Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway by Zhiliang Sun, Zhongshi Zhou, Kezheng Liao, Yanju Liu, Yanyun Liu, Chaoyang Wang, Zhihua Zhang, Zhihua Zhang, Li Wen

“…These findings suggest that EPT might hold potential value for the prevention and treatment of NAFLD.PurposeThis study aims to investigate the role of EPT in NAFLD and its multi - target synergistic mechanisms, and to preliminarily explore its impact on the early progression of NAFLD.MethodsThe detection of EPT components in rat blood was performed by UPLC-MS/MS. …”
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Comparative evaluation of three polymerase chain reaction primer sets for accurate molecular detection of Trypanosoma lewisi in wild rodents in Indonesia by Aditya Yudhana, Gusti Ayu Illiyin Putri Santosa, April Hari Wardhana, Frenky Laksana Putra, Ryanka Edila, Dyah Haryuningtyas Sawitri, Ratih Novita Praja, Muhammad Aqil Kurnianto, Aldi Gusnizar Rizaldy Tanjung, Marc Desquesnes, Makoto Matsubayashi

“…CATLew F/CATLew R detected 29 positives with 96.43% sensitivity and 97.22% specificity, whereas TC121/TC122 detected 21 positives, yielding 67.86% sensitivity and 97.22% specificity. …”
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Systemic lupus erythematosus complicated by severe Guillain-Barré syndrome: case report and literature review by Lifeng He, Zengrui Zhang, Ying Tan

“…Furthermore, we summarize the clinical characteristics of severe SLE-GBS reported thus far and propose the possibility of using medium-to-high dose corticosteroids in the acute progression stage of SLE-GBS. This report provides valuable insights for the analysis of disease characteristics and guidance for diagnosis and treatment of such cases.…”
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The possibility of using skin biopsy in the diagnosis of Lafora disease by L. S. Kraeva, S. V. Vtorushin, A. V. Kuzmina, D. V. Kozyritskaya

“…The diagnosis is made following visual, generalized tonic-clonic and myoclonic seizures, progressing dementia, cerebellar ataxia, detection of specific Lafora bodies during sweat gland biopsy and data of genetic testing.The article describes a clinical case of Lafora disease in a patient with disease onset at 11 years old caused by the mutation in the EPM2A (laforine) gene with focal sensory visual seizures with subsequent generalized tonic-clonic seizures, progressive motor impairments in the form of ataxia and gait abnormality as well as behavioral and cognitive disorders. …”
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An evaluation of hunter surveys to monitor relative abundance of bobcats by Tyler J. Mahard, John A. Litvaitis, Patrick Tate, Gregory C. Reed, Derek J. A. Broman

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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…However, its function in ESCC progression and tumor microenvironment (TME) remains to be explored. …”
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hsa_circ_0000518 Facilitates Non-Small-Cell Lung Cancer Progression via Moderating miR-330-3p and Positively Regulating SLC1A5 by Huilai Lv, Zhihua Shi, Aixia Sui, Yan Zhang, Liangbiao Peng, Mingbo Wang, Fan Zhang

“…Immunohistochemical staining for Ki67, vimentin, and E-cadherin was used to detect cell proliferation and metastasis, respectively. …”
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Comparison of Labour Progression between Nulliparous Pregnant Women of Advanced Maternal Age and Young Nulliparous Women with Spontaneous Vaginal Delivery: A Retrospective Study in... by Ryosuke Arakaki, Wataru Isono, Hiroaki Fukuda, Junya Tanaka, Arisa Minamino, Shiko Hayashi

“…Conclusions: We did not detect a clear impact of maternal age on labour progression in the groups of nulliparous women who had spontaneous vaginal delivery after women who underwent emergency caesarean section or intravenous uterotonic agent administration were excluded; however, further studies with larger sample sizes of women of advanced maternal age may be needed.…”
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Detection of SARS-CoV-2 RNA in wastewater from an enclosed college campus serves as an early warning surveillance system. by Jacob Kazenelson, Tori Jefferson, Ryan G Rhodes, Lawrence B Cahoon, Arthur R Frampton

“…Post-collection, total RNA was extracted and SARS-CoV-2 RNA in the samples was detected by qPCR. SARS-CoV-2 signal was detected on campus beginning on August 19 as classes began and the signal increased in both intensity and breadth as the Fall semester progressed. …”
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LncRNA APTR amplification serves as a potential glioma biomarker and promotes glioma progression via miR-6734-5p/ TCF7/LEF1 axis by Heng Chen, Mengzhen Huang, Jiayi Li, Shanshan Zhang, Cuiyun Sun, Wenjun Luo, Lin Yu

“…Background: Alu-mediated p21 transcriptional regulator (APTR) overexpression is detected in different human cancers; however, few reports have investigated APTR gene amplification conditions. …”
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P560: Implementing homocysteine into first-tier mass spectrometry tests in newborn screening for detection of homocystinurias in New York State by Jing Xiao, C. Austin Pickens, Konstantinos Petritis, Matthew Wojcik, Carlos Saavedra-Matiz, Joseph Orsini, Michele Caggana

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Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8+ T cells by granzyme B and perforin by Chang Zhang, Yeli Wang, Yao Yu, Yanchao Pang, Xiao Xiao, Leilei Hao

“…Background Rectal adenocarcinoma (READ) involves the dysregulated expression of alpha 2,8-Sialyltransferase1 (ST8Sia1) although its role during READ’s progression is unclear.Methods The mRNA level of ST8Sia1 was analyzed based on The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Tumor Immune Estimation Resource (TIMER) 2.0. …”
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IGF2BP3/CTCF Axis–Dependent NT5DC2 Promotes M2 Macrophage Polarization to Enhance the Malignant Progression of Lung Squamous Cell Carcinomas by Jifeng Sun, Hao Wang, Ran Zhang, Xiaoxuan Sun, Zhanbo Wu, Jun Wang, Yuwen Wang

“…The effect of NT5DC2 on the malignant progression of LUSC cells was analyzed using a xenograft mouse model assay. …”
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Effects of Secukinumab on Enthesiophyte and Erosion Progression in Psoriatic Arthritis-A One-year Double-blind, Randomized, Placebo-controlled Trial Utilizing High-resolution Perip... by Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K Ying, Kitty Y Kwok, James Griffith, Vivian Hung, Cheuk-Chun Szeto, Jack Jock-Wai Lee, Ling Qin, Lai-shan Tam

“…HR-pQCT of the MCPJ 2-4 were performed at baseline, week-24 and 1-year. Progression of enthesiophyte were defined as changes in enthesiophyte volume exceeding smallest detectable change (SDC) (0.12mm3) or the identification of any new enthesiophyte. …”
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LncRNA A2ml2 inhibits fatty liver hemorrhage syndrome progression and function as ceRNA to target LPL by sponging miR-143-5p by Qingxing Xiao, Sibao Yang, Yuwei Yang, Hongyu Ni, Zongdi Li, Chengwen Wang, Wuyang Liu, Yuxin Han, Yumei Li, Yonghong Zhang

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Early detection and classification of Alzheimer’s disease through data fusion of MRI and DTI images using the YOLOv11 neural network by Wided Hechkel, Abdelhamid Helali

“…Early detection and classification of AD are crucial for improving patient outcomes and slowing disease progression. …”
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Colorimetric Reverse Transcription Loop-Mediated Isothermal Amplification with Xylenol Orange Targeting Nucleocapsid Gene for Detection of Feline Coronavirus Infection by Kotchaporn Khumtong, Witsanu Rapichai, Wichayet Saejung, Piyamat Khamsingnok, Nianrawan Meecharoen, Siriluk Ratanabunyong, Hieu Van Dong, Supansa Tuanthap, Amonpun Rattanasrisomporn, Kiattawee Choowongkomon, Oumaporn Rungsuriyawiboon, Jatuporn Rattanasrisomporn

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Detection of structural-functional coupling abnormalities using multimodal brain networks in Alzheimer’s disease: A comparison of three computational models by Yinping Lu, Luyao Wang, Toshiya Murai, Jinglong Wu, Dong Liang, Zhilin Zhang

“…Our results showed that the communication and graph harmonic models demonstrated greater heterogeneity and were more sensitive than the statistical models in detecting AD-related pathological changes. In addition, S-F coupling increases with AD progression at the global, subnetwork, and regional node levels, especially in the medial prefrontal and anterior cingulate cortices. …”
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Early Detection for Determinant Factor of National Health Insurance Membership for Workers in Central Java Using C4.5 Algorithm by Aprianti Aprianti, Sifai Izzatul Alifah, Nurjanah Nurjanah, Ratna Wulan Widya, Ratnawati Juli, Ahsan Abdillah

“…At the same time, the AUC curve has a value of 0.941, which, according to Gorunescu, is included in the Superior Classification. The program is expected to prioritize fishermen groups as members of the NHI program.…”
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Computer Vision Algorithm for the detection of fracture cracks in Oil Hardening Non-Shrinking (OHNS) die steel after machining process by Akshansh Mishra, Vijaykumar S Jatti, Nitin K Khedkar, Rahul B. Dhabale, Ashwini V Jatti

“…This type of neural network receives input from an image and extracts features from the image while also providing learnable parameters to effectively do the classification, detection, and many other tasks. In the present work, U-Net convolutional neural network is implemented on Jupyter platform by using Python programming for fracture surface image segmentation in Oil Hardening Non-Shrinking (OHNS) die steel after the machining process. …”
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