A high HEMSTOP bleeding score is a major independent risk factor for postpartum hemorrhage: a prospective cohort study by Florian Deleu, Sophie Nebout, Edith Peynaud-Debayle, Laurent Mandelbrot, Hawa Keita

“…Recently, the HEMSTOP bleeding score has emerged as a tool for detecting preoperative inherited bleeding disorders. …”
Get full text

Avβ3 Single-Stranded DNA Aptamer Attenuates Vascular Smooth Muscle Cell Proliferation and Migration via Ras-PI3K/MAPK Pathway by Hong-Bing Wu, Zhi-Wei Wang, Feng Shi, Zong-Li Ren, Luo-Cheng Li, Xiao-Ping Hu, Rui Hu, Bo-Wen Li

“…Flow cytometry was performed to detect apoptosis and cell cycle progression. The effect of avβ3 ssDNA on the Ras-phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) signaling pathway was evaluated by quantitative reverse transcription polymerase chain reaction and western blot. …”
Get full text

Immunomodulatory Effects of Copper Bis-Glycinate In Vitro by Alexander Areesanan, Luise Wolf, Sven Nicolay, Amy Marisa Zimmermann-Klemd, Carsten Gründemann

“…At all the investigated concentrations of Cbg (0.05–100 μg/mL), ther was no considerable impact detected on the epithelial cells. However, the proliferation rate of stimulated PBMCs was affected progressively (3–50 μg/mL). …”
Get full text

Ischemic stroke of undetermined source as a priming event for brain metastasis: a case report and systematic literature review by Paolo Amisano, Antonio Ciacciarelli, Svetlana Lorenzano, Irene Berto, Sara Belcastro, Danilo Toni, Manuela De Michele

“…This case underscores the importance not only of a thorough oncologic workup in patients with ESUS, but also of a strict neuroradiological follow-up, as a delayed diagnosis of cancer-related stroke may allow malignancy progression, significantly worsening the prognosis and limiting therapeutic options.…”
Get full text

Coincidence of Concentric Vessel-Wall Contrast Enhancement in Moyamoya Disease and Acute Postoperative Ischemic Stroke During Revascularization Procedures by Patrick Haas, Till-Karsten Hauser, Lucas Moritz Wiggenhauser, Leonie Zerweck, Marcos Tatagiba, Nadia Khan, Constantin Roder

“…Background: Concentric vessel-wall contrast enhancement (VW-CE) of the terminal carotid artery and its proximal branches may be linked to ischemic strokes, disease activity and progression in Moyamoya disease (MMD). The objective of this retrospective cohort study is to analyze the association between VW-CE and perioperative acute ischemic stroke (PAIS) occurring within 24 h after revascularization. …”
Get full text

The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells by Li Li, Hadil Al‐Jallad, Aiwei Sun, Miltiadis Georgiopoulos, Rakan Bokhari, Jean Ouellet, Peter Jarzem, Hosni Cherif, Lisbet Haglund

“…Results Most EVs were exosomes and intermediate microvesicles with an increasing amount linked to disease progression. Of the proteins detected, 88.6% were shared across the non‐degenerate, mildly‐degenerate, and degenerate samples. …”
Get full text

Clinical significance of contrast extravasation on computed tomography immediately after thermal ablation for hepatic tumors by Dong Kyu Kim, Joon Ho Kwon, Kichang Han, Juil Park, Gyoung Min Kim, Man-Deuk Kim, Jong Yun Won

“…The pre- and post-ablation hemoglobin and hematocrit levels were measured. Local tumor progression-free survival (LTPFS) and overall survival (OS) rates were evaluated. …”
Get full text

Accelerated biological ageing as a complication of cancer therapy by O. O. Kovalov, M. Yu. Kolesnyk, O. V. Hancheva, I. F. Bielenichev, K. O. Kovalov

“…A clinical marker of aging is the deposition of calcium salts within coronary arteries based on the Agatston score detected using multidetector computed tomography. …”
Get full text

The effect of miR-381 on proliferation and prognosis of breast cancer by altering CCNA2 expression by Ming-Gang Cao, Yan Wang, Zhi-Min Yang, Yang Wang, Mei-Qing Wang, Shuai Zhuo, Yan Yang, Chun-Sheng Liu

“…The expression of miR-381 and CCNA2 in 162 breast cancer patients were detected to further reveal their impact and predictive value on progression-free survival (PFS) and overall survival (OS).Results After transfection of MDA-MB-231 and MCF-7 cells with miR-381 mimics, the expression of miR-381 was effectively up-regulated and CCNA2 was effectively down-regulated, while the opposite results were observed in tumour cell which transfected with miR-381 inhibitors. …”
Get full text

Transcriptomic analysis of the liver, jejunum, and uterus in different production stages of laying hens by Gi Ppeum Han, Byeonghwi Lim, Jun-Mo Kim, Deok Yun Kim, Hyun Woo Kim, Dong Yong Kil

“…Weighted gene co-expression network analysis was adopted to detect core modules and central genes, and finally identified 11 co-expression modules. …”
Get full text

Reliability and validity analysis of the Chinese version of the Quick Dementia Rating System (QDRS) by Hang Su, Jiehua Zhu, Yifan Wang, Jun Jin, Qihao Guo

“…Results C-QDRS scores increased progressively across groups: normal controls, objective subtle cognitive decline (obj-SCD), mild cognitive impairment (MCI), and AD. …”
Get full text

Characteristics of the portal vein thrombosis recurrence pattern without liver parenchymal invasion from colorectal cancer: a case report by Tetsuya Mochizuki, Tomoyuki Abe, Hironobu Amano, Kenji Nishida, Takuya Yano, Hiroshi Okuda, Tsuyoshi Kobayashi, Hideki Ohdan, Shuji Yonehara, Toshio Noriyuki, Masahiro Nakahara

“…Herein, we present a patient with progressive portal vein tumor thrombosis without liver parenchymal invasion following curative resection. …”
Get full text

Ascitic ovarian cancer is an adequate preclinical model of carcinomatosis to study intraperitoneal chemoperfusion treatment by G. S. Kireeva, O. A. Belyaeva, K. Yu. Senchik, V. G. Bespalov, A. N. Stukov, E. A. Gubareva, M. A. Maydin

“…In 2 and 5 rats from groups 2 and 3 respectively, metastases in paratracheal lymph nodes and tumor hydrothorax were detected with no evidence of peritoneal carcinomatosis. …”
Get full text

Integrated analysis of single-cell RNA sequencing and bulk transcriptome data identifies a pyroptosis-associated diagnostic model for Parkinson’s disease by Lin Wang, Yidan Qin, Jia Song, Jing Xu, Wei Quan, Hang Su, Huibin Zeng, Jian Zhang, Jia Li, Jiajun Chen

“…Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by an insidious onset. …”
Get full text

Metabonomics Analysis Reveals the Influence Mechanism of Three Potassium Levels on the Growth, Metabolism and Accumulation of Medicinal Components of <i>Bupleurum scorzonerifolium<... by Jialin Sun, Jianhao Wu, Alyaa Nasr, Zhonghua Tang, Weili Liu, Xiubo Liu, Wei Ma

“…The results showed that low and high potassium levels could promote the progression of main shoots and roots, but inhibited the accumulation of dry matter in lateral shoots and flowers. …”
Get full text

Severe visual loss from concurrent fulminant idiopathic intracranial hypertension and malignant arterial hypertension: Prompt suspicion matters by Bashaer Aldhahwani, Serena M. Shah, Hong Jiang, Byron L. Lam

“…Conclusion: Our case series underscores the need to promptly include IIH in the differential diagnosis in patients with bilateral optic disc edema including patients with malignant hypertension, particularly in those experiencing progressive visual loss, regardless of gender or BMI. …”
Get full text

Fungi Associated with Olive Tree (cv. ‘Nocellara del Belice’) Decay in Trapani Province (Sicily, Italy) by Marika Lamendola, Giulia Mirabile, Josè Muratore, Livio Torta

“…This hypothesis would seem to be confirmed by the progression of decay over time in the trees subjected to the irrigation system described but not reported in olive groves differently managed. …”
Get full text

HEG1 as a novel potential biomarker for the prognosis of lung adenocarcinoma by Xin Zou, Yue Zhang, Ning Wang, Jie Shi, Qinghai Li, Wanming Hao, Wenjing Zhu, Wei Han

“…Abstract Background Heart development protein with EGF‐like domains 1 (HEG1), generally related to angiogenesis and embryonic development, was reported to participate in the occurrence and progression of some tumors recently. However, the role of HEG1 in lung adenocarcinoma (LUAD) is unclear. …”
Get full text

Pyoderma gangrenosum as a clinical debut of Crohn's disease (clinical case) by O. V. Fatenkov, Yu. Yu. Pirogova, P. E. Konnov, A. A. Arsenyeva, E. V. Orlov

“…The aim of the work is to analyze a diagnostically complex clinical case from real medical practice, when Crohn's disease was detected after the onset of pyodermagangrenosum.Materials and methods. …”
Get full text

Novel insecticide resistance mutations associated with variable PBO synergy in Anopheles gambiae s.l. from the Democratic Republic of Congo by Bethanie Pelloquin, Fiacre Agossa, Holly Acford-Palmer, Tiffany Clark, Sheila B. Ogoma, Miriam Williams, Narcisse Basosila, Francis Watsenga, Emery Metelo, Richard M. Oxborough, Yibayiri Osee Sanogo, Ferdinand Ntoya, Emma Collins, Sophie Moss, Charles McLoughlin, Monica Campos, Jody Phelan, Mark Rowland, Thomas Walker, Noboru Minakawa, Emile Zola Manzambi, Eric Mukomena, Susana Campino, Louisa A. Messenger

Get full text