The efficacy of administration of the angiotensin-II receptor inhibitor in dogs at different stages of myxomatous mitral valve disease (MMVD) by R. M. Trofimiak, L. G. Slivinska

“…Progression of myxomatous mitral valve disease (MMVD) in dogs is accompanied by long-term activation of the sympathetic nervous system, renin-angiotensin-aldosterone system (RAAS) and morphological changes in the bicuspid valve. …”
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Lipids and Atherogenic Indices Fluctuation in Rheumatoid Arthritis Patients on Long-Term Tocilizumab Treatment by Fabio Cacciapaglia, Maria Grazia Anelli, Angela Rinaldi, Marco Fornaro, Giuseppe Lopalco, Crescenzio Scioscia, Giovanni Lapadula, Florenzo Iannone

“…During the first 24 weeks, we observed in TCZ-treated patients a progressive statistically significant (p<0.001) increase in Tot-Chol, LDL, HDL, and TG, which returned close to the baseline at 52 weeks. …”
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Exploring the mechanism of Lingbao Huxin Dan in the treatment of bradycardia based on atrioventricular node electrical signal conduction by Jing Zhang, Guobin Zheng, Shangjing Liu, Yaodong Miao, Shu Yang, Sheng Li, Zhihui Yang, Danping Zhuo, Rui Guo, Yang Guo, Rongjiang Shao, Yunqing Hua, Chuanrui Ma

“…Depending on its clinical features, improving the AV node conduction block may be an important tool to inhibit the progression of the disease. Lingbao Huxin Dan, which consists of several traditional Chinese medicines, is used for conditions similar to bradycardia and may be a potential therapeutic agent for bradycardia. …”
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Comparative Metabolomic Analysis of Three Medicinal <i>Paphiopedilum</i> Species Reveals Divergence in Antioxidant Capacity and Functional Compound Profiles by Jinhan Sang, Yishan Yang, Kanghua Xian, Jiang Su, Jianmin Tang, Chuanming Fu, Fengluan Tang, Xiao Wei

“…A total of 2201 metabolites were detected across the three species, with flavonoids emerging as the dominant class (480 compounds, accounting for 21.8% of total metabolites). …”
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Cardiovascular toxicity of antitumor therapy: effect on myocardial and vascular remodeling by Yu. Yu. Kirichenko, I. S. Ilgisonis, T. V. Ivanova, A. S. Zolotukhina, N. V. Khabarova, E. V. Privalova, Yu. N. Belenkov

“…All above-mentioned parameters significantly worsened after multiagent chemotherapy (progression of ED and vascular wall remodeling: occlusal index, 1,3 (1,2; 1,5) (p&lt;0,0002); stiffness index, 10,3 m/s (9,5; 11,2) (p&lt;0,0001); reflection index, 40,2% (35,5; 43,6) (p&lt;0,001) Decrease in left ventricular ejection fraction and diastolic function was detected. …”
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Longitudinal Overlap and Metabolite Analysis in Spectroscopic MRI-Guided Proton Beam Therapy in Pediatric High-Grade Glioma by Abinand C. Rejimon, Anuradha G. Trivedi, Vicki Huang, Karthik K. Ramesh, Natia Esiashvilli, Eduard Schreibmann, Hyunsuk Shim, Kartik Reddy, Bree R. Eaton

“…Analyzing Cho/NAA and Cho changes over time allowed differentiation between true progression and pseudoprogression, which conventional MRI alone struggles to achieve. …”
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Intra-Session Reliability and Predictive Value of Maximum Voluntary Isometric Contraction for Estimating One-Repetition Maximum in Older Women: A Randomised Split-Sample Study by José Aldo Hernández-Murúa, Ena Monserrat Romero-Pérez, Jorge Luis Guajardo-Cruztitla, Blas Sinahí Madrigal Olivares, Ángel Gallego-Selles, Diego González-Martín, Francisca Reyes-Merino, Nidia Sánchez-García, José Antonio de Paz

“…<b>Background:</b> Ageing is associated with a progressive decline in muscle strength, particularly in the lower limbs, which compromises functional independence. …”
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Cytomegalovirus-induced oncomodulation drives immune escape in glioblastoma by Harald Krenzlin, Felix Corr, Deepak Ailani, Philipp Einheuser, Thomas Bukur, Thomas Rößler, Alina Henrich, Raja Hollnagel, Alice Dauth, Libo Hu, Leon Schmidt, Marion Griessl, Michael Gutknecht, Noe Mercado, Beat Alessandri, Charles H. Cook, Florian Ringel, Sean E. Lawler, Niels A. Lemmermann, Naureen Keric

“…Cytomegalovirus (CMV) has been implicated in tumor progression and modulation in glioblastoma. To investigate this potential connection, CMV-associated changes in the glioblastoma immune landscape were characterized in vitro and in a murine glioblastoma model. …”
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HLA-mismatched stem cell microtransplant prolonged overall survival and promoted immunological reconstitution for multiple myeloma by Yangyang Lei, Yangyang Lei, Bo Cai, Zhiqing Liu, Anli Xie, Jianhui Qiao, Yi Wang, Xinrui Chen, Fei Peng, Yingxin Zhao, Jiaxin Chen, Wei Guan, Changlin Yu, Xiao Lou, Kaixun Hu, Ang Zhang, Qiyun Sun, Yajing Huang, Yajing Huang, Huisheng Ai, Mei Guo

“…The 6-year overall survival (OS) and progression-free survival (PFS) rates were 64.7% and 35.3%, respectively, with no graft-versus-host disease or non-relapse mortality. …”
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Clinical and microbiological effects of photodynamic therapy applied in non-surgical treatment of periodontitis by Arsić Zoran, Jovanović Radovan, Đorđević Aleksandar, Šehalić Meliha, Marjanović Dragan, Mikić Mirko, Vlahović Zoran, Mladenović Raša

“…The presence of microorganisms Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Treponema denticola was detected by the polymerase chain reaction (PCR) method. …”
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Real-world single-center data analysis of dual immunotherapy in advanced NSCLC: Efficacy, survival, and adverse events by Tao Luan, Jianqing Hao, Xiaohong Xie, Xinqing Lin, Shuaiying Wang, Baodan Yu, Qingqing Yang, Changchun Wang, Yang Luan, Gang Yang, Hanxiu Lu, Ping Sun, Yunhui Zhang, Nanshan Zhong, Chengzhi Zhou

“…Patients with high PD-L1 expression (≥50%) demonstrated improved progression-free survival (PFS, HR = 0.40) and overall survival (OS, HR = 0.31) but experienced a higher incidence of severe adverse events (40.6%).…”
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Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis by Yaqiong Tian, Xuan Zhou, Mi Tian, Lijun Ren, Ruyi Zou, Hanyi Jiang, Miaomiao Xie, Mei Huang, Jingjing Ding, Yin Liu, Jingyu Chen, Min Cao, Hourong Cai

“…Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis, nomogram model for its prognosis and acute exacerbation was constructed. …”
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Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation by Tania Rossi, Martina Valgiusti, Maurizio Puccetti, Giacomo Miserocchi, Michele Zanoni, Davide Angeli, Chiara Arienti, Ilaria Pace, Cristian Bassi, Ivan Vannini, Mattia Melloni, Erika Bandini, Milena Urbini, Massimo Negrini, Massimiliano Bonafè, Manuela Ferracin, Giulia Gallerani

“…Abstract Tumor dissemination is a key event in tumor progression. During this event, a main role is played by circulating tumor cells (CTCs), immune cells, and their interaction. …”
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Clinical characteristic of isolated thrombocytopenia in patients with bone marrow failure-related germline variants: a retrospective study from a single centre by Nanxi Dong, Jingjie Dong, Chuanao Xin, Peicheng Wang, Yaonan Hong, Rudan Zheng, Zexing Sun, Qi Liu, Yingying Shen, Xiawan Yang, Yiping Shen, Jianping Shen, Baodong Ye, Yuhong Zhou, Dijiong Wu

“…While whole-exome sequencing (WES) detects these variants, its cost limits routine use. …”
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Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis by Carolina de O Mendes-Aguiar, Camilla Lopes-Siqueira, Fabrício Pettito-Assis, Márcia Pereira-Oliveira, Manoel Paes de Oliveira-Neto, Claude Pirmez, Alda Maria Da-Cruz, Hiro Goto

“…It is the first time that IGF-I was detected in lesions of infectious cutaneous disease, specifically in American tegumentary leishmaniasis. …”
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Role of the Modified WHO Partograph in Improving Maternal and Neonatal Outcomes: A Prospective Observational Study by Sukeshini Bhagat, Shreyasi Chiwadshetti, Chhavi Kowe, Renema Datta, Mahesh Shinde, Pushti Shah, Divya Yadav, Samreen Chunawala, Abhay Gupta, Natanshi Kumar, Pranav Ghuge, Prajakta Kokane

“…Effective labor monitoring helps detect complications early, reducing risks. In 2017, WHO reported 295,000 maternal deaths, mostly in low- to middle-income countries, highlighting the need for improved care. …”
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Magnesium-induced phase transition and enhanced dielectric performance in ((Ba₀.₈₅Sr₀.₁₅)₁₋ₓMgₓTiO₃) ceramics synthesized by the sol-gel method by Mohammed Mesrar, Taj-dine Lamcharfi, Abdelhalim Elbasset, Farid Abdi, Laila Mesrar, Nor-Said Echatoui

“…Additionally, dielectric property measurements conducted over a frequency range of 1 kHz to 2 MHz demonstrated a broad phase transition, where dielectric permittivity progressively increases with Mg content while maintaining thermal stability over an extended temperature range. …”
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Voluntary exercise in mice triggers an anti-osteogenic and pro-tenogenic response in the ankle joint without affecting long bones by Anne Briolay, François Duboeuf, Séverine Delplace, Leyre Brizuela, Olivier Peyruchaud, David Magne, Carole Bougault

“…Running exercise seemed to preserve the tendon from its progressive ossification, as seen in numerous enthesopathies. …”
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KAT5 promotes tumor growth in androgen-independent prostate cancer by facilitating aerobic glycolysis by Wei He, Juping Zhao, Jun Dai, Chen Fang, Xin Huang, Chenghe Wang, Yi Gao, Fukang Sun, Xin Xie

“…KAT5 may involve in PCa tumor progression via p38-mediated aerobic glycolysis, which might be a promising anti-tumor strategy in PCa.…”
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Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort by Roberto Lozano-Rodríguez, Roberto Lozano-Rodríguez, Loreto Hierro, María José Quiles, Alejandro Pascual-Iglesias, Alejandro Pascual-Iglesias, Verónica Terrón-Arcos, Verónica Terrón-Arcos, Gema Muñoz-Bartolo, Esteban Frauca, Francisco J. Cueto, Francisco J. Cueto, Cristina Calvo, Cristina Calvo, Laura Córdoba-García, Laura Córdoba-García, Jesús Fernández-Felipe, Jesús Fernández-Felipe, Laura Hurtado-Navarro, Laura Hurtado-Navarro, Julia del Prado-Montero, Julia del Prado-Montero, Gonzalo Sáenz de Santa María-Diez, Gonzalo Sáenz de Santa María-Diez, Daniel Arvelo-Rosario, Daniel Arvelo-Rosario, Paloma Jara, Carlos del Fresno, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo

“…Adenovirus was detected in only 17.6% of PAHUA patients, suggesting it is unlikely to be the primary causative agent. …”
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