Phage therapy in antibiotic resistant pneumonia: immunomodulation or redistribution? by S. S. Bochkareva, I. M. Fedorova, O. N. Ershova, S. I. Koteleva, I. V. Kapustin, M. S. Blyakher, L. I. Novikova, A. V. Aleshkin, А. М. Vorobev

“…Statistical processing of the results was carried out using the Statistica 6 program according to the nonparametric Mann-Whitney U-test. …”
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The Cut-Off Values of Anthropometric Indices for Identifying Subjects at Risk for Metabolic Syndrome in Iranian Elderly Men by Mojgan Gharipour, Masoumeh Sadeghi, Minoo Dianatkhah, Shirin Bidmeshgi, Alireza Ahmadi, Marzieh Tahri, Nizal Sarrafzadegan

“…WC has the best ability to detect MetS which followed by WHtR and BMI had a lower discriminating value comparatively. …”
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Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis by Mohsen Yari, Milad Eidi, Mohammad-Amin Omrani, Zahra Fazeli, Mohammad Rahmanian, Soudeh Ghafouri-Fard

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Predominance of gram-negative multidrug-resistant pathogens causing lower respiratory tract infections among gene X-pert negative presumptive tuberculosis patients in Dar Es Salaam... by Irene Rabiel, Mtebe Majigo, Loveness Urio, Lilian Nkinda, Peter Richard Torokaa, Elieshiupendo M. Niccodem, Mabula Kasubi, Doreen Kamori, Joel Manyahi, Agricola Joachim

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Spatial and temporal analysis of Rift Valley fever outbreaks in livestock in Uganda: a retrospective study from 2013 to 2022 by Eugene Arinaitwe, David Kalenzi Atuhaire, Emmanuel Hasahya, Nakanjako Gladys K, Robert Mwebe, Gerald Nizeyimana, Mathias Afayoa, Frank Norbert Mwiine, Joseph Erume

“…Abstract Background Rift Valley fever (RVF) is a zoonotic disease caused by the Rift Valley fever virus (RVFV), primarily affecting livestock and transmitted by Aedes mosquitoes. First detected in Kenya in 1930, RVF has since spread across Africa, including Uganda, and to the Arabian Peninsula. …”
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Long-read sequencing reveals novel structural variation markers for key agronomic and quality traits of food-grade soybean by Zhibo Wang, Kassaye Belay, Kassaye Belay, Joe Paterson, Patrick Bewick, William Singer, Qijian Song, Bo Zhang, Song Li

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Combination of a therapeutic cancer vaccine targeting the endogenous retroviral envelope protein ERVMER34-1 with immune-oncology agents facilitates expansion of neoepitope-specific... by Renee N Donahue, Jeffrey Schlom, James L Gulley, Claudia Palena, Duane H Hamilton, Masafumi Iida, Maria del Mar Maldonado, Maria Gracia-Hernandez, Loc Huu Le

“…ERVMER34-1-specific T cells were detected in peripheral blood mononuclear cells (PBMCs) of patients with cancer but not healthy donors following an overnight stimulation. …”
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Multi-Omics and Sensory Analysis of <i>Coffea canephora</i>: Assessing the Impact of Roasting Speed on Safety and Energy Efficiency by Sara Triachini, Pier Paolo Becchi, Terenzio Bertuzzi, Ettore Capri, Mario Gabrielli, Luigi Lucini, Fosca Vezzulli

“…The roaster and gas valve employed may influence the efficacy of the “Energy Calculator” of the roasting program “Artisan” (v. 2.10.4), requiring an appropriate configuration. …”
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Childbirth experiences in women with polycystic ovary syndrome: A cohort study by Anne Engtrø Husby, Melanie Rae Simpson, Rebecka Dalbye, Marit Larsen, Eszter Vanky, Tone Shetelig Løvvik

“…The PregMet2 study (ClinicalTrials.gov, NCT01587378) investigated the use of metformin vs. placebo in pregnant women with PCOS. The Labour Progression Study (ClinicalTrials.gov, NCT02221427) compared the WHO partograph to Zhang's guidelines for progression of labor and were used as the reference population. …”
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Transcriptome sequencing–based analysis of the molecular mechanism underlying the effect of lncRNA AC003090.1 on osteoporosis by Huafeng Zhuang, Yongjun Lin, Chengye Lin, Miao Zheng, Yizhong Li, Xuedong Yao, Youjia Xu

“…Abstract Objective To analyze changes in the expression of osteoporosis (OP)-related genes across different bone types based on transcriptome sequencing, and to identify the key molecules and mechanisms involved in the progression of OP in order to better understand this process. …”
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Deciphering the roles of non-coding RNAs in liposarcoma development: Challenges and opportunities for translational therapeutic advances by Zhi Xiong Chong, Wan Yong Ho, Swee Keong Yeap

“…By affecting the expressions and activities of their downstream targets post-transcriptionally, dysregulations of miRNAs can alter different oncogenic signalling pathways, mediating liposarcoma progression. On the contrary, lncRNAs can sponge miRNAs to spare their downstream targets from translational repression, indirectly affecting miRNA-regulated oncogenic activities. …”
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Nectin-4 significance in malignant neoplasms of the female reproductive system: a review of current data by E. G. Romanov, K. A. Kokurina, A. A. Fedotova, Zh.E.A.K. Massolu, A. I. Andreeva, T. S. Khristoforova, R. A. Ivanova, K. V. Tarasova, M. A. Ivanov, A. E. Klyukina, M. A. Sharafan, E. V. Medvedko, M. P. Modenova

“…Its expression is associated with aggressive disease progression and drug resistance, especially in ovarian, endometrial and cervical cancers. …”
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Mutation-based, neoadjuvant treatment for advanced anaplastic thyroid carcinoma by Sabine Wächter, Detlef K. Bartsch, J. Riera Knorrenschild, Anika Pehl, Friederike Eilsberger, Andreas Pfestroff, Markus Luster, Katharina Holzer, Andreas Neubauer, Elisabeth Maurer

“…A BRAFV600E-mutation was detected in two patients. Following neoadjuvant therapy, eight patients showed tumor regression, whereas three exhibited an inadequate response, characterized by disease progression or a mixed response on FDG-PET/CT. …”
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Modern diagnostic potentials of studying structural and functional changes of the retina and the optic nerve in multiple sclerosis patients by A. Zh. Fursova, M. Yu. Zubkova, M. A. Vasilyeva, Yu. A. Gamza, N. A. Malkova, A. I. Prokaeva, F. K. Rabota

“…Significant functional and structural changes in the retina and the optic nerve were detected, correlating with the duration of the disease and with the clinical features of the course of multiple sclerosis. …”
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Improving the conditions of regional hemodinamics of the eyes as a method of treatment in optic neuropathy at short-sightedness of high degree. by N. G. Zavgorodnyaya, O. O. Denisova, N. A. Vesnina, N. A. Kudinova- Savchenko

“…Exclusion criteria were : myopia more than 6.0 diopters , progressive form of the disease , opaque optical surroundings, clinically significant comorbidity (glaucoma, diabetes, etc.). …”
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Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma by Zhixin Sun, Jacqueline M. Godbe, Alexander Zheleznyak, Brad Manion, Junhao Hu, Julie L. Prior, Kathleen Duncan, Ulugbek S. Kamilov, Monica Shokeen

“…Using precise CT-based alignment (DICE = 0.966 ± 0.005), we detected early disease progression and aggressive phenotypes. …”
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CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model by Shih-Hsuan Chan, Chin-Yu Lin, Hsuan-Jung Tseng, Lu-Hai Wang

“…Abstract Background CD24 plays a crucial role not only in promoting tumor progression and metastasis but also in modulating macrophage-mediated anti-tumor immunity. …”
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Changes in 25-hydroxy-vitamin D3 level and relevant factors in chronic kidney disease by SUN Da, WANG Jiao-jiao, WANG Li-ning, WANG Juan, LIU Lin-lin, LI Zi-long

“…Objective To measure the plasma level of 25-hydroxy-vitamin D3[25(OH)D3]in non-dialysis patients with chronic kidney disease(CKD) at different stages,and to investigate the correlations between the levels of 25(OH)D3 and the progression of CKD.Furthermore,we explored the effective application of active vitamin D in CKD.Methods We included 885 non-dialysis CKD patients and 11 patients with acute kidney disease(AKI) hospitalized in the Department of Nephrology in the First Affiliated Hospital of China Medical University from Nov.2014 to Nov.2015.Serum 25(OH)D3 levels and other clinical parameters were detected.We further analyzed the prevalence rate of vitamin D insufficiency and deficiency at different stages of CKD,the trend of other relevant biochemical parameters at various groups of vitamin D level,and the correlations between 25(OH) D3 level and the factors.Results(1) With the progression of kidney disease,remarkable increasing trend was found in prevalence rate of vitamin D severe deficiency..The 25(OH) D3 concentration in AKI was(15.8 ±9.16) ng/mL,which was significantly higher than that of each stages of CKD(P<0.05).With the decrease of 25(OH) D3 concentration,the level of blood pressure(systolic pressure and diastolic pressure) increased,proteinuria deteriorated,the level of serum albumin decreased,calciumphosphorus metabolic disorder(blood calcium decreased,blood phosphorus elevated) and lipid metabolic abnormality aggravated.The differences in 25(OH) D3 levels among the groups were statistically significant(P<0.05).But age,left ventricular ejection fraction,the kidney function indexes,bone metabolism indexes,serum uric acid,hemoglobin and C-ractive protein were not statistically significant(P>0.05).(2) 25(OH) D3 levels were correlated with proteinuria.The concentrations of 25(OH) D3 in moderate proteinuria group and massive proteinuria group were remarkably lower than those in micro-proteinuria group and normal group- respectively(P<C0.05).Remarkable distinction was.found in prevalence rate of vitamin D severe deficiency at various groups,and higher prevalence rate tended to favor more advanced proteinuria group.The discrepancies in deficiency prevalence were statistically significant(χ~2 = 251.75,P= 0.000).(3) Pearson’s correlation analyses revealed that serum albumin,calcium and hemoglobin were positively correlated with serum 25(OH) D3,whereas systolic pressure,diastolic pressure,24-h urine protein,serum phosphorous and blood lipids(TC,TG,LDL-C,and HDL-C) were negatively correlated with 25(OH) D3.Multiple linear regression analyses demonstrated that serum albumin,systolic pressure,24-h urine protein and hemoglobin were the independent risk factors of vitamin D deficiency in non-dialysis CKD patients.Conclusions In the northeast of China,vitamin D deficiency in non-dialysis CKD patients was frequent and serious.The change in 25(OH) D3 concentration was correlated with the clinical parameters of CKD.Serum albumin,systolic pressure,24-h urine protein and hemoglobin were the independent risk factors of vitamin D deficiency.…”
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RanViz: Ransomware Visualization and Classification Based on Time-Series Categorical Representation of API Calls by Vhuhwavho Mokoma, Avinash Singh

“…First, the sheer volume of Application Programming Interface (API) call data generated by ransomware during execution can overwhelm traditional analysis methods. …”
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The fish helminth fauna of Lake Sevan during a period of water level change by R. L. Hovhannisyan, M. Ya. Rukhkyan, L. D. Harutyunova, M. Z. Magomedova, P. D. Magomedova

“…Statistical processing of the material was carried out using the BioStat 2009 computer program. 124 specimens of molluscs were examined from the littoral of the Lake Sevan. …”
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