Cell death and serum markers of collagen metabolism during cardiac remodeling in Cavia porcellus experimentally infected with Trypanosoma cruzi. by Yagahira E Castro-Sesquen, Robert H Gilman, Henry Paico, Verónica Yauri, Noelia Angulo, Fredy Ccopa, Caryn Bern

“…Cardiac levels of CI, CIII, CIV increased progressively, but the highest levels were seen in the chronic phase and were primarily due to increase in CIII and CIV. …”
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Barriers hindering attendance and adherence to antenatal care visits among women in rural areas in Rwanda: An exploratory qualitative study. by Olive Tengera, Pamela Meharry, Aimable Nkurunziza, Yolanda Babenko-Mould, Joselyne Rugema, Stephen Rulisa, Laetitia Nyirazinyoye

“…<h4>Conclusions</h4>The identified factors hindering pregnant women's participation in ANC visits are modifiable in progressive countries such as Rwanda. Continued National support could reduce these barriers, increase ANC attendance, and meet the 2030 Sustainable Development Goal 3.…”
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Subacute Sclerosing Encephalitis in an Adult with Congenital HIV Infection – Case Report by Ihor Hryzhak, Olexandra Pryshlyak, Victoria Gryb, Marianna Prokopovich, Mykola Prokofiev, Olga Matviiuk, Nataliya Diomina, Lilia Hryzhak

“…In the cerebral spinal fluid, anti-measles IgG was detected at a titre of 3738,408 U/ml, and in the blood – 9.4 U/ml. …”
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High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution. by Emanuela Carlotti, David Wrench, Guglielmo Rosignoli, Jacek Marzec, Ajanthah Sangaralingam, Lena Hazanov, Miri Michaeli, Simon Hallam, Tracy Chaplin, Sameena Iqbal, Maria Calaminici, Bryan Young, Ramit Mehr, Peter Campbell, Jude Fitzgibbon, John G Gribben

“…Understanding the dynamics of evolution of Follicular Lymphoma (FL) clones during disease progression is important for monitoring and targeting this tumor effectively. …”
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Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. by Nicola J Platt, Suzana Gispert, Georg Auburger, Stephanie J Cragg

“…We used fast-scan cyclic voltammetry to detect DA release at carbon-fibre microelectrodes in acute striatal slices from two different lines of A53Tα-syn-overexpressing mice, at up to 24 months. …”
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Relationship between neutrophil/lymphocyte ratio and left ventricular hypertrophy in maintenance hemodialysis patients by LI Lei, CAO Fang, LENG Yan-fei

“…Objective To detect the neutrophil/lymphocyte ratio levels in maintenance hemodialysis(MHD)patients,and investigate their relationship with left ventricular hypertrophy(LVH).Methods A total of 96 patients undergoing MHD in Department of Nephrology of the First Hospital of Liangshan Prefecture from January 2018 to August 2019 were selected and divided into the high NLR group(NLR>3.31,n=47)and the low NLR group(NLR≤3.31,n=49).Baseline data,echocardiographic indexes [left atrial end-diastolic diameter(LAEDd),left ventricular end-systolic diameter(LVEDs),ejection fraction(EF),left ventricular mass index(LVMI)],laboratory indexes [NLR,brain natriuretic peptide(BNP),hemoglobin(HB),albumin(Alb),calcium)],blood lipid levels were compared to calculate the LVH incidence.All the patients were divided into LVH group and non LVH group according to whether LVH occurred or not.The high risk factors of LVH were analyzed by multivariate analysis,and the predictive value of NLR to LVH was analyzed by ROC curve.Results NLR was positively correlated with SBP,LAEDd,LVEDs,LVMI,NLR,BNP,Alb,LDL-C,Cholesterol,non-HDL-C,and Cr(P<0.05),and negatively correlated with DBP(P<0.05).The color Doppler ultrasonography indicated that the incidence of LVH in the high NLR group was higher than that in the low NLR group.Age,SBP,LAEDd,LVEDs,LVMI,NLR,BNP,Alb,LDL-C,TC,non-HDL-C,Cr were risk factors for LVH(P<0.05).The relative oddratio(OR)of NLR was the largest.NLR was a predictor of LVH(P<0.05).Conclusions NLR value is closely related to the occurrence and progression of LVH in MHD patients,so the monitoring of the NLR changes has significant value in the prevention and treatment of LVH.…”
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Investigation of the Pathogenesis of Liver Fibrosis Associated with Type 2 Diabetes Mellitus via Bioinformatic Analysis by Zhiyu Xiong, Kan Shu, Yingan Jiang

“…The upregulation of <i>THBS1</i> was observed in both diseases, and it is closely related to the progression of liver fibrosis and T2DM. Transcription factor analysis detected 29 regulators of these hub genes. …”
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An Overview About Figure-of-Eight Walk Test in Neurological Disorders: A Scoping Review by Gabriele Triolo, Roberta Lombardo, Daniela Ivaldi, Angelo Quartarone, Viviana Lo Buono

“…Sensitive to subtle functional changes, it is suitable for tracking disease progression and intervention efficacy. Conclusions: F8WT is reliable and clinically relevant, effectively identifying subtle, complex walking impairments in neurological disorders.…”
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Cladribine tablets in the new multiple sclerosis era by Fabio Buttari, Ettore Dolcetti, Francesca Romana Rizzo, Caterina Rizzi, Gianluca Lauritano, Angela Borrelli, Federica Azzolini, Roberta Fantozzi, Francesco Assogna, Antonella Conte, Diego Centonze

“…By synthesizing data from clinical trials and real-world studies, this review underscores the effectiveness of CladT in reducing relapse rates, disability progression and magnetic resonance imaging-detected disease activity and emphasizes the importance of early high-efficacy treatment for optimizing long-term outcomes. …”
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Cordycepin ameliorates diabetic nephropathy injury by activating the SLC7A11/GPX4 pathway by Bing Wu, Jing Wang, Xiaohui Yan, Gang Jin, Qiong Wang

“…Here, this work focused on probing the specific effects and potential mechanisms of CRD on DN progression. Methods High glucose (HG)‐induced mouse podocyte cell line (MPC5) was used for in vitro functional analyses. …”
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Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies. by Amy E Gilbert, Panagiotis Karagiannis, Tihomir Dodev, Alexander Koers, Katie Lacy, Debra H Josephs, Pooja Takhar, Jenny L C Geh, Ciaran Healy, Mark Harries, Katharine M Acland, Sarah M Rudman, Rebecca L Beavil, Philip J Blower, Andrew J Beavil, Hannah J Gould, James Spicer, Frank O Nestle, Sophia N Karagiannis

“…These data demonstrate the presence of a mature systemic B cell response in melanoma patients, which is reduced with disease progression, adding to previous reports of tumor-reactive antibodies in patient sera, and suggesting the merit of future work to elucidate the clinical relevance of activating humoral immune responses to cancer.…”
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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. by Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani

“…Protein kinase B (PKB/Akt) is a pivotal regulator of diverse metabolic, phenotypic, and antiapoptotic cellular controls and has been shown to be a key player in cancer progression. Here, using fluorescent reporters, we shown in cells that, contrary to in vitro analyses, 3-phosphoinositide-dependent protein kinase 1 (PDK1) is complexed to its substrate, PKB. …”
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Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict by Halla Gh. Mahmood, Shahbaa W. Sami

“…Conclusions: The results indicate that METH addiction leads to elevated laminin levels and liver enzyme activity, suggesting progressive liver fibrosis and injury correlating with the duration of substance abuse. …”
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Pattern recognition receptors: function, regulation and therapeutic potential by Ruochan Chen, Ju Zou, Jiawang Chen, Xiao Zhong, Rui Kang, Daolin Tang

“…Abstract Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). …”
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Adaptation to Climate Change in Coastal Countries of the European Union—An Evaluation of Plans and Strategies by Concepción Natalia Rodríguez-Rojo, María Luisa Pérez-Cayeiro, Juan Adolfo Chica-Ruiz

“…The results of this study indicate that there has been a notable and progressive increase in the adoption of adaptation plans and strategies that address problems faced by coastal areas. …”
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Pediatric HIV Infection Findings At The Time Of Diagnosis In A Tertiary Care Center In Turkey by Neslihan Mete Atasever, Elif Dede, Behiye Benaygül Kaçmaz, Ayper Somer, Selda Hançerli Törün

“…BACKGROUND: HIV, one of the important public health problems seen all over the world, progresses more rapidly and mortality is higher in children. …”
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Novel EPG5 Mutation Associated with Vici Syndrome Gene by Frouzandeh Mahjoubi, Samira Shabani, Sogand Khakbazpour, Aylar Khaligh Akhlaghi

“…Vici syndrome (also known as immunodeficiency with cleft lip/palate, cataract, and hypopigmentation and absent corpus callosum) is considered as a progressive neurodevelopmental multisystem disorder. …”
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STUDYING THE PREVALENCE AND NEGATIVE IMPACT OF DIFFERENT TYPES OF TOBACCO PRODUCTS ON ADOLESCENT HEALTH by D.O. Klymko

“…Developing diagnostic methods for detecting pulmonary fibrosis in pediatric patients with bronchial asthma is crucial, as it enables early identification of fibrotic changes, slows disease progression, and enhances the quality of life in affected children.…”
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Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases by WU Xiao-zhen, LIU Gang, LIU Man, TAO Lin, JIANG Jin-fang, YANG Xiao-ping

“…Immunohistochemistry was used to detect wnt4 and β-catenin in renal tissues in each group. …”
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CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1 by Rui Wang, Fei Wang

“…This work aspired to identify novel oncogenic circRNA driving NPC progression. Methods Bioinformatics analysis was performed to explore and predict underlying circRNA and downstream targets. …”
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