Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy in endocrine therapy-resistant breast cancer by Mingshuang Wang, Liwei Pang, Yingjie Sun, Jingjing Han, Jiani Fan, Wenhui Shen, Xiaonan Hu, Bingqian Yang, Haoming Ning, Yanan Kong, Duo Li, Wenshan Zhao, Ranran Shi, Ling Ran, Yuanming Qi, Yahong Wu

“…Endocrine therapy has shown significant clinical efficacy in estrogen receptor alpha (ERα)-positive breast cancer management, but the emergence of therapy-resistant mutations significantly undermines treatment outcomes, frequently leading to disease progression and metastasis. Among these resistance mechanisms, mutations in the ESR1 gene are particularly prevalent, detectable in 76% of endocrine therapy-resistant tumor specimens. …”
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Spatiotemporal Dynamics of Habitat Quality in Semi-Arid Regions: A Case Study of the West Songnen Plain, China by Hao Yu, Zhimin Liang, Rong Zhang, Mingming Jia, Shicheng Li, Xiaoyan Li, Huiying Li

“…However, slight opposite trends were detected between the mean habitat quality values and the habitat change areas in forests, waters, and bare land. …”
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Swine influenza A virus infection sets the local immunological landscape in subsequent infection with porcine reproductive and respiratory syndrome virus by Janaïna Grevelinger, Olivier Bourry, Selma Schmidt, François Meurens, Céline Deblanc, Caroline Hervet, Aline Perrin, Stéphane Gorin, Mireille Le Dimna, Stéphane Quéguiner, Thibaut Larcher, Patricia Renson, Frédéric Paboeuf, Wilhelm Gerner, Nicolas Bertho, Gaëlle Simon

“…Results demonstrated that primary swIAV infection did not exacerbate the clinical progression of PRRSV infection, nor did it result in significant differences in PRRSV loads or affect the alveolar macrophage population in the lungs of super-infected pigs as compared to those of pigs infected with PRRSV alone. …”
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Hepatocellular carcinoma patients with undetectable baseline hepatitis B viral DNA may benefit from immunotherapy by Yan Jian, Sicong Jiang, Zhimin Qiu, Meijian Wang, Hanzhi Dong, Lin Zhou, Yu-an Qiu

“…Patients were categorized based on HBV-DNA levels to evaluate correlations with progression-free survival (PFS), overall survival (OS), and adverse events. …”
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Exploring MAPK and mTOR Pathways in Feline Thyroid Tumors by Alexandra Monteiro, Tiago Bordeira Gaspar, Inês Borges, Sule Canberk, Mafalda Pinto, Isabel Pires, Paula Soares, Catarina Tavares

“…The expression patterns of pERK, pS6, and pAKT and their associations with clinical-pathological features seem to mirror the progression dynamics observed in human thyroid tumorigenesis. pAKT expression was associated with the presence of multiple tumor foci within the same thyroid lobe, suggesting its potential as a marker of aggressiveness in feline thyroid tumors. …”
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Crab shell polypeptides enhance calcium dynamics and osteogenic activity in osteoporosis by Xiaolei Dong, Xiaolei Dong, Guangmin Zhang, Chong Sun, Hui Zhang, Jinmeng Zhen, Xinlei Li, Xiaohui Xu, Jiane Liu, Xiangzhong Zhao, Yiming Zhang, Linlin Liu, Shaoqi Tian, Daijie Wang, Zheng Wang, Zheng Wang, Bing Li

“…BackgroundOsteoporosis (OP) is a chronic, systemic skeletal disorder characterized by progressive bone loss and microarchitectural deterioration, which increases fracture susceptibility and presents a challenging set of global healthcare problems. …”
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Long non-coding RNA AK023617 orchestrates atherosclerosis by regulating the circadian rhythm of immunity-related GTPase family M protein in macrophages by Rongzhe Lu, Hengxuan Cai, Yige Liu, Guanpeng Ma, Jiaxin Wang, Miao Yan, Zhenming Zhang, Bo Yu, Zhaoying Li, Shaohong Fang

“…In this study, we examined whether rhythmic lncRNAs are involved in the pathogenesis and progression of atherosclerosis and detected a novel circadian lncRNA-AK023617, which is positively correlated with the peak occurrence of major adverse cardiovascular events. …”
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Itaconate suppresses neonatal intestinal inflammation via metabolic reprogramming of M1 macrophage by Shuchen Huangfu, Chaoting Lan, Sitao Li, Huijuan Wang, Chun Yan, Yuling Yang, Bowen Tian, Yide Mu, Peizhi Zhao, Yan Tian, Yijia Wang, Wei Zhong, Limei Zhong, Yongyan Shi, Yufeng Liu

“…Abstract Background Necrotizing enterocolitis (NEC) is a rapidly progressive and severe gastrointestinal disorder in neonates that is marked by an inflammatory cascade initiated by mechanisms that remain incompletely understood, resulting in intestinal necrosis and systemic infections. …”
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Invasive solid papillary carcinoma with neuroendocrine differentiation of the breast: a case report and literature review by Xue Lin, Yoshiaki Matsumoto, Tomomi Nakakimura, Kazuo Ono, Shigeaki Umeoka, Masae Torii, Hiroshi Yoshibayashi, Masakazu Toi

“…Three years after surgery, multiple lung metastases were detected, and the patient was treated with a gonadotropin-releasing hormone agonist and an aromatase inhibitor. …”
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Ultrasound-Assisted Determination of Selenium in Organic Rice Using Deep Eutectic Solvents Coupled with Inductively Coupled Plasma Mass Spectrometry by Shanshan Zhang, Boyu Chen, Yu Liu, Haoyu Sun, Haixing Zhang, Na Li, Yang Qing, Jeevithan Elango, Dayun Zhao, Wenhui Wu

“…As the focus on green chemistry intensifies, researchers are progressively looking to incorporate biodegradable and environmentally friendly solvents. …”
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MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2/3 by Feilong Chen, Zhiyu Li, Tutu Wang, Yu Fu, Lei Lyu, Chengyuan Xing, Shunchang Li, Li

“…Our findings demonstrate that MOTS-c modulates the progression of T2DM complicated by liver fibrosis through a Keap1-Nrf2-Smad2/3 signaling pathway-dependent mechanism.…”
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Autoantibodies Targeting Vinculin Reveal Novel Insight into the Mechanisms of Autoimmune Podocytopathies by Hanyan Meng, Dongjie Wang, Chen Zheng, Chao Zhou, Xinrui Mao, Jinglan Gu, Xiaohui Qiao, Fei Liu, Jingjing Wang, Haidong Fu, Jianhua Mao, Qing Ye

“…Conclusions: Autoantibodies targeting vinculin act as pathogenic autoantibodies in INS and hold potential value for diagnosing and monitoring INS progression.…”
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Evaluation of pre-exposure vaccine effectiveness against mpox during the 2022–2023 mpox outbreak in the Madrid region (Spain): a test-negative design by José Francisco Barbas del Buey, Jesús Íñigo Martínez, Marcos Alonso García, Andrés Aragón Peña, Laura Montero Morales, Araceli Arce Arnáez

“…Therefore, it appears as a reliable measure to minimise the spread of mpox.The progressive increase in the effectiveness could justify the delay in the administration of the second dose in situations of shortage of vaccines or prioritisation in the vaccination of the maximum number of subjects at risk.Further studies evaluating the long-term effectiveness of the full vaccination would be appropriate.…”
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Exploring the role of Epstein-Barr virus infection on the clinical features and survival in locally advanced cervical cancer: a retrospective cohort study by Denisse Castro-Uriol, Denisse Castro-Uriol, Juana Vera, Bryan Valcarcel, Marco López-Ilasaca, Alejandro Yabar, Anaís Cámara, Luis Malpica, Brady Beltrán, Brady Beltrán

“…Real-time Polymerase chain reaction (RT-PCR) was used to detect EBNA-1 (Epstein-Barr nuclear antigen 1) and LMP-1 (Latent membrane protein 1). …”
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Evaluation of Lateral Ear Canal Ablation (LECA) as a Surgical Treatment Option for External Ear Canal Disease in Lop-Eared Pet Rabbits (<i>Oryctolagus cuniculus</i>) by Anne Willems, Johannes Hetterich, Milena Thöle, Michael Pees, Michael Fehr, Maximilian Reuschel

“…Loss to follow-up was observed in 5/25 of the cases and recurrent ear diseases were identified in 2/25 of the pet rabbits. Progression of the ear disease was detected in four cases. …”
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MiR-101-3p Promotes Tumor Cell Proliferation and Migration via the Wnt Signal Pathway in MNNG-Induced Esophageal Squamous Cell Carcinoma by Jianding Wang, Wenwen Zhang, Rui Zhang, Hanteng Yang, Yitong Li, Junling Wang, Chengyun Li

“…Down-regulated miR-101-3p may exert tumor suppressive effects by regulating the Wnt pathway and may be a useful biomarker for predicting ESCC progression.…”
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Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS by Wei Lu, Wei Lu, Rong Zeng, Meng Pan, Yuan Zhou, Huijuan Tang, Wanying Shen, Yijun Tang, Pan Lei, Pan Lei, Pan Lei

“…MRTX1133 was still detectable in liver, kidney, lung, spleen, heart, and pancreas after 24 h. …”
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eIF5A downregulated by mechanical overloading delays chondrocyte senescence and osteoarthritis by regulating the CREBBP-mediated Notch pathway by Jialuo Huang, Jianrong Zheng, Jianbin Yin, Rengui Lin, Junfeng Wu, Hao-Ran Xu, Jinjian Zhu, Haiyan Zhang, Guiqing Wang, Daozhang Cai

“…Western blot (WB) and quantitative polymerase chain reaction were employed to detect relevant indicators of cartilage function in chondrocytes. …”
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The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring by Yan Zhang, Rui Guo, Min Yin, Mei Shi, Ting Zhong, Shanshan Liu, Xia Li

“…A random forest model was created to predict immune age in monocytes, allowing for quantitative assessment of aging. Results We detected an increase in the number of inflammatory monocytes expressing IL1B and CXCL8 with age. …”
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Decreased Expression of Aquaporins as a Feature of Tubular Damage in Lupus Nephritis by Maxime Melchior, Marie Van Eycken, Charles Nicaise, Thomas Duquesne, Léa Longueville, Amandine Collin, Christine Decaestecker, Isabelle Salmon, Christine Delporte, Muhammad Soyfoo

“…<b>Background:</b> Tubulointerstitial hypoxia is a key factor for lupus nephritis progression to end-stage renal disease. Numerous aquaporins (AQPs) are expressed by renal tubules and are essential for their proper functioning. …”
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