Epidemiological description of fire blight introduction patterns to Central Asia and the Caucasus region based on CRISPR spacer typing and genome analysis by Fabio Rezzonico, Saykal Bobushova, Dali Gaganidze, Mahabat Konurbaeva, Sergey Mukhanov, Sara Jordan, Tinatin Sadunishvili, Nataliya Drenova, Theo H. M. Smits, Tinatin Doolotkeldieva

“…Abstract In the last two decades, fire blight has progressively spread eastward from Europe and the Mediterranean area to several pome-fruit producing regions of Asia. …”
Get full text

High expression of TIG3 predicts poor survival in patients with primary glioblastoma by Hongxiang Wang, Hanchong Xu, Tao Xu, Cong Tan, Mei Jiang, Yihong Chen, Xinyu Hu, Jinxu Zhou, Junyan Shen, Rong Qin, Daiyu Hu, Qilin Huang, Min Wang, Lian Wang, Dongxia Duan, Yong Yan, Juxiang Chen

“…TIG3 (tazarotene-induced gene 3) has been reported to suppress the progression of several malignancies, where this gene is universally downregulated. …”
Get full text

Intestinal microbiota in adults with cholangiocarcinoma identifies the dysregulated Blautia species and bile acid metabolic pathways by Tianyu De, Tian Ma, Wei Wang, Xusheng An, Di Liu, Hongkun Yin, Qi Wang, Ting Zhao, Hao Wang

“…The gut and bile microbiota, which can influence the gut-liver axis and disease progression, have not been thoroughly characterized in CCA patients. …”
Get full text

p53 in colorectal cancer: from a master player to a privileged therapy target by Sicheng Yan, Fuyuan Zhan, Yuxuan He, Yuehong Zhu, Zhihong Ma

“…Loss of genetic stability facilitates the conversion of proto-oncogenes into active oncogenes and the functional impairment of tumor suppressors, collectively propelling CRC progression. The tumor suppressor protein p53, a transcription factor, induces cell cycle arrest, apoptosis, and DNA damage repair under cellular stress, and prevents cancer development by regulating various cellular responses. …”
Get full text

Untargeted metabolomics investigating porcine reproductive and respiratory syndrome virus biomarkers of serum‐derived exosomes in piglets infected with PRRSV NADC30‐like CHsx1401... by Feng Cheng, Jia Li, Chunxiang Zhou, Lei Zhou, Ganqiu Lan, Jing Liang, Lixian Wang, Ligang Wang

“…A total of 41 differential metabolites were detected, with 14 upregulated and 27 downregulated metabolites with PRRSV infection. …”
Get full text

Development and characterization of experimental ZnO cement containing niobophosphate bioactive glass as filling temporary material by Paulo Vitor Campos Ferreira, Gabriel Flores Abuna, Bárbara Emanoele Costa Oliveira, Simonides Consani, Mário Sinhoreti, Ceci Nunes Carvalho, José Bauer

“…The NbG incorporation progressively increased the compressive strength values in the experimental groups. …”
Get full text

‘It does not end with delivery?’ Pregnancy-associated thrombotic microangiopathy in the setting of postpartum preeclampsia/eclampsia – case report by I. Ivanko, Ž. Dika, I. Ćelap, V. Vukosav, P. Gaćina, J. Josipović

“…No high-risk polymorphism for aHUS were detected, rather multiple common risk variants for complement mediated TMA. …”
Get full text

MDM2 inhibitor induces apoptosis in colon cancer cells through activation of the CHOP-DR5 pathway, independent of p53 phenotype by Manman Lu, Manman Lu, Yingli Ren, Sijia Feng, Shenggen Wang, Weiyue Xia, Baoru Gu, Yuhou Shen, Yuhou Shen, Aimin Yue, Aimin Yue, Na Li, Yongxi Zhang, Yongxi Zhang, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong

“…IntroductionMurine double minute 2 (MDM2), a key negative regulator of p53, forms a feedback loop with p53 to drive tumor progression, including colorectal cancer. Nutlin-3a, an MDM2 inhibitor, induces apoptosis in wild-type p53 tumors, but its effects on p53-mutated cancers and potential p53-independent apoptotic mechanisms remain unclear.MethodsWe investigated Nutlin-3a's effects on colon cancer cells with varying p53 phenotypes. …”
Get full text

Visualizing Aortic Inflammation by Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) by Asuka Suzuki, Koji Hayashi, Mamiko Sato, Yuka Nakaya, Toyoaki Miura, Naoko Takaku, Toshiko Iwasaki, Yasutaka Kobayashi

“…He remained asymptomatic and progressed well during rehabilitation, prompting continued observation. …”
Get full text

Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer by Ksenia Lenkova, Rita Khusainova, Raushaniya Minyazeva, Aliya Zaripova, Irina Gilyazova, Natalia Mokrysheva, Ildar Minniakhmetov

“…Results: A total of 148 nucleotide variants were detected within the cohort. Of these, 35 variants (23.6%) were classified as benign. …”
Get full text

Post-transplant indolent T cell lymphoproliferative disorder in living donor liver transplantation: a case report by Ryoichi Goto, Norio Kawamura, Masaaki Watanabe, Yasuyuki Koshizuka, Souichi Shiratori, Momoko Ara, Shohei Honda, Tomoko Mitsuhashi, Yoshihiro Matsuno, Tsuyoshi Shimamura, Akinobu Taketomi

“…Case presentation A 7-year-old boy had severe diarrhea and weight loss progressively at 7 years post-living donor liver transplantation (LDLT) for biliary atresia. …”
Get full text

Impact of Microbiota Diversity on Inflammatory Bowel Disease by Ashwag J. Alzahrani, Basma M. Al-Hebshi, Zolfekar A. Yahia, Effat A. Al-Judaibi, Khloud H. Alsaadi, Awatif A. Al-Judaibi

“…These results indicate that microbiota could play a role in the pathogenesis of IBD and suggest that microbial diversity can serve as a biomarker for diagnosing the disease and monitoring its progression.…”
Get full text

Projection neurons are necessary for the maintenance of the mouse olfactory circuit by Luis Sánchez-Guardado, Peyman Razavi, Bo Wang, Antuca Callejas-Marín, Carlos Lois

“…We used a genetic method to progressively eliminate the vast majority of M/T cells in early postnatal mice, and observed that the assembly of the OB bulb circuits proceeded normally. …”
Get full text

Integrative bioinformatic analysis identifies differentially expressed gene targets as potential biomarkers for anaplastic thyroid cancer by Angel Sebastian Treviño-Juarez, Jose Gerardo Gonzalez-Gonzalez, Rene Rodriguez-Gutierrez, Adriana Sanchez-Garcia, Camilo Daniel Gonzalez-Velazquez

“…To gain insights into the molecular mechanisms involved in its progression, we performed an integrative bioinformatic analysis. …”
Get full text

Genetic Investigation of Complement Pathway Genes in Type 2 Diabetic Retinopathy: An Inflammatory Perspective by Ming Ming Yang, Jun Wang, Hong Ren, Yun Duan Sun, Jiao Jie Fan, Yan Teng, Yan Bo Li

“…Among the six C5 SNPs, a marginal association was first detected between rs17611 and total DR patients (P=0.009, OR = 0.53 for recessive model). …”
Get full text

Viral-Track integrated single-cell RNA-sequencing reveals HBV lymphotropism and immunosuppressive microenvironment in HBV-associated hepatocellular carcinoma by Zhepeng Liu, Wajeeha Naz, Tanzeel Yousaf, Junwei Sun, Qijia Wu, Mingxiong Guo, Geng Tian, Guihong Sun

“…Abstract The tumor microenvironment (TME) is a crucial mediator of tumor progression and treatment response. Here, we compare the immune microenvironments of HBV and non-HBV hepatocellular carcinoma (HCC) and investigate the reason for the persistence of HBV infection in the liver. …”
Get full text

A clinical case of systemic amyloidosis in a cardiologists’s practice by V. G. Okorokov, O. V. Evsina, V. A. Fomina, G. O. Ivanova, E. S. Soldatov, D. V. Dianov, K. A. Tkachenko, A. V. Ganyuta

“…The high level of creatinine, normochromic anemia have detected. In June 2016 chronic pyelonephritis was diagnosed. …”
Get full text

Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy by A A Afonin, M V Komkova, G A Galkina, N V Morozova

“…NOx metabolites were detected with Griess reagent (Aldrich Chemical Co, USA). …”
Get full text

ACSM2B rs73530508 polymorphism affects susceptibility to esophageal cancer by regulating indolepropionic acid levels by Yun Chen, Ruijun Lin, Qianhua Luo, Tao Liu, Xiaoyan Li, Danling Zheng, Siman Su, Meini Chen, Jianxiang Huang, Yihui Huang, Shuyao Zhang

“…High-throughput sequencing techniques were utilized to detect candidate coding genetic variants, and dominant genetic models were used to elucidate the genotypic associations. …”
Get full text

Association between genetic variants in hsa-miR-27a and hsa-miR-146a genes and male infertility by Rajovski Srećko, Matijašević-Joković Suzana, Milanović Nikoleta, Radovanović Nemanja, Brkušanin Miloš, Savić-Pavićević Dušanka, Dobrijević Zorana, Brajušković Goran

“…Still, the number of participants with CC genotype in subjects diagnosed with asthenoteratozoospermia was null, while in controls, it reached 7.2%. We further detected the rs895819 genotype-dependent difference in rapid progressive sperm motility. …”
Get full text