Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics by Shuangsang Fang, Mengyang Xu, Lei Cao, Xiaobin Liu, Marija Bezulj, Liwei Tan, Zhiyuan Yuan, Yao Li, Tianyi Xia, Longyu Guo, Vladimir Kovacevic, Junhou Hui, Lidong Guo, Chao Liu, Mengnan Cheng, Li’ang Lin, Zhenbin Wen, Bojana Josic, Nikola Milicevic, Ping Qiu, Qin Lu, Yumei Li, Leying Wang, Luni Hu, Chao Zhang, Qiang Kang, Fengzhen Chen, Ziqing Deng, Junhua Li, Mei Li, Shengkang Li, Yi Zhao, Guangyi Fan, Yong Zhang, Ao Chen, Yuxiang Li, Xun Xu

“…To optimize this framework, we devise a universal container, a scope controller, and an integrative transformer tailored for multi-sample multimodal data storage, management, and processing. Stereopy showcases three representative applications: investigating specific cell communities and genes responsible for pathological changes, detecting spatiotemporal gene patterns by considering spatial and temporal features, and inferring three-dimensional niche-based cell-gene interaction network that bridges intercellular communications and intracellular regulations. …”
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Bering: joint cell segmentation and annotation for spatial transcriptomics with transferred graph embeddings by Kang Jin, Zuobai Zhang, Ke Zhang, Francesca Viggiani, Claire Callahan, Jian Tang, Bruce J. Aronow, Jian Shu

“…To streamline segmentation processes, we construct expansive pre-trained models, which yield high segmentation accuracy in new data through transfer learning and self-distillation. …”
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Investigating the effect of cochlear implant usage metrics on cortical auditory-evoked potential responses in adult recipients post-implantation by Caris Bogdanov, Caris Bogdanov, Helen Goulios, Wilhelmina H. A. M. Mulders, Dayse Tavora-Vieira, Dayse Tavora-Vieira, Dayse Tavora-Vieira

“…CI usage frequency was defined as the average number of hours per day of audio processor use, which was recorded using the CI programming software.ResultsOverall, 27 participants (65.85%) exhibited detectable eCAEP responses across one or more electrode contacts. …”
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Disulfidptosis-based molecular clustering and prognostic signatures predict patient survival and the immune landscape in patients with colon cancer by Liang Wen, Yongli Ma, Jinghui Li, Dengzhuo Chen, Chengzhi Huang, Ping Wang, Suqi Wen, Gexin Wen, Jizhen Guo, Guosheng Zhang, Junjiang Wang, Xueqing Yao

“…Abstract Introduction Disulfidptosis is a unique type of programmed cell death that is distinct from previously known forms of cell death, such as pyroptosis, apoptosis, and necroptosis. …”
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The ALMA Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO). II. Dust and Gas Disk Properties in the Ophiuchus Star-forming Region by Dary A. Ruiz-Rodriguez, Camilo González-Ruilova, Lucas A. Cieza, Ke Zhang, Leon Trapman, Anibal Sierra, Paola Pinilla, Ilaria Pascucci, Laura M. Pérez, Dingshan Deng, Carolina Agurto-Gangas, John Carpenter, Benoît Tabone, Giovanni P. Rosotti, Rossella Anania, James Miley, Kamber Schwarz, Aleksandra Kuznetsova, Miguel Vioque, Nicolas Kurtovic

“…In addition, we have detected outflows in three disks from ^12 CO observations.…”
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Metformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway by Xin Wang, Siyuan Li, Dong Fan, Yuyou Luo, Huitong Chen, Zhongyu Wang, Xingyi Yuan, Jing Liu, Zongming Wang

“…Methods Immunohistochemical staining was conducted on clinical samples from non-functioning pituitary adenomas (NFPA) patients and normal individuals to assess IL-6 and Programmed Death-Ligand 1(PD-L1) expression. PDFS cells were treated with IL-6 to evaluate their effects on cell viability, proliferation, and migration through various assays. …”
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Assessment and Application of Acylcarnitines Summations as Auxiliary Quantization Indicator for Primary Carnitine Deficiency by Haijuan Zhi, Siyu Chang, Ting Chen, Lili Liang, Wenjuan Qiu, Huiwen Zhang, Xuefan Gu, Lianshu Han

“…Background: Newborns are referred primary carnitine deficiency (PCD) when a low free carnitine (C0) concentration (<10 μmol/L) is detected, leading to high false-positive referrals. …”
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CECILIA: Ultradeep Rest-optical Spectra of Faint Galaxies at Cosmic Noon by Menelaos Raptis, Ryan F. Trainor, Allison L. Strom, Gwen C. Rudie, Noah S. J. Rogers, Charles C. Steidel, Michael V. Maseda, Caroline von Raesfeld, Nathalie A. Korhonen Cuestas

“…We present ultradeep JWST/NIRSpec spectroscopy of nine low-luminosity galaxies (−17 ≲  M _UV  ≲ −20, M _⋆  ≲ 10 ^9 M _⊙ ) at z  ∼ 2.5 from the CECILIA program, with ∼29.5 hr in G235M/F170LP and 1 hr in G395M/F290LP. …”
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Isolation and Characterization of L-Asparaginase-Producing Bacteria from the Arabian–Persian Gulf Region: First Report on <i>Bacillus xiamenensis</i> ASP-J1-4 as a Producer and Its... by Ghofran M. Al-Harbi, Essam Kotb, Abeer A. Almiman, Mahmoud M. Berekaa, Salwa Alhamad, Nada F. Alahmady, Meneerah A. Aljafary, Nadiyah M. Alqazlan, Reem I. Alyami, Joud M. Alqarni, Ebtesam Abdullah Al-Suhaimi

“…This study introduces the first deep screening program for L-ASNase-producing bacteria harboring in the Arabian–Persian Gulf region. …”
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Genetic diversity insights from population genomics and machine learning tools for Nordic Arctic charr (Salvelinus alpinus) populations by Christos Palaiokostas, Khrystyna Kurta, Fotis Pappas, Henrik Jeuthe, Ørjan Hagen, José Beirão, Matti Janhunen, Antti Kause

“…Furthermore, in the case of the Finnish population, the sampled animals originated from the only active conservation program for Arctic charr in the country with a potential interest in farming. …”
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UNCOVER: A NIRSpec Census of Lensed Galaxies at z = 8.50–13.08 Probing a High-AGN Fraction and Ionized Bubbles in the Shadow by Seiji Fujimoto, Bingjie Wang, John R. Weaver, Vasily Kokorev, Hakim Atek, Rachel Bezanson, Ivo Labbe, Gabriel Brammer, Jenny E. Greene, Iryna Chemerynska, Pratika Dayal, Anna de Graaff, Lukas J. Furtak, Pascal A. Oesch, David J. Setton, Sedona H. Price, Tim B. Miller, Christina C. Williams, Katherine E. Whitaker, Adi Zitrin, Sam E. Cutler, Joel Leja, Richard Pan, Dan Coe, Pieter van Dokkum, Robert Feldmann, Yoshinobu Fudamoto, Andy D. Goulding, Gourav Khullar, Danilo Marchesini, Michael Maseda, Themiya Nanayakkara, Erica J. Nelson, Renske Smit, Mauro Stefanon, Andrea Weibel

“…We present JWST NIRSpec prism spectroscopy of lensed galaxies at z ≳ 9 found behind the massive galaxy cluster Abell 2744 in the UNCOVER Cycle 1 Treasury Program. We confirm the redshift via emission lines and/or the Ly α break for 10 galaxies at z = 8.50–13.08 down to M _V = −17.3. …”
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Linking Diet and Homocysteine to complexity of coronary artery disease using SYNTAX score – A cross sectional study by Sowndarya Kollampare, Anupama Hegde, Arpit Jain, Padmanabh Kamath, Ramya Shenoy, Poornima A. Manjrekar

“…Results: HHcy (>15 μmol/L) was detected in 82 CAD patients and the point estimate of odds ratio was 1.157 with 95 % CI (1.056–1.267) of CAD. …”
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Gender features of the influence of depressive and dissominal symptoms on the quality of life of patients with psoriasis by N. S. Olshevskaya, N. A. Olshevsky, D. V. Prohorov, V. N. Klinkov, H. N. Primysheva, D. A. Sarachan, A. M. Kulichenko, S. G. Chinov

“…Consequently, it is advisable to include effects aimed at normalizing mood and sleep in the program of complex therapy of psoriasis, taking into account gender differences.…”
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<i>Rotavirus alphagastroenteritidis</i>: Circulating Strains After the Introduction of the Rotavirus Vaccine (Rotarix^®) in Luanda Province of Angola by Dikudila G. Vita, Cristina Santiso-Bellón, Manuel Lemos, Zoraima Neto, Elsa Fortes-Gabriel, Miguel Brito, Cruz S. Sebastião, Jesus Rodriguez-Diaz, Celso Cunha, Claudia Istrate

“…<i>alphagastroenteritidis</i> vaccine since 2014 as part of its routine childhood immunization program, no follow-up study has been conducted. The aim of this study was to evaluate the distribution of <i>R. alphagastroenteritidis</i> genotypes among children under five years of age, hospitalized with acute gastroenteritis (AGE), after the introduction of the rotavirus vaccine. …”
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Prediction of PD-L1 tumor positive score in lung squamous cell carcinoma with H&E staining images and deep learning by Qiushi Wang, Xixiang Deng, Pan Huang, Qiang Ma, Lianhua Zhao, Yangyang Feng, Yiying Wang, Yuan Zhao, Yan Chen, Peng Zhong, Peng He, Mingrui Ma, Peng Feng, Hualiang Xiao

“…BackgroundDetecting programmed death ligand 1 (PD-L1) expression based on immunohistochemical (IHC) staining is an important guide for the treatment of lung cancer with immune checkpoint inhibitors. …”
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An intracellular bacterial pathogen triggers RIG-I/MDA5-dependent necroptosis by Hang Xu, Huili Li, Boguang Sun, Li Sun

“…RIG-I and MDA5 are members of RIG-I-like receptors (RLRs) that detect viral RNA within the cytoplasm and subsequently initiate antiviral immune responses. …”
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The efficacy and peripheral blood predictors in recurrent platinum-resistant ovarian cancer patients treated with immune checkpoint inhibitors by Baoyue Pan, Xiaojing Zheng, Yongwen Huang, Wei Wei, Shije Xu, Siyu Chen, Jiaxin Yin, Yu Zhang, Jundong Li, Min Zheng

“…A multi-analyte flow assay was used to detect the concentrations of 13 inflammatory cytokines. …”
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FEASTS Combined with Interferometry. III. The Low Column Density H i Around M51 and Possibility of Turbulent-mixing Gas Accretion by Xuchen Lin, Jing Wang, Lister Staveley-Smith, Suoqing Ji, Dong Yang, Xinkai Chen, Fabian Walter, Hsiao-Wen Chen, Luis C. Ho, Peng Jiang, Nir Mandelker, Se-Heon Oh, Bo Peng, Céline Péroux, Zhijie Qu, Q. Daniel Wang

“…With a new joint-deconvolution pipeline, we combine the single-dish and interferometric atomic hydrogen (H i ) data of M51 observed by the Five-hundred-meter Aperture Spherical radio Telescope (FAST) (FEASTS program) and the Very Large Array (VLA) (THINGS). …”
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A High Incidence of Dusty Hα Emitters at z > 3 Among UltraVISTA Dropout Galaxies in COSMOS Revealed by JWST by Sophie E. van Mierlo, Karina I. Caputi, Matthew L. N. Ashby, Vasily Kokorev, Rafael Navarro-Carrera, Pierluigi Rinaldi

“…We have characterized 26 Spitzer/IRAC-selected sources from the SMUVS program that are undetected in the UltraVISTA DR5 H - and/or K _s -band images, covering 94 arcmin ^2 of the COSMOS field, which have deep multiwavelength JWST photometry. …”
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Genome-wide identification and characterization of BASIC PENTACYSTEINE transcription factors and their binding motifs in coconut palm by Zifen Lao, Jiali Mao, Runan Chen, Ran Xu, Zhuang Yang, Ying Wang, Junjie Zhou, Zhihua Mu, Hang Xu, Fengmei Li, Dongyi Huang, Yong Xiao, Jie Luo, Wei Xia

“…IntroductionBASIC PENTACYSTEINE (BPC) is a small transcription factor family known for its role in various developmental processes in plants, particularly in binding GA motifs and regulating flower and seed development. …”
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