Human papillomavirus genotyping using next generation sequencing (NGS) in cervical lesions: Genotypes by histologic grade and their relative proportion in multiple infections. by Jorge Alejandro Basiletti, Joan Valls, Tomás Poklépovich, María Dolores Fellner, Maryluz Rol, Rafael Alonso, Rita Mariel Correa, María Celeste Colucci, Mercedes Rodríguez de la Peña, Paula Gabriela Falabella, Agustina Saíno, Josefina Campos, Rolando Herrero, Maribel Almonte, María Alejandra Picconi

“…These results suggest that a reduction in genotypic diversity and/or an increase in the relative proportion of HR-HPVs in multiple infections can be considered as a biomarker for the potential risk of malignant progression.…”
Get full text

CIRC-0008798 and CIRC-0035967 as novel biomarkers in oral lichen planus and oral squamous cell carcinoma by Sara Bagheri Farahani, Farzaneh Jahangiri, Faranak Jamshidian

“…Our data may help researchers to predict the molecular mechanisms of novel circ-0008798 and circ-0035967 in the development and progression of oral cancer comprehensively. Moreover, the present data indicate that novel circ-0008798 and circ-0035967 targets may be a series of promising candidates as biomarkers for oral cancer. …”
Get full text

Gradient Descent Algorithm with Greedy Repositioning Using Power Deficit Aggregation of Wakes to Accelerate the Offshore Wind Farm Layout Optimization Problem in Irregular Concessi... by Angel Gaspar Gonzalez-Rodriguez, Juan Manuel Roldan-Fernandez, Javier Serrano-Gonzalez, José Vicente Muñoz-Díez

“…Irregular concession areas are easily treated using Stokes’ theorem to detect outer points.…”
Get full text

The Construction of ceRNA Regulatory Network Unraveled Prognostic Biomarkers and Repositioned Drug Candidates for the Management of Pancreatic Ductal Adenocarcinoma by Busra Aydin, Keziban Okutan, Ozge Onluturk Aydogan, Raghu Sinha, Beste Turanli

“…In addition to providing novel biomarkers for diagnosis that can be detected non-invasively, the secretion levels of hub genes-associated proteins were found in plasma, serum, and oral epithelium. …”
Get full text

LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke by Bin Liu, Wei Cao, Jian Xue

“…PI3K/AKT pathway might be involved in this regulating progression.…”
Get full text

Alterations of drug-resistant proteins in nasopharyngeal carcinoma after intensity-modulated radiation therapy with or without chemotherapy and correlation with clinicopathologic f... by GaoFeng Wang, Yuan Li

“…The short-term prognosis of the patients was observed and recorded, and the correlation between progression-free survival (PFS) and positive drug-resistant proteins was analyzed. …”
Get full text

Quantitative Expression of SFN, lncRNA CCDC18-AS1, and lncRNA LINC01343 in Human Breast Cancer as the Regulator Biomarkers in a Novel ceRNA Network: Based on Bioinformatics and Exp... by Mehrnoush Rishehri, Tahereh Etemadi, Leila Pisheh, Ghazaleh Koufigar, Mansoureh Azadeh

“…In this context, reports demonstrate that some long noncoding RNAs (lncRNAs) play significant regulatory roles in breast tumorigenesis and BC progression via various pathways and act as endogenous RNAs. …”
Get full text

Enhanced Bone Regeneration Using Demineralized Dentin Matrix: A Comparative Study in Alveolar Bone Repair by Nessma Sultan, Bassant Mowafey, Fatma Ata, Mona H. El-Zekrid, Soher Nagi Jayash

“…Histological analyses using H&E and Masson trichrome stains evaluated new bone formation, and immunohistochemistry detected osteopontin expression. Results: CBCT imaging revealed progressive increases in alveolar bone height and width across all groups over time. …”
Get full text

Tumor-derived exosomal miR-1247-3p promotes angiogenesis in bladder cancer by targeting FOXO1 by Zonglai Liu, Dan Du, Shizhong Zhang

“…Tumor-derived exosomes are highly correlated with tumor progression and angiogenesis. This study was designed to probe the role of tumor-derived exosomal miR-1247-3p in mediating the angiogenesis in bladder cancer. …”
Get full text

EZH2 expression in colorectal carcinoma: an evaluation of clinicopathological and prognostic value by Diren Vuslat Cagatay, Mecdi Gurhan Balci, Gizem Issin, Fatih Demir

“…No significant associations were detected with sex, stage, grade, lymph-node status, or vascular invasion. …”
Get full text

The real-world safety of Nivolumab: a pharmacovigilance analysis based on the FDA adverse event reporting system by Yutong Wu, Yue Zhou, Shiyue Xia, Zhaoyou Meng

“…The most frequently reported AEs included fatigue, dyspnea, musculoskeletal pain, decreased appetite, cough, nausea, and constipation. Notably, we detected several potential safety signals not currently listed in the prescribing information: Malignant neoplasm progression, weight decreased, sepsis myocarditis, encephalitis and hypotension.ConclusionsOur large-scale pharmacovigilance study identified significant safety signals associated with nivolumab, including previously unrecognized adverse drug reactions. …”
Get full text

Deep Learning for Multi-Tissue Cancer Classification of Gene Expressions (GeneXNet) by Tarek Khorshed, Mohamed N. Moustafa, Ahmed Rafea

“…Our proposed GeneXNet provides capabilities of detecting genetic alterations driving cancer progression by learning genomic signatures across multiple tissue types without requiring the prerequisite of gene feature selection. …”
Get full text

Expert Consensus on the Clinical Application of PI3K/AKT/mTOR Inhibitors in the Treatment of Breast Cancer (2025 Edition) by The Breast Cancer Expert Committee of the National Quality Control Center for Cancer, The Expert Committee on Cancer Prevention and Treatment of the Health China Research Center, The Society of Clinical Research on Oncology Medications of the China Anti‐Cancer Association, The Society of Onco‐Pathology of the China Anti‐Cancer Association

“…ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer. …”
Get full text

Orosomucoid 1 is a Potential Prognostic Biomarker for Uterine Sarcoma by Dan Yuan MS, Yue Huang MS, Ying Cai MS, Chi Zhang MS, Jin-Jing Wang MD, Jian-Guo Zhou MD

“…High ORM1 expression levels in US patients were associated with poor overall survival (OS) and progression-free survival (PFS) (P = .027 and P = .005, respectively). …”
Get full text

Artemisia sieberi: leave phytochemical screening, and biological activity with special emphasis on anticancer and anthelminthic efficacy by S.N. Maodaa, E.M. Al-Shaebi, A. Alatawi, R. Abdel-Gaber, S.A. Alawwad, D. A. Alhomoud, S. Al-Quraishy

“…Moreover, several anthelminthic drugs are associated with side effects and progressive increase in drug resistance. Currently, there is growing interest in discovering new antiparasitic agents from ethnomedicinal plants. …”
Get full text

In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain 23Na MRI study. by Aude-Marie Grapperon, Mohamed Mounir El Mendili, Adil Maarouf, Jean-Philippe Ranjeva, Maxime Guye, Annie Verschueren, Shahram Attarian, Wafaa Zaaraoui

“…ALS patients with limited TSC increase had slower progression of disability or predominant lower motor neuron phenotype or shorter disease duration.…”
Get full text

Prognostic effect of pretreatment serum gamma-glutamyl transferase in urological malignancies: a systematic review and meta-analysis by Feifan Song, Shiqiang Su, Xueqiao Zhang, Xiongjie Cui, Chao Li, Shen Li

“…The results indicated that elevated pretreatment serum GGT demonstrated a significant association with poorer overall survival (OS) (HR = 3.32, 95% CI: 2.51-4.39), cancer-specific survival (CSS) (HR = 1.95, 95% CI: 1.26-3.04), and progression-free survival (PFS) (HR = 2.34, 95% CI: 1.72-3.17). …”
Get full text

P26 | HUMAN CYTOMEGALOVIRUS-DRIVEN ADAPTIVE NK CELLS AND MATRIX METALLOPROTEINASES EXPRESSION AS KEY ELEMENTS IN ATHEROSCLEROTIC PLAQUE DESTABILIZATION

“…These adaptive NK cells have been associated with pq progression, though their role in pq destabilization remains to be fully understood. …”
Get full text

Rhabdomyolysis as an uncommon manifestation of anoctamin-5 muscular dystrophy by Tiago Dias da Costa, Marta Rodrigues, António Mateus-Pinheiro, Sónia Moreira

“…Although no muscle weakness was detected upon neurological examination, bilateral calf hypertrophy was noted. …”
Get full text

Impact of Experimentally Induced Pain on Logical Reasoning and Underlying Attention-Related Psychophysiological Mechanisms by Danièle Anne Gubler, Rahel Lea Zubler, Stefan Johannes Troche

“…., investing additional resources), which might not be detectable at the behavioral level but can be observed through psychophysiological measures. …”
Get full text