Multiparametric MRI for local staging in patients with suspected muscle-invasive bladder cancer: study protocol for a multicentre, non-inferiority randomised controlled trial (the... by Lambertus ALM Kiemeney, Janneke PC Grutters, Erik J.R.J. van der Hoeven, Janneke P.C. Grutters, Antoine G van der Heijden, Sebastiaan W van Koeverden, Lisa MC van Hoogstraten, Maarten de Rooij, Marloes van der Leest, Arnold Baars, Thierry N. Boellaard, Joost L. Boormans, Lars E.J. Bosboom, Quirijn J.A. van den Bouwhuijsen, Siebren Dijkstra, Cristina E. Firanescu, Jurgen J. Fütterer, Ernst P. van Haarst, Tom J.N. Hermans, Marina C. Hovius, Josephine C.B.M. Huige, Michael D.H. Kortleve, Anneke Kusters, Geert J.L.H. van Leenders, Saskia van der Meer, Richard P. Meijer, Harm H.E. van Melick, Laura S. Mertens, Gerd-Jan Molijn, Rinze Reinhard, Ivo G. Schoots, Petra C.G. Simons, Ruth Smit, Femke Struik, Julie Swillens, Charlotte J Tutein Nolthenius, Jeroen Veltman, Andre N. Vis, Thijn F. de Vocht, Jeanette van Vooren, Frank J. Wessels, Carl J. Wijburg, Dennis de Witte, Monique Arts-Thijssen, Guus Venderbosch

“…The primary outcome is 2-year progression-free survival. Progression will be assessed by imaging, according to the current standard of care. …”
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Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angola by Cruz S. Sebastião, Victor Pimentel, Domingos Jandondo, Joana M.K. Sebastião, Euclides Sacomboio, Marta Pingarilho, Miguel Brito, Edson Kuatelela Cassinela, Jocelyne Neto de Vasconcelos, Ana B. Abecasis, Joana Morais

“…The CCR5-Delta32, CCR2-64I, and SDF1-3′A genotypes were detected by conventional PCR and visualised on 2% agarose gel. …”
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From gut to proteomics: the impact of Roseburia intestinalis on post-translational modifications in colorectal cancer by Lu Li, Lu Li, Yong Zhang, Yong Zhang, Qianqian Wu, Qianqian Wu, Ziyu Jin, Ziyu Jin, Hongbing Xia, Huili Wu, Huili Wu, Kunkun Li, Kunkun Li, Lihong Wang, Lihong Wang

“…These findings offer insights into the underlying mechanisms that may influence CRC progression.…”
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Case Report: Hydroa vacciniforme-like lymphoproliferative disorder, an EBV-associated disease, successfully treated with hematopoietic stem cell transplantation by Eduardo Liquidano-Perez, Eduardo Liquidano-Perez, Gibert Maza-Ramos, Marco Yamazaki-Nakashimada, Rodolfo Rodríguez-Jurado, Alfonso G. Ramírez Ristori, Juan Carlos Bustamante-Ogando, Mario Ernesto Cruz-Munoz, Arturo Gutierrez-Guerrero, Marimar Saez-de-Ocariz, Sara Espinosa-Padilla, Nideshda Ramirez-Uribe, Selma C. Scheffler-Mendoza

“…IntroductionThe hydroa-vacciniforme-like lymphoproliferative disorder (HVLD) is a rare NK/T-cell condition affecting children in Latin America and Asia. It often progresses to systemic lymphoma, with Latin American patients experiencing worse outcomes compared to East Asians. …”
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Postoperative hepatitis B virus reactivation and its impact on survival in HBV-related hepatocellular carcinoma patients undergoing conversion therapy with interventional therapy c... by Shaowei Xu, Qingqing Pang, Meng Wei, Danxi Liu, Du Yuan, Tao Bai, Xiaobo Wang, Zhihong Tang, Feixiang Wu

“…Patients experiencing HBVr exhibited significantly shorter progression-free survival compared to those without reactivation. …”
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Clinical features of HAdV-55 in children with respiratory tract infections: a retrospective case series and literature review by Lifen Rao, Yueqiang Fu, Ying Lu, Jianhua Wei, Zhongying Yang, Mengling Qi, Chengjun Liu, Yushun Wan, Enmei Liu, Na Zang

“…The two critical patients exhibited progressive declines in total blood cell counts, hemoglobin levels and serum albumin levels within a short period. …”
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Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway by Huafang Jia, Mengru Liu, Hong Jiang, Zhen Qiao, Kaiyue Ren, Xixun Du, Xi Chen, Qian Jiao, Fengyuan Che

“…Immunofluorescence was used to detect dopaminergic (DAergic) neurons survival in the substantia nigra. …”
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Connexin46 in the nucleus of cancer cells: a possible role as transcription modulator by Ainoa Fernández-Olivares, Viviana P Orellana, Jesús Llanquinao, Gonzalo Nuñez, Pablo Pérez-Moreno, Sebastián Contreras-Riquelme, Alberto JM Martin, Fabio Mammano, Ivan E Alfaro, Juan F Calderón, Jimmy Stehberg, Mauricio A Sáez, Mauricio A. Retamal

“…Abstract Background Oncogenes drive cancer progression, but few are active exclusively in tumor cells. …”
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Case Report: Multiple peripheral nerve demyelinating lesions and cerebrovascular injury which resulted in extensive cerebral infarction in a XLP1 patient without EBV infection by Jiaxun Li, Dongcan Mo, Luyu Lv, Fuling Huang, Binyan Wu, Chunjuan He, Hao Wu, Wenpeng Pang, Yan Li, Liping Guo, Liping Guo, Man Luo

“…And we are able to gain valuable experience and lessons from the patient’s disease progression and prognosis.…”
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Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells by Peizhuang Zhao, Jiajia Ning, Jun Huang, Xue Huang

“…Its protective effects such as inhibiting pyroptosis in various inflammation-related diseases have been demonstrated, but whether resveratrol (RES) can also alleviate the progression of the disease by inhibiting pyroptosis in UC and the mechanism have rarely been studied. …”
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Clinical value of metagenomic next-generation sequencing in screening oropharyngeal colonization in patients undergoing allogeneic hematopoietic stem cell transplantation: a prospe... by Yuqi Zhang, Jianrong Ge, Yuhang Wang, Zaixiang Tang, Xiao Ma, JIsheng Liu, Depei Wu, Xiaojin Wu

“…Multivariate analysis confirmed oropharyngeal Enterobacteriaceae colonization as an independent risk factor for non-relapse mortality (NRM), overall survival (OS), and progression-free survival (PFS) (P = 0.024, 0.030, and 0.021, respectively). …”
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CLINICAL FEATURES AND MANAGEMENT OF PATIENTS WITH DYSPLASIA OF CERVICAL EPITHELIUM ON THE BACKGROUND OF ABNORMAL MICROBIOCENOSIS OF VAGINA by V. V. Schaefer, V. A. Krutova, L. M. Chuprinenko, T. V. Sobol, N. N. Podmohylny

“…Ill-defined cells were detected during cytological screening. All patients were divided into 2 groups. …”
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Mechanism of telomerase inhibitor BIBR1532 combined with autophagy inhibitor CQ in suppressing survival of melanoma cells by GONG Weihua, CHEN Lan, ZHAO Kun, KE Zhui, XU Qing, GUO Xianling

“…The cell viability was assessed using the cell counting kit-8 (CCK-8) assay, and the cell apoptosis was detected using the Annexin Ⅴ/propidium iodide (PI) double staining method. …”
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Effect of GLP-1/GLP-1R on the Polarization of Macrophages in the Occurrence and Development of Atherosclerosis by Li Yang, Long Chen, Dongfeng Li, Hao Xu, Jishun Chen, Xinwen Min, Meian He, Tangchun Wu, Jixin Zhong, Handong Yang, Jun Chen

“…GLP-1R may regulate the polarization of macrophages toward M2, thus playing a protective role in the progression of coronary atherosclerosis.…”
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Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine by Wenjing Feng, Mengwei Ju, Tao Wang, Shanshan Cui, Kexin Yang, Zhiting Guo, Miao Liu, Jiaxuan Tao, Huiyan Yu, Rong Xiao

“…The potential function of aberrant gut metabolites in oxysterols and m6A methylation driving MCI progression warrants further mechanistic investigation.…”
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Case Reports: Chemokine and Cytokine Profiling in Patients with Herpetic Uveitis by Nguyen NV, Linderman SL, Fashina T, Devine M, Conrady CD, Shantha JG, Ahmed R, Yeh S

“…Case 2 was a 30-year-old female with a two-month history of progressive pain and decreased vision OD. She was diagnosed with hypertensive anterior uveitis after diagnostic anterior chamber paracentesis. …”
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Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…Primary congenital glaucoma (PСG) is a visual organ pathology that leads to progressive blindness and poor vision in children. Its main cause is an anomaly of the anterior chamber angle. …”
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IMPACT OF ANXIETY AND DEPRESSIVE DISORDERS ON THE NEUROPEPTIDE-CYTOKINE STATUS OF IMMUNE SYSTEM IN VARIOUS VARIANTS OF THE CLINICAL COURSE OF CHRONIC ISCHEMIC HEART DISEASE by A. V. Gertsev, V. N. Ischuk, Yu. N. Zakrevskii

“…In such patients, affective disorders significantly may cause progression of atherosclerotic processes, thus complicating the course of cardiac pathology and prognosis. …”
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MiR-103-3p regulates chondrocyte autophagy, apoptosis, and ECM degradation through the PI3K/Akt/mTOR pathway by targeting CPEB3 by Jun Li, Farui Sun, Yuanjin Zhang, Xian Pan, Bo Li, Guofu Zhang, Qian Zhou

“…Abstract Background Chondrocyte apoptosis is associated with the severity of cartilage destruction and matrix degeneration in the progression of osteoarthritis. Increasing evidence indicates that autophagy has a significant cytoprotective effect against chondrocyte apoptosis. …”
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Fusobacterium nucleatum Enrichment in Colorectal Tumor Tissue: Associations With Tumor Characteristics and Survival Outcomes by Amanda I. Phipps, Courtney M. Hill, Genevieve Lin, Rachel C. Malen, Adriana M. Reedy, Orsalem Kahsai, Hamza Ammar, Keith Curtis, Ningxin Ma, Timothy W. Randolph, Jing Ma, Shuji Ogino, Polly A. Newcomb, Meredith AJ. Hullar

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