Aminophylline suppresses chronic renal failure progression by activating SIRT1/AMPK/mTOR-dependent autophagy by Liao Xin, Lu Jieyi, Huang Zhifeng, Lin Jinai, Zhang Miao, Chen Huanru, Lin Xiaoqing, Gao Xia, Gong Sitang

“…Functional protein expression is detected by western blot analysis or immunofluorescence microscopy. …”
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A Review of Exoplanet Detection Telescopes: Performance Design and Technology Optimization by Rui Sun, Qichang An, Xiaoxia Wu

“…In recent years, the progress in ground-based and space-based observation technologies has significantly enhanced the precision and efficiency of detection and promoted the implementation of more ground-based detection projects. …”
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MicroRNA‐378a‐3p contributes to ovarian cancer progression through downregulating PDIA4 by Yao Chanjiao, Chen Chunyan, Qiu Xiaoxin, Han Youjian

“…Western blot analysis was utilized to detect phosphatidylinositol‐3 kinase/serine/threonine kinase (PI3K/AKT) signaling pathway‐related protein expression and their phosphate expression levels. …”
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A research on the mechanism of SERPINA3 promoting malignant progression and gemcitabine resistance of pancreatic cancer by inhibiting ferroptosis by HE Yuan, GUO Juncheng, YE Zhibin, WANG Xiaohu, LI Haonan, HUANG Jingbiao

“…Background and purpose: Members of the serine protease inhibitor (SERPIN) family can influence tumorigenesis, progression, and prognosis by modulating processes such as apoptosis, invasion, metastasis, and angiogenesis in tumor cells. …”
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α5-nAChR/NETO2 contributed to chronic stress-promoted lung adenocarcinoma progression by Jingting Wang, Jiaying Cai, Zengping Wang, Shuran Yang, Jing Wang, Yanfei Jia, Haiji Sun, Xiaoli Ma

“…Nevertheless, the connection between α5-nAChR and NETO2 in LUAD progression induced by chronic stress remains unclear. …”
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Register of adult patients with noncompact left ventricular myocardium: classification of clinical forms and a prospective assessment of progression by E. V. Pavlenko, O. V. Blagova, N. V. Varionchik, A. V. Nedostup, V. P. Sedov, M. E. Polyak, E. V. Zaklyazminskaya

“…To study clinical forms of noncompact myocardium (NCM) in adults, the features of their manifestation, course and progression.Material and methods. The study included 116 adult patients with NCM of the left ventricle (LV) (67 men, mean age 46,3±15,1 years) and 42 patients with increased LV trabecularity (24 men, mean age 43,5±15,2 years). …”
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A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth. by Iratxe Zuazo-Gaztelu, David Lawrence, Ioanna Oikonomidi, Scot Marsters, Ximo Pechuan-Jorge, Catarina J Gaspar, David Kan, Ehud Segal, Kevin Clark, Maureen Beresini, Marie-Gabrielle Braun, Joachim Rudolph, Zora Modrusan, Meena Choi, Wendy Sandoval, Mike Reichelt, David C DeWitt, Pekka Kujala, Suzanne van Dijk, Judith Klumperman, Avi Ashkenazi

“…Immunoelectron microscopy detected some endogenous IRE1 protein at the nuclear envelope. …”
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Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…These results facilitate future research at the interface of genomic instability and replication stress during cancer progression.…”
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Survival analysis and clinical abnormalities in cats with progressive or regressive feline leukemia virus (FeLV) infection in Brazil. by Giovana Biezus, Thierry Grima de Cristo, Claudia Maria Flores Koehler, Flavia Yasmin de Quadros Kaveski, Thaís Sarria Viana Miranda, Paulo Eduardo Ferian, Renata Assis Casagrande

“…This study aimed to characterize the clinical presentations and effects of progressive and regressive outcomes of feline leukemia virus (FeLV) infection on the life expectancy of cats. …”
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Extracellular Mitochondrial‐Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction by Huihui Zhang, Zi Yan, Junyou Zhu, Ziyue Li, Lianglong Chen, Weihan Zheng, Zhenning Dai, Jiaxin Yang, Xinyi Yun, Yilin Wang, Hai Zhou, Ziwei Jiang, Qiuyi Yu, Shiyu Li, Wenhua Huang, Lei Yang

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CD44 and Its Role in Solid Cancers – A Review: From Tumor Progression to Prognosis and Targeted Therapy by João Martins Gama, Rui Caetano Oliveira

“…Immunohistochemistry effectively detects CD44 overexpression, enabling patients to be accurately selected for surgery and targeted anti-CD44 therapies. …”
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Radix Actinidia chinensis Suppresses Renal Cell Carcinoma Progression: Network Pharmacology Prediction and In Vivo Experimental Validation by Biao Liu, Liang Zhang

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CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance by Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang

“…CXCL6 modulates CCA progression through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping its lipid metabolism. …”
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A study on mechanisms of DMBT1’s regulation of occurrence and progression of chronic glomerulonephritis based on WNT signaling pathway by LU Zuo-kui, XU Wei-Jia, SHI Xou-yan

“…Objective To study the relative expression and methylation level of DMBT1 in human chronic glomerulonephritis(GGN), and to analyze the correlation of DMBT1 with the WNT/β-catenin signaling pathway in occurrence and progression of GGN.Methods The specimens of normal human kidney tissue( normal kidney tissue near the cancer tissue excised during kidney cancer surgery) from 30 cases of normal people, and damaged kidney tissue from 86 cases of GGN patients, were collected. …”
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Changes in JC virus-specific T cell responses during natalizumab treatment and in natalizumab-associated progressive multifocal leukoencephalopathy. by Molly R Perkins, Caroline Ryschkewitsch, Julia C Liebner, Maria Chiara G Monaco, Danielle Himelfarb, Sara Ireland, Annelys Roque, Heather L Edward, Peter N Jensen, Gina Remington, Thomas Abraham, Jaspreet Abraham, Benjamin Greenberg, Charles Kaufman, Chris LaGanke, Nancy L Monson, Xiaoning Xu, Elliot Frohman, Eugene O Major, Daniel C Douek

“…Progressive multifocal leukoencephalopathy (PML) induced by JC virus (JCV) is a risk for natalizumab-treated multiple sclerosis (MS) patients. …”
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Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice. by Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Issa Yusuf, Robert H Brown, Huaibin Cai, Zuoshang Xu

“…However, denervation was detected at the neuromuscular junction. These results demonstrate that low-level TDP-43 overexpression can cause diverse aspects of ALS, including late-onset and progressive motor dysfunction, neuroinflammation, and neurodegeneration. …”
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Expanding screening through the use of liquid biopsy for early cancer detection by Marta Perachino, Carolina Ortiz, Javier Carmona, Cristina Saura, Ana Vivancos

“…Screening programs have helped reduce cancer-specific mortality by detecting cancer at earlier stages. …”
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A positive feedback loop of SRSF9/USP22/ZEB1 promotes the progression of ovarian cancer by Jing Wang, Ming Hu, Jie Min, Xin Li

“…This study aimed to reveal the mechanism by which SRSF9 regulates OC progression. Cell proliferation was determined via CCK-8 assays, whereas cell migration and invasion were monitored via Transwell assays. …”
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Comparison of multi-state Markov models for cancer progression with different procedures for parameters estimation. An application to breast cancer by Leonardo Ventura, Giulia Carreras, Donella Puliti, Eugenio Paci, Marco Zappa, Guido Miccinesi

“…<p><strong>Background:</strong> the knowledge of sojourn time (the duration of the preclinical screen-detectable period) and screening test sensitivity is crucial for understanding the disease progression and the effectiveness of screening programmes. …”
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Escalating progression of mental health disorders during the COVID-19 pandemic: Evidence from a nationwide survey. by Li Ping Wong, Haridah Alias, Afiqah Alyaa Md Fuzi, Intan Sofia Omar, Azmawaty Mohamad Nor, Maw Pin Tan, Diana Lea Baranovich, Che Zarrina Saari, Sareena Hanim Hamzah, Ku Wing Cheong, Chiew Hwa Poon, Vimala Ramoo, Chong Chin Che, Kyaimon Myint, Suria Zainuddin, Ivy Chung

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