Molecular Targeted Enhanced Ultrasound Imaging of Flk1 Reveals Diagnosis and Prognosis Potential in a Genetically Engineered Mouse Prostate Cancer Model by Jim W. Xuan, Michael Bygrave, Fatma Valiyeva, Madeleine Moussa, Jonathan I. Izawa, Glenn S. Bauman, Alexander Klibanov, Fen Wang, Norman M. Greenberg, Aaron Fenster

“…Molecular imaging techniques used to detect the initiation of disease have the potential to provide the best opportunity for early treatment and cure. …”
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Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci. by Jacquelyn M Evans, Rooksana E Noorai, Kate L Tsai, Alison N Starr-Moss, Cody M Hill, Kendall J Anderson, Thomas R Famula, Leigh Anne Clark

“…However, the high incidence of the haplotype among healthy dogs indicated that additional genetic risk factors are likely involved in disease progression. We conducted genome-wide association studies in two modern breeds having common ancestry and detected strong associations with novel loci on canine chromosomes 10 (P-val = 2.3X10-12) and 31 (P-val = 3.95X10-8). …”
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TREATMENT MANAGEMENT IN MULTIPLE MYELOMA WITH RENAL DISORDER by Meryem Sener

“…Case: A 66-year-old male with progressive fatigue, dizziness, weight loss, and recurrent pneumonia was referred for anemia evaluation on 28.11.2024. …”
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A clinical study on community-acquired acute kidney injury requiring renal replacement therapy and its influencing factors by ZHANG Ting-min, JIANG Jun, REN Wei

“…The renal replacement therapy rate was 46.4%.(2) Hypovolemia, infection, history of nephrotoxic drug use, obstructive nephropathy, progression of chronic kidney disease were the main causes of community-acquired AKI. …”
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Unveiling HER2 immunoexpression in canine hepatoid gland neoplasms: clinicopathological and morphological associations by Hassadin Boonsriroj, Sahatchai Tangtrongsup, Jirapat Arunorat, Thanongsak Mamom, Pinkarn Chantawong

“…HER2-positive expression was detected in 50% of HGEs (score 2  +  ) and 73.3% of HGCs, with 36.4% of cases scoring 3   +   . …”
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Gut microbiota and osteoarthritis: epidemiology, mechanistic analysis, and new horizons for pharmacological interventions by Nianyi Sun, Nianyi Sun, Yinuo Zhao, Yinuo Zhao, Anren Zhang, Anren Zhang, Yu He

“…Emerging evidence suggests that gut microbiota dysbiosis is associated with the onset and progression of osteoarthritis (OA). While OA was traditionally considered a localized degenerative joint condition, it is now increasingly viewed as a systemic disorder involving low-grade inflammation and metabolic imbalance. …”
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The fibroblasts growth factor 21 study in patients with non-alcoholic fatty liver disease and hypertension comorbidities by O. Ya. Babak, K. A. Lapshyna

“…The results obtained characterize the cytokine FGF-21 as a promising predictor marker for NAFLD progression.…”
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AI-Driven Prediction of Symptom Trajectories in Cancer Care: A Deep Learning Approach for Chemotherapy Management by Joseph Finkelstein, Aref Smiley, Christina Echeverria, Kathi Mooney

“…The data were resampled into varying interval lengths to address this imbalance and improve the model’s ability to detect symptom escalation (n = 3 to n = 7 days). This allowed the model to predict significant changes in symptom severity across these intervals. …”
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Impact of arteriosclerosis on the functioning of arteriovenous fistula for hemodialysis by Stolić Radojica, Trajković Goran, Perić Vladan, Jovanović Aleksandar, Šubarić-Gorgieva Gordana

“…Numerous clinical studies have shown that the incidence of artheriosclerosis is higher in patients with progressive renal insufficiency. The aim of this study was to examine the incidence of artheriosclerosis in patients on chronic hemodialysis and its influence on survival and functioning of vascular access. …”
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Blood vessel invasion as a strong independent prognostic indicator in non-small cell lung cancer: a systematic review and meta-analysis. by Jun Wang, Jianpeng Chen, Xi Chen, Baocheng Wang, Kainan Li, Jingwang Bi

“…<h4>Background and objective</h4>Blood vessel invasion plays a very important role in the progression and metastasis of cancer. However, blood vessel invasion as a prognostic factor for survival in non-small cell lung cancer (NSCLC) remains controversial. …”
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Single-cell and multi-omics analysis reveals the role of stem cells in prognosis and immunotherapy of lung adenocarcinoma patients by Jianan Zheng, Haoran Lin, Wei Ye, Mingjun Du, Chenjun Huang, Jun Fan

“…BackgroundThe roles of stem cells in lung adenocarcinoma (LUAD) progression and therapeutic resistance have been recognized, yet their impact on patient prognosis and immunotherapy response remains unclear.MethodsSingle-cell RNA sequencing was performed to identify stem cell populations characterized by high expression of MKI67 and STMN1. …”
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Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. by Yasir Alhamdi, Daniel R Neill, Simon T Abrams, Hesham A Malak, Reham Yahya, Richard Barrett-Jolley, Guozheng Wang, Aras Kadioglu, Cheng-Hock Toh

“…We found that high PLY doses induced extensive cardiomyocyte lysis, but more interestingly, sub-lytic PLY concentrations triggered profound calcium influx and overload with subsequent membrane depolarization and progressive reduction in intracellular calcium transient amplitude, a key determinant of contractile force. …”
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Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models by Linyu Zhu, Menger Guo, Ling Wang, Shaomin Chen, Zhiyu Ye, Yuansheng Wu

“…Trifolirhizin may have therapeutic potential in improving the progression of psoriasis.…”
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The diagnostic and predictive potential of lncRNA CASC2 targeting miR-155 in systemic lupus erythematosus patients with nephritis complication by Nada R. Mohamed, Abeer l. Abd El-Fattah, Olfat Shaker, Ghadir A Sayed

“…The current study illustrated that both lncRNA CASC2 and miR-155 could act as valuable non-invasive diagnostic biomarkers for SLE and predicting LN among SLE patients, as well as their abilities to detect the disease severity and progression.…”
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Identifying the mitochondrial ribosomal protein MRPL13 as an oncogenic RBP that promotes proliferation, migration, and anti-apoptotic effects in esophageal cancer cells by Yaxi Song, Hui Wang, Shiyao Li, Weili Tao, Chunqing Li, Bin Wang, Caifeng Gong

“…RBP MRPL13 facilitated esophageal cancer progression.…”
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The triglyceride-glucose index as a predictor of cardiovascular abnormalities in obese patients by Refaat Fathy Abdelaal, Khaled Mohamed Ali Shehata, Michael Hany Shawky Gerges, Salma Mokhtar Osman

“…The TyG index has been progressively linked to the onset of CVD and unfavorable outcomes. …”
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Improving Cell Nuclei Segmentation in Pathological Tissues Using Self-Supervised Regression Method by Hesham Ali, Mostafa Hammouda, Mustafa Elattar, Sahar Selim

“…Digital pathology, integral to cancer diagnosis, heavily utilizes the analysis of whole slide images (WSIs) to detect cancer cells. Traditionally, WSIs are manually examined&#x2014;a process that is not only time-consuming but also subject to observer variability. …”
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EFFICACY OF GLOFITAMAB IN PRIMARY REFRACTORY LYMPHOMA: A CASE REPORT by Muzaffer Keklık, Kemal Fıdan, Ali Unal

“…The patient received dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (EPOCH-R) as first-line treatment. However, progression was detected by 18F-Fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) with computed tomography (CT). …”
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P36 | BIOLOGICAL ROLE OF DNA G-QUADRUPLEX DURING LIVER REGENERATION AFTER PARTIAL HEPATECTOMY

“…In WT mice, G4 positive cells were not detected at 0 hr after PHx, but were increased at 24 h and peaked at 36 h. …”
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Molecular sex differences in human serum. by Jordan M Ramsey, Emanuel Schwarz, Paul C Guest, Nico J M van Beveren, F Markus Leweke, Matthias Rothermundt, Bernhard Bogerts, Johann Steiner, Liliana Ruta, Simon Baron-Cohen, Sabine Bahn

“…<h4>Background</h4>Sex is an important factor in the prevalence, incidence, progression, and response to treatment of many medical conditions, including autoimmune and cardiovascular diseases and psychiatric conditions. …”
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