Estimation of Serum TLR-9,TNF-α, and IL-6 Levels in the Iraqi Patients Diagnosed as Acute Myelogenous Leukemia by Maryam Qasim Mohammed, Ali Hussein Alwan, Asmaa Amer Almukhtar

“…The ROC curve's findings revealed that all parameters have good sensitivity and specificity for detecting inflammation and disease activity in AML patients. …”
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Prediction of exacerbation frequency of AECOPD based on next-generation sequencing and its relationship with imbalance of lung and gut microbiota: a protocol of a prospective cohor... by Yinji Xu, Li Deng, Jiali Yan, Huachong Xu, Chunzhen Huang, Yiwen Lv, Qianxin Wu, Xiaoyin Chen

“…Introduction Patients with frequent acute exacerbation phenotype chronic obstructive pulmonary disease (AECOPD) have a higher hospitalisation rate than infrequent exacerbation, the disease progresses quickly and treatment is more difficult. …”
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Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells by Yueh-Lun Lee, Che-Jen Hsiao, Fan-Li Lin, Jing-Shiun Jan, Yung-Chen Chou, Yen-Yu Lin, Chih-Kuang Chen, Kwok-Keung Lam, George Hsiao

“…Much evidence has indicated that matrix metalloproteinases (MMPs) participate in the progression of neuroinflammatory disorders. The present study was undertaken to investigate the inhibitory effect and mechanism of the antipsychotic haloperidol on MMP activation in the stimulated THP-1 monocytic cells. …”
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Revisiting the Link Between Keratoconus and Mitral Valve Prolapse by Christian K. Five, Nina E. Hasselberg, Hilde Bjerkreim, Linda T. Aaserud, Anna Isotta Castrini, Cecilie Bugge, Eivind W. Aabel, Thomas Helle-Valle, Håvard Dalen, Olav Kristianslund, Kristina H. Haugaa

“…Keratoconus is a progressive eye disease that results in thinning of the cornea, leading to visual impairment. …”
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Fatty Acid Binding Protein 4 Regulates the Antigen‐Presenting Function of Dendritic Cells Resulting in T Cell Priming in Streptozotocin‐Induced Type 1 Diabetes Mice by Hailan Zou, Lingxiang Xie, Jingyi Hu, Rong Zhang, Yanfei Wang, Aimin Xu, Zhiguang Zhou, Xiaoyu Xiao, Yang Xiao

“…ABSTRACT Background Type 1 diabetes is an autoimmune disease with progressive destruction of insulin‐producing β cells in islets of Langerhans of the pancreas. …”
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Seeding activity of skin misfolded tau as a biomarker for tauopathies by Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Zahid Syed Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zou

“…They include Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick’s disease (PiD). …”
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Role of Iron in Children With Immunoglobulin A Nephropathy and Macrohematuria-Induced Acute Kidney Injury by Shingo Ishimori, Tomoko Horinouchi, Tomohiko Yamamura, Junya Fujimura, Naohiro Kamiyoshi, Hiroshi Kaito, Yuriko Tanaka, Hiroyoshi Matsukura, Wataru Shimabukuro, Yuko Shima, Azusa Kawaguchi, Yoshinori Araki, Koichi Nakanishi, Shigeo Hara, Kandai Nozu

“…Berlin Blue staining was detected predominantly at the injured tubulointerstitium, and the areas of staining in children with MH(+)AKI(−) and MH-AKI IgAN were significantly more extensive. …”
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GLP1R boosts survival, migration and invasion of endometrial cancer cells and protects against ferroptotic cell death by Wu Li, Wen Lyu, Songjun Liu, Fan Ruan, Xinmei Zhang

“…This study investigated the properties of GLP1R on EC in vitro.Methods The expression of GLP1R in EC was detected by RT-qPCR, immunohistochemistry, and western blotting. …”
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Use of a Silicon Microneedle Chip-Based Device for the Extraction and Subsequent Analysis of Dermal Interstitial Fluid in Heart Failure Patients by Markus Renlund, Laurenz Kopp Fernandes, Pelle Rangsten, Mikael Hillmering, Sara Mosel, Ziad Issa, Volkmar Falk, Alexander Meyer, Felix Schoenrath

“…The study is part of the European project DIGIPREDICT—Digital Edge AI-deployed DIGItal Twins for PREDICTing disease progression and the need for early intervention in infectious and cardiovascular diseases beyond COVID-19.…”
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Rapid Clinical Resolution and Differential Diagnosis of a Neurological Case of Feline Infectious Peritonitis (FIP) Using GS-441524 by Amy Huynh, Pamela Moraguez, Logan M. Watkins, Jonathan H. Wood, Ximena A. Olarte-Castillo, Gary R. Whittaker

“…Case summary: A 2-year-old male neutered domestic shorthair cat was presented with a progressive history of tetraparesis, ataxia, and inappetence over 4 days. …”
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Spatial and social determinants of tuberculosis in the Brazilian Amazon: a five-year multilevel and cluster-based analysis in Pará state, 2018-2022 by C. Andrade-Sales, P. A. Mendonça-Cavalcante, A. P. Simões-Castro, M. P. Moreira-Sena, A. P. Galvão-Fonseca, A. G. N. Cardoso-Mello, C. A. Abreu-Alberio, J. L. Fernandes-Vieira, L. W. Pereira-Sena

“…Spatial analysis revealed persistent high-risk clusters in the Metropolitan Region of Belém and a progressive expansion into Southeastern and South-Central municipalities. …”
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A Finite Element Approach to the Upper-Bound Bearing Capacity of Shallow Foundations Using Zero-Thickness Interfaces by Yu-Lin Lee, Yu-Tang Huang, Chi-Min Lee, Tseng-Hsing Hsu, Ming-Long Zhu

“…The model incorporates multi-segment zero-thickness interface elements to accurately simulate soil discontinuities and progressive failure mechanisms, based on the Mohr–Coulomb failure criterion. …”
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Novel variant in WT1 gene associated with MGD and unique kidney disease phenotype by Heba A. Hassan, Inas Mazen, Mona K. Mekkawy, Aya Elaidy, Alaa Kamel, Mona L. Essawi

“…Follow-up is essential in WT1-related disorders to prevent tumor development and/or end-stage renal failure progression.…”
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Inhibition of the LINE1-derived MET transcript induces apoptosis and oncoprotein knockdown in cancer cells by Umberto Miglio, Enrico Berrino, Daniele Avanzato, Ivan Molineris, Valentina Miano, Melissa Milan, Letizia Lanzetti, Eugenio Morelli, James M. Hughes, Michele De Bortoli, Anna Sapino, Tiziana Venesio

“…Among these, L1-MET, within mesenchymal epithelial transition (MET) oncogene, is particularly interesting, as its expression has been associated with the acquisition of tumorigenic phenotypes and cancer progression. We investigated the effects of targeting L1-MET in eight cancer cell lines derived from breast, lung, and gastrointestinal cancers, as well as in non-transformed human fibroblasts and lymphocytes, using specifically developed modified antisense oligonucleotides. …”
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Up-and-down determination of prophylactic norepinephrine boluses combined with crystalloid co-load for preventing post-spinal anesthesia hypotension during cesarean section by Chengfei Xu, Peipei Zhang, Chunying Dai, Jingjun Zhang, Honghao Wu, Qianying Liu, Zhiqiang Zhang, Fengwei Yin, Huadong Ni, Liang Cheng

“…The dosages of norepinephrine were established employing the up-and-down sequential allocation technique, starting with 8 µg and progressively rising by 1 µg increments. The primary objective was to detect the effective dosage (ED90 and ED50) of norepinephrine necessary to avoid hypotension following spinal anesthesia. …”
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Diagnostic potential of cell-free fetal nucleic acids in predicting pregnancy complications: A systematic review and meta-analysis on trisomy, pre-eclampsia, and gestational diabet... by Jiut Ram Keshari, Pritam Prakash, Seema Rani Sinha, Prem Prakash, Kirti Rani, Tarique Aziz, Shaily Shilpa

“…Objective: This article assesses the role of cff nucleic acids as potential diagnostic markers for the prediction and monitoring progression of severe pregnancy-related complications. …”
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Clinical analysis of histiocytic necrotizing lymphadenitis in adults with fever of unknown origin: a retrospective study by Nana Xie, Wencong Zhang, Fangbing Tian, Jia Chen, Wenyuan Zhang, Qiurong Ruan, Jianxin Song

“…Corticosteroid achieved favorable responses, with only 2 cases progressing during follow-up. Conclusion In clinical practice, patients with fever and lymphadenopathy should be given due attention. …”
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A national survey of physicians regarding active surveillance for low-risk thyroid cancer in Korea by Min Joo Kim, Jae Hoon Moon, Eun Kyung Lee, Young Shin Song, Kyong Yeun Jung, Ji Ye Lee, Ji-hoon Kim, Woojin Lim, Kyungsik Kim, Sue K. Park, Young Joo Park

“…Challenges in screening candidates for AS were highlighted, especially in detecting recurrent laryngeal nerve involvement and lymph node metastases. …”
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Evaluating the effect of voxel size on the accuracy of 3D volumetric analysis measurements of brain tumors by Rithvik S. Ghankot, Manwi Singh, Shelby T. Desroches, Noemi Jester, Amit Mahajan, Samantha Lorr, Frank D. Buono, Daniel H. Wiznia, Daniel H. Wiznia, Michele H. Johnson, Steven M. Tommasini, Steven M. Tommasini

“…IntroductionNeurofibromatosis type 2 related Schwannomatosis (NF2-SWN) is a genetic disorder characterized by the growth of vestibular schwannomas (VS), which often leads to progressive hearing loss and vestibular dysfunction. …”
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Persistent elevations of alkaline phosphatase as an early indicator of GM1 gangliosidosis by Iskren Menkovic, Monika Williams, Neelam Makhijani, Ruhan Wei, Sarah P. Young, Areeg El-Gharbawy, Ashlee R. Stiles

“…This case also highlights the utility of repeat skeletal surveys with abnormalities detected at 3 months of age.…”
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