Synergistic anti-osteoporosis effects of Anemarrhena asphodeloides bunge–Phellodendron chinense C.K. Schneid herb pair via ferroptosis suppression in ovariectomized mice by Xuehui Deng, Xuehui Deng, Wenlong Xiao, Wenlong Xiao, Bingfeng Lin, Fang Wang, Li Song, Nani Wang, Nani Wang, Nani Wang

“…IntroductionFerroptosis plays a crucial role in the progression of postmenopausal osteoporosis. Anemarrhena asphodeloides Bunge/Phellodendron chinense C.K. …”
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Comparative pharmacokinetics and pharmacodynamics of two formulations of agalsidase beta (agalsidase Biosidus) and Fabrazyme® by intravenous infusion in healthy male volunteers by Viridiana Berstein, Eduardo M. Pirotzky, Hernán D. Taconelli, M. Gabriela Gobbi, Lara Beider, Natali D. Salgueiro, Laila Dome, Roberto A. Diez, Hugo Sotelo, Sabrina Coppola

“…No differences were detected in adverse effects or antibody induction. …”
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Combination of immune checkpoint inhibitors and anthracyclines as a potential first-line regimen for dedifferentiated liposarcoma: systematic review and meta-analysis by Zhuang Aobo, Zhou Xiao, Xu Chengfei, Xi Zhe, Chen Yingxue, Zhang Chenhe, Xie Fuan, Yang Fan, Xiao Mengmeng, Ye Feng, Li Wengang

“…Data on overall response rate (ORR), progression-free survival, and grade III–V treatment-related adverse events were analyzed. …”
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Whole exome sequencing shows novel COL4A3 and COL4A4 variants as causes of Alport syndrome in Rio Grande do Norte, Brazil by Washington Candeia de Araújo, Raul Maia Falcão, Raquel Araujo Costa Uchoa, Carlos Alexandre Garcia, Arthur Quintiliano Bezerra da Silva, Kesia Larissa Medeiros Quirino, Francisco Paulo Freire-Neto, Genilson Pereira Gurgel, Paulo Ricardo Porfirio Nascimento, Leonardo Capistrano Ferreira, Priya Duggal, Jorge Estefano S. de Souza, Selma M. B. Jeronimo

“…Abstract Background Alport syndrome is a progressive and hereditary nephropathy characterized by hematuria and proteinuria as well as extra renal manifestations as hearing loss and eye abnormalities. …”
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Epiphyseal osteosarcoma with serial changes of pretreatment imaging findings: a case report by Kotaro Watanabe, Hirokazu Shimizu, Tamotsu Soma, Ken Kuwahara, Hiroaki Hiraga, Norimasa Iwasaki, Masatake Matsuoka, Akira Iwata

“…As of 1 year post-surgery, disease relapse had not been detected. Conclusions This case highlights the benefit of longitudinal imaging investigations, which assisted in making a crucial diagnosis with minimal delay and enabled timely initiation of treatment before further disease progression.…”
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Giant cell tumours of the tendon sheath: Clinical insights and surgical perspectives from three cases by Amrane Hemza, Boussha Toufik, Hasrouri Ilies, Mekideche Besma, Amrane Hamid, Benmayouf Nazim, Derdous Chaouki, Khernane Nacer

“…Three female patients aged 33, 47 and 62 years presented with progressively enlarging painful swellings in the hand or foot. …”
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Transvaginal flexible endoscopy for bleeding arteriovenous malformation hemostasis near a vesico-rectovaginal fistula by Reona Tsukii, MD, Kazuya Inoki, MD, MPH, PhD, Kenichi Konda, MD, PhD, Atsushi Katagiri, MD, PhD, Fuyuhiko Yamamura, MD, PhD, Takashi Mimura, MD, PhD, Hitoshi Yoshida, MD, PhD

“…Spontaneous hemostasis was achieved; nevertheless, she was readmitted to our hospital because of a recurrence of symptoms and progressively worsening anemia. Vaginoscopy revealed blood in the vagina; however, the source of bleeding was not detected, particularly by subsequent rectal endoscopy. …”
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Efficacy of corneal squamous cell carcinoma antigen-1 in early infancy in predicting atopic dermatitis and food allergy: A prospective study by Maki Ozawa, Chika Katagiri, Chieko Okamura, Masashi Miyai, Yukiko Matsunaga, Daichi Murata, Christopher Takaya Knight, Tomoko Onodera, Masayuki Asano, Junko Endo, Ryoko Omori, Toshiya Takahashi, Masatoshi Saito, Takushi Hanita, Shimpei Watanabe, Shinichi Sato, Nobuko Tabata, Osamu Iizawa, Yoshihide Asano, Setsuya Aiba

“…Background: Identification of predictive biomarkers is crucial for formulating preventive interventions and halting the progression of atopic march. Although controversial, the use of accessible markers to predict or detect early onset of atopic diseases is highly desirable. …”
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Periplakin Attenuates Liver Fibrosis via Reprogramming CD44Low Cells into CD44High Liver Progenitor CellsSummary by Lichao Zhang, Zhiyong Xiong, Zebin Chen, Meiyining Xu, Siyu Zhao, Xianzhi Liu, Kefeng Jiang, Yunyi Hu, Shurui Liu, Xi Sun, Zhongdao Wu, Jia Shen, Lifu F. Wang

“…Adenovirus overexpressing PPL was injected into the tail vein of mouse models to detect the regulatory effect of PPL on liver fibrosis. …”
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Radiological nodule behavior: A critical parameter in the surgical management of pediatric pulmonary metastases by Emre Divarcı, Ata Erdener, Hüdaver Alper, Yeşim Ertan, Haldun Öniz, Bengü Demirağ, Mehmet Kantar, Zafer Dökümcü, Serkan Arslan, Coşkun Özcan

“…All of the suspected new rising nodules should undergo surgical sampling to avoid unnecessary chemotherapy. Nodule progression under chemotherapy is a poor prognostic criteria for overall survival. …”
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Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells by Rui Zhang, Shuang Chen, Tingting Luo, Sha Guo, Jianhua Qu

“…In MM patients, Tim-3/Galectin-9 is elevated and associated with disease progression, by inhibiting the cytotoxic function of Th1, and also promoting Th2 and Th17 to be involved in immune escape of MM. …”
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HER2-low breast cancer. Diagnostics, treatment and its adverse events by Hanna Bartkowiak, Damian Grubski, Kacper Ziarnik, Filip Nadolny, Jędrzej Jabłoński, Martyna Kania, Agnieszka Adamowska, Alicja Śniatała

“…The objective was also to underscore the importance of detecting low and very low expression of HER2 receptors. …”
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Visfatin promotes multiple myeloma cell proliferation and inhibits apoptosis by inducing IL-6 production via NF-κB pathways by Wenting Tie, Tao Ma, Jia Liu, Zhigang Yi, Hao Xiong, Jun Bai, Yanhong Li, Lijuan Li, Liansheng Zhang

“…Conclusions In MM, visfatin promotes tumor progression by upregulating IL-6 production, which may be a novel therapeutic target for the treatment of MM patients.…”
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Clinical decision points for two plasma p‐tau217 laboratory developed tests in neuropathology confirmed samples by Anna E. Mammel, Ging‐Yuek Robin Hsiung, Ali Mousavi, Kelsey Hallett, Ian R. Mackenzie, Veronica Hirsch‐Reinshagen, Don Biehl, Pradip Gill, Mary Encarnacion, Hans Frykman

“…Specific plasma p‐tau217 assays may require distinct decision points for AD screening, diagnosis, and disease progression monitoring.…”
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CANCER-EMBRYONIC ANTIGEN IN PREDICTING THERAPEUTIC TUMOR PATHOMORPHISM AFTER NEOADJUVANT CHEMORADIOTHERAPY IN PATIENTS WITH RECTAL CANCER by D. V. Erygin, N. G. Minaeva, S. A. Ivanov, N. Yu. Dvinskikh, N. Yu. Novikov, B. A. Berdov, A. A. Nevolskikh, A. A. Karpov, Yu. Yu. Mikhalev, I. A. Evtekhov, L. O. Petrov

“…It was revealed that patients with III and IV degrees of therapeutic pathomorphosis initially had a CEA level lower, in comparison with patients with grade I-II. Clinical progression of the disease is diagnosed in 24% of cases (43/179). …”
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Foodborne Botulism Caused by <i>Clostridium botulinum</i> Subtype A5(b3) by Self-Packaged Vacuum Spicy Rabbit Heads by Wen Cui, Chuanmin Ma, Ming Liu, Yan Li, Lin Zhou, Yuwen Shi, Xuefang Xu, Hui Liu

“…Treatment for this case was delayed due to misdiagnosis and insufficient diagnostic capacity in three hospitals, which resulted in progressive clinical deterioration, and eventually, the patient was transferred to Shandong Public Health Clinical Center for specialized therapy. …”
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Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration by Ben Yi Tew, Gerald C. Gooden, Pei-An Lo, Pei-An Lo, Dimitrios Pollalis, Dimitrios Pollalis, Brandon Ebright, Brandon Ebright, Alex J. Kalfa, Alejandra Gonzalez-Calle, Alejandra Gonzalez-Calle, Biju Thomas, Biju Thomas, David N. Buckley, Thomas Simon, Zeyi Yang, Ege Iseri, Ege Iseri, Cody L. Dunton, Vadim Backman, Stan Louie, Stan Louie, Gianluca Lazzi, Gianluca Lazzi, Gianluca Lazzi, Mark S. Humayun, Mark S. Humayun, Bodour Salhia

“…We devised an epigenomic-based retinal health score, derived from DNA methylation changes observed with disease progression in RCS rats, and showed that TES improved the epigenomic health of the retina. …”
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Quercetin inhibits truncated isoform of dopamine- and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer by Han-Sheng Chang, Tzu-Chun Cheng, Shih-Hsin Tu, Chih-Hsiung Wu, You-Cheng Liao, Jungshan Chang, Min-Hsiung Pan, Li-Ching Chen, Yuan-Soon Ho

“…The truncated isoform of dopamine- and cAMP-regulated phosphoprotein (t-DARPP) has been reported to be involved in trastuzumab therapy resistance and promoting tumor progression. To evaluate the t-DARPP expression in BC, paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+ BC tumor tissues. …”
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Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis by Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Audrey Cras, Eduardo Angles-Cano

“…IntroductionMesenchymal stem cells (MSCs) participate in the dynamic remodeling of the extracellular matrix during wound healing, natural bleeding processes or cancer progression. Pericellular proteolysis is a key mechanism mediating the aforementioned processes.AimThis study primarily aimed to define mechanistic pathways of plasmin formation and its consequences on MSC phenotype and functioning. …”
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Targeting cGAS-STING: modulating the immune landscape of hepatic diseases by Feng Xue, Feng Xue, Yong-Kang Liu, Yong-Kang Liu, Xiao-Ying Chen, Shan-Shan Chen, Xiang-Rong Yu, Hua-Wen Li, Li-Gong Lu, Li-Gong Lu, Mu-He Chen, Mu-He Chen

“…Genomic instability during cancer progression can trigger this pathway by releasing DNA into the cytoplasm. …”
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