Comparison of Biomarkers Playing a Role in Pterygium Development in Pterygium and Recurrent Pterygium Tissues by Özgür Eroğul, Serkan Şen

“…The higher levels of <i>IL-10</i> in primary pterygium compared to recurrent pterygium indicate an enhanced early protective response aimed at limiting pterygium progression and controlling the inflammatory process.…”
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Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis by Chuchun Fang, Xuewei Liu, Chen Yu, Songlin Li, Xueying Liu, Shifeng Qiu, Hongbin Liang, Caiwen Ou, Jiancheng Xiu

“…Abstract Background Cancer-targeted therapies are progressively pivotal in oncological care. Observational studies underscore the emergence of cancer therapy-related cardiovascular toxicity (CTR-CVT), impacting patient outcomes. …”
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Association of Fetuin-A and inflammation levels with cardiac calcification in maintenance hemodialysis patients by ZHANG Fei-fei, GAO Yan-xia, ZHANG Xue-jing, CHAI Jian, YAO Xiao-tong

“…Objective To explore the importance of nontraditional risk factors for cardiac valve calcification in maintenance hemodialysis(MHD) patients.Methods Ninety-nine patients(53 males,and 46 females) subject to MHD for at least 6 months in the Blood Purification Center of the affiliated hospital of Qingdao University before March 2014,aged over 18 years were enrolled in this study.Echocardiography was used to detect the calcification.Patients were divided into two groups based on the echocardiographic findings,one as valve calcification group,and the other as valve non-calcification group.In addition,patients were separated into three groups based on the number of valve calcification:group A as zero valve calcification,group B as one valve calcification and group C as two valves calcification.Fetuin-A,IL-6 and hs-CRP were measured by ELISA.Results In the 99 patients,cardiac valve calcification was found in 40 patients(40.4%),in which aortic valve calcification was found in 30 patients(30.3%),mitral valve calcification in 27 patients(27.3%),and both aortic and mitral valves calcification in 17 patients(17.2%).Patients with valve calcification had older age,longer dialysis duration,higher serum phosphate and higher levels of intact parathyroid hormone,hs-CRP and IL-6,lower levels of albumin and Fetuin-A than those of the patients without valve calcification.Patient’s age,dialysis duration,serum phosphate,calcium phosphorus product(Ca× P),and the levels of IL-6 and hs-CRP were increased with the number of valves calcified,and serum albumin and FetuinA levels were decreased with the number of valves calcified.Serum Fetuin-A levels were negatively correlated with age(r=-0.246,P = 0.014),dialysis duration(r=-0.297,P = 0.003),parathyroid hormone levels(r =- 0.256,P = 0.011),serum IL-6 levels(r =- 0.492,P = 0.000),serum hs-CRP levels(r =- 0.272,P = 0.006) and valvular calcification(r =- 0.600,P = 0.001).However,serum fetuin-A levels were positively correlated with serum albumin(r = 0.298,P = 0.003).Conclusions Cardiac valve calcification is prevalent in MHD patients,especially aortic valve calcificatioa Serum fetuin-A showed an important association with valvular calcification and inflammation in MHD patients.Assessment of both serum levels of fetuin-A and inflammation may be of value to identify those subjects at higher risk of development and progression of cardiovascular events especially cardiac calcification.…”
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Novel Epigenetics Control (EpC) Nanocarrier for Cancer Therapy Through Dual-Targeting Approach to DNA Methyltransferase and Ten-Eleven Translocation Enzymes by Risa Mitsuhashi, Kiyoshi Sato, Hiroyoshi Kawakami

“…Background/Objectives: Aberrant hypermethylation in the promoter regions of tumor suppressor genes facilitates the pathogenesis and progression of cancer. Therefore, inhibitors targeting DNA methyltransferase (DNMT) have been tested in clinical studies. …”
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Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitis by Anup Dey, Matthew Butcher, Anne Gegonne, Ryoji Yagi, Keita Saeki, Eunju Lee, Dinah S. Singer, Jinfang Zhu, Keiko Ozato

“…In contrast, the number of T cells detected in the CNS of Brd4cKO mice was much fewer. …”
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Schisandrin B alleviates metabolic associated fatty liver disease by regulating the PPARγ signaling pathway and gut microbiota in mice by Jiuchen Wan, Chenjian Lang, Meng Gao, Feilong Liu, Xiyuan Feng, He Li, Chunmei Wang, Jinghui Sun

“…Sch B could improve the diversity and abundance of the gut microbiota, restore the normal composition of the gut microbiota at the phylum and genus levels, alleviate the disruption of the gut barrier caused by HFD, and enhance the expression of ZO-1 and Occludin proteins in colon tissue in MAFLD mice.ConclusionThis study showed Sch B can improve HFD-induced MAFLD, and the mechanism may be through regulating the PPARγ, Plin2, PCk1, Acsl4 and Fads1 signaling pathway, restoring the diversity of gut microbiota, and improving the gut barrier to delay the progression of MAFLD.…”
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Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis by Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

“…WGCNA was applied to detect genes linked to clinical characteristics in OS patients. …”
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Natural autoantibodies in healthy neonatals recognizing a peptide derived from the second conserved region of HIV-1 GP120 by Đorđević-Vujičić Ana, Gemović Branislava, Veljković Veljko, Glišić Sanja, Veljković Nevena

“…High sera reactivity with a peptide derived from human immunodeficiency virus HIV-1 envelope protein gp120, NTM1, correlate with non-progressive HIV-1 infection and also may have protective role in breast and prostate cancer. …”
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Monoclonal gammopathy in systemic lupus erythematosus is associated with distinctive clinical course, malignancy and mortality rate: a single-centre retrospective cohort study by Mariusz Korkosz, Andzelika Siwiec-Kozlik, Pawel Kozlik-Siwiec, Magdalena Spalkowska, Joanna Kosalka-Wegiel

“…The association between immunosuppression, MG incidence and progression warrants further research.…”
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Wegener’s granulomatosis in ophthalmic practice. Clinical case by M. M. Bikbov, A. E. Babushkin, G. Z. Israfilova

“…Wegener’s granulomatosis (WG) or granulomatosis with polyangiitis is a primary systemic necrotizing vasculitis of small and medium-sized vessels with the development of foci of granulomatous inflammation. This is a severe, progressive, presumably autoimmune disease associated with antineutrophil cytoplasmic antibodies, which is detected mainly in people over 50 years of age. …”
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Discrepancy of clinical, laboratory and instrumental picture in patients with pulmonary embolism by A. G. Pronin, A. R. Rakhmatullina, D. K. Glukhov

“…In patients with pulmonary embolism with a pronounced lesion of the pulmonary artery, due to the rapidly progressing course of the disease, it is possible that the еchocardiography criteria of the disease do not have time to develop. …”
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Expression of early biomarkers in gentamicin-induced nephrotoxicity in rats by Chen Menglu, Luo Qihui, Sun Fengjiao, Chen Zhengli, Li Mingyang, Zeng Wen, Gong Li, Cheng Anchun, Peng Xi, Fang Jing, Tang Li, Geng Yi, Chen Xiaolu

“…Consistent with gene expression analyses, KIM-1 and NGAL were undetectable in proximal tubules of control kidneys, but they were observed in epithelial cells that were affected by gentamicin toxicity as seen by cell degeneration and regeneration.In sum, the changes in gene and protein expressions of KIM-1 and NGAL were found to be correlated with the progressive histopathological alterations and preceded effects on traditional clinical parameters indicative of impaired kidney function. …”
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BRCA1 promoter methylation predicts PARPi response in ovarian cancer: insights from the KOMET study by Léna Nougarede, Florence Hazane-Puch, Florence de Fraipont, Emmanuelle Jacquet, Marie Bidart

“…Outcomes were measured based on progression-free survival (PFS) from diagnosis and from the initiation of PARPi treatment, as well as overall survival (OS). …”
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Comparative analysis of dietary pattern indices and their associations with chronic kidney disease: a comprehensive analysis of NHANES data (2000–2020) by Xianglong Meng, Xiuling Chen, Bo Zhang, Junru Wang

“…Predictive utility was assessed via marginal receiver operating characteristic (ROC) curves, and nonlinear associations were detected using restricted cubic splines (RCS). Subgroup analyses were conducted across different population characteristics. …”
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LncRNA FLG-AS1 inhibits esophageal squamous cell carcinoma by regulating the miR-23a-3p/HOXD10 axis by Zhigao Zhang, Fucheng Zhang, Chuan Xue, Xiaoling Song, Yaojun Wang

“…Conclusion FLG-AS1 effectively inhibits the progression of ESCC and counters cisplatin resistance through the modulation of the miR-23a-3p/HOXD10 axis. …”
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Mapping and visualizing the global research landscapes on drinking water and cancer by Shaher Zyoud, Sa’ed H. Zyoud

“…This analysis aims to systematically map the progression of research on the relationship between drinking water contaminants and cancer. …”
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Characterization of an in vitro model to study CD4+ T cell metabolism in dairy cows by U. Arshad, M. Cid de la Paz, H.M. White, L.R. Cangiano

“…The ECAR in CD4+ T lymphocytes increased progressively over time in PMA+IMY compared with CON, which indicated an increase in aerobic glycolysis in PMA+IMY compared with CON (CON = 46.9 vs. …”
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SMARCA4-deficient non-small cell lung cancer with metastasis to the sigmoid colon: a case report by Rong Xiao, Guang Fu, Xinglan Li, Tao Lu

“…However, a follow-up CT revealed progression in the sigmoid colon tumor. Consequently, the patient underwent laparoscopic radical sigmoid colectomy with regional lymph node dissection. …”
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Evaluation of the Apoptotic, Prooxidative and Therapeutic Effects of Odoroside A on Lung Cancer: An In Vitro Study Extended with In Silico Analyses of Human Lung Cancer Datasets by Fatma Seçer Çelik, Göksemin Fatma Şengül, Safaa Altveş, Canan Eroğlu Güneş

“…Kaplan–Meier plots with overall survival, disease-specific survival and progression free intervals were obtained from UCSC Xena to evaluate the prognostic value of caspases. …”
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Fibromyalgia as a Modifying Factor of Clinical Course of Rheumatoid Arthritis by Perebetyuk L.

“…Rheumatoid arthritis (RA) is one of the most common inflammatory joint disease, with a progressing severity and high disability. It is often combined with fibromyalgia (FM), which can modify its course. …”
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