Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases by Xiaolong Liu, Jianguo Lu, Xinyu Dong, Yizhuo Zhang, Guixing Jiang, Yanlong Cao, Defei Hong

“…Background Pancreatic cancer is very difficult to detect in its early stages, and its rapid progression and poor prognosis make it a significant therapeutic challenge. …”
Get full text

Observation and treatment of patients with progressive metastatic differentiated thyroid cancer after establishment of radioiodine refractoriness by E. V. Borodavina, S.  I. Kutukova, A. Yu. Shurinov, E. B. Vasil’eva, A. O. Guz, I. V. Grishkevich, S. D. Karateeva, A. R. Shakhmatova, R. S. Slobodyanskiy, O. V. Romanchuk, M. R. Mukhitova, M. P. Karpovich, S. P. Dmitriev, O. S. Saypeeva, K. A. Tolpeykina, S. S. Tolstov, A. V. Makarova, Ya. A. Tyugina, E. G. Ovchinnikova

“…During both treatment and dynamic observation, distant metastases are detected in 10–15 % of patients. In these cases, the patients continue treatment with radioactive iodine. …”
Get full text

Diagnostic value of serum origin recognition complex protein 1 in the progression of HBVrelated liver fibrosis by LIANG Hongqian, HUANG Long, REN Aoli, SU Minghua, HU Bobin, LI Qingmei, SU Tumei, YIN Qianbing, LI Aining, JIANG Jianning

“…Conclusion The level of serum ORC1 in patients with chronic HBV infection is related to the progression of liver fibrosis, and its elevated level increases the risk of progression of liver fibrosis. …”
Get full text

POLE2 silencing inhibits the progression of colorectal carcinoma cells via wnt signaling axis by Weihua Jian, Lei Zhang

Get full text

Isolated Subtalar Repositional Arthrodesis Compared with Triple Arthrodesis for the Treatment of Progressive Collapsing Foot Deformity by Sunghoo Kim MD, HoSeong Lee MD, PhD

“…Category: Hindfoot; Midfoot/Forefoot Introduction/Purpose: The optimal extent of arthrodesis for severe and rigid progressive collapsing foot deformity is controversial. …”
Get full text

Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma. by Thomas C Booth, Timothy J Larkin, Yinyin Yuan, Mikko I Kettunen, Sarah N Dawson, Daniel Scoffings, Holly C Canuto, Sarah L Vowler, Heide Kirschenlohr, Michael P Hobson, Florian Markowetz, Sarah Jefferies, Kevin M Brindle

“…<h4>Purpose</h4>To develop an image analysis technique that distinguishes pseudoprogression from true progression by analyzing tumour heterogeneity in T2-weighted images using topological descriptors of image heterogeneity called Minkowski functionals (MFs).…”
Get full text

Potential role of matrix metalloproteinase-8 as a predictive marker for peri-implant mucositis progress by Noor I Dhaidan, Ghada I Taha, Maher AL Shayeb

“…The purpose of this study was to detect the role of MMP-8 as a biomarker of active and aggressive peri-implant mucositis. …”
Get full text

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression by Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang

“…Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective therapies. …”
Get full text

MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions by Hai-Yu Mo, Ruo-Bing Wang, Meng-Yao Ma, Yi Zhang, Xin-Yu Li, Wang-Rong Wen, Yi Han, Tian Tian

“…Here, we aimed to identify the key metabolic enzymes that protect gastric cancer (GC) cells from oxidative stress.Methods: ROS level was detected by DCFH-DA probes. Multiple cell biological studies were performed to identify the underlying mechanisms. …”
Get full text

DNMT3B promotes the progression of pheochromocytoma by mediating the hypermethylation of LRP1B promoter by Min Sun, Yanrong Ma, Jing Wan, Bingli Zheng, Zhenfeng Shi, Jiuzhi Li

“…As a tumor suppressor gene, LRP1B is involved in the regulation of tumor progression. However, the precise regulatory mechanism of LRP1B in Pheo remains elusive. …”
Get full text

RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers by Xueda Hu, Jingyi Chen, Xiaoshun Shi, Fenglan Feng, King Wai Lau, Yaoqi Chen, Yusong Chen, Long Jiang, Fei Cui, Yalei Zhang, Xin Xu, Jin Li

Get full text

Research progress on formation mechanism of health factor 2,3,5,6-tetramethylpyrazine in Baijiu by HU Zhihui, CHEN Fang, GUO Xuefeng, ZHAO Tengfei, LUO Zhenbiao, WU Deguang

Get full text

Construction of a Dual-Fluorescence Reporter System to Monitor the Dynamic Progression of Pluripotent Cell Differentiation by Wu-Sheng Sun, Ju-Lan Chun, Jeong-Tae Do, Dong-Hwan Kim, Jin-Seop Ahn, Min-Kyu Kim, In-Sul Hwang, Dae-Jin Kwon, Seong-Soo Hwang, Jeong-Woong Lee

Get full text

C20orf27 promotes hepatocellular carcinoma progression via NT5E by Yu He, Wen Zhang, Ming Chang, Yuanjie Chen, Risheng Lin, Xinyu Ye, Wei Mao, Yubin Lu, Yi Lu, Erbao Chen

“…In this study, we identified C20orf27 as a critical gene that facilitates liver cancer progression. We detected that C20orf27 was upregulated in liver cancer samples. …”
Get full text

MICROVASCULAR CHANGES AND DIABETIC RETINOPATHY AND NEPHROPATHY PROGRESSION IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS by Valeria Draganova, Dimitar Dzhelebov, Hristinka Krasimirova Borisova-Zhecheva, Petya Goycheva

“…Conclusion: It is important to detect microvascular changes and start appropriate treatments early in the development of DR in children and young adults with T1DM to prevent progression. …”
Get full text

Clinical and diagnostic study of ovine chronic progressive pneumonia (Maedi-Visna) in sheep of Basrah, Iraq by Kamal M. AlSaad, Ali J. Lafta, Mohand H. Lafta, Jihad A. Ahmed

“…Moreover, Variable whitish patches on the parietal surface of the affected lung were also detected. The histopathological appearance shows lobar pneumonia consists of progressive inflammatory exudation filling the lobar alveolar spaces with severe infiltration of inflammatory cells and erythrocytes inside alveolar spaces. …”
Get full text

Analysis of the circadian rhythm of intraocular pressure in stable and progressive forms of primary open-angle glaucoma by T. N. Malishevskaya, D. G. Gubin, I. V. Nemcova, A. S. Vlasova, Ju. E. Filippova, E. E. Farikova, D. S. Bogdanova

“…To analyze the daily dynamics and the parameters of intraocular pressure circadian rhythm (IOP CR) in patients with primary open-angle glaucoma (POAG) (stable and progressive forms) and determine chronobiological regularities of glaucoma progression depending on the patterns of restructuring the daily dynamics of IOP CR and body temperature.Material and methods. …”
Get full text

ZSCAN16 expedites hepatocellular carcinoma progression via activating TBC1D31 by Xiaofang Wang, Bo Xiao, Fuping Zhong, Yong Zhou, Qibo Wang, Jihao Jiang

“…This paper sought to expound the function of Zinc finger and SCAN domain-containing protein 16 (ZSCAN16) and TBC1 domain family member 31 (TBC1D31) in HCC progression. Methods ZSCAN16 and TBC1D31 levels were detected by RT-qPCR, Western blot, and immunohistochemistry. …”
Get full text

Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases. by Euiheon Chung, Hiroshi Yamashita, Patrick Au, Bakhos A Tannous, Dai Fukumura, Rakesh K Jain

“…Thus techniques that can sensitively detect metastatic colonization and assess treatment response in real-time are urgently needed. …”
Get full text

Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis by Dan-Dan Yao, Xiao-Wei Yan, Yan Zhou, Zuo-Lin Li, Fang-Xin Qiu

“…Background Vascular calcification is common and progressive in patients with chronic kidney disease. …”
Get full text