Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease by Andres Maldonado-Naranjo, Mandy Miller Koop, Olivia Hogue, Jay Alberts, Andre Machado

“…The Cleveland Clinic Stylus provided quantitative kinematic measures of tremor and bradykinesia severity and detected significant improvements in these measures from medication and DBS therapy. …”
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A minimally invasive technique of core decompression and cancellous bone grafting of femoral head osteonecrosis by P.B. Rajeev, M. Jyothiprasanth, Albin Savio, Shery Valsan, C.R. Jithin

“…Background: Osteonecrosis, or avascular necrosis (AVN), is a severe condition affecting the hip joints, particularly in younger and middle-aged individuals. Detecting it early and managing it effectively is crucial to prevent secondary osteoarthritis and potential hip replacement surgery. …”
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Analysis of intracranial lesions in patients with HIV-associated cryptococcal meningitis by Wei Song, Li Liu, Tangkai Qi, Zhenyan Wang, Yang Tang, Jianjun Sun, Shuibao Xu, Junyang Yang, Jiangrong Wang, Jun Chen, Renfang Zhang, Yinzhong Shen

“…Mortality rates at 2 weeks, 8 weeks, and 2 years for those with detected lesions were 3%, 7.6%, and 13.2%, respectively. …”
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Evaluation of Iron Overload Between Age Groups Using Magnetic Resonance Imaging and Its Correlation with Iron Profile in Transfusion-dependent Thalassemia by Pustika Amalia Wahidiyat, Stephen Diah Iskandar, Damayanti Sekarsari

“…Analysis of T2* showed that pancreatic iron deposition progressed with increasing age. Serum ferritin had weak correlation with heart T2* MRI, moderate correlation with pancreas and liver T2* MRI. …”
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Evaluation of Serum IL-41 as a Potential Biomarker in a Group of Iraqi Patients with Rheumatoid Arthritis by Ayat F. Tawfeeq, Hayfaa S. AL-Hadithi, Faiq I. Gorial

“…A positive correlation was also detected between the serum IL-41 level and the ACCP. …”
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HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats. by Osiris Marroquin Belaunzaran, Sascha Kleber, Stefan Schauer, Martin Hausmann, Flora Nicholls, Maries Van den Broek, Sravan Payeli, Adrian Ciurea, Simon Milling, Frank Stenner, Jackie Shaw, Simon Kollnberger, Paul Bowness, Ulf Petrausch, Christoph Renner

“…The presence of B272 can be detected on leukocytes of HLA-B27+ Ankylosing spondylitis (AS) patients and HLA-B27 transgenic rats. …”
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Cyclosporine A causes gingival overgrowth via reduced G1 cell cycle arrest in gingival fibroblasts. by Reiri Takeuchi, Takatoshi Nomura, Manabu Yaguchi, Noriko Kuwahara, Yuta Amino, Chieko Taguchi, Itaru Suzuki, Haruka Suzuki, Teruaki Nagashima, Kazumune Arikawa, Yuichiro Okada, Takato Nomoto, Koichi Hiratsuka

“…Cell cycle system balances proliferation and anti-proliferation of gingival fibroblasts and plays a role in the maintenance of its population in gingival tissues. When cells detect and respond to abnormalities (e.g. DNA damage), cell cycle progression is arrested in the G1 phase until the completion of damage restoration. …”
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Double Trouble in the Basement! A Case of PLA2R-Associated Membranous Nephropathy with Atypical Anti-Glomerular Basement Membrane Disease by Renuka Tolani, Steffi Sathiyaraj, David Lyu, Luan Truong, Theresa Thurston, Ziad M. El-Zaatari, Ali R. Khan, Angelina Edwards, Shane A. Bobart

“…Despite intense chemotherapy with cisplatin, gemcitabine, and immunotherapy, the patient’s cholangiocarcinoma progressed, and he transitioned to hospice care. Conclusion: For our patient, rituximab resulted in remission of proteinuria. …”
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METTL3-mediated methylation of RAC2 contributes to cell motility, oxidative stress and inflammation in TNF‐α-stimulated rheumatoid arthritis fibroblast-like synovial cells by Hua Ren, Guohua Wei, Ziwei Kong, Mengyang Zhang, Yuejin Li, Sanjiao Liu, Yifan Guo

“…Conclusion The above results demonstrated that METTL3 facilitated the progression of RA via downregulating RAC2 in an m6A dependent mechanism in TNF‐α-treated MH7A cells.…”
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Role of Myeloid-Derived Suppressor Cells (MDSCs), Specifically Monocyte-Derived MDSCs, in Type 2 Diabetes-Related Diabetic Retinopathy by Xiang X, Zhang Z, Xu W, Huang Z, Zhang J

“…Our findings suggest that M-MDSCs, particularly in the proliferative stage of DR, may serve as potential biomarkers for disease progression and offer insights into future clinical or therapeutic strategies.Keywords: peripheral blood, fasting blood glucose, glycosylated hemoglobin…”
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Evaluation of fibre-reinforced composite splinting mobile the lower front teeth of patients who suffer from periodontitis by O. M. Slaba, Kh. А. Sichkoriz, L. Yu. Minko, M. Т. Sloboda

“…The splinting structure integrity was preserved in 67.24 % of patients for 3 years, and splinting defects were detected in 32.76 % of patients at different stages of the follow-up. …”
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Peroxiredoxin 1 Promotes Proinflammatory Cytokine Secretion in Human Dysplastic Oral Keratinocytes and Mouse Tongue Precancerous Tissues by Min Zhang, Wenjing Li, Jing Li, Wenchao Wang, Lingyu Li, Yunping Lu, Min Wang, Xiaofei Tang

“…DOK nuclear expression of NF-κB was detected via immunofluorescence assay and western blotting. …”
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Ergotamine Targets KIF5A to Facilitate Anoikis in Lung Adenocarcinoma by Bin Bao, Xiaojun Yu, Wujun Zheng, Jiewei Sun

“…ABSTRACT Background Kinesin family member 5A (KIF5A) has been reported to be closely related to cancer progression. The aim of this study was to investigate the effect of KIF5A on lung adenocarcinoma (LUAD) and its potential molecular mechanisms. …”
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Results of conservative treatment of locally advanced larynx squamous cell carcinoma using intraarterial regional polychemotherapy by D. A. Safarov, A. M. Mudunov, B. I. Dolgushin, A. A. Akhundov, I. A. Zaderenko, D. A. Peshko

“…Tumor stabilization was detected in 1 (3.5 %) patient. Two-year overall survival was 95.8 ± 4.1 %, progression-free survival was 90.1 ± 6.8 %.Conclusion. …”
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Significance of determination of hemodynamic phenotypes in early diagnosis of cardiovascular disorders in children with diabetes mellitus by H. O. Lezhenko, O. Ye. Pashkova, K. V. Samoilyk

“…At the same time, in children with diabetes, there was a significant increase in AASI from the first year of the disease with a progressive increase with its dynamics. The highest values of AASI were observed in dysfunctional hemodynamic phenotype. …”
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Prevalence and spectrum of haemoglobinopathies in females of reproductive age group- A first tertiary care center experience in Punjab, North India by Vikram Narang, Anshul Jain, Sumit Grover, Ankita Soni, Monika Narang, Ashima Taneja

“…To reduce the burden of these highly prevalent monogenic disorders, detecting them in the carrier stage is crucial to prevent disease progression. …”
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Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. by Hildegard Nikki Hall, Hemant Bengani, Robert B Hufnagel, Giuseppe Damante, Morad Ansari, Joseph A Marsh, Graeme R Grimes, Alex von Kriegsheim, David Moore, Lisa McKie, Jamalia Rahmat, Catia Mio, Moira Blyth, Wee Teik Keng, Lily Islam, Meriel McEntargart, Marcel M Mannens, Veronica Van Heyningen, Joe Rainger, Brian P Brooks, David R FitzPatrick

“…Classical aniridia is a congenital and progressive panocular disorder almost exclusively caused by heterozygous loss-of-function variants at the PAX6 locus. …”
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High-folate-low-vitamin B12 interaction syndrome by Claudia Cicchini, Antonio De Magistris, Alberto Del Sasso, Donatella Livoli, Francesco Rocco Pugliese

“…Vitamin B12 deficiency and a high folate value were detected, supporting the hypothesis of the high-folate-low-vitamin B12 interaction as a cause of vitamin B12 depletion. …”
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Monoglyceride supplementation modulates microbiom of small intestine in piglets by A. V. Gavrylenko, D. M. Masiuk

“…Similar to the aforementioned SCFAM effect on the E. coli content, but slightly different changes in the content of Staphylococcus spp. were determined in all studied small intestine sections in the SCFAM-exposed groups on the 56th and 77th day of life. A progressive increase in the content of Staphylococcus spp. was detected on the 77th day compared to that on the 56th day of life. …”
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Arterial hypertension as a consequence of endothelial glycocalyx dysfunction: a modern view of the problem of cardiovascular diseases by M. M. Ziganshina, A. R. Ziganshin, E. O. Khalturina, I. I. Baranov

“…The etiology of hypertension has not been fully elucidated, but it has been established that endothelial dysfunction is the most significant pathogenetic link in the formation and progression of the disease. The data obtained in the last 10-15 years on endothelial glycocalyx (eGC) studies indicate that endothelial dysfunction is preceded by destabilization and shedding of eGC with the appearance of its soluble components in the blood, which is equivalent to a process that can be designated as eGC dysfunction. …”
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