IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice by Heng-Mo Rong, Xiao-Jun Qian, Chao Zhang, Ting Li, Zhao-Hui Tong

“…Taken together, our results demonstrated that IL-17 and IL-10 could play the protective roles in the progression of PCP and the inverse correlation of them might be mediated by STAT3.…”
Get full text

Downregulated expression of dual-specificity phosphatase-1 in multiple myeloma as a predictor of poor survival outcomes by Dan Guo, Jinfeng Lu, Lemin Hong, Hong Liu, Hongming Huang

“…Objectives Multiple myeloma (MM) is an incurable hematological malignancy, Dual-specificity phosphatase-1 (DUSP1) plays a crucial role in the initiation and progression of various tumors. Here, we aim to elucidate the role of DUSP1 in MM.Methods DUSP1 mRNA expression was analyzed based on public datasets, and protein expression was determined by immunohistochemistry. …”
Get full text

Clinical significance and regulatory mechanism of miR-134-5p in rheumatic heart disease by Liangqin Yang, Juan Li, Ju Wang, Yaping Zhang, Yunyun Huang

“…This study aimed to explore the role of miR-134-5p in RHD progression. Methods A total of 167 subjects (80 non-RHD, 87 RHD) were included in this study. …”
Get full text

Interferon (IFN)-gamma (γ) inducible protein 10 (IP-10) in the diagnosis of latent and active tuberculosis in Bacille Calmette Guerin (BCG)-vaccinated pediatric population. by Magdalena Druszczynska, Michał Seweryn, Sebastian Wawrocki, Anna Pankowska, Anastasiia Kulbachko, Magdalena Jurczak, Magdalena Kowalewska-Pietrzak

“…<h4>Background</h4>Accurate diagnosis of tuberculosis (TB) in children continues to be challenging, primarily due to the low bacterial load characteristic of the disease and the obstacles in collecting sputum samples. Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.tb) infection (LTBI) that have a high risk of progressing to active TB disease remains a significant diagnostic hurdle.…”
Get full text

Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells by Jiankun Ren, Songwei Zhao, Junyu Lai

“…Type III collagen (COL3A1) can affect the progression and chemoresistance development of NSCLC. …”
Get full text

Inflammatory myofibroblastic tumor of the sigmoid colon: A case report by Suleiman Ayalew, Michael A. Negussie, Messay Gebrekidan, Dinksira Bekele Deneke, Mulat Asrade Alemayehu, Mesfin Tesera Wassie

“…Case presentation: A 2-year-old boy presented with a three-month history of painless, progressive abdominal swelling that began in the right lower abdomen and extended across to the left. …”
Get full text

Effectiveness of carbonate removal and demineralization inhibition in primary teeth using a 9.3-μm carbon dioxide laserWhy Is This Important? by Ali Badreddine, PhD, Vijayashankar Ramareddy, PhD, Charles Kerbage, PhD

“…Background: Studies on permanent dental enamel have shown that irradiation with a 9.3-μm carbon dioxide (CO2) laser can safely inhibit caries progression in vivo and carieslike lesion formation in vitro. …”
Get full text

EEG oscillations and related brain generators of phonation phases in long utterances by Said-Iraj Hashemi, Guy Cheron, Didier Demolin, Ana Maria Cebolla

“…Aerodynamic, acoustic, and electrophysiological signals were analyzed to detect the brain areas involved in different phases of prolonged phonation. …”
Get full text

Disproportionately Elevated Proinsulin Levels as an Early Indicator of β-Cell Dysfunction in Nondiabetic Offspring of Chinese Diabetic Patients by Ming Li, Dan Feng, Kui Zhang, Shan Gao, Juming Lu

“…Compared with HOMA-B, FPI/SI could detect β-cell failure in earlier stage of diabetes development.…”
Get full text

miR-138-5p Inhibits Vascular Mimicry by Targeting the HIF-1α/VEGFA Pathway in Hepatocellular Carcinoma by Hongwei Liu, Tao Tang, Xiujin Hu, Weihe Tan, Peng Zhou, Huixian Zhang, Yanmei Liu, Chen Chen, Meng Yang, Meifang Zhou, Shuxia Xuan, Bin Cheng, Weiguo Yin, Jinduan Lin

“…An increasing number of studies have revealed that the VM process is associated with cancer progression and metastasis. MiR-138-5p has been reported to act as a tumour suppressor in many cancers. …”
Get full text

Systemic Amyloidosis with Cardiac Involvement: Features of Course and Diagnostic Difficulties by E. V. Voloshinova, I. Yu. Khorkina, A. M. Dzuban, E. V. Yakovleva

“…The onset of the disease with carpal tunnel syndrome, the progressive distal neuropathy combined with autonomic dysfunction, the dominant cardiac involvement, the absence of renal amyloidosis according to autopsy data, and the duration of the disease from the time of clinical manifestation to death of 43 months are more indicative of ATTR amyloidosis. …”
Get full text

Differential Expression and Bioinformatics Analysis of Plasma-Derived Exosomal circRNA in Type 1 Diabetes Mellitus by Haipeng Pang, Wenqi Fan, Xiajie Shi, Shuoming Luo, Yimeng Wang, Jian Lin, Yang Xiao, Xia Li, Gan Huang, Zhiguo Xie, Zhiguang Zhou

“…Illumina Novaseq6000 platform was used to detect the exosomal circRNA expression profiles. Multiple bioinformatics analysis was applied to investigate the potential biological functions of exosomal circRNAs. …”
Get full text

Impact of CD40 (rs1883832) and CD40L (rs1126535) gene variants on laryngeal cancer susceptibility and their association with serum biomarker levels of sCD40 and sCD40L. by Alper Gümüş, Dilara Sönmez, Şeyda Demirkol, Mehmet Tolgahan Hakan, Ayşegül Verim, Yusufhan Süoğlu, İlhan Yaylım, Arzu Ergen

“…In contrast, no statistically significant difference in the genotypes of CD40L (rs1126535) was detected between laryngeal cancer patients and the control group (p = 0.12). …”
Get full text

Platelet-Derived Mitochondria Attenuate 5-FU-Induced Injury to Bone-Associated Mesenchymal Stem Cells by Yutong Chen, Zhixin Liu, Ning An, Jing Zhang, Weicheng Meng, Wenting Wang, Xiaoshuang Wu, Xingbin Hu, Yaozhen Chen, Wen Yin

“…Changes in the mitochondrial dynamics were detected by transmission electron microscopy, and the expression of mitochondrial fusion and fission genes was analyzed by qRT-PCR. …”
Get full text

Inhibitory Effect of β-Sitosterol on the Ang II-Induced Proliferation of A7r5 Aortic Smooth Muscle Cells by Yuankun Chen, Shumiao He, Ao Zeng, Siqing He, Xiaobao Jin, Chunmei Li, Wenjie Mei, Qun Lu

“…It achieved this by arresting cell cycle progression, promoting apoptosis, inhibiting autophagy, and suppressing the contractile–synthetic phenotypic switch. …”
Get full text

Characteristics of the expression of CX3CR1 in natural killer cells from peripheral blood and its association with gut microbiota in sepsis patients by Sucheng MU, Zhan SUN, Zhenju SONG

“…The mRNA expression of CX3CR1 was detected by qPCR, and the changes in CX3CR1 expression and its correlation with gut microbiota were analyzed. …”
Get full text

Predictors of Early Retinal Changes in Diabetes Mellitus by V. S. Kulybysheva, I. A. Ronzina, A. A. Gamidov, V. G. Motalov, V. N. Nikolenko

“…It is proved that mfER and MP allow to detect violations at the preclinical stage of DR and are necessary studies for the dynamic control of the progression of DR.…”
Get full text

Retinoblastoma Morphology after Local Chemotherapy by S. V. Saakyan, I. P. Khoroshilova-Maslova, S. S. Tadevosyan, A. Yu. Tsygankov, G. P. Zakharova, O. A. Ivanova, O. G. Panteleeva, A. A. Zharua

“…Complete regression of the tumor was detected in 3 out of 19 eyes, partial in 13 eyes. There were no signs of regression in 3 eyes. …”
Get full text

Optimization criteria for ordering myeloid neoplasm next‐generation sequencing by Savanah D. Gisriel, John G. Howe, Christopher A. Tormey, Richard Torres, Karl M. Hager, Henry M. Rinder, Alexa J. Siddon

“…Abstract Introduction Myeloid neoplasms (MNs) frequently harbor pathogenic mutations not detected by karyotyping and fluorescence in situ hybridization; hence, next‐generation sequencing (NGS) is necessary for diagnosis, risk stratification, and therapy. …”
Get full text

Orally Administrated Inulin-Modified Nanozymes for CT-Guided IBD Theranostics by Li X, Cao L, Li J, Li Z, Ma H, Cheng S, Xu H, Zhao Y

“…Excessive production of reactive oxygen species (ROS) at the inflammatory sites leads to the onset and progression of IBD. And the current non-invasive imaging methods are not ideal for the diagnosis and monitoring of IBD.Methods: Herein, we developed inulin (IN)-coated cerium oxide nanoparticles (CeO2@IN NPs) for treatment and monitoring of IBD guided by computed tomography (CT). …”
Get full text