Case Report: Two cases of chemotherapy refractory aggressive variant prostate cancer with extreme durable response to PARP inhibitor by Bohao Jiang, Yifan Bi, Yiming Chen, Jianbin Bi, Jian Deng, Gejun Zhang

“…BackgroundAggressive variant prostate cancer (AVPC) represents a distinct clinical subset characterized by resistance to novel hormone therapies and an unfavorable prognosis, frequently associated with the concurrent loss of tumor suppressor genes (TSG) such as PTEN, RB1, and TP53. While the progression-free survival (PFS) and overall survival (OS) of AVPC are relatively short, the optimal first-line treatment remains unclear.PresentationIn this case report, we presented two de novo AVPC cases who have ultimately benefited from the usage of PARP inhibitors. …”
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Trim21 deficiency alleviates osteoporosis by inhibiting osteoclast differentiation through regulating Txnip by Ya-Chen Peng, Yong-Sheng Ye, Qin-Xiao Hu, Zhi-Quan Hao, Zhen-Yan Li, Luo-Yong Jiang, Hao-Ran Peng, Ri-Xu Liu, Zhen-Gang Zha, Huan-Tian Zhang

“…Abstract Objective The tripartite motif containing 21 (Trim21), an E3 ubiquitin ligase, plays a crucial role in the progression of various skeletal diseases, particularly in osteoporosis. …”
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Targeting fibroblast activation protein in rheumatoid arthritis: from molecular imaging to precision therapeutics by Yupeng Huang, Yang Wu, Huan Liu, Yuehong Chen, Qibing Xie, Geng Yin

“…Activated fibroblast-like synoviocytes (FLS), which play a crucial role in the progression of RA, demonstrate tumor-like invasiveness and secrete inflammatory mediators. …”
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Deep sequencing of the gene reveals a potential risk allele for non–small cell lung cancer and supports the negative prognostic value of variants by Christophe Deben, Jolien Van den Bossche, Nele Van Der Steen, Filip Lardon, An Wouters, Ken Op de Beeck, Christophe Hermans, Julie Jacobs, Marc Peeters, Guy Van Camp, Christian Rolfo, Vanessa Deschoolmeester, Patrick Pauwels

“…Inactivating TP53 mutations acted as a predictor for both worse overall and progression-free survival in stage II–IV patients and patients treated with DNA-damaging (neo)adjuvant therapy. …”
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LncRNA TMPO-AS1 facilitates cervical cancer cell tumorigenesis and ferroptosis resistance via interaction with LCN2 by Ying Ju, Xu Liu, Jintong Na, Jian He, Liangliang Wu, Zhuoran Wang, Chunxiu Peng, Yuan Liao, Zhiyong Zhang

“…Here, the expression level of LICN-TMPO-AS1 in CESC was detected using quantitative real-time polymerase chain reaction. …”
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Influence of helicobacter pylori infection on Chinese adult males’ body muscle mass: a cross-sectional and cohort analysis by Ju-Hua Liu, Yun Li, Rui-Ning Nie, Jun-Xiang Li, Fang-Yuan Cheng, Yu-Xin Su, Yun-Feng Yang, Jian-Wei Gu

“…Using bioelectrical impedance analysis (BIA), body muscle mass was detected and total muscle mass, total skeletal muscle mass, and appendicular skeletal muscle mass index (ASMI) were recorded. …”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…Abstract Histone lactylation plays a crucial role in cancer progression, but its impact on breast cancer (BC) tumorigenesis is still unclear. …”
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Psychometric Hepatic Encephalopathy Tests and Electroencephalogram Results Among Cirrhotic Patients by Alaa Aboud Mohamed, Mostafa M. Elkholy, Ola O. Mangoud, Ahmed R. N. Ibrahim, Marwa O. Elgendy, Ali M. Abdel Fattah

“…This study aimed to investigate the progression of minimal hepatic encephalopathy, its effects on quality of life, its prognostic value, and its significance for daily functioning. …”
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Histologic evidence of neutrophil extracellular traps and fibrin(ogen) deposition in liver biopsies from patients with inflammatory liver disease by Fien A. von Meijenfeldt, Ton Lisman, Alessandra Pacheco, Yoh Zen, William Bernal

“…Experimental studies suggest that the interaction between neutrophils and platelets with local activation of coagulation could contribute to liver injury progression, but there have been limited studies in humans. …”
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Vector competence of Aedes albopictus for Tonate virus highlights transmission risks in temperate and tropical regions by Isabelle Moltini-Conclois, Wipaporn Khanom, Elliott F Miot, Ai-rada Pintong, Hermann Landry Munshili Njifon, Carole Ginebre, Valérie Choumet, Bruno Coutard, Cédric Mariac, Pierre Roques, Agathe M. G. Colmant, Géraldine Piorkowski, Julien Pompon, Dorothée Missé

“…A recurrent polymorphism at position 11,357 in the 3′UTR was detected in body tissues but not in heads of La Réunion mosquitoes, suggesting tissue-specific selection or bottlenecks. …”
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Altered brain complexity in first-episode antipsychotic-naïve patients with schizophrenia: A whole-brain voxel-wise study by Naici Liu, Rebekka Lencer, Christina Andreou, Mihai Avram, Heinz Handels, Wenjing Zhang, Sun Hui, Chengmin Yang, Stefan Borgwardt, John A. Sweeney, Su Lui, Alexandra I. Korda

“…The Chaos analysis approach was applied to detect alterations in brain structural complexity using the largest Lyapunov exponent (Lambda) as the key measure. …”
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Clinical Impact of CD19 Expression Assessed by Quantitative PCR in Lymphoma Patients Undergoing CAR‐T Therapy by Rafael Hernani, Laura Ventura, Begoña Heras, Alicia Serrano, Marcos Rivada, Carolina Martínez‐Ciarpaglini, Ana Benzaquén, Blanca Ferrer‐Lores, Ariadna Pérez, José Luis Piñana, Juan Carlos Hernández‐Boluda, Ignacio Arroyo, Paula Amat, Irene Pastor‐Galán, María José Remigia, Rosa Goterris, Montse Gómez, Anabel Teruel, Ana Saus, Consejo Ortí, María José Terol, Antonio Ferrández‐Izquierdo, Carlos Solano

“…CD19‐negative cohort showed worse 1‐year progression‐free survival (15 vs. 45%, p = 0.044) and a trend toward shorter duration of response (29 vs. 55%, p = 0.065). …”
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Age-dependent cortical overconnectivity in Shank3 mice is reversed by anesthesia by Elena Montagni, Manuel Ambrosone, Alessandra Martello, Lorenzo Curti, Federica Polverini, Laura Baroncelli, Guido Mannaioni, Francesco Saverio Pavone, Alessio Masi, Anna Letizia Allegra Mascaro

“…Our findings reveal that network hyperconnectivity, emerging from the barrel-field cortices during the juvenile stage, progressively expands to encompass the entire dorsal cortex in adult Shank3b+/− mice. …”
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Selective identification of polyploid hepatocellular carcinomas with poor prognosis by artificial intelligence-based pathological image recognition by Takanori Matsuura, Masatoshi Abe, Yoshiyuki Harada, Masahiro Kido, Hajime Nagahara, Yuzo Kodama, Yoshihide Ueda, Eiji Hara, Hirohiko Niioka, Tomonori Matsumoto

“…Abstract Background Polyploidy is frequently observed in cancer cells and is closely associated with chromosomal instability, which can lead to cancer progression. Polyploid cancers are more aggressive than diploid cancers, and polyploidy has been shown to be a prognostic marker for hepatocellular carcinoma (HCC). …”
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Psychobiotics Regulate the Anxiety Symptoms in Carriers of Allele A of IL-1β Gene: A Randomized, Placebo-Controlled Clinical Trial by P. Gualtieri, M. Marchetti, G. Cioccoloni, A. De Lorenzo, L. Romano, A. Cammarano, C. Colica, R. Condò, L. Di Renzo

“…Inflammatory cytokines can influence the onset and progression of several neurodegenerative mood disorders, and the IL-1β rs16944 SNP is related to high cytokine levels and potentially affects mood disorders. …”
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The course of Dandy — Walker syndrome in a child with Edwards syndrome by H. A. Sarkisyan, A. B. Smolyannikova, A. A. Fadeeva, E. I. Shabelnikova, O. I. Savvateeva, A. A. Shakirova, A. B. Chashchukhina

“…Dandy – Walker syndrome (Dandy – Walker syndrome) is a combined malformation of the brain, the identification of which may be an indication for expanding the diagnostic search in order to detect other malformations or chromosomal pathologies. …”
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Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer mice by Huizhu Liu, Xuejing Lv, Xin Zhao, Lanxing Yi, Ning Lv, Wendong Xu, Yuqiu Zhang

“…Here, we demonstrate that the sustained activation of spinal astrocytes and astrocyte-derived interleukin (IL)-17A promotes the progression of mouse bone cancer pain without sex differences. …”
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Sulindac exhibits anti-proliferative and anti-invasive effects and enhances the sensitivity to paclitaxel in ovarian cancer by Shuning Chen, Shuning Chen, Weimin Kong, Xiaochang Shen, Xiaochang Shen, Nikita Sinha, Jennifer Haag, Boer Deng, Boer Deng, Haomeng Zhang, Haomeng Zhang, Catherine John, Wenchuan Sun, Chunxiao Zhou, Chunxiao Zhou, Victoria L. Bae-Jump, Victoria L. Bae-Jump

“…ObjectiveChronic inflammation is a key contributor to carcinogenesis, progression, and chemoresistance in ovarian cancer, making inflammatory pathways a logical therapeutic target for the treatment of this disease. …”
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Effect of microstructure on hydrogen embrittlement sensitivity and failure mechanism of X52 pipeline steel by Qian Wu, Anfeng Yu, Yi Qin, Yuchen Wang, Weimin Zhao, Wenchen Wang

“…The outer wall region predominantly consists of polygonal ferrite with a minor fraction of granular bainite. A progressive increase in bainitic phase fraction was detected toward the inner wall, ultimately transitioning to bainite structures. …”
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Combination of spatial transcriptomics analysis and retrospective study reveals liver infection of SARS-COV-2 is associated with clinical outcomes of COVID-19Research in context by Shiqi Chen, Yi Zhang, Asha Ashuo, Shu Song, Lunzhi Yuan, Weixia Wang, Cong Wang, Zunguo Du, Yangtao Wu, Dan Tan, Chenlu Huang, Jingna Chen, Yaming Li, Jinjin Bai, Huilin Guo, Zehong Huang, Yi Guan, Ningshao Xia, Zhenghong Yuan, Jiming Zhang, Quan Yuan, Zhong Fang

“…Viral S and N proteins were detected in the livers of severe and deceased patients but not in those of moderate patients. …”
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