C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis. by Johnathan Cooper-Knock, Joanna J Bury, Paul R Heath, Matthew Wyles, Adrian Higginbottom, Catherine Gelsthorpe, J Robin Highley, Guillaume Hautbergue, Magnus Rattray, Janine Kirby, Pamela J Shaw

“…At the exon level, in lymphoblastoid cells derived from C9ORF72-ALS patients splicing consistency was lower than in lines derived from non-C9ORF72 ALS patients or controls; furthermore splicing consistency was lower in samples derived from patients with faster disease progression. Frequency of sense RNA foci showed a trend towards being higher in lymphoblastoid cells derived from patients with shorter survival, but there was no detectable correlation between disease severity and DNA expansion length.…”
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BRAF mutation in five cases of sinonasal ameloblastic tumors and their clinical course: a case report by Mioko Matsuo, Ryosuke Kuga, Tomomi Manako, Kazuki Hashimoto, Ryunosuke Kogo, Masanobu Sato, Takashi Nakagawa

“…Three were diagnosed with ameloblastoma, with one experiencing recurrence that progressed to a life-threatening condition owing to the lack of effective treatment. …”
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Construction of machine learning-based prognostic model of centrosome amplification-related genes for esophageal squamous cell carcinoma by LI Chaoqun, ZHENG Hongliang, HUANG Ping

“…Conclusion‍　‍DENR, TRIP13, TTF2 and TCFL5 are highly expressed and closely associated with poor prognosis of ESCC, suggesting their potential roles in the pathogenesis and progression of this malignancy. …”
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Descending necrotizing mediastinitis caused by Group A Streptococcus associated with influenza A infection by Ken-ichiro Kobayashi, Kenji Kubo, Nobuhiro Komiya

“…Subsequently, however, the appearance of erythema on the anterior neck and around the thyroid cartilage suggested a descending progression of the infection from the deep neck space. …”
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Absence of EpCAM in cervical cancer cells is involved in slug induced epithelial-mesenchymal transition by Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng, Nan Cui

“…Additionally, this study supports a potential way for Slug to initiate EMT progression in cervical cancer cells in addition to inhibiting E-cadherin.…”
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Effect of Dual Endothelin Receptor Antagonist on a Retinal Degeneration Animal Model by Regulating Choroidal Microvascular Morphology by Xiaowei Zhu, Xuming Lin, Ying Xu, Naiyang Li, Qing Zhou, Xiaowei Sun, Yuanbin Li

“…Plasma and local ET-1 was elevated in an animal model of RP, suggesting that it likely participates in the pathological progression of retinal degeneration and may thus provide a new intervention target. …”
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Electroacupuncture Regulates Macrophage Polarization to Alleviate the Neuropathic Pain Induced by Spared Nerve Injury by Shi G, Hao X, Tu JF, Chen W, Fu Y, Ma X, Liu C, Li H

“…The activation of macrophages and pro-inflammatory responses following peripheral nerve injury can effectively prevent the progression of neuropathic pain. Macrophage polarization to the M2 or M1 (respectively anti- and pro- inflammatory) phenotypes frequently occurs during neuroinflammation. …”
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The incidence of and risk factors for late presentation of childhood chronic kidney disease: A systematic review and meta-analysis. by Lucy Plumb, Emily J Boother, Fergus J Caskey, Manish D Sinha, Yoav Ben-Shlomo

“…<h4>Background</h4>When detected early, inexpensive measures can slow chronic kidney disease progression to kidney failure which, for children, confers significant morbidity and impacts growth and development. …”
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Prevalence of chronic diabetic complications and associated risk factors among follow-up diabetic patients: estimates from a referral national diabetes center in Yemen by Gamil Ghaleb Alrubaiee

“…Abstract Background Emergence and progression of diabetic complications are associated with several risk factors. …”
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Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy by Cemil Ertürk, Gürkan Çalışkan, Özcan Erel

“…The lowest and highest serum disulfide levels were detected in patients with grades 1 and 3, respectively (P < .001). …”
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Long-term follow-up of retinal amyloid angiopathy in a large Chinese family with hereditary amyloid transthyretin by Jiangning Xu, Nan Shu, Xi Liu, Peng Gu, Yi Wang, Shiying Li

“…We aimed to investigate the characteristics of disease progression of RAA in patients with ATTR Gly83Arg amyloidosis and evaluate the effect of RAA on vision. …”
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MicroRNA-337 inhibits cell proliferation and invasion of cervical cancer through directly targeting specificity protein 1 by Wei Dong, Baosheng Li, Juan Wang, Yipeng Song, Zicheng Zhang, Chengrui Fu

“…Therefore, the identification of specific microRNAs contributed to cervical cancer formation and progression would provide critical clues for the treatments for patients with this disease. …”
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On the Possibility of Expanding Indications for Refractive Correction of Ametropia (4 Clinical Cases) by A. D. Chuprov, Yu. V. Kanyukova, A. E. Voronina

“…During this period, stabilization of such parameters as intraocular pressure (IOP), progression of diabetic retinopathy, visual acuity was detected on all operated eyes. …”
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Association between uric acid to high-density lipoprotein cholesterol ratio and diabetic kidney disease in US adults by Chunmei Qin, Gang Li, Yunhua Yuan, Yi Zou

“…Weighted multivariate logistic regression was employed to evaluate the association between UHR and DKD, while restricted cubic spline analysis was performed to detect the shape of the dose–response relationships between UHR and DKD. …”
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Quid du port romain estuarien de Barzan (Charente-Maritime) ? by Vivien Mathé, Laurence Tranoy, Marion Druez, François Lévêque, Vincent Miailhe, Frédéric Pouget

“…The banks of the estuary were deeply eroded during the last glaciation and formed valleys that were subsequently flooded during the Holocene transgression. Later, the progressive inflow of fluvio-marine sediments became increasingly important in filling up the valleys that had become marshes. …”
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C-reactive protein-triglyceride glucose index and heart failure in US adults from NHANES 2001–2010 by Ningyi Cheng, Zhicheng Ma, Yukun Chen, Lei Jin, Liangwan Chen

“…Quartile analysis revealed a progressive increase in prevalent HF with higher CTI levels, and model 3 confirmed a nonlinear dose-response relationship (p < 0.001) with a threshold at 11.657. …”
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Defining long-term survivors in metastatic lung cancer: insights from a Delphi study in Spain by Enric Carcereny, Enric Carcereny, Manuel Domine, Ana Laura Ortega Granados

“…The definition of long-term survivors reached 58.3% consensus, defined as overall survival ≥ 3 years and/or progression-free survival ≥ 2 years. Identification of common features obtained 76.2% consensus on adenocarcinoma subtype of non-small-cell lung cancer, high PD-L1 expression, absence of brain metastasis, and fewer than two metastatic locations. …”
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Overexpression of MCL-1 in canine hepatocellular carcinoma and its efficacy as a prognostic marker by Jehun Baek, Jaeho Cho, Hun-kyeong Shin, Wan Hee Kim

“…The objective of this study was to detect MCL-1 protein in canine normal liver tissue and compare its expression level with that in HCC tissue using western blotting. …”
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Evaluation of the Anti-Alzheimer Activity of <i>Lycium barbarum</i> Polysaccharide in Aβ_1–42-Induced Neurotoxicity in Rat Model by Qingxin Lu, Yixin Meng, Haichi Feng, Xin Di, Xiaoli Guo

“…As a common neurodegenerative disorder, Alzheimer’s disease (AD) manifests as progressive memory loss, cognitive deficits, and dementia in older adults. …”
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The development and validation of a column chart for predicting the regression risk of CIN2 by Jingjing Ren, Hui Wang, Xiu Zhang, Min Hao

“…These factors include age at first sexual activity, ThinPrep cytologic test (TCT) results, Human papillomavirus (HPV) infection type, lesion area detected by colposcopy, and acetowhitening thickness. …”
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