artery in patients with isolated pulmonary stenosis: Arteriopathy or hemodynamic consequence? by Pietro Paolo Tamborrino, Michela Miglianti, Dario Freitas, Camelia Demetrescu, Christopher Rush, Claudia Montanaro, Alessandra Frigiola

“…The aim of our study was to detect the incidence of mPA dilatation and aneurysm in patients with isolated PV stenosis and the association with PV function. …”
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Tumor Cell‐Expressed Herpesvirus Entry Mediator Regulates Proliferation and Adaptive Immunity in Ovarian Cancer by Yun Lu, Yijun Zhang, Wenxuan Li, Haonan Jiang, Jiapo Wang, Xiaoqing Guo

“…Methods Specimens were used to detect HVEM expression via quantitative RT‐PCR and flow cytometry. …”
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Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer by Yanliang Chen, Chan Zhou, Xiaoqiao Zhang, Min Chen, Meifang Wang, Lisha Zhang, Yanhui Chen, Litao Huang, Junjun Sun, Dandan Wang, Yong Chen

“…Background Non-small cell lung cancer (NSCLC) is a fatal disease, and radioresistance is an important factor leading to treatment failure and disease progression. The objective of this research was to detect radioresistance-related genes (RRRGs) with prognostic value in NSCLC.Methods The weighted gene coexpression network analysis (WGCNA) and differentially expressed genes (DEGs) analysis were performed to identify RRRGs using expression profiles from TCGA and GEO databases. …”
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DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner by Jianling Song, Yanxia Chen, Yan Chen, Minzi Qiu, Wenliu Xiang, Ben Ke, Xiangdong Fang

“…Western blotting, IHC, and qRT-PCR were performed to detect molecular expression levels. Immunofluorescence was applied to determine the subcellular localization. …”
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Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol by Mary Shelton, Humphrey Mulenga, Stanley Kimbung Mbandi, Simon C Mendelsohn, Mark Hatherill, Fatoumatta Darboe, Thomas J Scriba

“…Introduction Current tuberculosis triage and predictive tools offer poor accuracy and are ineffective for detecting asymptomatic disease in people living with HIV (PLHIV). …”
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